Fzd2 (frizzled class receptor 2) - Rat Genome Database

Name: Fzd2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fzd2 (frizzled class receptor 2) Rattus norvegicus

Analyze

Symbol:

Fzd2

Name:

frizzled class receptor 2

RGD ID:

71012

Description:

Enables Wnt receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, non-canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled family receptor 2; frizzled homolog 2; frizzled homolog 2 (Drosophila); frizzled-2; Fz-10; fz-2; Fzd10; rFz2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD2 (frizzled class receptor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fzd2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fzd2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FZD2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd2 (frizzled class receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FZD7 (frizzled class receptor 7)	HGNC	OrthoDB
Homo sapiens (human):	KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	FZD2 (frizzled class receptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fzd2 (frizzled class receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd2 (frizzled class receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fz	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fzd2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	87,561,866 - 87,563,776 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	87,561,326 - 87,565,334 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	92,598,641 - 92,600,551 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,064,095 - 92,066,005 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	87,457,426 - 87,459,336 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	90,550,147 - 90,552,057 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	90,550,147 - 90,552,057 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,343,133 - 90,345,043 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	91,709,222 - 91,711,132 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	91,723,591 - 91,725,502 (+)	NCBI
Celera	10	86,269,032 - 86,270,942 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant Robinow syndrome 1 (ISO)

autosomal dominant Robinow syndrome 2 (ISO)

autosomal dominant Robinow syndrome 3 (ISO)

breast carcinoma (ISO)

Colonic Neoplasms (ISO)

COVID-19 (ISO)

Dwarfism (ISO)

genetic disease (ISO)

keratoconus (ISO)

Left Ventricular Hypertrophy (IEP)

leiomyoma (ISO)

myocardial infarction (IEP)

omodysplasia 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

2-nitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-phenylprop-2-enal (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

avobenzone (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

bromochloroacetic acid (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

chloroprene (ISO)

cisplatin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dieldrin (EXP)

diethyl malate (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

fluoranthene (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

graphite (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indometacin (ISO)

L-ascorbic acid (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

mitoxantrone (ISO)

nickel sulfate (ISO)

niclosamide (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

phosgene (ISO)

picrotoxin (EXP)

potassium bromate (ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

Salinomycin (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

simvastatin (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

tamoxifen (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

trichostatin A (ISO)

valproic acid (ISO)

valsartan (ISO)

vanillin (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IBA,IDA,IEA,ISO)

cell-cell signaling (ISO)

cellular response to growth factor stimulus (IEP)

cellular response to peptide hormone stimulus (IEP)

cellular response to vitamin D (IEP)

cochlea morphogenesis (IEA,ISO)

endothelial cell differentiation (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (IDA)

hard palate development (IEA,ISO)

inner ear receptor cell development (IEA,ISO)

membranous septum morphogenesis (IEA,ISO)

muscular septum morphogenesis (IEA,ISO)

non-canonical Wnt signaling pathway (IBA)

outflow tract morphogenesis (IEA,ISO)

planar cell polarity pathway involved in neural tube closure (IEA,ISO)

positive regulation of cytosolic calcium ion concentration (IDA)

positive regulation of DNA-binding transcription factor activity (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

sensory perception of smell (IEA,ISO)

ventricular septum morphogenesis (ISO)

Wnt signaling pathway (ISO)

Wnt signaling pathway, calcium modulating pathway (IDA)

Cellular Component

cytoplasm (IEA,ISO)

plasma membrane (IBA,IDA,IEA,ISO,TAS)

Molecular Function

G protein-coupled receptor activity (IEA)

identical protein binding (IPI)

PDZ domain binding (IEA,ISO)

protein binding (IPI,ISO)

protein heterodimerization activity (IPI)

Wnt receptor activity (IBA,IDA,IEA,ISO)

Wnt-protein binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.	Ahumada A, etal., Science 2002 Dec 6;298(5600):2006-10.
2.	Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization.	Blankesteijn WM, etal., J Mol Cell Cardiol. 1996 May;28(5):1187-91.
3.	A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart.	Blankesteijn WM, etal., Nat Med. 1997 May;3(5):541-4.
4.	Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology.	Catherino WH, etal., Fertil Steril. 2003 Aug;80(2):282-90.
5.	Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.	Chan SD, etal., J Biol Chem 1992 Dec 15;267(35):25202-7.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.	Jiang F, etal., J Hepatol. 2006 Sep;45(3):401-9. Epub 2006 May 3.
9.	Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.	Kaykas A, etal., Nat Cell Biol. 2004 Jan;6(1):52-8. Epub 2003 Dec 14.
10.	Gene Data Set	MGD Curation, June 12, 2002
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma.	Milovanovic T, etal., Int J Oncol. 2004 Nov;25(5):1337-42.
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	Analysis of Fz10 expression in mouse embryos.	Nunnally AP and Parr BA, Dev Genes Evol 2004 Mar;214(3):144-8. Epub 2004 Jan 31.
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
21.	Up-regulation of Frizzled-10 (FZD10) by beta-estradiol in MCF-7 cells and by retinoic acid in NT2 cells.	Saitoh T, etal., Int J Oncol 2002 Jan;20(1):117-20.
22.	Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling.	Xavier CP, etal., Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.

Additional References at PubMed

PMID:10395542	PMID:10893270	PMID:12839624	PMID:15809042	PMID:18215320	PMID:18929644	PMID:19038973	PMID:19388021	PMID:20802536	PMID:20940229	PMID:21423176	PMID:22510436
PMID:22521824	PMID:25120137	PMID:27878554	PMID:28733458	PMID:29276006

Genomics

Comparative Map Data

Fzd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	87,561,866 - 87,563,776 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	87,561,326 - 87,565,334 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	92,598,641 - 92,600,551 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,064,095 - 92,066,005 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	87,457,426 - 87,459,336 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	90,550,147 - 90,552,057 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	90,550,147 - 90,552,057 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,343,133 - 90,345,043 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	91,709,222 - 91,711,132 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	91,723,591 - 91,725,502 (+)	NCBI
Celera	10	86,269,032 - 86,270,942 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

FZD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	44,557,484 - 44,561,262 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	44,557,484 - 44,561,262 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	42,634,852 - 42,638,630 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	39,990,451 - 39,992,433 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	39,990,450 - 39,992,433	NCBI
Celera	17	39,345,439 - 39,347,421 (+)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	38,399,310 - 38,404,081 (+)	NCBI		HuRef
CHM1_1	17	42,870,888 - 42,874,706 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	45,411,390 - 45,415,168 (+)	NCBI		T2T-CHM13v2.0

Fzd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	102,495,257 - 102,498,884 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	102,495,222 - 102,498,884 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	102,604,431 - 102,608,058 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	102,604,396 - 102,608,058 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	102,465,745 - 102,469,372 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	102,420,625 - 102,422,672 (+)	NCBI		MGSCv36	mm8
Celera	11	114,314,619 - 114,318,312 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI

Fzd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	17,501,410 - 17,503,726 (+)	NCBI	ChiLan1.0	ChiLan1.0

FZD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	22,313,946 - 22,317,765 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	12,839,362 - 12,843,803 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	13,007,752 - 13,013,346 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

FZD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	18,888,711 - 18,890,549 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	18,888,696 - 18,890,525 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	18,275,000 - 18,278,038 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	19,578,886 - 19,581,949 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	19,580,230 - 19,581,927 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	18,433,221 - 18,436,253 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	18,616,401 - 18,619,457 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	18,760,592 - 18,763,652 (-)	NCBI		UU_Cfam_GSD_1.0

Fzd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	18,226,127 - 18,229,463 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	965,131 - 966,798 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936541	965,135 - 967,018 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	18,740,653 - 18,742,420 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	18,740,417 - 18,742,301 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	19,086,025 - 19,087,228 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FZD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	61,837,202 - 61,839,126 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	61,837,304 - 61,839,013 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	32,597,814 - 32,601,732 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	578,571 - 580,235 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	577,350 - 584,110 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fzd2
2 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	50
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000032944
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	72552416	93995749	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	74372084	94965338	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	94965338	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	78775516	98279596	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	80515287	91230079	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	80515287	101325465	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	82564856	92369470	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84007272	95933025	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84007272	95933025	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	84022321	93995963	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	85565469	103884409	Rat
631538	Oia5	Oil induced arthritis QTL 5			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87055121	107211142	Rat
2313856	Bp342	Blood pressure QTL 342	4.4	0.0001	life span trait (VT:0005372)	age at time of death (CMO:0001193)	10	87307617	96121100	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87307617	107211142	Rat

Markers in Region

PMC16008P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	87,563,205 - 87,563,592 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	90,551,487 - 90,551,873	NCBI	Rnor6.0
Rnor_5.0	10	90,344,473 - 90,344,859	UniSTS	Rnor5.0
RGSC_v3.4	10	91,710,562 - 91,710,948	UniSTS	RGSC3.4
Celera	10	86,270,372 - 86,270,758	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Fzd2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	87,562,741 - 87,563,398 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	90,551,023 - 90,551,679	NCBI	Rnor6.0
Rnor_5.0	10	90,344,009 - 90,344,665	UniSTS	Rnor5.0
RGSC_v3.4	10	91,710,098 - 91,710,754	UniSTS	RGSC3.4
Celera	10	86,269,908 - 86,270,564	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Fzd2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	87,562,910 - 87,563,251 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	90,551,192 - 90,551,532	NCBI	Rnor6.0
Rnor_5.0	10	90,344,178 - 90,344,518	UniSTS	Rnor5.0
RGSC_v3.4	10	91,710,267 - 91,710,607	UniSTS	RGSC3.4
Celera	10	86,270,077 - 86,270,417	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		24	6	6		6			56	21	32	11
Low	3	19	41	25	19	25	8	11	18	14	9		8
Below cutoff			10	10		10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_172035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L02530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000032944 ⟹ ENSRNOP00000036154

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,561,326 - 87,565,334 (+)	Ensembl
Rnor_6.0 Ensembl	10	90,550,147 - 90,552,057 (+)	Ensembl

RefSeq Acc Id:

NM_172035 ⟹ NP_742032

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,561,866 - 87,563,776 (+)	NCBI
Rnor_6.0	10	90,550,147 - 90,552,057 (+)	NCBI
Rnor_5.0	10	90,343,133 - 90,345,043 (+)	NCBI
RGSC_v3.4	10	91,709,222 - 91,711,132 (+)	RGD
Celera	10	86,269,032 - 86,270,942 (+)	RGD

Sequence:

show sequence

AGGGGAAGGCGCGCGGTCTCTGGGTTGGGGGCGGGGGCTGGGGGGCGCCCAGGAGCCGAGTGGG
GGGCGGCGGCCAGCATGCGGGCCCGCAGCGCCCTGCCCCGCAGCGCCCTGCCCCGCCTGCTGCT
GCCACTGCTGCTGCTGCCGGCTGCCGGGCCGGCTCAGTTCCACGGGGAGAAGGGCATCTCCATC
CCGGACCACGGCTTCTGCCAGCCCATCTCCATCCCGCTGTGCACGGACATCGCCTACAACCAGA
CCATCATGCCCAACCTTCTTGGGCACACGAACCAAGAGGACGCGGGCCTGGAGGTGCATCAATT
CTACCCGCTGGTGAAGGTGCAGTGCTCGCCCGAGCTGCGCTTCTTCCTGTGCTCCATGTACGCT
CCGGTGTGCACGGTGCTGGAGCAGGCCATCCCGCCGTGCCGCTCCATCTGCGAACGCGCGCGCC
AAGGCTGCGAGGCGCTCATGAACAAGTTCGGCTTCCAGTGGCCCGAGCGCCTCCGCTGCGAGCA
TTTCCCGCGTCACGGCGCGGAGCAGATCTGCGTGGGCCAGAACCACTCCGAGGACGGAACTCCT
GCGCTACTCACCACCGCGCCACCGTCTGGGCTGCAGCCTGGCGCTGGTGGCACCCCGGGCGGCC
CTGGCGGTGGTGGCGCGCCCCCGCGCTACGCCACTCTGGAGCACCCTTTCCACTGTCCCCGCGT
CCTCAAGGTGCCGTCCTATCTCAGCTATAAGTTTCTGGGTGAGCGCGATTGTGCCGCGCCCTGC
GAGCCTGCACGGCCCGACGGCTCCATGTTCTTCTCGCACCACCACACTCGTTTTGCCCGTCTCT
GGATCCTCACATGGTCGGTGCTGTGCTGCGCTTCTACTTTCTTCACGGTCACCACCTCTTTAGT
GGCCATGCAGCGATTCCGCTACCCAGAGCGGCCCATCATCTTCCTGTCCGGTTGCTACACCATG
GTGTCAGTGGCCTACATTGCGGGCTTCGTGCTCCAGGAGCGCGTGGTGTGCAACGAGCGCTTCT
CTGAGGACGGTTATCGCACGGTGGGGCAGGGCACTAAGAAAGAAGGCTGTACTATACTCTTCAT
GATGCTCTACTTCTTCAGTATGGCCAGCTCCATCTGGTGGGTGATTCTGTCCCTCACCTGGTTC
CTGGCAGCCGGTATGAAGTGGGGCCACGCGGCCATCGAGGCCAATTCGCAGTACTTCCACCTGG
CCGCCTGGGCGGTGCCGGCCGTCAAAACCATCACCATCCTGGCCATGGGCCAGATCGACGGCGA
CCTGCTGAGCGGCGTGTGCTTCGTGGGCCTCAACAGGCTGGACCCGCTGCGAGGCTTCGTGCTG
GCGCCGCTCTTCGTGTACCTGTTCATCGGCACATCCTTCCTGCTGGCGGGCTTCGTGTCACTCT
TCCGCATCCGCACCATCATGAAGCACGACGGCACCAAGACGGAGCCGCTGGAGAGGCTCATGGT
GCGTATCGGCGTCTTCTCCGTGCTCTACACCGTACCGGCCACCATCGTCATCGCCTGCTACTTC
TATGAGCAGGCCTTCCGCGAGCACTGGGAGCGCTCGTGGGTAAGCCAGCACTGCAAGAGCCTAG
CCATCCCCTGCCCGGCCCACTACACGCCCCGCACGTCGCCCGACTTCACAGTCTACATGATCAA
ATACCTCATGACGCTCATCGTGGGCATCACGTCGGGCTTCTGGATCTGGTCCGGCAAGACGCTG
CACTCGTGGAGGAAGTTCTACACGCGTCTCACCAACAGCCGGCATGGAGAGACCACCGTGTGAA
GCGGTCTCGCTGCTGGGCGCCCCCCTCTCCCAGGTCCGGACTGCAACCGTGCCCTCCTTCACTC
GGGAGGGGGGTGCACCCTACGGACTCCTATTTTATTTTTTTAAATAAAGAACAGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_742032	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41172	(Get FASTA)	NCBI Sequence Viewer
	Q08464	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_742032 ⟸ NM_172035
- Peptide Label:	precursor
- UniProtKB:	G3V954 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPN LLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEA LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGTPALLTTAPPSGLQPGAGGTPGGPGGGG APPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSHHHTRFARLWILTW SVLCCASTFFTVTTSLVAMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGY RTVGQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHAAIEANSQYFHLAAWAV PAVKTITILAMGQIDGDLLSGVCFVGLNRLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRT IMKHDGTKTEPLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCP AHYTPRTSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV hide sequence

RefSeq Acc Id:

ENSRNOP00000036154 ⟸ ENSRNOT00000032944

Protein Domains

FZ G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q08464-F1-model_v2	AlphaFold	Q08464	1-570	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697792

Promoter ID:

EPDNEW_R8316

Type:

initiation region

Name:

Fzd2_1

Description:

frizzled class receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	90,550,240 - 90,550,300	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71012	AgrOrtholog
BioCyc Gene	G2FUF-23095	BioCyc
Ensembl Genes	ENSRNOG00000021962	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000036154	ENTREZGENE
	ENSRNOP00000036154.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032944	ENTREZGENE
	ENSRNOT00000032944.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Frizzled/SFRP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled/Smoothened_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FZ2_CRD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64512	UniProtKB/Swiss-Prot
NCBI Gene	64512	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11309:SF34	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF01392	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	FZD2	RGD
PhenoGen	Fzd2	PhenoGen
PRINTS	FRIZZLED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50038	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	FRI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF63501	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	FZD2_RAT	UniProtKB/Swiss-Prot
	G3V954	ENTREZGENE, UniProtKB/TrEMBL
	Q08464	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Fzd2	frizzled class receptor 2	Fzd2	frizzled family receptor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Fzd2	frizzled family receptor 2	Fzd2	frizzled homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-08-15	Fzd2	frizzled homolog 2 (Drosophila)	Fzd10	Drosophila polarity gene (frizzled) homologue	Data Merged	737654	APPROVED
2003-04-28	Fzd10	Drosophila polarity gene (frizzled) homologue			Symbol withdrawn	625702	WITHDRAWN
2002-08-07	Fzd10	Drosophila polarity gene (frizzled) homologue			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-07-09	Fzd2	frizzled homolog 2 (Drosophila)			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)