Fzd2 (frizzled class receptor 2) - Rat Genome Database

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Gene: Fzd2 (frizzled class receptor 2) Chinchilla lanigera
Analyze
Symbol: Fzd2
Name: frizzled class receptor 2
RGD ID: 8712514
Description: ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell-cell signaling (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal dominant Robinow syndrome 2 (ortholog); autosomal dominant Robinow syndrome 3 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: frizzled family receptor 2; frizzled-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,501,410 - 17,503,726 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillabreast carcinoma  ISOFZD2 (Homo sapiens)9068941protein:increased expression:breastRGDPMID:15492823 and REF_RGD_ID:2298699
Fzd2ChinchillaCOVID-19  ISOFZD2 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Fzd2ChinchillaLeft Ventricular Hypertrophy  ISOFzd2 (Rattus norvegicus)9068941mRNA:increased expression:heart left ventricleRGDPMID:8762054 and REF_RGD_ID:4107053
Fzd2Chinchillaleiomyoma  ISOFZD2 (Homo sapiens)9068941mRNA and protein:increased expression:myometriumRGDPMID:12909487 and REF_RGD_ID:2298700
Fzd2Chinchillamyocardial infarction  ISOFzd2 (Rattus norvegicus)9068941mRNA:increased expression:heart left ventricleRGDPMID:9142123 and REF_RGD_ID:4107058
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillaautosomal dominant Robinow syndrome 1  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant Robinow syndrome 1ClinVarPMID:24458798 more ...
Fzd2Chinchillaautosomal dominant Robinow syndrome 2  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant Robinow syndrome 2ClinVarPMID:24458798 more ...
Fzd2Chinchillaautosomal dominant Robinow syndrome 3  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant Robinow syndrome 3ClinVarPMID:25741868 and PMID:29276006
Fzd2ChinchillaDwarfism  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVarPMID:28492532
Fzd2Chinchillahereditary breast ovarian cancer syndrome  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast-ovarian cancer more ...ClinVarPMID:38922859
Fzd2Chinchillakeratoconus  ISOFZD2 (Homo sapiens)8554872ClinVar Annotator: match by term: KeratoconusClinVarPMID:28492532
Fzd2Chinchillaomodysplasia 2  ISOFZD2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24458798 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2ChinchillaColonic Neoplasms  ISOFZD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21188121
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillaomodysplasia 2  ISOFZD2 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillacanonical Wnt signaling pathway involved_inISOFZD2 (Homo sapiens)9068941 PMID:18215320 more ...BHF-UCLPMID:18215320 more ...
Fzd2Chinchillacanonical Wnt signaling pathway involved_inISOFzd2 (Rattus norvegicus)9068941PMID:24080158ParkinsonsUK-UCLPMID:24080158 and REF_RGD_ID:10448946
Fzd2Chinchillacell-cell signaling acts_upstream_of_or_withinISOFzd2 (Mus musculus)9068941 PMID:15809042MGIPMID:15809042
Fzd2Chinchillacellular response to growth factor stimulus  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:1334084 and REF_RGD_ID:61590
Fzd2Chinchillacellular response to peptide hormone stimulus  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:1334084 and REF_RGD_ID:61590
Fzd2Chinchillacellular response to vitamin D  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:1334084 and REF_RGD_ID:61590
Fzd2Chinchillacochlea morphogenesis acts_upstream_of_or_withinISOMGI:21352729068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillaendothelial cell differentiation acts_upstream_of_or_withinISOMGI:1031249068941 PMID:15809042MGIPMID:15809042
Fzd2Chinchillaendothelial cell differentiation acts_upstream_of_or_withinISOFzd2 (Mus musculus)9068941 PMID:15809042MGIPMID:15809042
Fzd2ChinchillaG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:12471263 and REF_RGD_ID:727481
Fzd2Chinchillahard palate development acts_upstream_of_or_withinISOMGI:11966259068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillahard palate development acts_upstream_of_or_withinISOMGI:44426119068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillainner ear receptor cell development acts_upstream_of_or_withinISOMGI:21352729068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillamembranous septum morphogenesis acts_upstream_of_or_withinISOMGI:1196625 and MGI:21352729068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillamuscular septum morphogenesis acts_upstream_of_or_withinISOMGI:1196625 and MGI:21352729068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillaoutflow tract morphogenesis acts_upstream_of_or_withinISOMGI:11966259068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillapositive regulation of cytosolic calcium ion concentration  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:12471263 and REF_RGD_ID:727481
Fzd2Chinchillapositive regulation of DNA-templated transcription involved_inISOFZD2 (Homo sapiens)9068941 PMID:18215320 and PMID:18929644BHF-UCLPMID:18215320 and PMID:18929644
Fzd2Chinchillasensory perception of smell acts_upstream_of_or_withinISOMGI:44426119068941 PMID:20940229MGIPMID:20940229
Fzd2Chinchillaventricular septum morphogenesis acts_upstream_of_or_withinISOMGI:11966259068941 PMID:20940229MGIPMID:20940229
1 to 20 of 22 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillacytoplasm located_inISOFZD2 (Homo sapiens)9068941 PMID:19038973BHF-UCLPMID:19038973
Fzd2Chinchillaplasma membrane located_inISOFzd2 (Rattus norvegicus)9068941PMID:14688793BHF-UCLPMID:14688793 and REF_RGD_ID:8553956
Fzd2Chinchillaplasma membrane located_inISOFZD2 (Homo sapiens)9068941 PMID:18929644BHF-UCLPMID:18929644

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2Chinchillaidentical protein binding enablesISOUniProtKB:Q084649068941PMID:14688793IntActPMID:14688793 and REF_RGD_ID:8553956
Fzd2ChinchillaPDZ domain binding enablesISOUniProtKB:O14640 more ...9068941 PMID:19388021UniProtPMID:19388021
Fzd2Chinchillaprotein binding enablesISOUniProtKB:P396889068941 PMID:25417160IntActPMID:25417160
Fzd2Chinchillaprotein binding enablesISOPR:Q9Z1389068941 PMID:12839624MGIPMID:12839624
Fzd2Chinchillaprotein binding enablesISOUniProtKB:Q9Z1389068941 PMID:12839624BHF-UCLPMID:12839624
Fzd2Chinchillaprotein binding enablesISOPR:Q9R0Q39068941 PMID:35353806MGIPMID:35353806
Fzd2Chinchillaprotein binding enablesISOUniProtKB:P18177-PRO_00000726369068941 PMID:27680706 and PMID:29748286UniProtPMID:27680706 and PMID:29748286
Fzd2Chinchillaprotein binding enablesISOUniProtKB:M4NKV99068941 PMID:29748286IntActPMID:29748286
Fzd2Chinchillaprotein binding enablesISOUniProtKB:Q084639068941PMID:14688793IntActPMID:14688793 and REF_RGD_ID:8553956
Fzd2Chinchillaprotein heterodimerization activity enablesISOUniProtKB:Q084639068941PMID:14688793BHF-UCLPMID:14688793 and REF_RGD_ID:8553956
Fzd2ChinchillaWnt receptor activity  ISOFzd2 (Rattus norvegicus)9068941 RGDPMID:12471263 and REF_RGD_ID:727481
Fzd2ChinchillaWnt receptor activity enablesISOFzd2 (Mus musculus)9068941 PMID:10893270MGIPMID:10893270
Fzd2ChinchillaWnt receptor activity enablesISOFZD2 (Homo sapiens)9068941 PMID:28733458WBPMID:28733458
1 to 13 of 13 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2ChinchillaWnt signaling pathway  ISOFzd2 (Mus musculus)9068941 RGD 

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fzd2ChinchillaWnt signaling, non-canonical pathway  ISOFZD2 (Homo sapiens)9068941 PIDPID:200020

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:30032202  



Fzd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,501,410 - 17,503,726 (+)NCBIChiLan1.0ChiLan1.0
FZD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,557,484 - 44,561,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,557,484 - 44,561,262 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,634,852 - 42,638,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,990,451 - 39,992,433 (+)NCBINCBI36Build 36hg18NCBI36
Build 341739,990,450 - 39,992,433NCBI
Celera1739,345,439 - 39,347,421 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,399,310 - 38,404,081 (+)NCBIHuRef
CHM1_11742,870,888 - 42,874,706 (+)NCBICHM1_1
T2T-CHM13v2.01745,411,390 - 45,415,168 (+)NCBIT2T-CHM13v2.0
Fzd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,495,257 - 102,498,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,495,222 - 102,498,884 (+)EnsemblGRCm39 Ensembl
GRCm3811102,604,431 - 102,608,058 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,604,396 - 102,608,058 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,465,745 - 102,469,372 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,420,625 - 102,422,672 (+)NCBIMGSCv36mm8
Celera11114,314,619 - 114,318,312 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.45NCBI
Fzd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,061,988 - 88,063,898 (+)NCBIGRCr8
mRatBN7.21087,561,866 - 87,563,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,561,326 - 87,565,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,598,641 - 92,600,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,064,095 - 92,066,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,457,426 - 87,459,336 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,550,147 - 90,552,057 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,550,147 - 90,552,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,343,133 - 90,345,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,709,222 - 91,711,132 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,723,591 - 91,725,502 (+)NCBI
Celera1086,269,032 - 86,270,942 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
FZD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,351,899 - 20,354,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,313,946 - 22,318,336 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,839,362 - 12,843,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,007,752 - 13,013,346 (-)NCBIpanpan1.1PanPan1.1panPan2
FZD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,888,711 - 18,890,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,888,696 - 18,890,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,275,000 - 18,278,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,578,886 - 19,581,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,580,230 - 19,581,927 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,433,221 - 18,436,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,616,401 - 18,619,457 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,760,592 - 18,763,652 (-)NCBIUU_Cfam_GSD_1.0
Fzd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,226,127 - 18,229,463 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541965,131 - 966,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541965,135 - 967,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,740,653 - 18,742,420 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,740,417 - 18,742,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,086,025 - 19,087,228 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,837,202 - 61,839,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,837,304 - 61,839,013 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,597,814 - 32,601,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795578,571 - 580,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795577,350 - 584,110 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_005394650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01043754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBBH01225132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_005394650   ⟹   XP_005394707
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545117,501,410 - 17,503,726 (+)NCBI
Sequence:
Protein RefSeqs XP_005394707 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005394707   ⟸   XM_005394650
- Sequence:



Database
Acc Id
Source(s)
NCBI Gene Fzd2 ENTREZGENE


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Fzd2  frizzled class receptor 2    frizzled family receptor 2  Symbol and/or name change 5135510 APPROVED