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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Grin2c | Rat | 1,2-dichloroethane | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of GRIN2C mRNA | CTD | PMID:28960355 | Grin2c | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of GRIN2C mRNA | CTD | PMID:17942748 | Grin2c | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNA | CTD | PMID:17942748 | Grin2c | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of GRIN2C mRNA | CTD | PMID:32741896 | Grin2c | Rat | 17beta-estradiol 3-benzoate | increases expression | EXP | | 6480464 | estradiol 3-benzoate results in increased expression of GRIN2C mRNA | CTD | PMID:21277884 | Grin2c | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Grin2c | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:22467012 | Grin2c | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:32756504 | Grin2c | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:33078273 | Grin2c | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Grin2c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNA | CTD | PMID:17942748 | Grin2c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Grin2c (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRIN2C mRNA | CTD | PMID:24680724 | Grin2c | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Grin2c (Mus musculus) | 6480464 | bisphenol S affects the methylation of GRIN2C gene | CTD | PMID:31683443 | Grin2c | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of GRIN2C mRNA | CTD | PMID:21346803 | Grin2c | Rat | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of GRIN2C mRNA | CTD | PMID:22545673 | Grin2c | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of GRIN2C mRNA | CTD | PMID:23630614 | Grin2c | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of GRIN2C mRNA | CTD | PMID:23630614 and PMID:25378103 | Grin2c | Rat | aflatoxin B1 | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of GRIN2C mRNA | CTD | PMID:21641981 and PMID:22100608 | Grin2c | Rat | all-trans-retinoic acid | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of GRIN2C mRNA | CTD | PMID:36189433 | Grin2c | Rat | ammonium chloride | affects response to substance | ISO | Grin2c (Mus musculus) | 6480464 | GRIN2C protein affects the susceptibility to Ammonium Chloride | CTD | PMID:12971910 | Grin2c | Rat | ammonium chloride | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | traxoprodil mesylate promotes the reaction [GRIN2C protein affects the susceptibility to Ammonium Chloride] | CTD | PMID:12971910 | Grin2c | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRIN2C mRNA | CTD | PMID:16483693 | Grin2c | Rat | aristolochic acid A | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of GRIN2C mRNA | CTD | PMID:33212167 | Grin2c | Rat | arsenite(3-) | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | arsenite results in decreased expression of GRIN2C mRNA | CTD | PMID:33053406 | Grin2c | Rat | benzo[a]pyrene | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of GRIN2C mRNA | CTD | PMID:21569818 | Grin2c | Rat | benzo[a]pyrene | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of GRIN2C mRNA | CTD | PMID:32234424 | Grin2c | Rat | benzo[a]pyrene | increases methylation | ISO | GRIN2C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GRIN2C promoter | CTD | PMID:27901495 | Grin2c | Rat | benzo[b]fluoranthene | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of GRIN2C mRNA | CTD | PMID:26377693 | Grin2c | Rat | bexarotene | increases expression | EXP | | 6480464 | bexarotene results in increased expression of GRIN2C mRNA | CTD | PMID:17630414 | Grin2c | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA | CTD | PMID:25607892 | Grin2c | Rat | bisphenol A | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | bisphenol A results in decreased expression of GRIN2C mRNA | CTD | PMID:32156529 | Grin2c | Rat | bisphenol A | decreases methylation | ISO | Grin2c (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of GRIN2C promoter | CTD | PMID:27312807 | Grin2c | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRIN2C mRNA | CTD | PMID:25181051 and PMID:34947998 | Grin2c | Rat | bisphenol A | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | bisphenol A results in increased expression of GRIN2C mRNA | CTD | PMID:31715268 | Grin2c | Rat | Butylparaben | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA | CTD | PMID:25607892 | Grin2c | Rat | cadmium dichloride | decreases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of GRIN2C mRNA | CTD | PMID:38382870 | Grin2c | Rat | carbon nanotube | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of GRIN2C mRNA | CTD | PMID:25554681 | Grin2c | Rat | celecoxib | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] | CTD | PMID:21589914 | Grin2c | Rat | choline | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene | CTD | PMID:20938992 | Grin2c | Rat | cisplatin | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Cisplatin results in increased expression of GRIN2C mRNA | CTD | PMID:27392435 | Grin2c | Rat | cisplatin | multiple interactions | ISO | GRIN2C (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of GRIN2C mRNA | CTD | PMID:27392435 | Grin2c | Rat | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of GRIN2C mRNA | CTD | PMID:22008526 | Grin2c | Rat | clozapine | decreases expression | EXP | | 6480464 | Clozapine results in decreased expression of GRIN2C mRNA | CTD | PMID:18923069 | Grin2c | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIN2C mRNA | CTD | PMID:20187946 | Grin2c | Rat | cordycepin | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | cordycepin results in increased expression of GRIN2C mRNA | CTD | PMID:34858524 | Grin2c | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of GRIN2C mRNA | CTD | PMID:26577399 and PMID:27523638 | Grin2c | Rat | diazinon | increases expression | EXP | | 6480464 | Diazinon results in increased expression of GRIN2C mRNA | CTD | PMID:17452286 and PMID:19440498 | Grin2c | Rat | Dibutyl phosphate | affects expression | ISO | GRIN2C (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of GRIN2C mRNA | CTD | PMID:37042841 | Grin2c | Rat | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of GRIN2C mRNA | CTD | PMID:19440498 | Grin2c | Rat | dizocilpine maleate | decreases expression | EXP | | 6480464 | Dizocilpine Maleate results in decreased expression of GRIN2C mRNA | CTD | PMID:11169168 | Grin2c | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of GRIN2C mRNA | CTD | PMID:29391264 | Grin2c | Rat | enzacamene | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA | CTD | PMID:25607892 | Grin2c | Rat | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of GRIN2C mRNA | CTD | PMID:20655511 | Grin2c | Rat | ethanol | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | Ethanol results in increased expression of GRIN2C mRNA | CTD | PMID:30319688 | Grin2c | Rat | ethyl methanesulfonate | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of GRIN2C mRNA | CTD | PMID:23649840 | Grin2c | Rat | excitatory amino acid agonist | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Excitatory Amino Acid Agonists results in increased expression of GRIN2C mRNA | CTD | PMID:28987794 | Grin2c | Rat | felbamate | multiple interactions | EXP | | 6480464 | felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein] | CTD | PMID:10690753 | Grin2c | Rat | folic acid | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene | CTD | PMID:20938992 | Grin2c | Rat | fonofos | increases methylation | ISO | GRIN2C (Homo sapiens) | 6480464 | Fonofos results in increased methylation of GRIN2C promoter | CTD | PMID:22847954 | Grin2c | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of GRIN2C protein | CTD | PMID:15200423 | Grin2c | Rat | haloperidol | increases expression | EXP | | 6480464 | Haloperidol results in increased expression of GRIN2C mRNA | CTD | PMID:15860345 | Grin2c | Rat | hydrogen peroxide | affects expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of GRIN2C mRNA | CTD | PMID:20044591 | Grin2c | Rat | hydrogen peroxide | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of GRIN2C mRNA | CTD | PMID:12414654 | Grin2c | Rat | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of GRIN2C mRNA | CTD | PMID:21396975 | Grin2c | Rat | indole-3-methanol | increases expression | EXP | | 6480464 | indole-3-carbinol results in increased expression of GRIN2C mRNA | CTD | PMID:23824016 | Grin2c | Rat | kainic acid | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | Kainic Acid results in decreased expression of GRIN2C mRNA | CTD | PMID:21589914 | Grin2c | Rat | kainic acid | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] and PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA] | CTD | PMID:21589914 | Grin2c | Rat | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of GRIN2C mRNA | CTD | PMID:20080153 | Grin2c | Rat | L-methionine | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene | CTD | PMID:20938992 | Grin2c | Rat | lead diacetate | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | lead acetate results in increased expression of GRIN2C mRNA | CTD | PMID:24260418 | Grin2c | Rat | lead nitrate | increases expression | EXP | | 6480464 | lead nitrate results in increased expression of GRIN2C mRNA | CTD | PMID:23358146 | Grin2c | Rat | melphalan | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Melphalan results in increased expression of GRIN2C mRNA | CTD | PMID:22363485 | Grin2c | Rat | menadione | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Vitamin K 3 results in increased expression of GRIN2C mRNA | CTD | PMID:12414654 | Grin2c | Rat | methotrexate | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Methotrexate results in increased expression of GRIN2C mRNA | CTD | PMID:21678067 | Grin2c | Rat | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of GRIN2C mRNA | CTD | PMID:19409459 | Grin2c | Rat | minocycline | multiple interactions | EXP | | 6480464 | Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] | CTD | PMID:19660546 | Grin2c | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of GRIN2C mRNA | CTD | PMID:36189433 | Grin2c | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of GRIN2C mRNA | CTD | PMID:36189433 | Grin2c | Rat | monosodium L-glutamate | increases expression | EXP | | 6480464 | Sodium Glutamate results in increased expression of GRIN2C mRNA | CTD | PMID:11872244 | Grin2c | Rat | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of GRIN2C mRNA | CTD | PMID:15183518 | Grin2c | Rat | N-Nitrosopyrrolidine | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in increased expression of GRIN2C mRNA | CTD | PMID:32234424 | Grin2c | Rat | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of GRIN2C mRNA | CTD | PMID:19440498 | Grin2c | Rat | O-methyleugenol | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | methyleugenol results in increased expression of GRIN2C mRNA | CTD | PMID:32234424 | Grin2c | Rat | p-menthan-3-ol | decreases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Menthol results in decreased expression of GRIN2C mRNA | CTD | PMID:26760959 | Grin2c | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of GRIN2C mRNA | CTD | PMID:23824016 | Grin2c | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of GRIN2C mRNA | CTD | PMID:18198484 | Grin2c | Rat | parathion | increases methylation | ISO | GRIN2C (Homo sapiens) | 6480464 | Parathion results in increased methylation of GRIN2C promoter | CTD | PMID:22847954 | Grin2c | Rat | PCB138 | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:20297801 | Grin2c | Rat | PCB138 | multiple interactions | ISO | Grin2c (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Grin2c | Rat | pentobarbital | affects expression | EXP | | 6480464 | Pentobarbital affects the expression of GRIN2C mRNA | CTD | PMID:9814547 | Grin2c | Rat | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of GRIN2C mRNA | CTD | PMID:22008526 | Grin2c | Rat | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of GRIN2C mRNA | CTD | PMID:22008526 and PMID:22484513 | Grin2c | Rat | poly(cytidylic acid) | multiple interactions | EXP | | 6480464 | Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] | CTD | PMID:19660546 | Grin2c | Rat | poly(cytidylic acid) | increases expression | EXP | | 6480464 | Poly C results in increased expression of GRIN2C mRNA | CTD | PMID:19660546 | Grin2c | Rat | propanal | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of GRIN2C mRNA | CTD | PMID:26079696 | Grin2c | Rat | resveratrol | multiple interactions | ISO | GRIN2C (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of GRIN2C mRNA | CTD | PMID:23557933 | Grin2c | Rat | rotenone | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | Rotenone results in decreased expression of GRIN2C mRNA | CTD | PMID:35919817 | Grin2c | Rat | silicon dioxide | decreases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of GRIN2C mRNA | CTD | PMID:25895662 | Grin2c | Rat | sodium arsenite | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | sodium arsenite results in increased expression of GRIN2C mRNA | CTD | PMID:37682722 | Grin2c | Rat | terbufos | increases methylation | ISO | GRIN2C (Homo sapiens) | 6480464 | terbufos results in increased methylation of GRIN2C promoter | CTD | PMID:22847954 | Grin2c | Rat | tert-butyl hydroperoxide | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of GRIN2C mRNA | CTD | PMID:12414654 | Grin2c | Rat | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of GRIN2C mRNA | CTD | PMID:32741896 | Grin2c | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of GRIN2C mRNA | CTD | PMID:30723492 | Grin2c | Rat | thalidomide | decreases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Thalidomide results in decreased expression of GRIN2C mRNA | CTD | PMID:32756504 | Grin2c | Rat | thiram | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Thiram results in increased expression of GRIN2C mRNA | CTD | PMID:38568856 | Grin2c | Rat | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of GRIN2C mRNA | CTD | PMID:30012374 | Grin2c | Rat | titanium dioxide | decreases methylation | ISO | Grin2c (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of GRIN2C gene | CTD | PMID:35295148 | Grin2c | Rat | titanium dioxide | increases methylation | ISO | Grin2c (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of GRIN2C gene | CTD | PMID:35295148 | Grin2c | Rat | triclosan | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Triclosan results in increased expression of GRIN2C mRNA | CTD | PMID:30510588 | Grin2c | Rat | trimellitic anhydride | decreases expression | ISO | Grin2c (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of GRIN2C mRNA | CTD | PMID:19042947 | Grin2c | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of GRIN2C mRNA | CTD | PMID:33078273 | Grin2c | Rat | triptonide | increases expression | ISO | Grin2c (Mus musculus) | 6480464 | triptonide results in increased expression of GRIN2C mRNA | CTD | PMID:33045310 | Grin2c | Rat | urethane | increases expression | ISO | GRIN2C (Homo sapiens) | 6480464 | Urethane results in increased expression of GRIN2C mRNA | CTD | PMID:28818685 | Grin2c | Rat | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of GRIN2C mRNA | CTD | PMID:32428529 | Grin2c | Rat | valproic acid | increases methylation | ISO | GRIN2C (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of GRIN2C gene | CTD | PMID:29154799 | Grin2c | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of GRIN2C mRNA | CTD | PMID:29427782 | |