Fdxr (ferredoxin reductase) - Rat Genome Database

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Gene: Fdxr (ferredoxin reductase) Rattus norvegicus
Analyze
Symbol: Fdxr
Name: ferredoxin reductase
RGD ID: 621648
Description: Enables NADPH binding activity and NADPH-adrenodoxin reductase activity. Involved in NADPH oxidation. Located in mitochondrion. Orthologous to human FDXR (ferredoxin reductase); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenodoxin reductase; AR; ferredoxin--NADP(+) reductase; NADPH:adrenodoxin oxidoreductase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,006,845 - 101,015,582 (-)NCBIGRCr8
mRatBN7.210100,507,863 - 100,516,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,568,049 - 105,576,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,031,109 - 105,039,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,428,857 - 100,437,546 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,817,724 - 103,826,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,468,590 - 104,477,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,342,684 - 105,351,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,357,187 - 105,365,878 (-)NCBI
Celera1099,084,255 - 99,092,947 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
adenine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
theophylline  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, etal., J Cell Biol. 1990 Oct;111(4):1373-81.
5. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
6. Differential capacity for cholesterol transport and processing in large and small rat luteal cells. McLean MP, etal., Endocrinology. 1992 Nov;131(5):2203-12.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, etal., Biochim Biophys Acta 1999 Oct 12;1434(2):284-95.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Fdxr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,006,845 - 101,015,582 (-)NCBIGRCr8
mRatBN7.210100,507,863 - 100,516,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,568,049 - 105,576,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,031,109 - 105,039,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,428,857 - 100,437,546 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,817,724 - 103,826,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,468,590 - 104,477,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,342,684 - 105,351,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,357,187 - 105,365,878 (-)NCBI
Celera1099,084,255 - 99,092,947 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
FDXR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,862,497 - 74,872,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,862,497 - 74,873,031 (-)EnsemblGRCh38hg38GRCh38
GRCh371772,858,619 - 72,869,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,370,214 - 70,380,751 (-)NCBINCBI36Build 36hg18NCBI36
Build 341770,370,220 - 70,380,692NCBI
Celera1769,451,871 - 69,462,405 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,269,147 - 68,279,670 (-)NCBIHuRef
CHM1_11772,923,450 - 72,933,984 (-)NCBICHM1_1
T2T-CHM13v2.01775,754,283 - 75,764,782 (-)NCBIT2T-CHM13v2.0
Fdxr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,158,850 - 115,167,925 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,158,850 - 115,167,876 (-)EnsemblGRCm39 Ensembl
GRCm3811115,268,024 - 115,277,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,268,024 - 115,277,050 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,129,339 - 115,138,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,084,115 - 115,093,059 (-)NCBIMGSCv36mm8
Celera11127,033,656 - 127,042,608 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.84NCBI
Fdxr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,746,670 - 1,755,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,746,759 - 1,755,316 (-)NCBIChiLan1.0ChiLan1.0
FDXR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,899,791 - 90,910,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,722,695 - 95,733,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,808,123 - 68,818,642 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,364,343 - 74,374,852 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,364,343 - 74,374,852 (-)Ensemblpanpan1.1panPan2
FDXR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,567,411 - 5,577,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,567,328 - 5,577,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,246,975 - 6,256,975 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,239,485 - 6,249,477 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,239,458 - 6,249,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,276,453 - 6,286,449 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,387,040 - 6,397,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,447,362 - 6,457,354 (+)NCBIUU_Cfam_GSD_1.0
Fdxr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,188,212 - 6,196,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594215,155 - 223,771 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594215,165 - 223,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDXR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,372,009 - 6,382,769 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,372,224 - 6,382,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,362,701 - 6,373,244 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12pNCBI
FDXR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,785,669 - 46,796,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,785,591 - 46,796,187 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,571,055 - 17,581,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdxr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,713,519 - 4,722,612 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,714,341 - 4,722,588 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fdxr
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000004592
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 34 26 2 26 57 34
Low 3 37 23 15 17 15 8 11 17 35 7 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000085636   ⟹   ENSRNOP00000075248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)Ensembl
Rnor_6.0 Ensembl10103,817,704 - 103,826,448 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103108   ⟹   ENSRNOP00000079013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,507,865 - 100,516,658 (-)Ensembl
RefSeq Acc Id: NM_024153   ⟹   NP_077067
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,006,846 - 101,015,535 (-)NCBI
mRatBN7.210100,507,865 - 100,516,556 (-)NCBI
Rnor_6.010103,817,724 - 103,826,413 (-)NCBI
Rnor_5.010104,468,590 - 104,477,279 (+)NCBI
RGSC_v3.410105,342,684 - 105,351,374 (-)RGD
Celera1099,084,255 - 99,092,947 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086911   ⟹   XP_038942839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,006,845 - 101,015,582 (-)NCBI
mRatBN7.210100,507,863 - 100,516,449 (-)NCBI
RefSeq Acc Id: NP_077067   ⟸   NM_024153
- Peptide Label: precursor
- UniProtKB: P56522 (UniProtKB/Swiss-Prot),   A6HKL4 (UniProtKB/TrEMBL),   A0A8I6G2P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075248   ⟸   ENSRNOT00000085636
RefSeq Acc Id: XP_038942839   ⟸   XM_039086911
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000079013   ⟸   ENSRNOT00000103108
Protein Domains
FAD/NAD(P)-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56522-F1-model_v2 AlphaFold P56522 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697881
Promoter ID:EPDNEW_R8406
Type:initiation region
Name:Fdxr_1
Description:ferredoxin reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010103,826,465 - 103,826,525EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621648 AgrOrtholog
BioCyc Gene G2FUF-22693 BioCyc
Ensembl Genes ENSRNOG00000058497 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032918 UniProtKB/Swiss-Prot
  ENSRNOG00060021431 UniProtKB/Swiss-Prot
  ENSRNOG00065021609 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085636 ENTREZGENE
  ENSRNOT00000085636.2 UniProtKB/Swiss-Prot
  ENSRNOT00000103108.1 UniProtKB/TrEMBL
  ENSRNOT00055056940 UniProtKB/Swiss-Prot
  ENSRNOT00060037143 UniProtKB/Swiss-Prot
  ENSRNOT00065036736 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308634 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferredox_Rdtase_adrenod UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105420 IMAGE-MGC_LOAD
NCBI Gene 79122 ENTREZGENE
PANTHER FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fdxr PhenoGen
PIRSF FNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADXRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058497 RatGTEx
  ENSRNOG00055032918 RatGTEx
  ENSRNOG00060021431 RatGTEx
  ENSRNOG00065021609 RatGTEx
Superfamily-SCOP FAD/NAD(P)-binding domain UniProtKB/TrEMBL
  Nucleotide-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot
UniProt A0A8I6G2P7 ENTREZGENE, UniProtKB/TrEMBL
  A6HKL4 ENTREZGENE, UniProtKB/TrEMBL
  ADRO_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fdxr  ferredoxin reductase    adrenodoxin reductase  Name updated 1299863 APPROVED
2002-08-07 Fdxr  adrenodoxin reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to adrenodoxin (Ad) by ionic interaction 727285