Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) Rattus norvegicus
Analyze
Symbol: Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
RGD ID: 1305028
Description: Enables chromatin binding activity. Involved in hippocampus development and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region; heterochromatin; and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: enhancer of zeste homolog 1; enhancer of zeste homolog 1 (Drosophila); histone-lysine N-methyltransferase EZH1; LOC303547
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,626,307 - 86,662,257 (-)NCBIGRCr8
mRatBN7.21086,126,023 - 86,162,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,126,015 - 86,161,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,162,463 - 91,188,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,641,259 - 90,667,579 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,034,424 - 86,060,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,104,026 - 89,139,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,902,522 - 88,938,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,211,249 - 90,237,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,227,546 - 90,252,203 (-)NCBI
Celera1084,843,423 - 84,869,785 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1RatNeurodevelopmental Disorders  ISORGD:13128138554872ClinVar Annotator: match by term: EZH1-neurodevelopmental syndromeClinVarPMID:25741868|PMID:37314226|PMID:37433783

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1Rat1,2-dimethylhydrazine multiple interactionsISORGD:13128146480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EZH1 mRNACTDPMID:22206623
Ezh1Rat1,2-dimethylhydrazine increases expressionISORGD:131281464804641,2-Dimethylhydrazine results in increased expression of EZH1 mRNACTDPMID:22206623
Ezh1Rat17beta-estradiol affects expressionISORGD:13128146480464Estradiol affects the expression of EZH1 mRNACTDPMID:15598610
Ezh1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13128146480464Tetrachlorodibenzodioxin affects the expression of EZH1 mRNACTDPMID:21570461
Ezh1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of EZH1 mRNACTDPMID:32109520
Ezh1Rat2,4-dinitrotoluene affects expressionEXP 64804642,4-dinitrotoluene affects the expression of EZH1 mRNACTDPMID:21346803
Ezh1Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of EZH1 mRNACTDPMID:21346803
Ezh1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of EZH1 mRNACTDPMID:30047161
Ezh1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of EZH1 mRNACTDPMID:30047161
Ezh1Ratantirheumatic drug increases expressionISORGD:13128136480464Antirheumatic Agents results in increased expression of EZH1 mRNACTDPMID:24449571
Ezh1Ratarsane multiple interactionsISORGD:13128136480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Ezh1Ratarsenic atom multiple interactionsISORGD:13128136480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Ezh1Ratbelinostat increases expressionISORGD:13128136480464belinostat results in increased expression of EZH1 mRNACTDPMID:27188386
Ezh1Ratbenzo[a]pyrene decreases expressionEXP 6480464Benzo(a)pyrene results in decreased expression of EZH1 mRNACTDPMID:21839799
Ezh1Ratbenzo[a]pyrene affects methylationISORGD:13128136480464Benzo(a)pyrene affects the methylation of EZH1 promoterCTDPMID:27901495
Ezh1Ratbenzo[a]pyrene decreases expressionISORGD:13128146480464Benzo(a)pyrene results in decreased expression of EZH1 mRNACTDPMID:22228805
Ezh1Ratbisphenol A affects expressionISORGD:13128136480464bisphenol A affects the expression of EZH1 mRNACTDPMID:20170705
Ezh1Ratbisphenol A increases expressionISORGD:13128136480464bisphenol A results in increased expression of EZH1 mRNACTDPMID:29275510
Ezh1Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of EZH1 mRNACTDPMID:25181051|PMID:30816183
Ezh1Ratcadmium dichloride decreases expressionISORGD:13128136480464Cadmium Chloride results in decreased expression of EZH1 mRNACTDPMID:38568856

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1Ratchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Ezh1Ratchromatin remodeling involved_inIEAInterPro:IPR0453181600115GO_REF:0000002InterProGO_REF:0000002
Ezh1Ratchromatin remodeling involved_inISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Ratfacultative heterochromatin formation involved_inISORGD:13128141624291 PMID:20064376RGDPMID:20064376
Ezh1Rathepatocyte homeostasis acts_upstream_of_or_withinISORGD:13128141624291MGI:107940 PMID:25477280RGDPMID:25477280
Ezh1Ratheterochromatin formation involved_inISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Ratheterochromatin formation involved_inIBAFB:FBgn0000629|MGI:107940|MGI:1097695|PANTHER:PTN000768863|UniProtKB:Q10MI4|UniProtKB:Q15910|UniProtKB:Q5VN061600115GO_REF:0000033GO_CentralGO_REF:0000033
Ezh1Rathippocampus development  IEP 9587811 RGD 
Ezh1Ratliver regeneration acts_upstream_of_or_withinISORGD:13128141624291MGI:107940 PMID:25477280RGDPMID:25477280
Ezh1Ratmethylation involved_inIEAUniProtKB-KW:KW-04891600115GO_REF:0000043UniProtGO_REF:0000043
Ezh1Ratnegative regulation of transcription by RNA polymerase II involved_inISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Ratnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISORGD:13128141624291 PMID:19303854RGDPMID:19303854
Ezh1Ratpositive regulation of transcription by RNA polymerase II  IMP 9587811 RGD 
Ezh1Ratresponse to tetrachloromethane acts_upstream_of_or_withinISORGD:13128141624291MGI:107940 PMID:25477280RGDPMID:25477280
Ezh1Ratsubtelomeric heterochromatin formation involved_inISORGD:13128141624291UniProtKB:P38827 PMID:9214638RGDPMID:9214638
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Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1Ratchromosome, telomeric region located_inISORGD:13128141624291UniProtKB:P38827 PMID:9214638RGDPMID:9214638
Ezh1RatESC/E(Z) complex part_ofISORGD:13128131624291 PMID:20075857RGDPMID:20075857
Ezh1RatESC/E(Z) complex part_ofIEAUniProtKB:Q92800|ensembl:ENSP000004046581600115GO_REF:0000107EnsemblGO_REF:0000107
Ezh1RatESC/E(Z) complex part_ofIBAFB:FBgn0000629|MGI:107940|MGI:1097695|PANTHER:PTN002907402|UniProtKB:Q15910|UniProtKB:Q928001600115GO_REF:0000033GO_CentralGO_REF:0000033
Ezh1RatESC/E(Z) complex part_ofISORGD:13128141624291 PMID:19026781, PMID:20064376, PMID:20144788, PMID:22438827, PMID:31451685RGDPMID:19026781|PMID:20064376|PMID:20144788|PMID:22438827|PMID:31451685
Ezh1Ratheterochromatin located_inISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Ratnucleoplasm located_inISORGD:1312813|UniProtKB:Q92800-1|UniProtKB:Q92800-3|UniProtKB:Q92800-41624291 RGDGO_REF:0000052
Ezh1Ratnucleoplasm located_inIEAUniProtKB:Q92800|ensembl:ENSP000004046581600115GO_REF:0000107EnsemblGO_REF:0000107
Ezh1Ratnucleus located_inISORGD:13128141624291 PMID:9584197RGDPMID:9584197
Ezh1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Ezh1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Ezh1Ratnucleus is_active_inIBAFB:FBgn0000629|MGI:107940|MGI:1097695|PANTHER:PTN000768863|TAIR:locus:2005501|TAIR:locus:2132178|TAIR:locus:2196110|UniProtKB:Q10MI4|UniProtKB:Q15910|UniProtKB:Q5VN06|UniProtKB:Q92800|WB:WBGene000032201600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
1 to 20 of 27 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1Ratchromatin binding  IDA 9587811 RGD 
Ezh1Ratchromatin binding enablesIBAMGI:107940|PANTHER:PTN000768863|RGD:1305028|RGD:1595860|UniProtKB:Q15910|UniProtKB:Q928001600115GO_REF:0000033GO_CentralGO_REF:0000033
Ezh1RatDNA binding NOT|enablesISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Rathistone binding contributes_toISORGD:13128141624291 PMID:19026781RGDPMID:19026781
Ezh1Rathistone H3 methyltransferase activity enablesIEAARBA:ARBA000349471600115GO_REF:0000117UniProtGO_REF:0000117
Ezh1Rathistone H3K27 methyltransferase activity enablesIBAFB:FBgn0000629|MGI:107940|MGI:1097695|PANTHER:PTN000768863|TAIR:locus:2005501|UniProtKB:Q10MI4|UniProtKB:Q15910|UniProtKB:Q5VN06|UniProtKB:Q92800|WB:WBGene00003220|ZFIN:ZDB-GENE-041111-2591600115GO_REF:0000033GO_CentralGO_REF:0000033
Ezh1Rathistone H3K27 methyltransferase activity enablesIEAInterPro:IPR021654|InterPro:IPR0444381600115GO_REF:0000002InterProGO_REF:0000002
Ezh1Rathistone H3K27 methyltransferase activity enablesIEAInterPro:IPR0216541600115GO_REF:0000002InterProGO_REF:0000002
Ezh1Rathistone H3K27 methyltransferase activity enablesIEAUniProtKB:Q92800|ensembl:ENSP000004046581600115GO_REF:0000107EnsemblGO_REF:0000107
Ezh1Rathistone H3K27 methyltransferase activity enablesIEAARBA:ARBA000448391600115GO_REF:0000117UniProtGO_REF:0000117
Ezh1Rathistone H3K27 methyltransferase activity enablesISORGD:13128131624291 PMID:33514705RGDPMID:33514705
Ezh1Rathistone H3K27 methyltransferase activity enablesISORGD:13128141624291 PMID:19303854RGDPMID:19303854
Ezh1Rathistone H3K27 trimethyltransferase activity enablesIEAEC:2.1.1.3561600115GO_REF:0000003UniProtGO_REF:0000003
Ezh1Rathistone methyltransferase activity enablesIEAInterPro:IPR0453181600115GO_REF:0000002InterProGO_REF:0000002
Ezh1Ratmethyltransferase activity enablesIEAUniProtKB-KW:KW-04891600115GO_REF:0000043UniProtGO_REF:0000043
Ezh1Ratmolecular condensate scaffold activity enablesISORGD:13128131624291 PMID:33514705RGDPMID:33514705
Ezh1Ratmolecular condensate scaffold activity enablesIEAUniProtKB:Q92800|ensembl:ENSP000004046581600115GO_REF:0000107EnsemblGO_REF:0000107
Ezh1Ratnucleosome binding enablesIEAUniProtKB:Q92800|ensembl:ENSP000004046581600115GO_REF:0000107EnsemblGO_REF:0000107
Ezh1Ratnucleosome binding enablesISORGD:13128131624291 PMID:33514705RGDPMID:33514705
Ezh1Ratprotein binding enablesISORGD:1312813,UniProtKB:Q92800-21624291UniProtKB:O75530-2 PMID:32296183RGDPMID:32296183
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ezh1Rathistone modification pathway   ISORGD:13128139479058 RGD 
Ezh1Rathistone modification pathway   ISORGD:13128139479059 RGD 

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Henriquez B, etal., Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.
4. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
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PMID:9214638   PMID:9584197   PMID:19026781   PMID:19303854   PMID:20064376   PMID:20075857   PMID:20144788   PMID:22438827   PMID:25477280   PMID:31451685  



Ezh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,626,307 - 86,662,257 (-)NCBIGRCr8
mRatBN7.21086,126,023 - 86,162,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,126,015 - 86,161,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,162,463 - 91,188,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,641,259 - 90,667,579 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,034,424 - 86,060,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,104,026 - 89,139,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,902,522 - 88,938,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,211,249 - 90,237,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,227,546 - 90,252,203 (-)NCBI
Celera1084,843,423 - 84,869,785 (-)NCBICelera
Cytogenetic Map10q31NCBI
EZH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,700,275 - 42,745,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,700,275 - 42,745,049 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,852,293 - 40,897,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,105,819 - 38,150,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,105,819 - 38,150,574NCBI
Celera1737,507,762 - 37,552,422 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,617,368 - 36,662,170 (-)NCBIHuRef
CHM1_11741,087,908 - 41,132,634 (-)NCBICHM1_1
T2T-CHM13v2.01743,557,412 - 43,602,180 (-)NCBIT2T-CHM13v2.0
Ezh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,081,941 - 101,117,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,081,941 - 101,117,289 (-)EnsemblGRCm39 Ensembl
GRCm3811101,191,115 - 101,226,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,191,115 - 101,226,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,052,429 - 101,087,764 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,007,206 - 101,044,038 (-)NCBIMGSCv36mm8
Celera11112,487,231 - 112,522,681 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.37NCBI
Ezh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,548,858 - 16,564,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,548,898 - 16,563,449 (-)NCBIChiLan1.0ChiLan1.0
EZH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,240,711 - 22,285,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,130,797 - 24,175,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,572,868 - 14,618,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,814,061 - 14,842,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,814,054 - 14,842,295 (+)Ensemblpanpan1.1panPan2
EZH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,271,729 - 20,292,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,264,552 - 20,290,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,724,769 - 19,754,876 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,981,842 - 21,011,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,981,878 - 21,011,945 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,767,995 - 19,797,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,032,956 - 20,063,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,136,953 - 20,167,063 (+)NCBIUU_Cfam_GSD_1.0
Ezh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,609,211 - 19,644,761 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,428,677 - 17,465,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,430,383 - 17,465,889 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,115,297 - 20,141,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,107,744 - 20,139,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,304,800 - 20,338,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EZH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,544,483 - 63,592,651 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,558,551 - 63,587,501 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,337,734 - 34,385,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,454,361 - 1,470,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ezh1
162 total Variants

Predicted Target Of
Summary Value
Count of predictions:363
Count of miRNA genes:210
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000027640
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat

1 to 10 of 79 rows
RH129834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,126,064 - 86,126,262 (+)MAPPERmRatBN7.2
Rnor_6.01089,104,068 - 89,104,265NCBIRnor6.0
Rnor_5.01088,902,564 - 88,902,761UniSTSRnor5.0
RGSC_v3.41090,211,290 - 90,211,487UniSTSRGSC3.4
Celera1084,843,464 - 84,843,661UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH134861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,133,121 - 86,133,313 (+)MAPPERmRatBN7.2
Rnor_6.01089,111,125 - 89,111,316NCBIRnor6.0
Rnor_5.01088,909,621 - 88,909,812UniSTSRnor5.0
RGSC_v3.41090,218,347 - 90,218,538UniSTSRGSC3.4
Celera1084,850,521 - 84,850,712UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
MARC_15753-15754:1017935735:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,629,058 - 86,629,870 (+)Marker Load Pipeline
mRatBN7.21086,128,774 - 86,129,586 (+)MAPPERmRatBN7.2
Rnor_6.01089,106,778 - 89,107,589NCBIRnor6.0
Rnor_5.01088,905,274 - 88,906,085UniSTSRnor5.0
RGSC_v3.41090,214,000 - 90,214,811UniSTSRGSC3.4
Celera1084,846,174 - 84,846,985UniSTS
Cytogenetic Map10q32.1UniSTS
BARC0021  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,629,817 - 86,630,300 (+)Marker Load Pipeline
mRatBN7.21086,129,533 - 86,130,016 (+)MAPPERmRatBN7.2
Rnor_6.01089,107,537 - 89,108,019NCBIRnor6.0
Rnor_5.01088,906,033 - 88,906,515UniSTSRnor5.0
RGSC_v3.41090,214,759 - 90,215,241UniSTSRGSC3.4
Celera1084,846,933 - 84,847,415UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000027640   ⟹   ENSRNOP00000027640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,126,026 - 86,161,921 (-)Ensembl
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101475   ⟹   ENSRNOP00000089467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,126,015 - 86,161,917 (-)Ensembl
RefSeq Acc Id: NM_001107051   ⟹   NP_001100521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,308 - 86,652,620 (-)NCBI
mRatBN7.21086,126,024 - 86,152,338 (-)NCBI
Rnor_6.01089,104,027 - 89,130,339 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
RGSC_v3.41090,211,249 - 90,237,563 (-)RGD
Celera1084,843,423 - 84,869,785 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247318   ⟹   XP_006247380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,257 (-)NCBI
mRatBN7.21086,126,023 - 86,162,001 (-)NCBI
Rnor_6.01089,104,026 - 89,139,978 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247319   ⟹   XP_006247381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,112 (-)NCBI
mRatBN7.21086,126,023 - 86,161,848 (-)NCBI
Rnor_6.01089,104,026 - 89,139,890 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768052   ⟹   XP_008766274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,240 (-)NCBI
mRatBN7.21086,126,023 - 86,162,001 (-)NCBI
Rnor_6.01089,104,026 - 89,139,978 (-)NCBI
Sequence:
Protein RefSeqs NP_001100521 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247380 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247381 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766274 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027640
  ENSRNOP00000027640.7
  ENSRNOP00000089467.1
RefSeq Acc Id: NP_001100521   ⟸   NM_001107051
- UniProtKB: A6HJ95 (UniProtKB/TrEMBL),   F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247380   ⟸   XM_006247318
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247381   ⟸   XM_006247319
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766274   ⟸   XM_008768052
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027640   ⟸   ENSRNOT00000027640
CXC   SET

Name Modeler Protein Id AA Range Protein Structure
AF-F1LZH3-F1-model_v2 AlphaFold F1LZH3 1-747 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23193 BioCyc
Ensembl Genes ENSRNOG00000020336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027640 ENTREZGENE
  ENSRNOT00000027640.7 UniProtKB/TrEMBL
  ENSRNOT00000101475.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
InterPro CXC_dom UniProtKB/TrEMBL
  EZH1/2-like UniProtKB/TrEMBL
  EZH1/2_MCSS UniProtKB/TrEMBL
  EZH1_SET UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/TrEMBL
  Pre-SET_CXC UniProtKB/TrEMBL
  SANT_DNA-bd UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/TrEMBL
KEGG Report rno:303547 UniProtKB/TrEMBL
NCBI Gene 303547 ENTREZGENE
PANTHER PTHR45747 UniProtKB/TrEMBL
  PTHR45747:SF1 UniProtKB/TrEMBL
Pfam Ezh2_MCSS UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/TrEMBL
  preSET_CXC UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Ezh1 PhenoGen
PROSITE CXC UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020336 RatGTEx
SMART CXC UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6A7B9_RAT UniProtKB/TrEMBL
  A6HJ95 ENTREZGENE, UniProtKB/TrEMBL
  F1LZH3 ENTREZGENE, UniProtKB/TrEMBL
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-06 Ezh1  enhancer of zeste 1 polycomb repressive complex 2 subunit  Ezh1  enhancer of zeste homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ezh1  enhancer of zeste homolog 1 (Drosophila)   Ezh1_predicted  enhancer of zeste homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ezh1_predicted  enhancer of zeste homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED