HISTONE MODIFICATION PATHWAY (PW:0001338)

View Ontology Report

Description

Epigenetic changes, the modification and remodeling of chromatin, play a key role in the differential expression of genes. Chromatin modification and remodeling directly affect the relative relaxation or compaction of chromatin and thus, the extent to which DNA replication, transcription, damage response and repair, associated RNA processing and splicing are promoted or are silenced, respectively. The basic unit of chromatin is the nucleosome - it consists of 145-147 base pairs of DNA wrapped ar

Pathway Diagram:

Elsevier Inc. arginine lysine chromatin remodeling pathway DNA modification pathway ubiquitinlysine methyllysine phosphoSTY methylarginine acetyllysine COMPASS complexes --+> gene expression Kmehylases ---> lysine PRC2 complex Kmehylases PTM histone octamer lncRNAs, chromatin modification lncRNAs, chromatin modification ---> gene expression unmodified-Kreaders Rmethylases ---> arginine Rmethylases Kdeacetylases ---| gene expression Kac-readers ---> gene expression Kme-readers ---> gene expression Kdeubiquitinases --+> gene expression Kdemethylases ---> methyllysine Kdeacetylases ---> acetyllysine histone chaperones ---- PTM histone octamer histone chaperones ---- histone octamer Kme-readers ---- methyllysine acetyllysine ---- Kac-readers lysine ---- unmodified-Kreaders PRC1 complex ---> lysine methylarginine ---- Rme-readers COMPASS complexes PRC1 complex Kacetylases Kacetylases ---> lysine P-readers ---- phosphoSTY histone octamer <--> PTM histone octamer PRC2 complex ---| gene expression Kacetylases --+> gene expression PRC1 complex ---| gene expression Kdeacetylases Kac-readers Kme-readers Kdemethylases Kdeubiquitinases P-readers Rme-readers histone octamer gene expression PRC2 complex ---> lysine COMPASS complexes ---> lysine Kdeubiquitinases ---> ubiquitinlysine histone chaperones
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Genes in Pathway:

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histone modification pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aebp2 AE binding protein 2 JBrowse link 4 174,799,378 174,863,260 RGD:9479059
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:9068945
G Asf1a anti-silencing function 1A histone chaperone JBrowse link 20 34,894,419 34,909,265 RGD:9068945
G Asf1b anti-silencing function 1B histone chaperone JBrowse link 19 25,077,918 25,092,491 RGD:9068945
G Ash1l ASH1 like histone lysine methyltransferase JBrowse link 2 188,252,592 188,389,251 RGD:7242632
G Ash2l ASH2 like histone lysine methyltransferase complex subunit JBrowse link 16 71,011,315 71,033,171 RGD:9479053
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:9479061
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:9479074
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:9479058
RGD:9479060
G Bptf bromodomain PHD finger transcription factor JBrowse link 10 95,248,573 95,350,162 RGD:9479075
RGD:9479074
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:9479061
G Brd1 bromodomain containing 1 JBrowse link 7 129,676,119 129,724,303 RGD:9479075
G Brd2 bromodomain containing 2 JBrowse link 20 3,910,555 3,921,074 RGD:9479075
G Brd3 bromodomain containing 3 JBrowse link 3 5,995,204 6,054,467 RGD:9479075
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:9479075
G Brd7 bromodomain containing 7 JBrowse link 19 19,672,780 19,701,484 RGD:9479075
G Brdt bromodomain testis associated JBrowse link 14 3,437,876 3,462,613 RGD:9479075
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit JBrowse link 6 137,762,230 137,808,573 RGD:9479074
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:9479047
G Cbx2 chromobox 2 JBrowse link 10 108,132,105 108,140,935 RGD:9479058
RGD:9479060
G Cbx4 chromobox 4 JBrowse link 10 108,190,947 108,196,455 RGD:9479058
RGD:9479060
G Cbx5 chromobox 5 JBrowse link 7 144,819,673 144,865,014 RGD:9479074
G Cbx6 chromobox 6 JBrowse link 7 121,047,996 121,058,109 RGD:9479058
RGD:9479060
G Cbx7 chromobox 7 JBrowse link 7 121,136,067 121,153,503 RGD:9479058
RGD:9479060
G Cbx8 chromobox 8 JBrowse link 10 108,148,073 108,150,511 RGD:9479058
RGD:9479060
G Chaf1a chromatin assembly factor 1 subunit A JBrowse link 9 11,000,869 11,027,631 RGD:9068945
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link 11 34,101,248 34,121,371 RGD:9068945
G Chd1 chromodomain helicase DNA binding protein 1 JBrowse link 1 57,692,828 57,756,762 RGD:9479074
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:9104959
RGD:9479075
G Cxxc1 CXXC finger protein 1 JBrowse link 18 70,192,520 70,197,871 RGD:9479053
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:9068945
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:7242632
G Dpf3 double PHD fingers 3 JBrowse link 6 106,660,569 106,971,310 RGD:9479074
G Dpy30 dpy-30 histone methyltransferase complex regulatory subunit JBrowse link 6 22,296,128 22,316,894 RGD:9479053
G Eed embryonic ectoderm development JBrowse link 1 154,189,252 154,216,340 RGD:9479058
RGD:9479059
G Ehmt1 euchromatic histone lysine methyltransferase 1 JBrowse link 3 1,966,974 2,123,858 RGD:7242632
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:7242632
RGD:9479074
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:9104959
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link 10 89,104,026 89,139,978 RGD:9479058
RGD:9479059
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:7242632
RGD:9479059
RGD:9479058
G H2afx H2A histone family, member X JBrowse link 8 48,665,652 48,666,981 RGD:9075965
G H2afy H2A histone family, member Y JBrowse link 17 9,282,109 9,344,698 RGD:9074213
G H2afy2 H2A histone family, member Y2 JBrowse link 20 31,352,924 31,402,483 RGD:9074213
G H2afz H2A histone family, member Z JBrowse link 2 243,105,224 243,107,333 RGD:9074213
G H3f3a H3 histone family member 3A JBrowse link 13 99,091,246 99,102,828 RGD:9075965
G H3f3b H3 histone family member 3B JBrowse link 10 104,573,666 104,575,890 RGD:9075965
G Hat1 histone acetyltransferase 1 JBrowse link 3 58,022,395 58,070,067 RGD:9104959
G Hcfc1 host cell factor C1 JBrowse link X 156,812,012 156,837,227 RGD:9479053
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:9104959
G Hdac10 histone deacetylase 10 JBrowse link 7 130,102,335 130,109,036 RGD:9104959
G Hdac11 histone deacetylase 11 JBrowse link 4 122,781,095 122,798,355 RGD:9104959
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:9104959
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:9104959
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:9104959
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:9104959
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:9104959
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:9104959
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:9104959
G Hira histone cell cycle regulator JBrowse link 11 86,168,196 86,276,430 RGD:9068945
G Hjurp Holliday junction recognition protein JBrowse link 9 95,347,739 95,362,228 RGD:9068945
G Ing2 inhibitor of growth family, member 2 JBrowse link 16 47,714,756 47,725,836 RGD:9479074
G Jarid2 jumonji and AT-rich interaction domain containing 2 JBrowse link 17 20,183,440 20,365,219 RGD:9479058
RGD:9479059
G Jmjd1c jumonji domain containing 1C JBrowse link 20 22,751,743 22,914,080 RGD:7242632
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:9104959
RGD:9479074
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:9104959
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:9104959
G Kat6a lysine acetyltransferase 6A JBrowse link 16 73,942,669 74,020,750 RGD:9104959
G Kat6b lysine acetyltransferase 6B JBrowse link 15 2,811,933 2,966,833 RGD:9104959
G Kat7 lysine acetyltransferase 7 JBrowse link 10 83,095,067 83,128,342 RGD:9104959
G Kat8 lysine acetyltransferase 8 JBrowse link 1 199,360,645 199,372,925 RGD:9104959
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:7242632
G Kdm1b lysine demethylase 1B JBrowse link 17 17,987,972 18,028,808 RGD:7242632
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:7242632
G Kdm2b lysine demethylase 2B JBrowse link 12 39,021,924 39,161,954 RGD:7242632
G Kdm3a lysine demethylase 3A JBrowse link 4 99,503,160 99,547,315 RGD:7242632
G Kdm3b lysine demethylase 3B JBrowse link 18 27,593,823 27,631,129 RGD:7242632
G Kdm4a lysine demethylase 4A JBrowse link 5 136,967,650 137,014,402 RGD:7242632
RGD:9479074
RGD:9479148
G Kdm4b lysine demethylase 4B JBrowse link 9 10,656,035 10,734,127 RGD:7242632
G Kdm4c lysine demethylase 4C JBrowse link 5 90,800,139 91,012,662 RGD:7242632
G Kdm4e lysine demethylase 4E JBrowse link 8 12,968,192 12,994,050 RGD:7242632
G Kdm5a lysine demethylase 5A JBrowse link 4 152,892,388 152,972,196 RGD:7242632
G Kdm5b lysine demethylase 5B JBrowse link 13 51,384,371 51,455,392 RGD:7242632
G Kdm5c lysine demethylase 5C JBrowse link X 22,302,664 22,349,298 RGD:7242632
G Kdm6b lysine demethylase 6B JBrowse link 10 56,000,494 56,009,582 RGD:7242632
G Kdm7a lysine demethylase 7A JBrowse link 4 66,915,603 66,957,971 RGD:7242632
G Kdm8 lysine demethylase 8 JBrowse link 1 196,838,460 196,854,192 RGD:7242632
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:7242632
RGD:9479053
G Kmt2b lysine methyltransferase 2B JBrowse link 1 89,022,889 89,042,176 RGD:7242632
G Kmt2c lysine methyltransferase 2C JBrowse link 4
4
82,506
6,083,650
109,986
6,294,413
RGD:7242632
RGD:9479053
G Kmt2d lysine methyltransferase 2D JBrowse link 7 140,507,137 140,542,479 RGD:7242632
RGD:9479053
G Kmt2e lysine methyltransferase 2E JBrowse link 4 8,187,751 8,255,578 RGD:7242632
G Kmt5b lysine methyltransferase 5B JBrowse link 1 219,000,844 219,050,211 RGD:7242632
G Kmt5c lysine methyltransferase 5C JBrowse link 1 72,666,662 72,674,271 RGD:7242632
G L3mbtl1 L3MBTL1, histone methyl-lysine binding protein JBrowse link 3 159,316,580 159,348,914 RGD:9479074
G Lbr lamin B receptor JBrowse link 13 100,431,390 100,450,209 RGD:9479148
G LOC100909949 N-lysine methyltransferase SETD8-like JBrowse link 2 148,262,128 148,264,689 RGD:7242632
G LOC100911180 histone-lysine N-methyltransferase SETDB1-like RGD:7242632
G LOC100911617 protein arginine N-methyltransferase 6-like JBrowse link 2 213,173,403 213,180,727 RGD:9479047
G Mcph1 microcephalin 1 JBrowse link 16 75,904,087 76,110,624 RGD:9479074
G Mdc1 mediator of DNA damage checkpoint 1 JBrowse link 20 3,405,017 3,419,831 RGD:9479074
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:9479053
G Mtf2 metal response element binding transcription factor 2 JBrowse link 14 2,656,776 2,701,027 RGD:9479058
RGD:9479059
G Mysm1 myb-like, SWIRM and MPN domains 1 JBrowse link 5 113,902,115 113,939,083 RGD:9479061
G Nap1l1 nucleosome assembly protein 1-like 1 JBrowse link 7 54,213,305 54,237,880 RGD:9068945
G Nasp nuclear autoantigenic sperm protein JBrowse link 5 135,446,485 135,472,113 RGD:9068945
G Ncoa6 nuclear receptor coactivator 6 JBrowse link 3 150,919,317 150,990,391 RGD:9479053
G Nsd1 nuclear receptor binding SET domain protein 1 JBrowse link 17 9,840,859 9,955,391 RGD:7242632
G Nsd3 nuclear receptor binding SET domain protein 3 JBrowse link 16 71,126,276 71,237,118 RGD:7242632
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:9479074
G Pagr1 Paxip1-associated glutamate-rich protein 1 JBrowse link 1 198,448,790 198,451,078 RGD:9479053
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:9479053
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:9479075
G Pcgf1 polycomb group ring finger 1 JBrowse link 4 113,911,129 113,913,718 RGD:9479058
RGD:9479060
G Pcgf3 polycomb group ring finger 3 JBrowse link 14 2,247,805 2,297,155 RGD:9479058
RGD:9479060
G Pcgf5 polycomb group ring finger 5 JBrowse link 1 254,974,688 255,090,925 RGD:9479058
RGD:9479060
G Pcgf6 polycomb group ring finger 6 JBrowse link 1 266,811,418 266,831,022 RGD:9479058
RGD:9479060
G Phc1 polyhomeotic homolog 1 JBrowse link 4 155,093,947 155,118,838 RGD:9479058
RGD:9479060
G Phc2 polyhomeotic homolog 2 JBrowse link 5 146,832,552 146,931,444 RGD:9479058
RGD:9479060
G Phc3 polyhomeotic homolog 3 JBrowse link 2 116,028,735 116,103,227 RGD:9479058
RGD:9479060
G Phf1 PHD finger protein 1 JBrowse link 20 5,526,926 5,531,940 RGD:9479058
RGD:9479074
RGD:9479148
RGD:9479059
G Phf19 PHD finger protein 19 JBrowse link 3 13,957,136 13,978,283 RGD:9479058
RGD:9479074
RGD:9479148
RGD:9479059
G Phf2 PHD finger protein 2 JBrowse link 17 16,240,458 16,274,626 RGD:7242632
G Phf8 PHD finger protein 8 JBrowse link X 21,063,487 21,168,750 RGD:7242632
G Prdm16 PR/SET domain 16 JBrowse link 5 171,662,277 171,711,561 RGD:7242632
G Prdm2 PR/SET domain 2 JBrowse link 5 161,769,587 161,879,150 RGD:7242632
G Prdm6 PR/SET domain 6 JBrowse link 18 48,433,747 48,538,834 RGD:7242632
G Prdm8 PR/SET domain 8 JBrowse link 14 13,052,776 13,073,583 RGD:7242632
G Prdm9 PR/SET domain 9 JBrowse link 1 57,533,602 57,555,155 RGD:7242632
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:9479047
G Prmt2 protein arginine methyltransferase 2 JBrowse link 20 13,154,513 13,212,613 RGD:9479047
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:9479047
G Prmt7 protein arginine methyltransferase 7 JBrowse link 19 38,189,605 38,237,155 RGD:9479047
G Rag2 recombination activating 2 JBrowse link 3 91,191,837 91,200,134 RGD:9479074
G Rbbp4 RB binding protein 4, chromatin remodeling factor JBrowse link 5 147,499,880 147,535,240 RGD:9479058
RGD:9479059
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit JBrowse link 13 49,250,301 49,277,152 RGD:9479053
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:9479058
RGD:9479059
G Ring1 ring finger protein 1 JBrowse link 20 3,812,287 3,815,834 RGD:9479058
RGD:9479060
G Rnf2 ring finger protein 2 JBrowse link 13 68,829,714 68,859,920 RGD:9479058
RGD:9479060
G Setd2 SET domain containing 2 JBrowse link 8 118,802,478 118,888,224 RGD:7242632
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:7242632
G Sgf29 SAGA complex associated factor 29 JBrowse link 1 198,066,974 198,100,494 RGD:9479148
RGD:9479074
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9104959
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:9104959
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:9104959
G Sirt4 sirtuin 4 JBrowse link 12 46,862,358 46,876,593 RGD:9104959
G Sirt5 sirtuin 5 JBrowse link 17 23,986,710 24,013,854 RGD:9104959
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:9104959
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:9104959
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 JBrowse link 1 244,615,811 244,783,736 RGD:9479075
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:9479075
G Smyd1 SET and MYND domain containing 1 JBrowse link 4 99,071,122 99,125,143 RGD:7242632
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:7242632
G Smyd3 SET and MYND domain containing 3 JBrowse link 13 97,330,120 97,807,813 RGD:7242632
G Spin1 spindlin 1 JBrowse link 16 884,854 930,527 RGD:9479148
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:9068945
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit JBrowse link 15 28,574,841 28,611,959 RGD:9068945
G Suv39h1 suppressor of variegation 3-9 homolog 1 JBrowse link X 146,532,002 146,533,538 RGD:7242632
G Suv39h2 suppressor of variegation 3-9 homolog 2 JBrowse link 17 78,762,897 78,782,016 RGD:7242632
G Suz12 SUZ12 polycomb repressive complex 2 subunit JBrowse link 10 67,325,101 67,371,588 RGD:9479058
RGD:9479059
G Taf1 TATA-box binding protein associated factor 1 JBrowse link X 71,412,291 71,486,456 RGD:9479074
RGD:9479075
G Tdrd3 tudor domain containing 3 JBrowse link 15 70,732,164 70,864,855 RGD:9479148
RGD:9479163
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:9479148
RGD:9479074
G Trim24 tripartite motif-containing 24 JBrowse link 4 65,632,278 65,684,746 RGD:9479074
G Trim33 tripartite motif-containing 33 JBrowse link 2 205,783,252 205,863,426 RGD:9479074
RGD:9479075
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:9479148
RGD:9479074
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:9479061
G Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:9479061
G Usp21 ubiquitin specific peptidase 21 JBrowse link 13 89,655,016 89,661,150 RGD:9479061
G Usp22 ubiquitin specific peptidase 22 JBrowse link 10 47,429,201 47,453,298 RGD:9479061
G Usp3 ubiquitin specific peptidase 3 JBrowse link 8 72,207,970 72,284,871 RGD:9479061
G Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:9479061
G Uty ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome JBrowse link Y 1,065,274 1,206,127 RGD:9479053
RGD:7242632
G Wdr5 WD repeat domain 5 JBrowse link 3 6,061,892 6,080,724 RGD:9479053
RGD:9479074
G Wdr82 WD repeat domain 82 JBrowse link 8 114,866,769 114,886,208 RGD:9479053
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:9479074

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the histone modification pathway
Pathway TermsGene Symbols
ADP-ribosylation pathway, mono and poly-ribosylationAplf
aldosterone signaling pathwayCrebbp , Daxx
altered SWI/SNF family mediated chromatin remodeling pathwayPbrm1 , Smarca4
amyotrophic lateral sclerosis disease pathwayDaxx
androgen signaling pathwayCarm1 , Crebbp , Ep300 , Prmt1
ataxia telangiectasia-mutated (ATM) signaling pathwayBrcc3 , H2afx , Kat5 , Kdm4a , L3mbtl1 , Mdc1 , Tp53bp1 , Usp16 , Usp3 , Usp44
calcium/calmodulin dependent kinase 2 signaling pathwayHdac4 , Hdac5
carnitine biosynthetic pathwaySetd7
cell cycle pathway, mitoticCrebbp , Ep300 , Hdac1 , Hdac2 , Ywhaz
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2 , Rbbp4 , Rbbp7
cholesterol biosynthetic pathwayLbr
chronic myeloid leukemia pathwayHdac1 , Hdac2
cisplatin drug pathwaySsrp1
colorectal cancer pathwayBirc5
cortisol signaling pathwayCrebbp , Ep300 , Smarca4
DNA modification pathwayCxxc1 , Kdm2a , Kdm2b , Kmt2a , Kmt2c , Uhrf1
estrogen signaling pathwayCarm1 , Crebbp , Ep300 , Ncoa6 , Prmt1
forkhead class A signaling pathwayCrebbp , Ep300
granulocyte-macrophage colony-stimulating factor signaling pathwayYwhaz
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Rbbp4 , Rbbp7
histone modification pathwayAebp2 , Aplf , Asf1a , Asf1b , Ash1l , Ash2l , Bap1 , Birc5 , Bmi1 , Bptf , Brcc3 , Brd1 , Brd2 , Brd3 , Brd4 , Brd7 , Brdt , Brf1 , Carm1 , Cbx2 , Cbx4 , Cbx5 , Cbx6 , Cbx7 , Cbx8 , Chaf1a , Chaf1b , Chd1 , Crebbp , Cxxc1 , Daxx , Dot1l , Dpf3 , Dpy30 , Eed , Ehmt1 , Ehmt2 , Ep300 , Ezh1 , Ezh2 , H2afx , H2afy , H2afy2 , H2afz , H3f3a , H3f3b , Hat1 , Hcfc1 , Hdac1 , Hdac10 , Hdac11 , Hdac2 , Hdac3 , Hdac4 , Hdac5 , Hdac6 , Hdac7 , Hdac9 , Hira , Hjurp , Ing2 , Jarid2 , Jmjd1c , Kat2a , Kat2b , Kat5 , Kat6a , Kat6b , Kat7 , Kat8 , Kdm1a , Kdm1b , Kdm2a , Kdm2b , Kdm3a , Kdm3b , Kdm4a , Kdm4b , Kdm4c , Kdm4e , Kdm5a , Kdm5b , Kdm5c , Kdm6b , Kdm7a , Kdm8 , Kmt2a , Kmt2b , Kmt2c , Kmt2d , Kmt2e , Kmt5b , Kmt5c , L3mbtl1 , Lbr , LOC100909949 , LOC100911180 , LOC100911617 , Mcph1 , Mdc1 , Men1 , Mtf2 , Mysm1 , Nap1l1 , Nasp , Ncoa6 , Nsd1 , Nsd3 , Orc1 , Pagr1 , Paxip1 , Pbrm1 , Pcgf1 , Pcgf3 , Pcgf5 , Pcgf6 , Phc1 , Phc2 , Phc3 , Phf1 , Phf19 , Phf2 , Phf8 , Prdm16 , Prdm2 , Prdm6 , Prdm8 , Prdm9 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Rag2 , Rbbp4 , Rbbp5 , Rbbp7 , Ring1 , Rnf2 , Setd2 , Setd7 , Sgf29 , Sirt1 , Sirt2 , Sirt3 , Sirt4 , Sirt5 , Sirt6 , Sirt7 , Smarca2 , Smarca4 , Smyd1 , Smyd2 , Smyd3 , Spin1 , Ssrp1 , Supt16h , Suv39h1 , Suv39h2 , Suz12 , Taf1 , Tdrd3 , Tp53bp1 , Trim24 , Trim33 , Uhrf1 , Usp12 , Usp16 , Usp21 , Usp22 , Usp3 , Usp44 , Uty , Wdr5 , Wdr82 , Ywhaz
homocysteine metabolic pathwayCarm1 , Dot1l , Prmt1 , Prmt5 , Suv39h2
Huntington disease pathwayCrebbp , Ep300 , Hdac1 , Hdac2
hypoxia inducible factor pathwayCrebbp , Ep300 , Hdac7
influenza A virus infection pathwayCrebbp , Ep300
INO80 family mediated chromatin remodeling pathwayKat5
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhaz
insulin-like growth factor signaling pathwayYwhaz
interleukin-3 signaling pathwayHdac1 , Ywhaz
ISWI family mediated chromatin remodeling pathwayBptf , Rbbp4 , Rbbp7
Jak-Stat signaling pathwayCrebbp , Ep300
long term potentiationCrebbp , Ep300
lysine degradation pathwayAsh1l , Dot1l , Ehmt1 , Ehmt2 , Kmt2d , Kmt2e , Kmt5b , Kmt5c , Nsd1 , Nsd3 , Setd2 , Setd7 , Suv39h2
methionine cycle/metabolic pathwayCarm1 , Dot1l , Ezh2 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Setd7 , Smyd2 , Suv39h2
mitogen activated protein kinase signaling pathwayDaxx
mTOR signaling pathwayYwhaz
Mycobacterium tuberculosis infection pathwayCrebbp , Ep300
neurotrophic factor signaling pathwayYwhaz
non-homologous end joining pathway of double-strand break repairAplf , Tp53bp1
Notch signaling pathwayCrebbp , Ep300 , Hdac1 , Hdac2 , Kat2a , Kat2b , Kdm1a
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p53 signaling pathwayCrebbp , Daxx , Ep300 , Hdac1 , Kat2a , Kat2b , Kat5 , Kat8 , Prmt5 , Setd7 , Sirt1 , Smyd2
pancreatic cancer pathwayPbrm1 , Smarca4
phosphatidylinositol 3-kinase-Akt signaling pathwayYwhaz
platelet-derived growth factor signaling pathwayYwhaz
primary immunodeficiency disease pathwayRag2
prostate cancer pathwayCrebbp , Ep300
renal cell cancer pathwayCrebbp , Ep300 , Kdm5c , Pbrm1 , Setd2 , Uty
RNA polymerase I transcription pathwayCrebbp , Sirt1 , Sirt7 , Ssrp1 , Supt16h
RNA polymerase II transcription elongation pathwaySsrp1 , Supt16h
RNA polymerase II transcription initiation pathwayKat2a , Kat2b , Sgf29 , Taf1 , Usp22 , Wdr5
RNA polymerase III transcription pathwayBrf1
RNA transport pathwayPrmt5
Sirtuin mediated pathwaySirt1 , Sirt2 , Sirt3 , Sirt4 , Sirt5 , Sirt6 , Sirt7
SWI/SNF family mediated chromatin remodeling pathwayBrd7 , Dpf3 , Pbrm1 , Smarca2 , Smarca4
systemic lupus erythematosus pathwayH2afx , H2afy , H2afy2 , H2afz , H3f3b
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300
type II interferon signaling pathwayCrebbp , Ep300
Wnt signaling pathwayCrebbp , Ep300
Wnt signaling, canonical pathwayCrebbp , Smarca4
Phenotype Annotations Associated with Genes in the histone modification pathway

References Associated with the histone modification pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: