HISTONE MODIFICATION PATHWAY (PW:0001338)

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Description

Epigenetic changes, the modification and remodeling of chromatin, play a key role in the differential expression of genes. Chromatin modification and remodeling directly affect the relative relaxation or compaction of chromatin and thus, the extent to which DNA replication, transcription, damage response and repair, associated RNA processing and splicing are promoted or are silenced, respectively. The basic unit of chromatin is the nucleosome - it consists of 145-147 base pairs of DNA wrapped ar

Pathway Diagram:

Elsevier Inc. arginine lysine chromatin remodeling pathway DNA modification pathway phosphoSTY methylarginine ubiquitinlysine methyllysine acetyllysine histone chaperones Kdeubiquitinases ---> ubiquitinlysine COMPASS complexes ---> lysine PRC2 complex ---> lysine gene expression histone octamer Rme-readers P-readers Kdeubiquitinases Kdemethylases Kme-readers Kac-readers Kdeacetylases Kacetylases ---> gene expression P-readers ---- phosphoSTY Kacetylases ---> lysine Kacetylases methylarginine ---- Rme-readers PRC1 complex ---> lysine acetyllysine ---- Kac-readers Kme-readers ---- methyllysine histone chaperones ---- histone octamer histone chaperones ---- PTM histone octamer Kdeacetylases ---> acetyllysine Kdemethylases ---> methyllysine Kme-readers ---> gene expression Kac-readers ---> gene expression Rmethylases Rmethylases ---> arginine unmodified-Kreaders lncRNAs, chromatin modification ---> gene expression lncRNAs, chromatin modification PTM histone octamer Kmehylases Kmehylases ---> lysine lysine ---- unmodified-Kreaders COMPASS complexes PRC1 complex PRC2 complex PRC1 complex ---| gene expression COMPASS complexes --+> gene expression PRC2 complex ---| gene expression Kdeubiquitinases --+> gene expression Kdeacetylases ---| gene expression
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Genes in Pathway:

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histone modification pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aebp2 AE binding protein 2 JBrowse link 4 174,799,378 174,863,260 RGD:9479059
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:9068945
G Asf1a anti-silencing function 1A histone chaperone JBrowse link 20 34,894,419 34,909,265 RGD:9068945
G Asf1b anti-silencing function 1B histone chaperone JBrowse link 19 25,077,918 25,092,491 RGD:9068945
G Ash1l ASH1 like histone lysine methyltransferase JBrowse link 2 188,252,592 188,389,251 RGD:7242632
G Ash2l ASH2 like histone lysine methyltransferase complex subunit JBrowse link 16 71,011,315 71,033,171 RGD:9479053
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:9479061
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:9479074
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:9479058
RGD:9479060
G Bptf bromodomain PHD finger transcription factor JBrowse link 10 95,248,573 95,350,162 RGD:9479075
RGD:9479074
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:9479061
G Brd1 bromodomain containing 1 JBrowse link 7 129,676,119 129,724,303 RGD:9479075
G Brd2 bromodomain containing 2 JBrowse link 20 3,910,555 3,921,074 RGD:9479075
G Brd3 bromodomain containing 3 JBrowse link 3 5,995,204 6,054,467 RGD:9479075
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:9479075
G Brd7 bromodomain containing 7 JBrowse link 19 19,672,780 19,701,484 RGD:9479075
G Brdt bromodomain testis associated JBrowse link 14 3,437,876 3,462,613 RGD:9479075
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit JBrowse link 6 137,762,230 137,808,573 RGD:9479074
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:9479047
G Cbx2 chromobox 2 JBrowse link 10 108,132,105 108,140,935 RGD:9479058
RGD:9479060
G Cbx4 chromobox 4 JBrowse link 10 108,190,947 108,196,455 RGD:9479058
RGD:9479060
G Cbx5 chromobox 5 JBrowse link 7 144,819,673 144,865,014 RGD:9479074
G Cbx6 chromobox 6 JBrowse link 7 121,047,996 121,058,109 RGD:9479058
RGD:9479060
G Cbx7 chromobox 7 JBrowse link 7 121,136,067 121,153,503 RGD:9479058
RGD:9479060
G Cbx8 chromobox 8 JBrowse link 10 108,148,073 108,150,511 RGD:9479058
RGD:9479060
G Chaf1a chromatin assembly factor 1 subunit A JBrowse link 9 11,000,869 11,027,631 RGD:9068945
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link 11 34,101,248 34,121,371 RGD:9068945
G Chd1 chromodomain helicase DNA binding protein 1 JBrowse link 1 57,692,828 57,756,762 RGD:9479074
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:9104959
RGD:9479075
G Cxxc1 CXXC finger protein 1 JBrowse link 18 70,192,520 70,197,871 RGD:9479053
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:9068945
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:7242632
G Dpf3 double PHD fingers 3 JBrowse link 6 106,660,569 106,971,310 RGD:9479074
G Dpy30 dpy-30 histone methyltransferase complex regulatory subunit JBrowse link 6 22,296,128 22,316,894 RGD:9479053
G Eed embryonic ectoderm development JBrowse link 1 154,189,252 154,216,340 RGD:9479058
RGD:9479059
G Ehmt1 euchromatic histone lysine methyltransferase 1 JBrowse link 3 1,966,974 2,123,858 RGD:7242632
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:7242632
RGD:9479074
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:9104959
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link 10 89,104,026 89,139,978 RGD:9479058
RGD:9479059
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:7242632
RGD:9479059
RGD:9479058
G H2afx H2A histone family, member X JBrowse link 8 48,665,652 48,666,981 RGD:9075965
G H2afy H2A histone family, member Y JBrowse link 17 9,282,109 9,344,698 RGD:9074213
G H2afy2 H2A histone family, member Y2 JBrowse link 20 31,352,924 31,402,483 RGD:9074213
G H2afz H2A histone family, member Z JBrowse link 2 243,105,224 243,107,333 RGD:9074213
G H3f3a H3 histone family member 3A JBrowse link 13 99,091,246 99,102,828 RGD:9075965
G H3f3b H3 histone family member 3B JBrowse link 10 104,573,666 104,575,890 RGD:9075965
G Hat1 histone acetyltransferase 1 JBrowse link 3 58,022,395 58,070,067 RGD:9104959
G Hcfc1 host cell factor C1 JBrowse link X 156,812,012 156,837,227 RGD:9479053
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:9104959
G Hdac10 histone deacetylase 10 JBrowse link 7 130,102,335 130,109,036 RGD:9104959
G Hdac11 histone deacetylase 11 JBrowse link 4 122,781,095 122,798,355 RGD:9104959
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:9104959
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:9104959
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:9104959
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:9104959
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:9104959
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:9104959
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:9104959
G Hira histone cell cycle regulator JBrowse link 11 86,168,196 86,276,430 RGD:9068945
G Hjurp Holliday junction recognition protein JBrowse link 9 95,347,739 95,362,228 RGD:9068945
G Ing2 inhibitor of growth family, member 2 JBrowse link 16 47,714,756 47,725,836 RGD:9479074
G Jarid2 jumonji and AT-rich interaction domain containing 2 JBrowse link 17 20,183,440 20,365,219 RGD:9479058
RGD:9479059
G Jmjd1c jumonji domain containing 1C JBrowse link 20 22,751,743 22,914,080 RGD:7242632
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:9104959
RGD:9479074
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:9104959
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:9104959
G Kat6a lysine acetyltransferase 6A JBrowse link 16 73,942,669 74,020,750 RGD:9104959
G Kat6b lysine acetyltransferase 6B JBrowse link 15 2,811,933 2,966,833 RGD:9104959
G Kat7 lysine acetyltransferase 7 JBrowse link 10 83,095,067 83,128,342 RGD:9104959
G Kat8 lysine acetyltransferase 8 JBrowse link 1 199,360,645 199,372,925 RGD:9104959
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:7242632
G Kdm1b lysine demethylase 1B JBrowse link 17 17,987,972 18,028,808 RGD:7242632
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:7242632
G Kdm2b lysine demethylase 2B JBrowse link 12 39,021,924 39,161,954 RGD:7242632
G Kdm3a lysine demethylase 3A JBrowse link 4 99,503,160 99,547,315 RGD:7242632
G Kdm3b lysine demethylase 3B JBrowse link 18 27,593,823 27,631,129 RGD:7242632
G Kdm4a lysine demethylase 4A JBrowse link 5 136,967,650 137,014,402 RGD:7242632
RGD:9479074
RGD:9479148
G Kdm4b lysine demethylase 4B JBrowse link 9 10,656,035 10,734,127 RGD:7242632
G Kdm4c lysine demethylase 4C JBrowse link 5 90,800,139 91,012,662 RGD:7242632
G Kdm4e lysine demethylase 4E JBrowse link 8 12,968,192 12,994,050 RGD:7242632
G Kdm5a lysine demethylase 5A JBrowse link 4 152,892,388 152,972,196 RGD:7242632
G Kdm5b lysine demethylase 5B JBrowse link 13 51,384,371 51,455,392 RGD:7242632
G Kdm5c lysine demethylase 5C JBrowse link X 22,302,664 22,349,298 RGD:7242632
G Kdm6b lysine demethylase 6B JBrowse link 10 56,000,494 56,009,582 RGD:7242632
G Kdm7a lysine demethylase 7A JBrowse link 4 66,915,603 66,957,971 RGD:7242632
G Kdm8 lysine demethylase 8 JBrowse link 1 196,838,460 196,854,192 RGD:7242632
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:7242632
RGD:9479053
G Kmt2b lysine methyltransferase 2B JBrowse link 1 89,022,889 89,042,176 RGD:7242632
G Kmt2c lysine methyltransferase 2C JBrowse link 4
4
82,506
6,083,650
109,986
6,294,413
RGD:7242632
RGD:9479053
G Kmt2d lysine methyltransferase 2D JBrowse link 7 140,507,137 140,542,479 RGD:7242632
RGD:9479053
G Kmt2e lysine methyltransferase 2E JBrowse link 4 8,187,751 8,255,578 RGD:7242632
G Kmt5b lysine methyltransferase 5B JBrowse link 1 219,000,844 219,050,211 RGD:7242632
G Kmt5c lysine methyltransferase 5C JBrowse link 1 72,666,662 72,674,271 RGD:7242632
G L3mbtl1 L3MBTL1, histone methyl-lysine binding protein JBrowse link 3 159,316,580 159,348,914 RGD:9479074
G Lbr lamin B receptor JBrowse link 13 100,431,390 100,450,209 RGD:9479148
G LOC100909949 N-lysine methyltransferase SETD8-like JBrowse link 2 148,262,128 148,264,689 RGD:7242632
G LOC100911180 histone-lysine N-methyltransferase SETDB1-like RGD:7242632
G LOC100911617 protein arginine N-methyltransferase 6-like JBrowse link 2 213,173,403 213,180,727 RGD:9479047
G Mcph1 microcephalin 1 JBrowse link 16 75,904,087 76,110,624 RGD:9479074
G Mdc1 mediator of DNA damage checkpoint 1 JBrowse link 20 3,405,017 3,419,831 RGD:9479074
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:9479053
G Mtf2 metal response element binding transcription factor 2 JBrowse link 14 2,656,776 2,701,027 RGD:9479058
RGD:9479059
G Mysm1 myb-like, SWIRM and MPN domains 1 JBrowse link 5 113,902,115 113,939,083 RGD:9479061
G Nap1l1 nucleosome assembly protein 1-like 1 JBrowse link 7 54,213,305 54,237,880 RGD:9068945
G Nasp nuclear autoantigenic sperm protein JBrowse link 5 135,446,485 135,472,113 RGD:9068945
G Ncoa6 nuclear receptor coactivator 6 JBrowse link 3 150,919,317 150,990,391 RGD:9479053
G Nsd1 nuclear receptor binding SET domain protein 1 JBrowse link 17 9,840,859 9,955,391 RGD:7242632
G Nsd3 nuclear receptor binding SET domain protein 3 JBrowse link 16 71,126,276 71,237,118 RGD:7242632
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:9479074
G Pagr1 Paxip1-associated glutamate-rich protein 1 JBrowse link 1 198,448,790 198,451,078 RGD:9479053
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:9479053
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:9479075
G Pcgf1 polycomb group ring finger 1 JBrowse link 4 113,911,129 113,913,718 RGD:9479058
RGD:9479060
G Pcgf3 polycomb group ring finger 3 JBrowse link 14 2,247,805 2,297,155 RGD:9479058
RGD:9479060
G Pcgf5 polycomb group ring finger 5 JBrowse link 1 254,974,688 255,090,925 RGD:9479058
RGD:9479060
G Pcgf6 polycomb group ring finger 6 JBrowse link 1 266,811,418 266,831,022 RGD:9479058
RGD:9479060
G Phc1 polyhomeotic homolog 1 JBrowse link 4 155,093,947 155,118,838 RGD:9479058
RGD:9479060
G Phc2 polyhomeotic homolog 2 JBrowse link 5 146,832,552 146,931,444 RGD:9479058
RGD:9479060
G Phc3 polyhomeotic homolog 3 JBrowse link 2 116,028,735 116,103,227 RGD:9479058
RGD:9479060
G Phf1 PHD finger protein 1 JBrowse link 20 5,526,926 5,531,940 RGD:9479058
RGD:9479074
RGD:9479148
RGD:9479059
G Phf19 PHD finger protein 19 JBrowse link 3 13,957,136 13,978,283 RGD:9479058
RGD:9479074
RGD:9479148
RGD:9479059
G Phf2 PHD finger protein 2 JBrowse link 17 16,240,458 16,274,626 RGD:7242632
G Phf8 PHD finger protein 8 JBrowse link X 21,063,487 21,168,750 RGD:7242632
G Prdm16 PR/SET domain 16 JBrowse link 5 171,662,277 171,711,561 RGD:7242632
G Prdm2 PR/SET domain 2 JBrowse link 5 161,769,587 161,879,150 RGD:7242632
G Prdm6 PR/SET domain 6 JBrowse link 18 48,433,747 48,538,834 RGD:7242632
G Prdm8 PR/SET domain 8 JBrowse link 14 13,052,776 13,073,583 RGD:7242632
G Prdm9 PR/SET domain 9 JBrowse link 1 57,533,602 57,555,155 RGD:7242632
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:9479047
G Prmt2 protein arginine methyltransferase 2 JBrowse link 20 13,154,513 13,212,613 RGD:9479047
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:9479047
G Prmt7 protein arginine methyltransferase 7 JBrowse link 19 38,189,605 38,237,155 RGD:9479047
G Rag2 recombination activating 2 JBrowse link 3 91,191,837 91,200,134 RGD:9479074
G Rbbp4 RB binding protein 4, chromatin remodeling factor JBrowse link 5 147,499,880 147,535,240 RGD:9479058
RGD:9479059
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit JBrowse link 13 49,250,301 49,277,152 RGD:9479053
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:9479058
RGD:9479059
G Ring1 ring finger protein 1 JBrowse link 20 3,812,287 3,815,834 RGD:9479058
RGD:9479060
G Rnf2 ring finger protein 2 JBrowse link 13 68,829,714 68,859,920 RGD:9479058
RGD:9479060
G Setd2 SET domain containing 2 JBrowse link 8 118,802,478 118,888,224 RGD:7242632
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:7242632
G Sgf29 SAGA complex associated factor 29 JBrowse link 1 198,066,974 198,100,494 RGD:9479148
RGD:9479074
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9104959
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:9104959
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:9104959
G Sirt4 sirtuin 4 JBrowse link 12 46,862,358 46,876,593 RGD:9104959
G Sirt5 sirtuin 5 JBrowse link 17 23,986,710 24,013,854 RGD:9104959
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:9104959
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:9104959
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 JBrowse link 1 244,615,811 244,783,736 RGD:9479075
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:9479075
G Smyd1 SET and MYND domain containing 1 JBrowse link 4 99,071,122 99,125,143 RGD:7242632
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:7242632
G Smyd3 SET and MYND domain containing 3 JBrowse link 13 97,330,120 97,807,813 RGD:7242632
G Spin1 spindlin 1 JBrowse link 16 884,854 930,527 RGD:9479148
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:9068945
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit JBrowse link 15 28,574,841 28,611,959 RGD:9068945
G Suv39h1 suppressor of variegation 3-9 homolog 1 JBrowse link X 146,532,002 146,533,538 RGD:7242632
G Suv39h2 suppressor of variegation 3-9 homolog 2 JBrowse link 17 78,762,897 78,782,016 RGD:7242632
G Suz12 SUZ12 polycomb repressive complex 2 subunit JBrowse link 10 67,325,101 67,371,588 RGD:9479058
RGD:9479059
G Taf1 TATA-box binding protein associated factor 1 JBrowse link X 71,412,291 71,486,456 RGD:9479074
RGD:9479075
G Tdrd3 tudor domain containing 3 JBrowse link 15 70,732,164 70,864,855 RGD:9479148
RGD:9479163
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:9479148
RGD:9479074
G Trim24 tripartite motif-containing 24 JBrowse link 4 65,632,278 65,684,746 RGD:9479074
G Trim33 tripartite motif-containing 33 JBrowse link 2 205,783,252 205,863,426 RGD:9479074
RGD:9479075
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:9479148
RGD:9479074
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:9479061
G Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:9479061
G Usp21 ubiquitin specific peptidase 21 JBrowse link 13 89,655,016 89,661,150 RGD:9479061
G Usp22 ubiquitin specific peptidase 22 JBrowse link 10 47,429,201 47,453,298 RGD:9479061
G Usp3 ubiquitin specific peptidase 3 JBrowse link 8 72,207,970 72,284,871 RGD:9479061
G Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:9479061
G Uty ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome JBrowse link Y 1,065,274 1,206,127 RGD:9479053
RGD:7242632
G Wdr5 WD repeat domain 5 JBrowse link 3 6,061,892 6,080,724 RGD:9479053
RGD:9479074
G Wdr82 WD repeat domain 82 JBrowse link 8 114,866,769 114,886,208 RGD:9479053
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:9479074

Pathway Gene Annotations

Disease Annotations Associated with Genes in the histone modification pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisCbx2
46, XY Sex Reversal 5Cbx2
abdominal obesity-metabolic syndromeSirt3
Abnormal ReflexesKdm5c
acanthosis nigricansPrmt7
acute kidney failureHdac2 , Hdac3 , Hdac5 , Sirt1
acute lymphocytic leukemiaEzh2 , Kmt2a
acute monocytic leukemiaKmt2a
acute myeloid leukemiaBmi1 , Brd4 , Brd7 , Crebbp , Ehmt2 , Ezh2 , Kat6a , Kmt2a , Kmt2b , Kmt2c , Nsd1 , Nsd3
acute myelomonocytic leukemiaKmt2a
acute pancreatitisBirc5 , Bmi1
acute promyelocytic leukemiaBirc5 , Kmt2e
adenocarcinomaBirc5 , Kmt2a , Kmt2c
adenoid cystic carcinomaBap1 , Brd1 , Crebbp , Ep300 , Jmjd1c , Kat6a , Kdm6b , Kmt2c , Nsd1 , Setd2 , Smarca2 , Uhrf1
adenomaMen1 , Suz12
adjustment disorderHdac5
adrenocortical carcinomaBap1 , Daxx , H3f3a , Men1
adult T-cell leukemiaBirc5
Aicardi-Goutieres syndromeKat5
alcohol use disorderHdac2
alopeciaBrd4
alopecia areataEhmt2 , Hdac1 , Hdac2 , Hdac7 , Kdm1a , Kdm4a , Kdm4b , Kdm4c , Kdm5a
Alzheimer's diseaseBptf , Crebbp , Ep300 , Hdac2 , Paxip1 , Sirt1 , Sirt3
amphetamine abusePrdm2 , Smyd3
amyotrophic lateral sclerosisBptf , Hdac4 , Sirt1
amyotrophic lateral sclerosis type 1Crebbp
Anadysplasia-Like, Spontaneously Remitting Spondylometaphyseal DysplasiaLbr
AnaphylaxisHdac3
Anaplastic Thyroid CarcinomaCbx7
androgen insensitivity syndromeKat7
Anemia, RefractoryBirc5
Anemia, Refractory, with Excess of BlastsBirc5
AngiofibromaMen1
ankylosing spondylitisKdm5a
anxiety disorderHdac2 , Kdm3b
aortic aneurysmHdac4
aortic valve stenosisJarid2
appendiceal neoplasmNap1l1
asphyxiating thoracic dystrophy 1Lbr
asthmaCarm1 , Hdac2 , Prmt1 , Prmt2 , Prmt5
astrocytomaBrd7 , H3f3a , Kmt2d
ataxia telangiectasiaHdac4
atherosclerosisSirt1
attention deficit hyperactivity disorderCrebbp , Hdac5
autism spectrum disorderBrd1 , Hdac10 , Hira , Jarid2 , Pagr1
autistic disorderAsf1a , Crebbp , Jarid2 , Jmjd1c , Kdm4c , Kdm5c , Kmt2e , Nsd1
Autoimmune DiseasesSirt1
autosomal dominant mental retardation 51Kmt5b
autosomal dominant mental retardation 52Ash1l
autosomal dominant non-syndromic intellectual disabilityKat6b , Smarca2
autosomal dominant non-syndromic intellectual disability 32Kat6a
autosomal dominant polycystic kidney diseaseBrd4
Autosomal Recessive Primary MicrocephalyMcph1
azoospermiaBrdt
B- and T-cell mixed leukemiaDot1l , Kmt2a
B-Cell LeukemiaBrd2
B-cell lymphomaBrd2 , Cbx7 , Ezh2 , Kat5
Bardet-Biedl syndrome 1Kmt2d
Bardet-Biedl syndrome 6Kmt2d
basal cell carcinomaBap1
Beckwith-Wiedemann syndromeNsd1
Binge DrinkingSirt1
bipolar disorderBrd1 , Kat6b
bladder urothelial carcinomaCrebbp , Ep300
blepharophimosisKat6b
blepharophimosis-intellectual disability syndrome, SBBYS typeKat6b
body dysmorphic disorderHdac2
bone giant cell tumorH3f3a
Bone NeoplasmsBap1
brachydactylyHdac4
Brachydactyly, Type EHdac4
Brain HypoxiaEp300
brain infarctionSirt1
Brain InjuriesBirc5 , Sirt1
Brain NeoplasmsH3f3a , Sirt1
breast cancerKat6b , Kdm4b , Kdm4c , Kdm5b , Mcph1 , Ncoa6 , Smarca4
Breast NeoplasmsAsf1b , Bap1 , Birc5 , Carm1 , Cbx7 , Ep300 , Ezh2 , H2afx , Hdac1 , Kat2b , Kat5 , Kat6a , Kat7 , Kat8 , Kdm1a , Kdm3b , Kdm4a , Kdm4c , Kdm5a , Kdm5b , Kdm5c , Kdm6b , Kdm8 , Kmt2b , Kmt2d , Kmt2e , L3mbtl1 , Mcph1 , Mdc1 , Setd2 , Sirt1 , Tp53bp1 , Uty
bronchitisHdac2
Burkitt lymphomaSmarca4
Carcinoid TumorMen1
Carcinoid Tumors, IntestinalNap1l1
Carcinoid Tumors, LungMen1
carcinomaH3f3b , Ywhaz
cardiac arrestEp300
CardiomegalyBrf1 , Ep300 , Hdac2 , Kat8 , Kdm4a , Sirt1 , Sirt4 , Sirt6
cardiomyopathyEp300
Carotid Artery InjuriesHdac4
Carotid AtherosclerosisSirt1
Castration-Resistant Prostatic NeoplasmsChd1 , Trim24
central nervous system diseaseCrebbp
Central Nervous System NeoplasmsBap1
Cerebellofaciodental SyndromeBrf1
cervical cancerKdm3a , Kmt2a , Kmt2e
cervix uteri carcinoma in situHdac1 , Hdac2 , Hdac6
Chemical and Drug Induced Liver InjuryBrd4 , H2afx , Sgf29
childhood absence epilepsyYwhaz
cholangiocarcinomaBap1 , Hdac6 , Kmt2c , Pbrm1
cholestasisKmt2b
chondroblastomaH3f3b
Chondrodysplasia with Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, and MicrophthalmiaHdac6
choroid plexus carcinomaNsd1
Chromosome 2q37 Deletion SyndromeHdac4
Chromosome AberrationsKmt2a
Chromosome BreakageH2afx
chronic myeloid leukemiaBirc5
chronic myelomonocytic leukemiaEzh2
chronic obstructive pulmonary diseaseHdac2
clear cell adenocarcinomaCbx7 , Daxx
clear cell renal cell carcinomaEp300 , Kat8 , Pbrm1
Cleft Palate, Psychomotor Retardation, and Distinctive Facial FeaturesKdm1a
Cocaine-Related DisordersEhmt2 , Hdac4 , Hdac5 , Smarca4
Coffin-Siris syndromeSmarca2 , Smarca4
Coffin-Siris syndrome 4Smarca4
Cognition DisordersHdac2
Cohen-Gibson SyndromeEed
colitisSirt1
colon adenocarcinomaDaxx
colon cancerKdm3a , Ncoa6
colon carcinomaEp300
Colonic NeoplasmsBap1 , Birc5 , Brd4 , Chaf1a , Hdac1 , Hdac2 , Hdac3 , Hdac5 , Hdac7 , Kdm1a , Kdm5b , Men1 , Uhrf1
Colonic PolypsHdac2
colorectal adenocarcinomaKmt2b
colorectal cancerEp300 , Kdm4b
Colorectal NeoplasmsBirc5 , Bmi1 , Brd7 , Cbx5 , Cbx7 , Crebbp , Ehmt2 , Ep300 , Kdm2a , Kdm3b , Kdm4b , Kdm5b , Nap1l1
Combined Cellular and Humoral Immune Defects with GranulomasRag2
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyCbx2
Congenital Disorder of Glycosylation Type 2MHdac6 , Suv39h1
congestive heart failureBirc5 , Ep300 , Kat8 , Kdm2a , Sirt1 , Sirt3
contact dermatitisHdac4
Cornelia de Lange syndromeBrd4 , Kmt2a
Coronary DiseaseKat2b
Craniofacial AbnormalitiesEp300
craniosynostosisEzh2 , Kat6b
Critical IllnessKdm1a
cryptorchidismKat6b , Kdm5a
Cutaneous Malignant Melanoma, Susceptibility To, 1Ezh2 , Kat6b
Cystadenoma, SerousDaxx
DehydrationYwhaz
demyelinating diseaseHdac1 , Sirt1
Developmental DisabilitiesBptf , Ehmt1 , Ep300 , Mcph1 , Nsd1
diabetes mellitusMen1 , Sirt1
Diabetic NephropathiesEp300 , Hdac2 , Hdac4 , Hdac5 , Prmt1 , Uty
diabetic retinopathyEp300 , Kdm1a , Mysm1 , Sgf29 , Sirt1
Diamond-Blackfan anemiaKdm6b
diffuse large B-cell lymphomaEzh2 , Kmt2d
DiGeorge syndromeHira , Kat6a
dilated cardiomyopathyPhc1
dilated cardiomyopathy 1ADot1l
Dilated Cardiomyopathy 1LLPrdm16
Disease ProgressionBmi1 , Kdm1a
ductal carcinoma in situBirc5
Duodenal NeoplasmsMen1
DwarfismOrc1
dystoniaKmt2b
DYSTONIA 28, CHILDHOOD-ONSETKmt2b
Dystonic DisordersKmt2b
Early Infantile Epileptic Encephalopathy 3Jmjd1c
early myoclonic encephalopathyJmjd1c
eating disorderHdac4
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsHcfc1
endometrial cancerMcph1
Endometrial HyperplasiaBirc5
Endometrial NeoplasmsBirc5 , Ep300 , Ezh2 , Hdac1 , Hdac2 , Hdac3 , Suz12
Endometrioid CarcinomasBirc5 , Daxx
endometriosisBirc5 , Hdac1 , Hdac2 , Ncoa6
endomyocardial fibrosisSirt4
EndotoxemiaEp300
EosinophiliaRag2
EpendymomaHdac3 , Kat6b , Men1 , Suv39h1
epilepsySirt1
Epilepsy, Progressive Myoclonic, 10Prdm8
esophageal carcinomaEp300
Esophageal NeoplasmsEp300 , Smyd2
esophagus squamous cell carcinomaCbx8 , Crebbp , Ehmt1 , Ehmt2 , Ep300 , Kat2b , Kdm4c , Kdm5b , Kmt2c , Kmt2d , Uty
Ewing sarcomaKdm3a
Experimental ArthritisHdac6 , Rag2
Experimental Autoimmune EncephalomyelitisSirt1
Experimental Autoimmune MyocarditisSirt1
Experimental Diabetes MellitusEp300 , Ezh2 , Hdac1 , Hdac2 , Hdac4 , Kmt5c , Sirt1 , Smarca4
Experimental Liver CirrhosisBirc5 , Sirt1 , Trim24 , Ywhaz
extrahepatic cholestasisSetd7
familial adenomatous polyposisHdac2
familial hypercholesterolemiaSmarca4
fatty liver diseaseSirt1 , Sirt7
Female InfertilityNasp
Fetal Growth RetardationHdac1 , Hdac2 , Orc1
fibromaBrf1
FibrosisHdac3 , Hdac4 , Sirt1
follicular adenomaMen1
follicular lymphomaCrebbp , Ezh2 , Kmt2d
Follicular Thyroid CancerCbx7
gastric adenocarcinomaCrebbp
gastrinomaMen1
gastrointestinal stromal tumorMen1
genetic diseaseAsh1l , Bptf , Brd4 , Crebbp , Ehmt1 , Ep300 , Ezh2 , H3f3a , H3f3b , Hcfc1 , Hdac1 , Hdac2 , Hdac3 , Hdac4 , Kat6a , Kat6b , Kdm5b , Kdm5c , Kdm6b , Kmt2a , Kmt2b , Kmt2d , Kmt5b , Nsd1 , Orc1 , Phf8 , Setd2 , Smarca2 , Smarca4 , Taf1
Genetic Predisposition to DiseaseBap1
Genitopatellar SyndromeKat6b
Genomic InstabilitySirt1
Germ Cell and Embryonal NeoplasmsBirc5 , Phc1
gestational diabetesMen1 , Sirt3
GigantismNsd1
glaucomaCrebbp
glioblastoma multiformeBmi1 , Brd2 , Brd4 , Brd7 , Cbx6 , Cbx7 , Cbx8 , Chaf1b , Crebbp , H2afx , H3f3a , Suz12
glomerulonephritisEp300
GlucagonomaMen1
glucose intoleranceSirt1
gonadal dysgenesisCbx2
Greenberg DysplasiaLbr
Growth Deficiency and Mental Retardation with Facial DysmorphismKmt2a
growth hormone secreting pituitary adenomaMen1
head and neck cancerKdm4c
Head and Neck NeoplasmsBap1
head and neck squamous cell carcinomaCrebbp , Ep300
heart diseaseEp300 , Hdac1 , Hdac3 , Sirt1
Heavy Metal ToxicityDaxx
hemophagocytic lymphohistiocytosisRag2
hepatitis BKat2a
hepatoblastomaNap1l1
hepatocellular adenomaCarm1
hepatocellular carcinomaBirc5 , Carm1 , Cbx4 , Cbx7 , Crebbp , Ep300 , Ezh2 , Hdac2 , Hdac4 , Kat2b , Kdm1a , Kdm3a , Kmt2a , Kmt2b , Kmt2c , Trim24
Hereditary Neoplastic SyndromesBap1 , Brcc3 , Chd1 , H2afy , Hdac3 , Kdm3b , Men1 , Prdm6 , Smarca4
hereditary spastic paraplegia 4Dpy30
Hernias, Diaphragmatic, CongenitalEp300
Hirschsprung Disease 1Crebbp
Hirschsprung's diseaseAebp2
HirsutismEp300
human immunodeficiency virus infectious diseaseKmt2e , Sirt1
Huntington's diseaseCrebbp , Ep300 , Hdac1 , Hdac3 , Hdac7 , Kdm5c , Sirt1
HyperalgesiaEp300 , Men1
hyperinsulinismBrd2
HyperparathyroidismMen1
Hyperparathyroidism 1Men1
HyperplasiaBrd4 , Kdm1a
HypertelorismNsd1
hypertensionEp300 , H2afx , Hdac6 , Men1 , Ywhaz
hypertrophic cardiomyopathyKat8
HypertrophySirt1
Hypertrophy, Left VentricularBrd4 , Ezh2 , Pbrm1 , Sirt1 , Smarca4
Hypertrophy, Right VentricularHdac1 , Hdac5
HypoalgesiaHdac4
HypoxiaKdm3a , Nap1l1
Hypoxia-Ischemia, BrainDaxx , Hdac3
ichthyosis vulgarisLbr
idiopathic pulmonary fibrosisBrd4 , Ehmt2
impotenceHdac3 , Hdac4 , Sirt1
infertilityEhmt2
Insulin ResistanceSirt1 , Sirt4
insulinomaMen1
intellectual disabilityAsf1a , Ash2l , Bptf , Brf1 , Chaf1b , Ehmt1 , Ep300 , Hcfc1 , Hdac4 , Kat6a , Kdm5a , Kdm5c , Kdm6b , Kmt2a , Nsd1 , Phc1 , Phf8 , Smarca2
intermittent claudicationSirt2
invasive ductal carcinomaEzh2
iron deficiency anemiaKat5
juvenile myelomonocytic leukemiaEzh2
juvenile myoclonic epilepsyBrd2
juvenile rheumatoid arthritisJmjd1c , Kat6b
Kabuki syndromeHcfc1 , Kmt2a , Kmt2b , Kmt2d
Kallmann syndromeKmt2d
Kat6a SyndromeKat6a
Kidney NeoplasmsBap1 , Birc5 , Mcph1
Kidney Reperfusion InjuryDaxx , Ep300 , H2afx , Sirt1
Kleefstra syndromeEhmt1 , Kmt2c
KLEEFSTRA SYNDROME 2Kmt2c
Language Development DisordersAsf1a , Hdac2 , Kmt5b , Nsd1
Lead Poisoning, Nervous SystemEp300
Left Ventricular Noncompaction 8Prdm16
leiomyomaEzh2 , Kat6b
leukemiaBap1 , Daxx , Kmt2a , Kmt2e , Setd2
Leukemia, ExperimentalCbx7
Leukemia, Myeloid, Accelerated PhaseBmi1
Leydig cell tumorPrmt5
lipomaBap1 , Men1
liver cancerCrebbp
liver cirrhosisHdac2
Liver InjurySirt1
liver neoplasmAsh1l , Bap1 , Cbx7 , H2afx , Hcfc1 , Kmt5c
Liver Neoplasms, ExperimentalBirc5 , Hat1 , Kat6a
Liver Reperfusion InjuryH2afx , Sirt1
long QT syndromeSirt6
lung adenocarcinomaBap1 , Cbx5 , Cbx7 , Crebbp , Dot1l , Ehmt2 , Ep300
lung cancerNcoa6
Lung InjurySirt1
Lung NeoplasmsBap1 , Birc5 , Cbx5 , Cbx7 , Ehmt2 , Kdm4a , Kdm4b , Mdc1 , Smarca4
lung small cell carcinomaCrebbp , Ep300 , Kmt2a , Smarca4
lung squamous cell carcinomaCrebbp , Ep300
Luscan-Lumish syndromeSetd2
Lymphatic MetastasisBirc5 , Brd7 , Ehmt2
lymphoid leukemiaKmt2a
lymphomaEzh2
lymphopeniaLbr , Mysm1
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveNsd1
macular degenerationSirt1
male infertilityKmt2d
Malformations of Cortical Development, Group IIHdac6
malignant gliomaBirc5 , Bmi1 , Brd7 , Chaf1a , Chaf1b , H3f3a , Hdac3 , Sirt2 , Suz12
MALIGNANT GRANULAR CELL TUMORBrd7
malignant mesotheliomaBap1 , Hdac4 , Setd2 , Smarca2
malignant peripheral nerve sheath tumorKdm4b
Mammary Neoplasms, AnimalH3f3b , Ywhaz
Mammary Neoplasms, ExperimentalH2afx , H3f3b , Ywhaz
McKusick Kaufman SyndromeKmt2d
medulloblastomaBrd2 , Brd3 , Brd4 , Crebbp , Ehmt1 , Ep300 , Kat6a , Kdm4b , Kdm4c , Smarca4
Megakaryoblastic Leukemia of Down SyndromeEzh2
megakaryocytic leukemiaBirc5 , Ezh2
MegalencephalyNsd1
Meier-Gorlin syndromeOrc1
melanomaAsf1a , Brd2 , Brd4 , Crebbp , Ehmt2 , Ep300 , Ezh2 , Hdac2 , Hdac3 , Hdac6 , Kat6b , Kdm7a , Suz12
membranoproliferative glomerulonephritisEp300
Memory DisordersHdac2
meningiomaBap1
mental depressionHdac5
Mental Retardation, X-Linked 3Hcfc1
Mental Retardation, X-Linked, Syndromic 33Taf1
MesotheliomaBap1
Metabolic Bone DiseasesNsd1
Metabolic SyndromeHdac3 , Sirt1
MetaplasiaRag2
microcephalyAsf1a , Ep300 , Kdm2b , Mcph1 , Nsd1 , Orc1
Microcephaly 11, Primary, Autosomal RecessivePhc1
microcephaly and chorioretinopathy 3Tp53bp1
Microcephaly, Primary Autosomal Recessive, 1Mcph1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveH2afx
Microsatellite InstabilityHdac2 , Setd2
middle cerebral artery infarctionHdac4 , Hdac5 , Hdac9 , Sirt1
migrainePrdm16
Mobility LimitationEhmt1
Mobius syndromeKdm6b
mouth diseaseChaf1a , Chaf1b
Mouth NeoplasmsSirt3
Mucinous CystadenomaDaxx
mucoepidermoid carcinomaBap1
Multiple AbnormalitiesCrebbp , Ep300 , Hcfc1 , Hdac1 , Kat6b , Kmt2a , Smarca4
Multiple Endocrine NeoplasiaMen1
multiple endocrine neoplasia type 1Men1
multiple myelomaCbx7
multiple sclerosisHdac1
Muscle HypotoniaEp300 , Hdac2
Muscle SpasticityCrebbp
myelodysplastic syndromeBap1 , Bmi1 , Crebbp , Ezh2 , Kmt2e
myelodysplastic/myeloproliferative neoplasmEzh2
myelofibrosisEzh2
myeloid leukemiaCbx7 , Hdac2 , Kmt2a , Kmt2e , Nsd3
myeloid neoplasmEzh2
myocardial infarctionBirc5 , Sirt1 , Sirt3
Myocardial Reperfusion InjuryH2afx , Sirt1 , Suv39h1
myopiaEp300
nasopharynx carcinomaBap1 , Kdm3a
Neoplasm InvasivenessKdm1a
Neoplasm MetastasisBrd4 , Cbx4 , Cbx5 , Daxx , Ehmt2 , Hdac3 , Sirt1
Neoplasm Recurrence, LocalH2afx , Ywhaz
Neoplastic ProcessesChaf1b
Neovascularization, PathologicBmi1
nephrogenic diabetes insipidusSirt1
nephronophthisis-like nephropathy 1Ep300
Nerve DegenerationSirt1
Nerve Sheath NeoplasmsEed , Suz12
neural tube defectKat2a , Kdm2b
neurilemmomaEed , Suz12
neuroblastomaChaf1a , Nsd1
neurodegenerative diseaseSirt1
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIESBptf
Neurodevelopmental DisordersAsh1l , Kmt2a , Kmt2c , Kmt2e , Kmt5b , Phf2 , Setd2
neuroendocrine tumorBap1 , Daxx , Men1
neurofibromaKdm6b , Suz12
neuronal ceroid lipofuscinosis 1Sirt1
Neuropathy, PainfulEp300
Nevi and MelanomasBap1
Nevus, Epithelioid and Spindle CellBap1
Nevus, PigmentedSuz12
Nicolaides Baraitser SyndromeSmarca2
non-Hodgkin lymphomaEzh2 , Kmt2a
non-small cell lung carcinomaBirc5 , Brd7 , Hdac3 , Kat2a , Kdm1a , Kdm2a , Kdm3b , Kdm5a
nonalcoholic fatty liver diseaseEzh2 , Rag2 , Sirt1 , Sirt2 , Sirt3 , Sirt4 , Sirt6
Noonan syndromeKat6b
obesityBrd2 , Ep300 , Hdac4 , Kdm3a , Sirt1 , Sirt3 , Sirt6 , Smarca4
Occupational DiseasesBrcc3
oligospermiaBrdt
Omenn syndromeRag2
Optic Nerve InjuriesEp300
oral squamous cell carcinomaCbx2 , Chaf1b , Mcph1
osteoporosisSirt1
osteosarcomaBmi1 , Brd4 , Ezh2 , Sirt1
Ovarian NeoplasmsBap1 , Birc5 , Brd7 , Hdac1 , Hdac2 , Hdac3 , Hdac6 , Mcph1 , Nasp , Smarca4
ovary epithelial cancerDaxx , Ehmt2
pancreatic cancerBap1 , Daxx , Ezh2 , Men1 , Nap1l1 , Pbrm1 , Smarca4 , Tp53bp1
pancreatic ductal carcinomaBmi1 , Cbx7 , Hdac1 , Kdm2b , Men1 , Rnf2
pancreatic endocrine carcinomaDaxx
Pancreatic Intraepithelial NeoplasiaBmi1 , Cbx7 , Hdac1
Pancreatic Islet Cell TumorsDaxx
Pancreatitis, Acute NecrotizingBirc5
Pancreatitis, ChronicBmi1 , Rnf2
Papillary Thyroid CancerCbx7
paragangliomaBap1
ParalysisSirt1
paraplegiaKdm5c
Parasitic Liver DiseasesKmt2c
parathyroid adenomaMen1
patent ductus arteriosusPrdm6
Patent Ductus Arteriosus 3Prdm6
Pelger-Huet anomalyLbr
Peyronie's diseaseHdac2
photosensitivity diseaseBrd2
Phyllodes TumorKmt2d , Setd2
PILAROWSKI-BJORNSSON SYNDROMEChd1
Pituitary NeoplasmsMen1
pleomorphic xanthoastrocytomaHdac9 , Kdm7a , Kmt2e , Trim24
Pneumococcal PneumoniaSirt1
pneumoniaSirt1
Polycystic Kidney DiseasesHdac6
Polycystic Liver Disease 1Hdac6
PolymicrogyriaEhmt1
PolyploidyH2afx
pre-eclampsiaNsd1
pre-malignant neoplasmSuv39h1
precursor lymphoblastic lymphoma/leukemiaCrebbp , Hdac1 , Hdac2 , Hdac4 , Kdm2b , Kdm3b , Kmt2a , Uty
precursor T-lymphoblastic lymphoma/leukemiaEzh2 , Smarca4
prediabetes syndromeSirt3
Pregnancy in DiabeticsBrcc3
PresbycusisSirt3
primary biliary cirrhosisLbr
Primary Hyperoxaluria Type 1Hdac4
primary hyperparathyroidismMen1
primary pulmonary hypertensionHdac1 , Hdac4 , Hdac5
progeriaSirt6
progressive myoclonus epilepsyPrdm8
prolactinomaMen1
prostate cancerCbx7 , Chaf1b , Hira , Kat7 , Kdm3a , Phf2
prostate carcinoma in situCarm1 , Hdac1
Prostatic NeoplasmsAsh1l , Bap1 , Birc5 , Brd4 , Carm1 , Cbx5 , Chaf1b , Chd1 , Crebbp , Daxx , Ep300 , Ezh2 , Hdac1 , Hdac2 , Hdac3 , Hdac6 , Kat5 , Kat6a , Kdm3a , Kdm4a , Kdm4b , Kdm4c , Kdm5a , Kdm5b , Kmt2a , Kmt2b , Kmt2c , Kmt2d , Kmt2e , Phf8 , Setd2 , Sirt1 , Smarca4 , Uty
psoriasisCarm1
pulmonary emphysemaHdac2
pulmonary fibrosisBrd4
pulmonary hypertensionBirc5 , Brd4 , Hdac1 , Hdac2 , Hdac3 , Hdac4 , Hdac5 , Tp53bp1
renal cell carcinomaBap1 , Birc5 , Kdm4c , Kdm5c , Kdm6b , Pbrm1 , Setd2 , Uty
Reperfusion InjuryBirc5 , Ep300 , Sirt7
Retina Reperfusion InjuryHdac2 , Rnf2
retinal degenerationHdac4
retinal diseaseSirt1
retinoblastomaKdm1b
RetrognathiaEp300 , Lbr
Reynolds SyndromeLbr
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
Rubinstein-Taybi syndromeCrebbp , Ep300
Salivary Gland NeoplasmsChaf1b
sarcomaSmarca4
schizophreniaAsh2l , Brd1 , Ehmt1 , Kdm1a , Kdm2b , Kdm5c , Pagr1 , Sgf29 , Ywhaz
scoliosisCrebbp , Nsd1
seminomaPrmt5
senile cataractSirt1
SepsisEp300 , Hdac4 , Hdac6
severe combined immunodeficiencyRag2
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positiveRag2
sex differentiation diseaseCbx2
Sezary's diseaseCrebbp , Kmt2c , Kmt2d , Smarca4
Shock, HemorrhagicSirt1
SHORT STATURE, BRACHYDACTYLY, INTELLECTUAL DEVELOPMENTAL DISABILITY, AND SEIZURESPrmt7
skin melanomaBap1 , Chaf1b
Skin NeoplasmsNsd1
small cell carcinomaBirc5 , Smarca4
Smith-Magenis syndromeBirc5 , Bptf , Cbx2 , Cbx4 , Cbx8 , Ezh1 , H3f3b , Hdac5 , Kat2a , Kat7 , Kdm5c , Kmt2d , Sirt7 , Suz12 , Usp22
Sotos syndromeNsd1
Spermatogenic Failure 21Brdt
spina bifidaCrebbp , Rnf2 , Suz12
Spinal Cord InjuriesKdm6b
spinal muscular atrophyHdac4
Spinocerebellar AtaxiasKat2a
Spondylocostal Dysostosis 5Pagr1
squamous cell carcinomaBirc5 , Crebbp , Ep300 , Hdac1 , Hdac2 , Kmt2c , Sirt3
status epilepticusH2afx
Stevens-Johnson syndromeEp300
stomach cancerKdm4b
Stomach NeoplasmsBap1 , Birc5 , Cbx7 , Hdac2 , Kdm4a , Kdm4c , Kdm5a , Kmt2a , Kmt2c , Mdc1
StrokeHdac1 , Hdac2 , Hdac4 , Hdac9
syndromic X-linked intellectual disability Claes-Jensen typeKdm5c
syndromic X-linked intellectual disability Siderius typePhf8
systemic lupus erythematosusChaf1a , Ep300 , Lbr
systemic sclerodermaSirt1 , Sirt7
T-Cell LymphomaCbx7 , Ep300 , Kdm2b , Kmt2d
tauopathyHdac1
temporal lobe epilepsyHdac2
Testicular NeoplasmsBap1
tethered spinal cord syndromeCrebbp
tetralogy of FallotPhc1
Thoracic NeoplasmsSmarca4
thrombosisSirt1
Thumb DeformityCrebbp , Ep300
thymomaBap1 , Pbrm1
thyroid adenomaMen1
thyroid Hurthle cell carcinomaCbx7
Thyroid NeoplasmsBrd4 , Men1 , Prdm2 , Trim24
transient cerebral ischemiaDaxx , Eed , Ep300 , H2afx , Kdm1a , Sirt6
transitional cell carcinomaBirc5 , Brd4 , Cbx7 , Crebbp , Daxx , Ep300 , Kmt2a , Kmt2c
TremorAsf1a
Tumor Predisposition SyndromeBap1
type 1 diabetes mellitusHdac1 , Hdac2 , Hdac3
type 2 diabetes mellitusEp300 , Hdac1 , Hdac2 , Kmt2d , Ncoa6 , Sirt1 , Sirt3
Upper Extremity Deformities, CongenitalEzh2
urinary bladder cancerBap1 , Birc5 , Bptf , Cbx7 , Crebbp , Ep300 , Hdac4 , Kdm4a , Kdm4b , Kdm5b , Kmt2a , Kmt2c , Kmt2d , Prdm2
Urologic NeoplasmsBirc5
Usher syndrome type 1Prdm16
Uterine Cervical NeoplasmsBirc5 , Crebbp , Ep300 , Hdac1 , Hdac2 , Hdac6 , Mdc1
Uterine NeoplasmsBap1
uveal melanomaBap1 , Kdm5b
ventricular septal defectDpf3 , Smarca4
Vesicular StomatitisEhmt2
vipomaMen1
visual epilepsyBrd1 , Hdac2 , Hdac4 , Kat6b , Kdm3b , Kmt2d , Kmt5b , Ywhaz
Waardenburg's syndromeAebp2
Wallerian DegenerationSirt1
Weaver syndromeEzh1 , Ezh2 , Nsd1
Weight GainNsd1
withdrawal disorderKdm4c
Wolff-Parkinson-White syndromePrdm16
X-linked dystonia-parkinsonismTaf1
Pathway Annotations Associated with Genes in the histone modification pathway
Pathway TermsGene Symbols
ADP-ribosylation pathway, mono and poly-ribosylationAplf
aldosterone signaling pathwayCrebbp , Daxx
altered SWI/SNF family mediated chromatin remodeling pathwayPbrm1 , Smarca4
amyotrophic lateral sclerosis pathwayDaxx
androgen signaling pathwayCarm1 , Crebbp , Ep300 , Prmt1
ataxia telangiectasia-mutated (ATM) signaling pathwayBrcc3 , H2afx , Kat5 , Kdm4a , L3mbtl1 , Mdc1 , Tp53bp1 , Usp16 , Usp3 , Usp44
calcium/calmodulin dependent kinase 2 signaling pathwayHdac4 , Hdac5
carnitine biosynthetic pathwaySetd7
cell cycle pathway, mitoticCrebbp , Ep300 , Hdac1 , Hdac2 , Ywhaz
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2 , Rbbp4 , Rbbp7
cholesterol biosynthetic pathwayLbr
chronic myeloid leukemia pathwayHdac1 , Hdac2
cisplatin drug pathwaySsrp1
colorectal cancer pathwayBirc5
cortisol signaling pathwayCrebbp , Ep300 , Smarca4
DNA modification pathwayCxxc1 , Kdm2a , Kdm2b , Kmt2a , Kmt2c , Uhrf1
estrogen signaling pathwayCarm1 , Crebbp , Ep300 , Ncoa6 , Prmt1
forkhead class A signaling pathwayCrebbp , Ep300
granulocyte-macrophage colony-stimulating factor signaling pathwayYwhaz
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Rbbp4 , Rbbp7
histone modification pathwayAebp2 , Aplf , Asf1a , Asf1b , Ash1l , Ash2l , Bap1 , Birc5 , Bmi1 , Bptf , Brcc3 , Brd1 , Brd2 , Brd3 , Brd4 , Brd7 , Brdt , Brf1 , Carm1 , Cbx2 , Cbx4 , Cbx5 , Cbx6 , Cbx7 , Cbx8 , Chaf1a , Chaf1b , Chd1 , Crebbp , Cxxc1 , Daxx , Dot1l , Dpf3 , Dpy30 , Eed , Ehmt1 , Ehmt2 , Ep300 , Ezh1 , Ezh2 , H2afx , H2afy , H2afy2 , H2afz , H3f3a , H3f3b , Hat1 , Hcfc1 , Hdac1 , Hdac10 , Hdac11 , Hdac2 , Hdac3 , Hdac4 , Hdac5 , Hdac6 , Hdac7 , Hdac9 , Hira , Hjurp , Ing2 , Jarid2 , Jmjd1c , Kat2a , Kat2b , Kat5 , Kat6a , Kat6b , Kat7 , Kat8 , Kdm1a , Kdm1b , Kdm2a , Kdm2b , Kdm3a , Kdm3b , Kdm4a , Kdm4b , Kdm4c , Kdm4e , Kdm5a , Kdm5b , Kdm5c , Kdm6b , Kdm7a , Kdm8 , Kmt2a , Kmt2b , Kmt2c , Kmt2d , Kmt2e , Kmt5b , Kmt5c , L3mbtl1 , Lbr , LOC100909949 , LOC100911180 , LOC100911617 , Mcph1 , Mdc1 , Men1 , Mtf2 , Mysm1 , Nap1l1 , Nasp , Ncoa6 , Nsd1 , Nsd3 , Orc1 , Pagr1 , Paxip1 , Pbrm1 , Pcgf1 , Pcgf3 , Pcgf5 , Pcgf6 , Phc1 , Phc2 , Phc3 , Phf1 , Phf19 , Phf2 , Phf8 , Prdm16 , Prdm2 , Prdm6 , Prdm8 , Prdm9 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Rag2 , Rbbp4 , Rbbp5 , Rbbp7 , Ring1 , Rnf2 , Setd2 , Setd7 , Sgf29 , Sirt1 , Sirt2 , Sirt3 , Sirt4 , Sirt5 , Sirt6 , Sirt7 , Smarca2 , Smarca4 , Smyd1 , Smyd2 , Smyd3 , Spin1 , Ssrp1 , Supt16h , Suv39h1 , Suv39h2 , Suz12 , Taf1 , Tdrd3 , Tp53bp1 , Trim24 , Trim33 , Uhrf1 , Usp12 , Usp16 , Usp21 , Usp22 , Usp3 , Usp44 , Uty , Wdr5 , Wdr82 , Ywhaz
homocysteine metabolic pathwayCarm1 , Dot1l , Prmt1 , Prmt5 , Suv39h2
Huntington's disease pathwayCrebbp , Ep300 , Hdac1 , Hdac2
hypoxia inducible factor pathwayCrebbp , Ep300 , Hdac7
influenza A pathwayCrebbp , Ep300
INO80 family mediated chromatin remodeling pathwayKat5
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhaz
insulin-like growth factor signaling pathwayYwhaz
interleukin-3 signaling pathwayHdac1 , Ywhaz
ISWI family mediated chromatin remodeling pathwayBptf , Rbbp4 , Rbbp7
Jak-Stat signaling pathwayCrebbp , Ep300
long term potentiationCrebbp , Ep300
lysine degradation pathwayAsh1l , Dot1l , Ehmt1 , Ehmt2 , Kmt2d , Kmt2e , Kmt5b , Kmt5c , Nsd1 , Nsd3 , Setd2 , Setd7 , Suv39h2
methionine cycle/metabolic pathwayCarm1 , Dot1l , Ezh2 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Setd7 , Smyd2 , Suv39h2
mitogen activated protein kinase signaling pathwayDaxx
mTOR signaling pathwayYwhaz
neurotrophic factor signaling pathwayYwhaz
non-homologous end joining pathway of double-strand break repairAplf , Tp53bp1
Notch signaling pathwayCrebbp , Ep300 , Hdac1 , Hdac2 , Kat2a , Kat2b , Kdm1a
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p53 signaling pathwayCrebbp , Daxx , Ep300 , Hdac1 , Kat2a , Kat2b , Kat5 , Kat8 , Prmt5 , Setd7 , Sirt1 , Smyd2
pancreatic cancer pathwayPbrm1 , Smarca4
phosphatidylinositol 3-kinase-Akt signaling pathwayYwhaz
platelet-derived growth factor signaling pathwayYwhaz
primary immunodeficiency pathwayRag2
prostate cancer pathwayCrebbp , Ep300
renal cell carcinoma pathwayCrebbp , Ep300 , Kdm5c , Pbrm1 , Setd2 , Uty
RNA polymerase I transcription pathwayCrebbp , Sirt1 , Sirt7 , Ssrp1 , Supt16h
RNA polymerase II transcription elongation pathwaySsrp1 , Supt16h
RNA polymerase II transcription initiation pathwayKat2a , Kat2b , Sgf29 , Taf1 , Usp22 , Wdr5
RNA polymerase III transcription pathwayBrf1
RNA transport pathwayPrmt5
Sirtuin mediated pathwaySirt1 , Sirt2 , Sirt3 , Sirt4 , Sirt5 , Sirt6 , Sirt7
SWI/SNF family mediated chromatin remodeling pathwayBrd7 , Dpf3 , Pbrm1 , Smarca2 , Smarca4
systemic lupus erythematosus pathwayH2afx , H2afy , H2afy2 , H2afz , H3f3b
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300
tuberculosis pathwayCrebbp , Ep300
type II interferon signaling pathwayCrebbp , Ep300
Wnt signaling pathwayCrebbp , Ep300
Wnt signaling, canonical pathwayCrebbp , Smarca4
Phenotype Annotations Associated with Genes in the histone modification pathway

References Associated with the histone modification pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: