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Gene: Gfap (glial fibrillary acidic protein) Rattus norvegicus
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Symbol: Gfap
Name: glial fibrillary acidic protein
Description: Exhibits integrin binding activity and kinase binding activity. Involved in positive regulation of glial cell proliferation; regulation of chaperone-mediated autophagy; and response to wounding. Localizes to the astrocyte projection and cytoplasmic side of lysosomal membrane. Predicted to colocalize with the lysosome. Biomarker of brain edema and retinal disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein); PARTICIPATES IN chaperone mediated autophagy pathway; INTERACTS WITH (+)-alpha-tocopherol; (RS)-amphetamine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; intermediate filament
Orthologs:
Homo sapiens (human) : GFAP (glial fibrillary acidic protein)  HGNC  Alliance
Mus musculus (house mouse) : Gfap (glial fibrillary acidic protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gfap (glial fibrillary acidic protein)
Pan paniscus (bonobo/pygmy chimpanzee) : GFAP (glial fibrillary acidic protein)
Canis lupus familiaris (dog) : GFAP (glial fibrillary acidic protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gfap (glial fibrillary acidic protein)
Sus scrofa (pig) : GFAP (glial fibrillary acidic protein)
more info ...
Allele / Splice: Gfapem1Ionsz  
Genetic Models: SD-Gfapem1(2A-Chr2-EYFP)Ionsz
Is Marker For: Strains:   F344/NRrrc   SD-Tg(Gfap-Tk1)Jog  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01090,990,762 - 90,999,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01090,763,150 - 90,771,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,059,881 - 92,068,555 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11092,074,249 - 92,082,949 (-)NCBI
Celera1086,555,367 - 86,564,160 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
RH 3.4 Map10920.49RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gfap
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2679
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.