Gfap (glial fibrillary acidic protein) - Rat Genome Database

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Gene: Gfap (glial fibrillary acidic protein) Rattus norvegicus
Symbol: Gfap
Name: glial fibrillary acidic protein
RGD ID: 2679
Description: Enables integrin binding activity and kinase binding activity. A structural constituent of cytoskeleton. Involved in positive regulation of glial cell proliferation and regulation of chaperone-mediated autophagy. Located in astrocyte projection and cytoplasmic side of lysosomal membrane. Biomarker of brain edema and retinal disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein); PARTICIPATES IN chaperone mediated autophagy pathway; INTERACTS WITH (+)-pilocarpine; (R)-carnitine; (R,R,R)-alpha-tocopherol.
Type: protein-coding
Previously known as: glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; intermediate filament
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gfapem1Ionsz   Gfapem1Mes   Gfapem2Mes  
Genetic Models: SD-Gfapem1Mes /Rrrc SD-Gfapem2Mes /Rrrc SD-Gfapem1(2A-Chr2-EYFP)Ionsz
Is Marker For: Strains:   F344/NRrrc   SD-Tg(Gfap-Tk1)Jog  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21087,852,891 - 87,861,631 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,852,890 - 87,861,589 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,888,973 - 92,897,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,355,379 - 92,364,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,748,725 - 87,757,408 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,990,762 - 90,999,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,990,762 - 90,999,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,763,150 - 90,771,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,059,881 - 92,068,555 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,074,249 - 92,082,949 (-)NCBI
Celera1086,555,367 - 86,564,160 (-)NCBICelera
RH 3.4 Map10920.49RGD
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-Ethylhexanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (ISO)
abacavir  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
amentoflavone  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
antimony(0)  (EXP,ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
atrazine  (EXP,ISO)
azithromycin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (EXP)
Brodifacoum  (EXP)
bromochloroacetic acid  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin a  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP,ISO)
captan  (ISO)
carbendazim  (EXP)
carbofuran  (EXP)
carbonyl sulfide  (EXP)
carmustine  (EXP,ISO)
carvacrol  (EXP)
chlordecone  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysin  (EXP)
Citreoviridin  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
Cyanoginosin  (EXP)
cyhalothrin  (EXP)
cyprodinil  (ISO)
dabigatran  (ISO)
dantrolene  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (ISO)
digoxin  (EXP)
dihydrogen  (EXP)
dimethoate  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium  (EXP)
disodium selenite  (EXP,ISO)
dizocilpine maleate  (EXP)
dopaminechrome (enol form)  (EXP)
doxorubicin  (EXP)
ebselen  (EXP)
emodin  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenitrothion  (EXP)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP)
fluoxetine  (ISO)
folic acid  (EXP,ISO)
furan  (EXP)
galactose  (EXP)
galangin  (EXP)
gamma-aminobutyric acid  (EXP)
gefitinib  (EXP)
glufosinate  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
ifosfamide  (EXP)
imidacloprid  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
KN-93  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(II) chloride  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP,ISO)
luteolin  (ISO)
lycopene  (EXP,ISO)
Magnolol  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
memantine  (EXP,ISO)
mepanipyrim  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methionine sulfoximine  (EXP)
methotrexate  (EXP,ISO)
methylene blue  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin LF  (EXP)
microcystin-LR  (EXP)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
morin  (EXP)
morphine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nicotine  (ISO)
nifedipine  (EXP)
nitric oxide  (EXP)
Nonylphenol  (EXP)
O-acetyl-L-carnitine  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phencyclidine  (ISO)
phenethyl caffeate  (EXP)
Phenoxybenzamine  (EXP)
physostigmine  (ISO)
poly(I:C)  (EXP)
potassium chloride  (EXP)
probenecid  (ISO)
probucol  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propionic acid  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethanil  (ISO)
pyrithiamine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP)
reactive oxygen species  (EXP)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
scopolamine  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
Soman  (EXP)
staurosporine  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
strychnine  (EXP)
tadalafil  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP,ISO)
thiophanate-methyl  (ISO)
thymoquinone  (EXP)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trichostatin A  (EXP)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
U-73122  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP)
warfarin  (ISO)
wogonin  (EXP,ISO)
ziram  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. Aamodt AH, etal., J Neurol. 2021 Mar 20. pii: 10.1007/s00415-021-10517-6. doi: 10.1007/s00415-021-10517-6.
2. The exact expression of glial fibrillary acidic protein (GFAP) in trigeminal ganglion and dental pulp. Ajima H, etal., Arch Histol Cytol 2001 Dec;64(5):503-11.
3. Intermediate filament change in astrocytes following mild cortical contusion. Baldwin SA and Scheff SW, Glia. 1996 Mar;16(3):266-75.
4. Identification of regulators of chaperone-mediated autophagy. Bandyopadhyay U, etal., Mol Cell. 2010 Aug 27;39(4):535-47. doi: 10.1016/j.molcel.2010.08.004.
5. Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients. Brouns R, etal., Clin Chem. 2010 Mar;56(3):451-8. Epub 2009 Dec 3.
6. Chaperone-mediated autophagy: roles in disease and aging. Cuervo AM and Wong E, Cell Res. 2014 Jan;24(1):92-104. doi: 10.1038/cr.2013.153. Epub 2013 Nov 26.
7. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats. Gohara T, etal., J Anesth. 2010 Apr;24(2):225-33. Epub 2010 Jan 29.
11. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
12. Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19. Kanberg N, etal., Neurology. 2020 Sep 22;95(12):e1754-e1759. doi: 10.1212/WNL.0000000000010111. Epub 2020 Jun 16.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Marco EM, etal., Pharmacol Biochem Behav. 2017 Jan;152:68-80. doi: 10.1016/j.pbb.2016.11.005. Epub 2016 Nov 25.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Transcriptional profiling of spinal cord injury-induced central neuropathic pain. Nesic O, etal., J Neurochem. 2005 Nov;95(4):998-1014. Epub 2005 Oct 10.
18. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Olave I, etal., Genes Dev. 2002 Oct 1;16(19):2509-17.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
21. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. Pekny M, etal., J Cell Biol. 1999 May 3;145(3):503-14.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Roymans D, etal., Exp Cell Res. 2000 Nov 25;261(1):127-38.
25. Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Rozovsky I, etal., Endocrinology 2002 Feb;143(2):636-46.
26. Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats. Toyooka T, etal., J Neurotrauma. 2011 Apr;28(4):607-18. Epub 2011 Mar 24.
27. Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. Triolo D, etal., J Cell Sci. 2006 Oct 1;119(Pt 19):3981-93.
28. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
29. Characterization of GFAP expression and cell proliferation in the rat median eminence following hypophysectomy. Vazquez R, etal., Histol Histopathol 2001 Oct;16(4):1107-16.
30. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
31. Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry. Yoshimura Y, etal., Biochem Biophys Res Commun 2002 Jan 25;290(3):948-54.
Additional References at PubMed
PMID:1629938   PMID:2153890   PMID:7897704   PMID:8692820   PMID:8793730   PMID:9364068   PMID:10336251   PMID:10816608   PMID:10989258   PMID:11064363   PMID:11283023   PMID:11487638  
PMID:11834298   PMID:12074840   PMID:12177195   PMID:12355421   PMID:12477932   PMID:12533615   PMID:12837269   PMID:12878680   PMID:15135219   PMID:15195688   PMID:15281060   PMID:15378652  
PMID:15476586   PMID:15489334   PMID:15531134   PMID:15656993   PMID:15732097   PMID:15804429   PMID:15840648   PMID:15862905   PMID:15965470   PMID:16048809   PMID:16097052   PMID:16196195  
PMID:16332461   PMID:16374706   PMID:16606365   PMID:16612832   PMID:16806201   PMID:16850587   PMID:16860801   PMID:16879601   PMID:16986516   PMID:17008879   PMID:17203480   PMID:17245710  
PMID:17334943   PMID:17409479   PMID:17443351   PMID:17485853   PMID:17634366   PMID:17684014   PMID:18076286   PMID:18360886   PMID:18443417   PMID:18483855   PMID:18633737   PMID:18707003  
PMID:19000745   PMID:19056393   PMID:19137572   PMID:19141977   PMID:19182904   PMID:19235900   PMID:19383423   PMID:19559073   PMID:19646951   PMID:19661770   PMID:19726345   PMID:19770604  
PMID:20197608   PMID:20423852   PMID:20479526   PMID:20531390   PMID:20578039   PMID:20732387   PMID:20826656   PMID:20876578   PMID:21046809   PMID:21139996   PMID:21168404   PMID:21211284  
PMID:21212183   PMID:21284970   PMID:21343257   PMID:21371476   PMID:21385309   PMID:21470923   PMID:21524663   PMID:21679183   PMID:21683086   PMID:21892662   PMID:21906524   PMID:22475395  
PMID:22610521   PMID:22871113   PMID:23076037   PMID:23110394   PMID:23447615   PMID:23515288   PMID:23861879   PMID:24035762   PMID:24379073   PMID:24481447   PMID:24567055   PMID:24582971  
PMID:24747049   PMID:25110093   PMID:25181319   PMID:25182537   PMID:25282817   PMID:25312986   PMID:25416956   PMID:25448608   PMID:25752945   PMID:25763798   PMID:25798055   PMID:25837926  
PMID:25898931   PMID:25910212   PMID:25931508   PMID:26561800   PMID:26994384   PMID:27003918   PMID:27133445   PMID:27166167   PMID:27579183   PMID:28652433   PMID:28705472   PMID:29350434  
PMID:29476059   PMID:29852171   PMID:30126346   PMID:30334860   PMID:32070010   PMID:32357304   PMID:32910393   PMID:34065959   PMID:35913387   PMID:37796476  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21087,852,891 - 87,861,631 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,852,890 - 87,861,589 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,888,973 - 92,897,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,355,379 - 92,364,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,748,725 - 87,757,408 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,990,762 - 90,999,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,990,762 - 90,999,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,763,150 - 90,771,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,059,881 - 92,068,555 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,074,249 - 92,082,949 (-)NCBI
Celera1086,555,367 - 86,564,160 (-)NCBICelera
RH 3.4 Map10920.49RGD
Cytogenetic Map10q32.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381744,903,159 - 44,915,500 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,903,159 - 44,916,937 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,980,527 - 42,992,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,338,519 - 40,348,394 (-)NCBINCBI36Build 36hg18NCBI36
Build 341740,338,518 - 40,348,394NCBI
Celera1739,693,499 - 39,703,421 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,748,049 - 38,758,000 (-)NCBIHuRef
CHM1_11743,219,135 - 43,229,061 (-)NCBICHM1_1
T2T-CHM13v2.01745,757,042 - 45,769,413 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911102,778,162 - 102,791,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,778,162 - 102,791,738 (-)EnsemblGRCm39 Ensembl
GRCm3811102,887,336 - 102,897,200 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,887,336 - 102,900,912 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,748,650 - 102,758,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,704,767 - 102,713,221 (-)NCBIMGSCv36mm8
Celera11114,598,382 - 114,608,239 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.48NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545117,695,835 - 17,703,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,695,835 - 17,703,894 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11721,885,949 - 21,895,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,407,211 - 12,417,072 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,579,754 - 12,589,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,579,754 - 12,591,961 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1918,569,868 - 18,579,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,569,892 - 18,579,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,955,308 - 17,964,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,243,310 - 19,252,910 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,243,327 - 19,310,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,120,937 - 18,130,529 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,299,941 - 18,309,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,456,787 - 18,466,393 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560217,919,377 - 17,928,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,265,436 - 1,275,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,265,915 - 1,275,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1218,456,263 - 18,466,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,456,268 - 18,466,594 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,700,993 - 18,711,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11661,489,090 - 61,499,672 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,489,421 - 61,500,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,238,179 - 32,248,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624795394,436 - 401,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795395,298 - 400,781 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gfap
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:439
Count of miRNA genes:220
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000003948, ENSRNOT00000034401
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat

Markers in Region
D10Kyo1   No map positions available.
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,862,024 - 87,862,338 (+)MAPPERmRatBN7.2
Rnor_6.01090,999,895 - 91,000,208NCBIRnor6.0
Rnor_5.01090,772,283 - 90,772,596UniSTSRnor5.0
RGSC_v3.41092,069,015 - 92,069,328UniSTSRGSC3.4
Celera1086,564,620 - 86,564,933UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,856,969 - 87,857,135 (+)MAPPERmRatBN7.2
Rnor_6.01090,994,841 - 90,995,006NCBIRnor6.0
Rnor_5.01090,767,229 - 90,767,394UniSTSRnor5.0
RGSC_v3.41092,063,960 - 92,064,125UniSTSRGSC3.4
Celera1086,559,446 - 86,559,611UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,852,911 - 87,853,116 (+)MAPPERmRatBN7.2
Rnor_6.01090,990,783 - 90,990,987NCBIRnor6.0
Rnor_5.01090,763,171 - 90,763,375UniSTSRnor5.0
RGSC_v3.41092,059,902 - 92,060,106UniSTSRGSC3.4
Celera1086,555,388 - 86,555,592UniSTS
RH 3.4 Map10892.6UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,860,798 - 87,860,965 (+)MAPPERmRatBN7.2
Rnor_6.01090,998,669 - 90,998,835NCBIRnor6.0
Rnor_5.01090,771,057 - 90,771,223UniSTSRnor5.0
RGSC_v3.41092,067,789 - 92,067,955UniSTSRGSC3.4
Celera1086,563,394 - 86,563,560UniSTS
RH 3.4 Map10920.49UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,852,916 - 87,853,134 (+)MAPPERmRatBN7.2
Rnor_6.01090,990,788 - 90,991,005NCBIRnor6.0
Rnor_5.01090,763,176 - 90,763,393UniSTSRnor5.0
RGSC_v3.41092,059,907 - 92,060,124UniSTSRGSC3.4
Celera1086,555,393 - 86,555,610UniSTS
Cytogenetic Map10q32.1UniSTS

Related Rat Strains
The following Strains have been annotated to Gfap

Genetic Models
This gene Gfap is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 6 12 12 3 12 37
Low 3 11 38 27 16 27 3 3 27 4 33 7 3
Below cutoff 26 7 2 2 5 5 10 30 8 4 5


RefSeq Acc Id: ENSRNOT00000034401   ⟹   ENSRNOP00000032389
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,852,890 - 87,861,589 (-)Ensembl
Rnor_6.0 Ensembl1090,990,762 - 90,999,506 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093167   ⟹   ENSRNOP00000076153
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,994,104 - 90,994,437 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093266   ⟹   ENSRNOP00000076226
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,855,575 - 87,861,589 (-)Ensembl
Rnor_6.0 Ensembl1090,993,446 - 90,995,982 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113966   ⟹   ENSRNOP00000094303
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,852,890 - 87,861,589 (-)Ensembl
RefSeq Acc Id: NM_017009   ⟹   NP_058705
Rat AssemblyChrPosition (strand)Source
mRatBN7.21087,852,891 - 87,861,565 (-)NCBI
Rnor_6.01090,990,762 - 90,999,435 (-)NCBI
Rnor_5.01090,763,150 - 90,771,823 (-)NCBI
RGSC_v3.41092,059,881 - 92,068,555 (-)RGD
Celera1086,555,367 - 86,564,160 (-)RGD
RefSeq Acc Id: XM_039085178   ⟹   XP_038941106
Rat AssemblyChrPosition (strand)Source
mRatBN7.21087,855,573 - 87,861,631 (-)NCBI
RefSeq Acc Id: NP_058705   ⟸   NM_017009
- UniProtKB: Q9R1Q3 (UniProtKB/Swiss-Prot),   Q7TQ31 (UniProtKB/Swiss-Prot),   A7REI0 (UniProtKB/Swiss-Prot),   Q9Z2S0 (UniProtKB/Swiss-Prot),   P47819 (UniProtKB/Swiss-Prot),   A6HJN5 (UniProtKB/TrEMBL),   A0A8I6GKP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032389   ⟸   ENSRNOT00000034401
RefSeq Acc Id: ENSRNOP00000076153   ⟸   ENSRNOT00000093167
RefSeq Acc Id: ENSRNOP00000076226   ⟸   ENSRNOT00000093266
RefSeq Acc Id: XP_038941106   ⟸   XM_039085178
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GKP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094303   ⟸   ENSRNOT00000113966
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47819-F1-model_v2 AlphaFold P47819 1-430 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697798
Promoter ID:EPDNEW_R8323
Type:single initiation site
Description:glial fibrillary acidic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,999,448 - 90,999,508EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2679 AgrOrtholog
BioCyc Gene G2FUF-23065 BioCyc
Ensembl Genes ENSRNOG00000002919 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055002377 UniProtKB/Swiss-Prot
  ENSRNOG00055029258 UniProtKB/Swiss-Prot
  ENSRNOG00060012414 UniProtKB/Swiss-Prot
  ENSRNOG00065030890 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034401 ENTREZGENE
  ENSRNOT00000034401.6 UniProtKB/Swiss-Prot
  ENSRNOT00000093266.2 UniProtKB/Swiss-Prot
  ENSRNOT00000113966.1 UniProtKB/TrEMBL
  ENSRNOT00055003781 UniProtKB/Swiss-Prot
  ENSRNOT00055050713 UniProtKB/Swiss-Prot
  ENSRNOT00060021080 UniProtKB/Swiss-Prot
  ENSRNOT00065053239 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Intermed_filament_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24387 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45652:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filament_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gfap PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002919 RatGTEx
  ENSRNOG00055002377 RatGTEx
  ENSRNOG00055029258 RatGTEx
  ENSRNOG00060012414 RatGTEx
  ENSRNOG00065030890 RatGTEx
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2Q6C8_RAT UniProtKB/TrEMBL
  A1E251_RAT UniProtKB/TrEMBL
  A1E252_RAT UniProtKB/TrEMBL
UniProt Secondary A7REI0 UniProtKB/Swiss-Prot
  Q7TQ31 UniProtKB/Swiss-Prot
  Q9R1Q3 UniProtKB/Swiss-Prot
  Q9Z2S0 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gfap  Glial fibrillary acidic protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease involved in wound healing 70384
gene_other marker for astrogilial cells 70384
gene_other marker for astrogilial cells 70740
gene_process major component of glial intermediate filament 70384
gene_process major component of glial intermediate filament 70740