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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:106336480464CTDFluoxetine results in increased expression of GFAP mRNA, Fluoxetine results in increased expression of GFAP protein

PMID:20857517
increases response to substanceISORGD:106336480464CTDGFAP protein results in increased susceptibility to Fluoxetine

PMID:22113448
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.