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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapincreases expressionEXP 6480464CTDStreptozocin results in increased expression of GFAP mRNA; Streptozocin results in increased expression of GFAP proteinPMID:24333387 PMID:38049026
Gfapmultiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein]; Vitamin B 12 inhibits the reaction [Streptozocin results in increased expression of GFAP protein]PMID:24333387 PMID:38049026
Gfapdecreases expressionISOGfap (Mus musculus)6480464CTDStreptozocin results in decreased expression of GFAP proteinPMID:28499986
Gfapmultiple interactionsISOGfap (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]; Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]PMID:28499986
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