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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:106336480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein

PMID:19199078, PMID:23747572, PMID:24995576, PMID:27182044, PMID:28185818
multiple interactionsISORGD:106336480464CTD[Probenecid co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in increased expression of GFAP protein, amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein], benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein], CNB 001 inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein], Dieldrin promotes the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein], telmisartan inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein], Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in decreased expression of GFAP protein], zonisamide inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of GFAP protein]

PMID:16809432, PMID:19199078, PMID:23747572, PMID:24995576, PMID:25064079, PMID:28185818
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.