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Gene: Nme2 (NME/NM23 nucleoside diphosphate kinase 2) Rattus norvegicus
Symbol: Nme2
Name: NME/NM23 nucleoside diphosphate kinase 2
RGD ID: 619877
Description: Exhibits several functions, including identical protein binding activity; intermediate filament binding activity; and kinase activity. Involved in several processes, including cellular response to glucose stimulus; nucleotide metabolic process; and response to growth hormone. Localizes to mitochondrial membrane and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME1-NME2 (NME1-NME2 readthrough); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-azacytidine.
Type: protein-coding
Also known as: expressed in non-metastatic cells 2; histidine protein kinase NDKB; NDK B; NDKB; NDP kinase alpha; NDP kinase B; nm23-2; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase; nucleoside diphosphate kinase B; P18; p18-12d
Homo sapiens (human) : NME2 (NME/NM23 nucleoside diphosphate kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)  MGI  Alliance
Canis lupus familiaris (dog) : NME2 (non-metastatic cells 2, protein (NM23B) expressed in)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)
Sus scrofa (pig) : NME2 (NME/NM23 nucleoside diphosphate kinase 2)
Chlorocebus sabaeus (African green monkey) : NME2 (NME/NM23 nucleoside diphosphate kinase 2)
more info ...
Related Pseudogenes: Nme2-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01081,648,216 - 81,653,717 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,648,216 - 81,653,717 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,478,178 - 81,483,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,582,766 - 82,588,269 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11082,597,135 - 82,602,639 (-)NCBI
Celera1077,694,496 - 77,700,026 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Nme2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619877
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.