Enables several functions, including identical protein binding activity; intermediate filament binding activity; and kinase activity. Involved in several processes, including cellular response to glucose stimulus; response to growth hormone; and ribonucleoside triphosphate biosynthetic process. Located in intermediate filament; mitochondrial membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of NME2 protein]
Tretinoin promotes the reaction [tributyltin results in decreased expression of NME2 protein] and Tretinoin promotes the reaction [triphenyltin chloride results in decreased expression of NME2 protein]
[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NME2 mRNA and [bisphenol A co-treated with Estradiol] results in decreased expression of NME2 mRNA
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of NME2 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of NME2 protein
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of NME2 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of NME2 protein
Recombinant rat nucleoside diphosphate kinase isoforms (alpha and beta): purification, properties and application to immunological detection of native isoforms in rat tissues.
Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells.
Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells.
Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase.
Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression.
Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro.
Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.
Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.
Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.
12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.