NME1 (NME/NM23 nucleoside diphosphate kinase 1) - Rat Genome Database

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Gene: NME1 (NME/NM23 nucleoside diphosphate kinase 1) Homo sapiens
Analyze
Symbol: NME1
Name: NME/NM23 nucleoside diphosphate kinase 1
RGD ID: 735393
HGNC Page HGNC:7849
Description: Enables several functions, including magnesium ion binding activity; nuclease activity; and purine ribonucleoside triphosphate binding activity. Involved in positive regulation of epithelial cell proliferation. Located in cytosol; nucleus; and ruffle membrane. Implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Biomarker of breast cancer (multiple); carcinoma (multiple); ovarian cancer; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AWD; expressed in non-metastatic cells 1; GAAD; granzyme A-activated DNase; metastasis inhibition factor nm23; NB; NBS; NDK A; NDKA; NDP kinase A; NDPK-A; NDPKA; NM23; NM23-H1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; tumor metastatic process-associated protein
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: NME1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,153,559 - 51,162,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1751,153,559 - 51,162,428 (+)EnsemblGRCh38hg38GRCh38
GRCh371749,230,920 - 49,239,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,585,919 - 46,594,449 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,585,918 - 46,594,449NCBI
Celera1745,692,176 - 45,700,706 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,600,187 - 44,608,715 (+)NCBIHuRef
CHM1_11749,295,556 - 49,304,086 (+)NCBICHM1_1
T2T-CHM13v2.01752,020,874 - 52,029,483 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (EXP)
(Z)-3-butylidenephthalide  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calycosin  (EXP)
captan  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (EXP)
fulvestrant  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
graphite  (EXP)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (EXP)
L-ascorbic acid  (EXP)
lipopolysaccharide  (EXP)
methidathion  (ISO)
methimazole  (ISO)
methylseleninic acid  (EXP)
myricetin  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nimesulide  (ISO)
okadaic acid  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
pyrimidifen  (EXP)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tamoxifen  (ISO)
Terfenadine  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenylstannane  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. NM23 gene expression in human prostatic carcinomas and benign prostatic hyperplasias: altered expression in combined androgen blockaded carcinomas. Borchers H, etal., J Urol. 1996 Jun;155(6):2080-4.
2. NM23 gene expression in human breast carcinomas: loss of correlation with cell proliferation in the advanced phase of tumor progression. Caligo MA, etal., Int J Cancer. 1997 Feb 20;74(1):102-11.
3. Nm23-H1 mutation in neuroblastoma. Chang CL, etal., Nature. 1994 Aug 4;370(6488):335-6.
4. Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells. Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
7. Analysis of nm23 gene expressions in human bladder and renal cancers. Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31.
8. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58.
9. Increased expression of the NME1 gene is associated with metastasis in epithelial ovarian cancer. Leary JA, etal., Int J Cancer. 1995 Jun 22;64(3):189-95.
10. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. Lutz S, etal., Br J Pharmacol. 2003 Nov;140(6):1019-26. Epub 2003 Oct 14.
11. Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion. Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8.
12. Allelic loss and somatic differentiation in human male germ cell tumors. Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51.
13. Prognostic value of nm23 protein expression in renal cell carcinomas. Nakagawa Y, etal., Oncology. 1998 Jul-Aug;55(4):370-6.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Immunohistochemical analysis of nucleoside diphosphate kinases in oral squamous cell carcinomas. Otsuki K, etal., Oncology. 1997 Jan-Feb;54(1):63-8.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
21. nm23 in ovarian cancer: correlation with clinical outcome and other clinicopathologic and biochemical prognostic parameters. Scambia G, etal., J Clin Oncol. 1996 Feb;14(2):334-42.
22. Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins. Tian R, etal., Dig Dis Sci. 2008 Jan;53(1):65-72. Epub 2007 May 11.
23. Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer. Tokunaga Y, etal., Int J Cancer. 1993 Aug 19;55(1):66-71.
24. Potential prognostic value in human breast cancer of cytosolic Nme1 protein detection using an original hen specific antibody. Toulas C, etal., Br J Cancer. 1996 Mar;73(5):630-5.
25. Expression of nm23-H1 and nm23-H2 protein in endometrial carcinoma. Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73.
26. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:1851158   PMID:2015608   PMID:2056128   PMID:2509941   PMID:2566996   PMID:7821789   PMID:7916650   PMID:8245015   PMID:8270257   PMID:8297127   PMID:8392752   PMID:8395939  
PMID:8810265   PMID:8858107   PMID:9480811   PMID:9488696   PMID:9513729   PMID:9593706   PMID:10512675   PMID:10602478   PMID:10611312   PMID:10618642   PMID:11042679   PMID:11231635  
PMID:11274357   PMID:11277919   PMID:11280768   PMID:11319942   PMID:11555662   PMID:11687967   PMID:11701125   PMID:11726210   PMID:11776896   PMID:11835509   PMID:11918081   PMID:11919189  
PMID:11935309   PMID:11960382   PMID:11963831   PMID:11998956   PMID:12007505   PMID:12105213   PMID:12135660   PMID:12137595   PMID:12163590   PMID:12174914   PMID:12200143   PMID:12405283  
PMID:12452062   PMID:12474051   PMID:12477932   PMID:12490715   PMID:12524539   PMID:12601555   PMID:12624546   PMID:12628186   PMID:12669312   PMID:12684753   PMID:12859952   PMID:12883690  
PMID:12910292   PMID:12972261   PMID:14499630   PMID:14558955   PMID:14664140   PMID:14744259   PMID:14960567   PMID:15040016   PMID:15073128   PMID:15129904   PMID:15280446   PMID:15334673  
PMID:15489334   PMID:15512982   PMID:15568401   PMID:15592684   PMID:15645378   PMID:15650182   PMID:15684389   PMID:15757202   PMID:15777972   PMID:15833843   PMID:15870434   PMID:15882758  
PMID:16011248   PMID:16044917   PMID:16130169   PMID:16189514   PMID:16232196   PMID:16277028   PMID:16313181   PMID:16317582   PMID:16415009   PMID:16466905   PMID:16531762   PMID:16631833  
PMID:16739125   PMID:16739379   PMID:16759016   PMID:16814409   PMID:16848180   PMID:16862176   PMID:16891807   PMID:16944571   PMID:16957985   PMID:17008916   PMID:17103045   PMID:17155928  
PMID:17197349   PMID:17283532   PMID:17314099   PMID:17348207   PMID:17359290   PMID:17578003   PMID:17591363   PMID:17655525   PMID:17688968   PMID:17695492   PMID:17885583   PMID:17918157  
PMID:17975005   PMID:18029348   PMID:18058029   PMID:18089805   PMID:18154714   PMID:18219290   PMID:18239814   PMID:18301251   PMID:18307927   PMID:18330957   PMID:18408655   PMID:18440302  
PMID:18457437   PMID:18470881   PMID:18476632   PMID:18635542   PMID:18668641   PMID:18676749   PMID:18700747   PMID:18728402   PMID:18810774   PMID:18815136   PMID:18996649   PMID:19024519  
PMID:19026164   PMID:19060904   PMID:19170058   PMID:19183483   PMID:19186179   PMID:19263457   PMID:19266025   PMID:19332021   PMID:19513384   PMID:19615732   PMID:19619546   PMID:19624895  
PMID:19655221   PMID:19664043   PMID:19664078   PMID:19724852   PMID:19852809   PMID:19946888   PMID:19951590   PMID:19956735   PMID:20099494   PMID:20101217   PMID:20113651   PMID:20145075  
PMID:20209495   PMID:20304626   PMID:20403806   PMID:20448457   PMID:20508983   PMID:20559153   PMID:20560137   PMID:20570897   PMID:20599259   PMID:20671611   PMID:20713695   PMID:20841469  
PMID:20872186   PMID:20877624   PMID:20955383   PMID:20959063   PMID:21045303   PMID:21080107   PMID:21081666   PMID:21085602   PMID:21121676   PMID:21169412   PMID:21176535   PMID:21221850  
PMID:21265090   PMID:21270158   PMID:21273640   PMID:21350102   PMID:21442621   PMID:21448569   PMID:21469425   PMID:21478336   PMID:21484438   PMID:21553004   PMID:21575865   PMID:21630459  
PMID:21653829   PMID:21769563   PMID:21846466   PMID:21873635   PMID:21913743   PMID:21988832   PMID:22035418   PMID:22268729   PMID:22290468   PMID:22328561   PMID:22349375   PMID:22364921  
PMID:22421058   PMID:22429576   PMID:22451184   PMID:22531683   PMID:22658674   PMID:22683585   PMID:22718351   PMID:22863883   PMID:22869372   PMID:22903495   PMID:22920000   PMID:22939629  
PMID:23137649   PMID:23158994   PMID:23376485   PMID:23443559   PMID:23448979   PMID:23464856   PMID:23479363   PMID:23519676   PMID:23533145   PMID:23553196   PMID:23583378   PMID:23679306  
PMID:23694823   PMID:23725501   PMID:23734265   PMID:23768014   PMID:23818346   PMID:23856325   PMID:24096484   PMID:24133580   PMID:24337577   PMID:24457600   PMID:24811176   PMID:24858271  
PMID:24915993   PMID:24970086   PMID:24981860   PMID:25010650   PMID:25017017   PMID:25048347   PMID:25119778   PMID:25199839   PMID:25277180   PMID:25321081   PMID:25373728   PMID:25416956  
PMID:25501107   PMID:25502805   PMID:25582197   PMID:25609649   PMID:25748386   PMID:25766862   PMID:25808322   PMID:25910212   PMID:25963833   PMID:26217791   PMID:26344197   PMID:26561776  
PMID:26565392   PMID:26618866   PMID:26634527   PMID:26760575   PMID:26825905   PMID:26831064   PMID:27094059   PMID:27107014   PMID:27222072   PMID:27342126   PMID:27432908   PMID:27449069  
PMID:27499296   PMID:27509166   PMID:27518571   PMID:27592483   PMID:27604954   PMID:27684187   PMID:27888614   PMID:27926873   PMID:28161101   PMID:28216015   PMID:28302793   PMID:28376369  
PMID:28401162   PMID:28442010   PMID:28514442   PMID:28515276   PMID:28614246   PMID:28712289   PMID:28767310   PMID:28831131   PMID:28991262   PMID:29035376   PMID:29058705   PMID:29128334  
PMID:29187211   PMID:29229926   PMID:29251738   PMID:29407582   PMID:29449217   PMID:29507755   PMID:29525404   PMID:29567887   PMID:29665387   PMID:29697269   PMID:29700912   PMID:29777862  
PMID:29970055   PMID:30158514   PMID:30396920   PMID:30425250   PMID:30455355   PMID:30458180   PMID:30575818   PMID:30763256   PMID:30827726   PMID:30875636   PMID:30995489   PMID:31046837  
PMID:31123173   PMID:31180492   PMID:31300519   PMID:31436131   PMID:31515488   PMID:31586073   PMID:31598678   PMID:31709864   PMID:31734851   PMID:31980649   PMID:31995728   PMID:32022430  
PMID:32041737   PMID:32140074   PMID:32249768   PMID:32296183   PMID:32344865   PMID:32392889   PMID:32462300   PMID:32552912   PMID:32698014   PMID:32781191   PMID:32824412   PMID:32877691  
PMID:33060197   PMID:33194618   PMID:33402463   PMID:33421524   PMID:33838681   PMID:33903070   PMID:33916271   PMID:33961781   PMID:34012098   PMID:34079125   PMID:34133714   PMID:34383978  
PMID:34428256   PMID:34830075   PMID:34948065   PMID:35013218   PMID:35031058   PMID:35122331   PMID:35140242   PMID:35256949   PMID:35259022   PMID:35438846   PMID:35446349   PMID:35545034  
PMID:35562734   PMID:35563538   PMID:35696571   PMID:35777956   PMID:35831314   PMID:35939247   PMID:35944360   PMID:35987950   PMID:36116139   PMID:36180891   PMID:36215168   PMID:36244648  
PMID:36373674   PMID:36538041   PMID:36610398   PMID:36762613   PMID:36768287   PMID:37298313   PMID:37616343   PMID:38029727   PMID:38113892  


Genomics

Comparative Map Data
NME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,153,559 - 51,162,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1751,153,559 - 51,162,428 (+)EnsemblGRCh38hg38GRCh38
GRCh371749,230,920 - 49,239,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,585,919 - 46,594,449 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,585,918 - 46,594,449NCBI
Celera1745,692,176 - 45,700,706 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,600,187 - 44,608,715 (+)NCBIHuRef
CHM1_11749,295,556 - 49,304,086 (+)NCBICHM1_1
T2T-CHM13v2.01752,020,874 - 52,029,483 (+)NCBIT2T-CHM13v2.0
Nme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,849,751 - 93,859,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,847,805 - 93,859,347 (-)EnsemblGRCm39 Ensembl
GRCm381193,958,925 - 93,968,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,956,979 - 93,968,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,820,239 - 93,829,835 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,718,303 - 94,727,903 (-)NCBIMGSCv36mm8
MGSCv361193,775,015 - 93,784,611 (-)NCBIMGSCv36mm8
Celera11103,573,962 - 103,581,369 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.89NCBI
Nme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,403,939 - 79,426,620 (-)NCBIGRCr8
mRatBN7.21078,907,036 - 78,929,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1078,906,083 - 78,916,408 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,517,884 - 83,527,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,015,983 - 83,025,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,487,338 - 78,496,721 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,657,152 - 81,666,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,657,153 - 81,666,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,487,114 - 81,496,485 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,591,705 - 82,601,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11082,606,074 - 82,615,445 (-)NCBI
Celera1077,703,467 - 77,712,916 (-)NCBICelera
Cytogenetic Map10q26NCBI
NME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21967,341,196 - 67,349,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11772,148,244 - 72,156,797 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01745,243,588 - 45,252,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11750,113,321 - 50,121,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1750,113,622 - 50,131,636 (+)Ensemblpanpan1.1panPan2
NME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,990,336 - 26,998,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,990,469 - 26,998,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha926,321,054 - 26,326,903 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,784,176 - 27,792,716 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,784,309 - 27,792,772 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,552,843 - 26,558,695 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,812,400 - 26,818,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,942,481 - 26,948,330 (+)NCBIUU_Cfam_GSD_1.0
NME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1227,416,346 - 27,436,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11227,416,308 - 27,435,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,484,195 - 27,502,922 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242912
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,186,039 - 42,195,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,185,260 - 42,195,616 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607712,895,727 - 12,905,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in NME1
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q21.32-22(chr17:49137864-52147810)x1 copy number loss See cases [RCV000053432] Chr17:49137864..52147810 [GRCh38]
Chr17:47215226..50225170 [GRCh37]
Chr17:44570225..47580169 [NCBI36]
Chr17:17q21.32-22
pathogenic
GRCh38/hg38 17q21.33-22(chr17:49974533-56807609)x1 copy number loss See cases [RCV000053433] Chr17:49974533..56807609 [GRCh38]
Chr17:48051897..54884970 [GRCh37]
Chr17:45406896..52239969 [NCBI36]
Chr17:17q21.33-22
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1 copy number loss not provided [RCV000513510] Chr17:46481089..51396368 [GRCh37]
Chr17:17q21.32-22
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_000269.3(NME1):c.341+10T>G single nucleotide variant not provided [RCV000901750] Chr17:51161282 [GRCh38]
Chr17:49238643 [GRCh37]
Chr17:17q21.33
benign
NM_000269.3(NME1):c.-5+762del deletion not provided [RCV001355285] Chr17:51154424 [GRCh38]
Chr17:49231785 [GRCh37]
Chr17:17q21.33
uncertain significance
NM_000269.3(NME1):c.452A>G (p.Tyr151Cys) single nucleotide variant Inborn genetic diseases [RCV002723448] Chr17:51161838 [GRCh38]
Chr17:49239199 [GRCh37]
Chr17:17q21.33
uncertain significance
NM_000269.3(NME1):c.428C>T (p.Thr143Met) single nucleotide variant Inborn genetic diseases [RCV003342064] Chr17:51161814 [GRCh38]
Chr17:49239175 [GRCh37]
Chr17:17q21.33
likely benign
NM_000269.3(NME1):c.-5+604G>A single nucleotide variant not specified [RCV003489059] Chr17:51154266 [GRCh38]
Chr17:49231627 [GRCh37]
Chr17:17q21.33
benign
NM_000269.3(NME1):c.342-53C>A single nucleotide variant not specified [RCV003489089] Chr17:51161675 [GRCh38]
Chr17:49239036 [GRCh37]
Chr17:17q21.33
benign
NM_000269.3(NME1):c.-5+600C>G single nucleotide variant not specified [RCV003489181] Chr17:51154262 [GRCh38]
Chr17:49231623 [GRCh37]
Chr17:17q21.33
benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR28hsa-miR-28-3pOncomiRDBexternal_infoNANA22240480

Predicted Target Of
Summary Value
Count of predictions:2685
Count of miRNA genes:945
Interacting mature miRNAs:1133
Transcripts:ENST00000013034, ENST00000336097, ENST00000393196, ENST00000456492, ENST00000465188, ENST00000475573, ENST00000480143, ENST00000487481, ENST00000511355, ENST00000512768
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:196135  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371749,239,194 - 49,239,379UniSTSGRCh37
Build 361746,594,193 - 46,594,378RGDNCBI36
Celera1745,700,450 - 45,700,635RGD
Cytogenetic Map17q21.3UniSTS
HuRef1744,608,459 - 44,608,644UniSTS
RH68986  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371749,230,804 - 49,230,935UniSTSGRCh37
Build 361746,585,803 - 46,585,934RGDNCBI36
Celera1745,692,060 - 45,692,191RGD
Cytogenetic Map17q21.3UniSTS
HuRef1744,600,071 - 44,600,202UniSTS
GeneMap99-GB4 RH Map17347.15UniSTS
NCBI RH Map17604.8UniSTS
D17S1989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371749,239,209 - 49,239,387UniSTSGRCh37
Build 361746,594,208 - 46,594,386RGDNCBI36
Celera1745,700,465 - 45,700,643RGD
Cytogenetic Map17q21.3UniSTS
HuRef1744,608,474 - 44,608,652UniSTS
Stanford-G3 RH Map172209.0UniSTS
Whitehead-YAC Contig Map17 UniSTS
GeneMap99-G3 RH Map172710.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2085 1744 1617 522 1213 364 3810 1256 3573 348 1436 1549 175 1 1181 2257 5 2
Low 354 1245 109 102 737 101 547 940 161 71 24 64 23 531 1
Below cutoff 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF487339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL360166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL360191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE727815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF965472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG531372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG715560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG757842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI666785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM479520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU600979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ900933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000013034   ⟹   ENSP00000013034
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,665 - 51,161,898 (+)Ensembl
RefSeq Acc Id: ENST00000336097   ⟹   ENSP00000337060
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,576 - 51,162,061 (+)Ensembl
RefSeq Acc Id: ENST00000393196   ⟹   ENSP00000376892
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,559 - 51,162,168 (+)Ensembl
RefSeq Acc Id: ENST00000456492   ⟹   ENSP00000387682
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,154,044 - 51,155,759 (+)Ensembl
RefSeq Acc Id: ENST00000465188
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,154,337 - 51,156,063 (+)Ensembl
RefSeq Acc Id: ENST00000475573   ⟹   ENSP00000435498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,597 - 51,162,035 (+)Ensembl
RefSeq Acc Id: ENST00000480143   ⟹   ENSP00000429318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,578 - 51,161,586 (+)Ensembl
RefSeq Acc Id: ENST00000487481
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,572 - 51,156,546 (+)Ensembl
RefSeq Acc Id: ENST00000511355   ⟹   ENSP00000428553
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,581 - 51,162,428 (+)Ensembl
RefSeq Acc Id: ENST00000512768
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1751,153,580 - 51,160,602 (+)Ensembl
RefSeq Acc Id: NM_000269   ⟹   NP_000260
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381751,153,559 - 51,162,168 (+)NCBI
GRCh371749,230,920 - 49,239,450 (+)ENTREZGENE
Build 361746,585,919 - 46,594,449 (+)NCBI Archive
HuRef1744,600,187 - 44,608,715 (+)ENTREZGENE
CHM1_11749,295,556 - 49,304,086 (+)NCBI
T2T-CHM13v2.01752,020,874 - 52,029,483 (+)NCBI
Sequence:
RefSeq Acc Id: NM_198175   ⟹   NP_937818
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381751,153,559 - 51,162,089 (+)NCBI
GRCh371749,230,920 - 49,239,450 (+)ENTREZGENE
Build 361746,585,919 - 46,594,449 (+)NCBI Archive
HuRef1744,600,187 - 44,608,715 (+)ENTREZGENE
CHM1_11749,295,556 - 49,304,086 (+)NCBI
T2T-CHM13v2.01752,020,874 - 52,029,404 (+)NCBI
Sequence:
RefSeq Acc Id: NP_937818   ⟸   NM_198175
- Peptide Label: isoform a
- UniProtKB: P15531 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_000260   ⟸   NM_000269
- Peptide Label: isoform b
- UniProtKB: Q86XQ2 (UniProtKB/Swiss-Prot),   Q6FGK3 (UniProtKB/Swiss-Prot),   Q9UDJ6 (UniProtKB/Swiss-Prot),   P15531 (UniProtKB/Swiss-Prot),   A0A384MTW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000337060   ⟸   ENST00000336097
RefSeq Acc Id: ENSP00000429318   ⟸   ENST00000480143
RefSeq Acc Id: ENSP00000387682   ⟸   ENST00000456492
RefSeq Acc Id: ENSP00000428553   ⟸   ENST00000511355
RefSeq Acc Id: ENSP00000376892   ⟸   ENST00000393196
RefSeq Acc Id: ENSP00000013034   ⟸   ENST00000013034
RefSeq Acc Id: ENSP00000435498   ⟸   ENST00000475573
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15531-F1-model_v2 AlphaFold P15531 1-152 view protein structure

Promoters
RGD ID:6794409
Promoter ID:HG_KWN:26610
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000013034,   NM_001018136,   NM_198175,   OTTHUMT00000268662,   OTTHUMT00000268757,   OTTHUMT00000268761,   OTTHUMT00000268762,   UC002ITK.1,   UC010DBX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361746,585,726 - 46,586,226 (+)MPROMDB
RGD ID:6794382
Promoter ID:HG_KWN:26611
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   Lymphoblastoid
Transcripts:ENST00000311032,   ENST00000393199,   OTTHUMT00000268760
Position:
Human AssemblyChrPosition (strand)Source
Build 361746,585,811 - 46,586,762 (+)MPROMDB
RGD ID:6851906
Promoter ID:EP73759
Type:multiple initiation site
Name:HS_NME1
Description:Non-metastatic cells 1, protein (NM23A) expressed in.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361746,585,940 - 46,586,000EPD
RGD ID:7235693
Promoter ID:EPDNEW_H23591
Type:initiation region
Name:NME1_1
Description:NME/NM23 nucleoside diphosphate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23592  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381751,153,609 - 51,153,669EPDNEW
RGD ID:7235691
Promoter ID:EPDNEW_H23592
Type:initiation region
Name:NME1_2
Description:NME/NM23 nucleoside diphosphate kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23591  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381751,155,627 - 51,155,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7849 AgrOrtholog
COSMIC NME1 COSMIC
Ensembl Genes ENSG00000239672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000013034.3 UniProtKB/Swiss-Prot
  ENST00000336097 ENTREZGENE
  ENST00000336097.7 UniProtKB/Swiss-Prot
  ENST00000393196 ENTREZGENE
  ENST00000393196.8 UniProtKB/Swiss-Prot
  ENST00000456492.1 UniProtKB/TrEMBL
  ENST00000475573.5 UniProtKB/TrEMBL
  ENST00000480143.5 UniProtKB/TrEMBL
  ENST00000511355.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000239672 GTEx
HGNC ID HGNC:7849 ENTREZGENE
Human Proteome Map NME1 Human Proteome Map
InterPro NDK-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4830 ENTREZGENE
OMIM 156490 OMIM
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEOSIDE DIPHOSPHATE KINASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA249 PharmGKB
PRINTS NUCDPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NDP_KINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54919 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384MTW7 ENTREZGENE, UniProtKB/TrEMBL
  C9K028_HUMAN UniProtKB/TrEMBL
  E5RHP0_HUMAN UniProtKB/TrEMBL
  E7ERL0_HUMAN UniProtKB/TrEMBL
  NDKA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FGK3 ENTREZGENE
  Q86XQ2 ENTREZGENE
  Q9UDJ6 ENTREZGENE
UniProt Secondary Q6FGK3 UniProtKB/Swiss-Prot
  Q86XQ2 UniProtKB/Swiss-Prot
  Q9UDJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-26 NME1  NME/NM23 nucleoside diphosphate kinase 1  NME1  non-metastatic cells 1, protein (NM23A) expressed in  Symbol and/or name change 5135510 APPROVED