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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cromoglycate(2-)
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Accession:CHEBI:59039 term browser browse the term
Definition:The dicarboxylate anion of cromoglycic acid.
Synonyms:exact_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate)
 related_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylate);   Formula=C23H14O11;   InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)/p-2;   InChIKey=IMZMKUWMOSJXDT-UHFFFAOYSA-L;   SMILES=OC(COc1cccc2oc(cc(=O)c12)C([O-])=O)COc1cccc2oc(cc(=O)c12)C([O-])=O;   cromoglycate
 xref: Beilstein:3659374
 cyclic_relationship: is_conjugate_base_of CHEBI:59774


show annotations for term's descendants           Sort by:
cromoglycate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 affects binding EXP Chromoglycate binds to Nme2 protein RGD PMID:20082612 RGD:4107023 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538 		JBrowse link
disodium cromoglycate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein] CTD PMID:35114312 PMID:36464070 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions		 ISO
EXP		 Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]		 CTD PMID:36464070 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cromolyn Sodium results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adora3 adenosine A3 receptor decreases activity EXP Cromolyn Sodium results in decreased activity of ADORA3 protein CTD PMID:15641640 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein] CTD PMID:28732690 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cst3 cystatin C multiple interactions EXP Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein CTD PMID:35961540 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Gpr35 G protein-coupled receptor 35 affects localization
multiple interactions		 ISO
EXP		 Cromolyn Sodium affects the localization of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]		 CTD PMID:20919992 PMID:22967846 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein] CTD PMID:36464070 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins1 insulin 1 increases expression ISO Cromolyn Sodium results in increased expression of INS1 protein CTD PMID:23784744 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein CTD PMID:35961540 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 EXP
ISO		 [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein		 CTD PMID:28732690 PMID:35961540 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein CTD PMID:35961540 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 EXP Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA		 CTD PMID:14577597 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein] CTD PMID:36464070 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Retn resistin decreases expression ISO Cromolyn Sodium results in decreased expression of RETN protein CTD PMID:23784744 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein] CTD PMID:36464070 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein] CTD PMID:35114312 PMID:36464070 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein] CTD PMID:35114312 PMID:36464070 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein] CTD PMID:36464070 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein] CTD PMID:15033348 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion		 ISO
EXP		 [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]		 CTD PMID:35007524 PMID:35114312 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        ion 16707
          anion 16084
            organic anion 3613
              carboxylic acid anion 2480
                dicarboxylic acid anion 250
                  dicarboxylic acid dianion 250
                    cromoglycate(2-) 33
                      disodium cromoglycate 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic ion 9870
                              organic anion 3613
                                carboxylic acid anion 2480
                                  dicarboxylic acid anion 250
                                    dicarboxylic acid dianion 250
                                      cromoglycate(2-) 33
                                        disodium cromoglycate 32
paths to the root