Nme2 (NME/NM23 nucleoside diphosphate kinase 2) - Rat Genome Database

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Gene: Nme2 (NME/NM23 nucleoside diphosphate kinase 2) Mus musculus
Analyze
Symbol: Nme2
Name: NME/NM23 nucleoside diphosphate kinase 2
RGD ID: 1552274
MGI Page MGI
Description: Predicted to enable several functions, including G-quadruplex DNA binding activity; anion binding activity; and kinase activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of myeloid leukocyte differentiation; and ribonucleoside triphosphate biosynthetic process. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: expressed in non-metastatic cells 2 protein; histidine protein kinase NDKB; MGC107562; MGC107563; NDK B; NDP kinase B; NM23-H; NM23-H2; nm23-M; nm23-M2; NM23B; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleoside-diphosphate kinase 2; P18
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Nme-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,840,640 - 93,847,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,840,640 - 93,847,085 (-)EnsemblGRCm39 Ensembl
GRCm381193,949,814 - 93,956,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,949,814 - 93,956,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,811,129 - 93,817,321 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,765,904 - 93,772,097 (-)NCBIMGSCv36mm8
Celera11103,564,861 - 103,571,040 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
astaxanthin  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cocaine  (ISO)
cromoglycate(2-)  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
fentin chloride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
Mesaconitine  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quinoline  (ISO)
rotenone  (ISO)
sarin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
triphenylstannane  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death. Arnaud-Dabernat S, etal., Exp Cell Res. 2004 Dec 10;301(2):293-304.
2. Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells. Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7.
3. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
4. Analysis of nm23 gene expressions in human bladder and renal cancers. Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma. Konishi N, etal., Jpn J Cancer Res. 1993 Oct;84(10):1050-4.
7. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58.
8. Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium. Lutz S, etal., Cardiovasc Res. 2001 Jan;49(1):48-55.
9. Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression. Mandai M, etal., Cancer Res. 1994 Apr 1;54(7):1825-30.
10. Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion. Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
13. Allelic loss and somatic differentiation in human male germ cell tumors. Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis. Rayner K, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R743-50. Epub 2006 Aug 3.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Alterations of the metastasis suppressor gene nm23 and the proto-oncogene c-myc in human testicular germ cell tumors. Schmidt B, etal., J Urol. 1997 Nov;158(5):2000-5.
21. Expression of nm23-H1 and nm23-H2 protein in endometrial carcinoma. Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73.
22. Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. Wee XK, etal., Br J Pharmacol. 2010 Jan 1;159(2):449-61. Epub 2010 Jan 15.
23. 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. Wei SJ, etal., J Biol Chem. 2004 Feb 13;279(7):5993-6004. Epub 2003 Nov 17.
Additional References at PubMed
PMID:1325378   PMID:1337998   PMID:8543593   PMID:8600152   PMID:8858107   PMID:9488696   PMID:9507200   PMID:9881672   PMID:10349636   PMID:10452942   PMID:11042159   PMID:11076861  
PMID:11152623   PMID:12383506   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15102471   PMID:15247270   PMID:15489334   PMID:15782199   PMID:15928304   PMID:16011243   PMID:16082520  
PMID:16141072   PMID:16141073   PMID:16919471   PMID:17532299   PMID:17634366   PMID:18614015   PMID:18799693   PMID:19235734   PMID:19723774   PMID:19805292   PMID:19837676   PMID:20884616  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22006949   PMID:22080566   PMID:22192927   PMID:23940300   PMID:24194600   PMID:24674776   PMID:24970086   PMID:25147336   PMID:25261685  
PMID:25748386   PMID:25900369   PMID:26088577   PMID:26299592   PMID:26896769   PMID:27604954   PMID:27626380   PMID:27927712   PMID:29382714   PMID:30002415   PMID:30411342   PMID:30713523  
PMID:31162944   PMID:32325033   PMID:32466219   PMID:32554809   PMID:32675240   PMID:32860079   PMID:33024267   PMID:33086728   PMID:34433909   PMID:34709266   PMID:37672589  


Genomics

Comparative Map Data
Nme2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,840,640 - 93,847,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,840,640 - 93,847,085 (-)EnsemblGRCm39 Ensembl
GRCm381193,949,814 - 93,956,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,949,814 - 93,956,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,811,129 - 93,817,321 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,765,904 - 93,772,097 (-)NCBIMGSCv36mm8
Celera11103,564,861 - 103,571,040 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.88NCBI
NME2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,165,536 - 51,171,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1751,165,435 - 51,171,744 (+)EnsemblGRCh38hg38GRCh38
GRCh371749,242,897 - 49,249,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,597,890 - 46,604,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,598,810 - 46,604,103NCBI
Celera1745,704,144 - 45,710,358 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,612,062 - 44,618,375 (+)NCBIHuRef
CHM1_11749,307,431 - 49,313,740 (+)NCBICHM1_1
T2T-CHM13v2.01752,032,848 - 52,039,047 (+)NCBIT2T-CHM13v2.0
Nme2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,394,999 - 79,400,418 (-)NCBIGRCr8
mRatBN7.21078,898,097 - 78,903,514 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1078,897,770 - 78,903,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,508,941 - 83,514,439 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,007,040 - 83,012,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,478,407 - 78,483,899 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,648,216 - 81,653,717 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,648,216 - 81,653,717 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,478,178 - 81,483,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,582,766 - 82,588,269 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11082,597,135 - 82,602,639 (-)NCBI
Celera1077,694,496 - 77,700,026 (-)NCBICelera
Cytogenetic Map10q26NCBI
NME2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21967,353,449 - 67,359,441 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11772,160,643 - 72,166,512 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01745,255,982 - 45,261,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11750,126,867 - 50,131,776 (+)NCBIpanpan1.1PanPan1.1panPan2
NME2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1927,002,114 - 27,005,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl927,001,733 - 27,015,934 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha926,330,716 - 26,333,823 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,795,956 - 27,799,595 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,795,346 - 27,799,595 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,562,504 - 26,565,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,822,054 - 26,825,171 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,952,138 - 26,955,247 (+)NCBIUU_Cfam_GSD_1.0
Nme2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560226,435,190 - 26,440,351 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649010,633,454 - 10,649,914 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649010,634,788 - 10,640,182 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1227,439,260 - 27,445,027 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11227,439,529 - 27,445,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,507,399 - 27,513,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242911
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,176,690 - 42,182,041 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,176,524 - 42,182,019 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607712,886,379 - 12,891,712 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nme2
269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSMUST00000021217, ENSMUST00000072566
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
13524529Bodwtq10_mbody wweight QTL 10 (mouse)119067951297699512Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse

Markers in Region
d10mgh23  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381193,951,796 - 93,951,919UniSTSGRCm38
MGSCv371193,813,110 - 93,813,233UniSTSGRCm37
Celera11103,566,838 - 103,566,961UniSTS
Cytogenetic Map11CUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001077529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK012447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV458476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY274368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY514605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF437324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021217   ⟹   ENSMUSP00000021217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1193,840,640 - 93,847,085 (-)Ensembl
GRCm38.p6 Ensembl1193,949,814 - 93,956,259 (-)Ensembl
RefSeq Acc Id: ENSMUST00000072566   ⟹   ENSMUSP00000103476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1193,840,643 - 93,846,609 (-)Ensembl
GRCm38.p6 Ensembl1193,949,817 - 93,955,783 (-)Ensembl
RefSeq Acc Id: NM_001077529   ⟹   NP_001070997
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,840,640 - 93,846,609 (-)NCBI
GRCm381193,949,814 - 93,955,783 (-)NCBI
MGSCv371193,811,129 - 93,817,321 (-)RGD
Celera11103,564,860 - 103,571,289 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008705   ⟹   NP_032731
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,840,640 - 93,847,082 (-)NCBI
GRCm381193,949,814 - 93,956,256 (-)NCBI
MGSCv371193,811,129 - 93,817,321 (-)RGD
Celera11103,564,860 - 103,571,289 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032731   ⟸   NM_008705
- UniProtKB: Q01768 (UniProtKB/Swiss-Prot),   Q5NC82 (UniProtKB/TrEMBL),   B0LAA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001070997   ⟸   NM_001077529
- UniProtKB: Q01768 (UniProtKB/Swiss-Prot),   Q5NC82 (UniProtKB/TrEMBL),   B0LAA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103476   ⟸   ENSMUST00000072566
RefSeq Acc Id: ENSMUSP00000021217   ⟸   ENSMUST00000021217
Protein Domains
Nucleoside diphosphate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01768-F1-model_v2 AlphaFold Q01768 1-152 view protein structure

Promoters
RGD ID:6821437
Promoter ID:MM_KWN:9225
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000002954,   UC007KXS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361193,816,891 - 93,818,562 (-)MPROMDB
RGD ID:8676182
Promoter ID:EPDNEW_M16121
Type:initiation region
Name:Nme2_2
Description:Mus musculus NME/NM23 nucleoside diphosphate kinase 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16122  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381193,955,641 - 93,955,701EPDNEW
RGD ID:8676184
Promoter ID:EPDNEW_M16122
Type:initiation region
Name:Nme2_1
Description:Mus musculus NME/NM23 nucleoside diphosphate kinase 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16121  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381193,955,876 - 93,955,936EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97356 AgrOrtholog
Ensembl Genes ENSMUSG00000020857 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021217 ENTREZGENE
  ENSMUST00000021217.11 UniProtKB/Swiss-Prot
  ENSMUST00000072566 ENTREZGENE
  ENSMUST00000072566.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NDK-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97356 ENTREZGENE
NCBI Gene 18103 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEOSIDE DIPHOSPHATE KINASE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nme2 PhenoGen
PRINTS NUCDPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NDP_KINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDPK_LIKE UniProtKB/Swiss-Prot
SMART NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54919 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0LAA8 ENTREZGENE, UniProtKB/TrEMBL
  NDKB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5NC82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-05 Nme2  NME/NM23 nucleoside diphosphate kinase 2  Nme2  non-metastatic cells 2, protein (NM23B) expressed in  Symbol and/or name change 5135510 APPROVED