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Gene: NME2 (NME/NM23 nucleoside diphosphate kinase 2) Homo sapiens
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Symbol: NME2
Name: NME/NM23 nucleoside diphosphate kinase 2
Description: Exhibits several functions, including GDP binding activity; nucleoside diphosphate kinase activity; and transcription coactivator activity. Involved in several processes, including integrin-mediated signaling pathway; nucleoside phosphate metabolic process; and positive regulation of keratinocyte differentiation. Localizes to several cellular components, including the cell periphery; lamellipodium; and ruffle. Implicated in teratoma. Biomarker of arteriosclerosis; congestive heart failure; ovarian cancer (multiple); prostatic hypertrophy; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; histidine protein kinase NDKB; MGC111212; MGC2212; NDK B; NDKB; NDP kinase B; NDPK-B; NDPKB; NM23-H2; NM23B; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleotide diphosphate kinase B; PUF
Orthologs:
Mus musculus (house mouse) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)  Alliance
Canis lupus familiaris (dog) : NME2 (non-metastatic cells 2, protein (NM23B) expressed in)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)
Sus scrofa (pig) : NME2 (NME/NM23 nucleoside diphosphate kinase 2)
more info ...
Related Pseudogenes: NME2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,165,536 - 51,171,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371749,242,796 - 49,249,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,597,890 - 46,604,104 (+)NCBINCBI36hg18NCBI36
Build 341746,598,810 - 46,604,103NCBI
Celera1745,704,144 - 45,710,358 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1744,612,062 - 44,618,375 (+)NCBIHuRef
CHM1_11749,307,431 - 49,313,740 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NME2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346564
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.