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Gene: NME2 (NME/NM23 nucleoside diphosphate kinase 2) Homo sapiens
Symbol: NME2
Name: NME/NM23 nucleoside diphosphate kinase 2
Description: Exhibits several functions, including GDP binding activity; nucleoside diphosphate kinase activity; and transcription coactivator activity. Involved in several processes, including integrin-mediated signaling pathway; nucleoside phosphate metabolic process; and positive regulation of keratinocyte differentiation. Localizes to several cellular components, including the cell periphery; lamellipodium; and ruffle. Implicated in teratoma. Biomarker of arteriosclerosis; congestive heart failure; ovarian cancer (multiple); prostatic hypertrophy; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; histidine protein kinase NDKB; MGC111212; MGC2212; NDK B; NDKB; NDP kinase B; NDPK-B; NDPKB; NM23-H2; NM23B; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleotide diphosphate kinase B; PUF
Mus musculus (house mouse) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)  Alliance
Canis lupus familiaris (dog) : NME2 (non-metastatic cells 2, protein (NM23B) expressed in)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nme2 (NME/NM23 nucleoside diphosphate kinase 2)
Sus scrofa (pig) : NME2 (NME/NM23 nucleoside diphosphate kinase 2)
more info ...
Related Pseudogenes: NME2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381751,165,536 - 51,171,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371749,242,796 - 49,249,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,597,890 - 46,604,104 (+)NCBINCBI36hg18NCBI36
Build 341746,598,810 - 46,604,103NCBI
Celera1745,704,144 - 45,710,358 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1744,612,062 - 44,618,375 (+)NCBIHuRef
CHM1_11749,307,431 - 49,313,740 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NME2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346564
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.