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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDStreptozocin results in increased expression of GFAP mRNA, Streptozocin results in increased expression of GFAP protein

PMID:24333387
multiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA], Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP protein], Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA], Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein]

PMID:24333387
decreases expressionISORGD:106336480464CTDStreptozocin results in decreased expression of GFAP protein

PMID:28499986
multiple interactionsISORGD:106336480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein], Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]

PMID:28499986
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.