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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:91460
Term: KN-93
Definition: A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replaced by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II.
Chemical ID: MESH:C072105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapmultiple interactionsEXP 6480464CTDKN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]PMID:21879721
Gfapmultiple interactionsISOGfap (Mus musculus)6480464CTDKN 93 inhibits the reaction [Vincristine results in increased expression of GFAP protein]PMID:34286406
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