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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:8426
Term: probenecid
Definition: A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Chemical ID: MESH:D011339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:106336480464CTD[Probenecid co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in increased expression of GFAP protein, Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in decreased expression of GFAP protein]

PMID:25064079
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.