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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapmultiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Methotrexate results in decreased expression of GFAP mRNA]PMID:30502384
Gfapdecreases expressionISOGfap (Mus musculus)6480464CTDFolic Acid results in decreased expression of GFAP mRNAPMID:25629700
Gfapdecreases expressionISOGFAP (Homo sapiens)6480464CTDFolic Acid results in decreased expression of GFAP mRNAPMID:21867686
Gfapmultiple interactionsISOGfap (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFAP gene; Folic Acid inhibits the reaction [Methotrexate results in decreased expression of GFAP mRNA]; Folic Acid inhibits the reaction [Methotrexate results in decreased expression of GFAP protein]PMID:20938992 PMID:30502384
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