GFAP (glial fibrillary acidic protein) - Rat Genome Database

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Pathways
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Gene: GFAP (glial fibrillary acidic protein) Pan paniscus
Analyze
Symbol: GFAP
Name: glial fibrillary acidic protein
RGD ID: 11716710
Description: ENCODES a protein that exhibits integrin binding (ortholog); kinase binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN astrocyte development (ortholog); Bergmann glial cell differentiation (ortholog); D-aspartate import across plasma membrane (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH Alexander disease (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN cytoplasmic side of lysosomal membrane (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,917,405 - 19,927,264 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,885,949 - 21,895,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,407,211 - 12,417,072 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,579,754 - 12,589,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,579,754 - 12,591,961 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GFAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,917,405 - 19,927,264 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,885,949 - 21,895,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,407,211 - 12,417,072 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,579,754 - 12,589,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,579,754 - 12,591,961 (+)Ensemblpanpan1.1panPan2
GFAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,903,159 - 44,915,500 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,903,159 - 44,916,937 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,980,527 - 42,992,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,338,519 - 40,348,394 (-)NCBINCBI36Build 36hg18NCBI36
Build 341740,338,518 - 40,348,394NCBI
Celera1739,693,499 - 39,703,421 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,748,049 - 38,758,000 (-)NCBIHuRef
CHM1_11743,219,135 - 43,229,061 (-)NCBICHM1_1
T2T-CHM13v2.01745,757,042 - 45,769,413 (-)NCBIT2T-CHM13v2.0
Gfap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,778,162 - 102,791,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,778,162 - 102,791,738 (-)EnsemblGRCm39 Ensembl
GRCm3811102,887,336 - 102,897,200 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,887,336 - 102,900,912 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,748,650 - 102,758,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,704,767 - 102,713,221 (-)NCBIMGSCv36mm8
Celera11114,598,382 - 114,608,239 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.48NCBI
Gfap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,352,987 - 88,361,661 (-)NCBIGRCr8
mRatBN7.21087,852,891 - 87,861,631 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,852,890 - 87,861,589 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,888,973 - 92,897,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,355,379 - 92,364,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,748,725 - 87,757,408 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,990,762 - 90,999,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,990,762 - 90,999,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,763,150 - 90,771,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,059,881 - 92,068,555 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,074,249 - 92,082,949 (-)NCBI
Celera1086,555,367 - 86,564,160 (-)NCBICelera
RH 3.4 Map10920.49RGD
Cytogenetic Map10q32.1NCBI
Gfap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,695,835 - 17,703,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,695,835 - 17,703,894 (-)NCBIChiLan1.0ChiLan1.0
GFAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,569,868 - 18,579,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,569,892 - 18,579,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,955,308 - 17,964,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,243,310 - 19,252,910 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,243,327 - 19,310,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,120,937 - 18,130,529 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,299,941 - 18,309,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,456,787 - 18,466,393 (+)NCBIUU_Cfam_GSD_1.0
Gfap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,919,377 - 17,928,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,265,436 - 1,275,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,265,915 - 1,275,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,456,263 - 18,466,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,456,268 - 18,466,594 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,700,993 - 18,711,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GFAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,489,090 - 61,499,672 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,489,421 - 61,500,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,238,179 - 32,248,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795394,436 - 401,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795395,298 - 400,781 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062171   ⟹   ENSPPAP00000039261
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,754 - 12,589,748 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062177   ⟹   ENSPPAP00000039268
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,754 - 12,585,753 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062185   ⟹   ENSPPAP00000039275
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,917 - 12,591,961 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062194   ⟹   ENSPPAP00000039284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,917 - 12,591,961 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062196   ⟹   ENSPPAP00000039286
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,917 - 12,588,027 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062198   ⟹   ENSPPAP00000039288
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1712,579,917 - 12,585,284 (+)Ensembl
RefSeq Acc Id: XM_003806514   ⟹   XP_003806562
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21919,917,407 - 19,927,264 (+)NCBI
NHGRI_mPanPan11721,885,949 - 21,895,804 (+)NCBI
Mhudiblu_PPA_v01712,407,212 - 12,417,072 (+)NCBI
PanPan1.11712,579,754 - 12,589,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063598652   ⟹   XP_063454722
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21919,917,405 - 19,922,485 (+)NCBI
RefSeq Acc Id: XM_063598653   ⟹   XP_063454723
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21919,917,405 - 19,924,824 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003806562   ⟸   XM_003806514
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000039286   ⟸   ENSPPAT00000062196
RefSeq Acc Id: ENSPPAP00000039288   ⟸   ENSPPAT00000062198
RefSeq Acc Id: ENSPPAP00000039284   ⟸   ENSPPAT00000062194
RefSeq Acc Id: ENSPPAP00000039275   ⟸   ENSPPAT00000062185
RefSeq Acc Id: ENSPPAP00000039261   ⟸   ENSPPAT00000062171
RefSeq Acc Id: ENSPPAP00000039268   ⟸   ENSPPAT00000062177
RefSeq Acc Id: XP_063454723   ⟸   XM_063598653
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063454722   ⟸   XM_063598652
- Peptide Label: isoform X1
Protein Domains
IF rod


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042303 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062171.1 UniProtKB/TrEMBL
  ENSPPAT00000062177.1 UniProtKB/TrEMBL
  ENSPPAT00000062185.1 UniProtKB/TrEMBL
  ENSPPAT00000062194.1 UniProtKB/TrEMBL
  ENSPPAT00000062196.1 UniProtKB/TrEMBL
  ENSPPAT00000062198.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  Intermed_filament_DNA-bd UniProtKB/TrEMBL
KEGG Report pps:100978176 UniProtKB/TrEMBL
NCBI Gene GFAP ENTREZGENE
PANTHER GLIAL FIBRILLARY ACIDIC PROTEIN UniProtKB/TrEMBL
  PTHR45652:SF9 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Filament_head UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A2R9CBF8_PANPA UniProtKB/TrEMBL
  A0A2R9CBG0_PANPA UniProtKB/TrEMBL
  A0A2R9CBI2_PANPA UniProtKB/TrEMBL
  A0A2R9CBN5_PANPA UniProtKB/TrEMBL
  A0A2R9CE48_PANPA UniProtKB/TrEMBL
  A0A2R9CE65_PANPA UniProtKB/TrEMBL
  Q7YRR4_PANPA UniProtKB/TrEMBL