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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of GFAP proteinPMID:27093858
Gfapmultiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of GFAP protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of GFAP protein]; Resveratrol inhibits the reaction [Oxidopamine results in increased expression of GFAP protein]PMID:17888892 PMID:25727173 PMID:34302886
Gfapincreases expressionISOGFAP (Homo sapiens)6480464CTDresveratrol results in increased expression of GFAP proteinPMID:22530672 PMID:23651583
Gfapmultiple interactionsISOGfap (Mus musculus)6480464CTDResveratrol inhibits the reaction [Aluminum Chloride results in increased expression of GFAP protein]; Resveratrol inhibits the reaction [CDK5R1 protein results in increased expression of GFAP protein]; Resveratrol inhibits the reaction [PPT1 gene mutant form results in increased expression of GFAP protein]PMID:17581637 PMID:21224254 PMID:34614429
Gfapmultiple interactionsISOGFAP (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of GFAP mRNA; Resveratrol promotes the reaction [Temozolomide results in increased expression of GFAP protein]; Temozolomide promotes the reaction [Resveratrol results in increased expression of GFAP protein]PMID:22530672 PMID:23557933
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