Wnt3 (Wnt family member 3) - Rat Genome Database

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Gene: Wnt3 (Wnt family member 3) Rattus norvegicus
Analyze
Symbol: Wnt3
Name: Wnt family member 3
RGD ID: 3972
Description: Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; limb bud formation; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of extent of cell growth. Located in cytoplasm. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: INT4; proto-oncogene Wnt-3; wingless-related MMTV integration site 3; Wingless-type MMTV integration site 3, homolog; wingless-type MMTV integration site family, member 3; wingless-type MMTV integration site family, member 3 (mapped); Wnt3_mapped
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21088,680,248 - 88,724,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,680,248 - 88,724,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,718,545 - 93,762,264 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01093,183,701 - 93,227,397 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01088,577,058 - 88,620,776 (+)NCBIRnor_WKY
Rnor_6.01091,830,709 - 91,874,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,830,654 - 91,874,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,597,106 - 91,641,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,925,605 - 92,969,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1087,379,436 - 87,423,461 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
2. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco G, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12747-52. Epub 2003 Oct 13.
3. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Erdreich-Epstein A and Shackleford GM, Growth Factors 1998;15(2):149-58.
4. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Fujise T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1150-6. Epub 2006 Dec 28.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Niemann S, etal., Am J Hum Genet. 2004 Mar;74(3):558-63. Epub 2004 Feb 5.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
15. Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts. Schroeder JA, etal., Oncogene. 2000 Jun 29;19(28):3193-9.
16. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
17. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
PMID:1300513   PMID:8167409   PMID:8168088   PMID:10431240   PMID:10557084   PMID:12569130   PMID:15194435   PMID:15588944   PMID:17558443   PMID:17921881   PMID:18028899   PMID:18044981  
PMID:18313787   PMID:18403408   PMID:18716223   PMID:19000841   PMID:19690384   PMID:20039315   PMID:22922600   PMID:23324743   PMID:23469192   PMID:24363087   PMID:24562386   PMID:25640183  
PMID:27226528   PMID:28733458   PMID:31694396   PMID:32949181  


Genomics

Comparative Map Data
Wnt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21088,680,248 - 88,724,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,680,248 - 88,724,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,718,545 - 93,762,264 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01093,183,701 - 93,227,397 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01088,577,058 - 88,620,776 (+)NCBIRnor_WKY
Rnor_6.01091,830,709 - 91,874,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,830,654 - 91,874,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,597,106 - 91,641,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,925,605 - 92,969,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1087,379,436 - 87,423,461 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
WNT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381746,762,506 - 46,818,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1746,762,506 - 46,833,154 (-)EnsemblGRCh38hg38GRCh38
GRCh371744,839,872 - 44,896,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q21.31-q21.32NCBI
HuRef1740,218,240 - 40,274,537 (-)NCBIHuRef
CHM1_11744,903,996 - 44,960,278 (-)NCBICHM1_1
T2T-CHM13v2.01747,623,975 - 47,680,171 (-)NCBIT2T-CHM13v2.0
Wnt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,665,001 - 103,708,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,664,976 - 103,708,783 (+)EnsemblGRCm39 Ensembl
GRCm3811103,774,175 - 103,818,021 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,774,150 - 103,817,957 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711103,635,489 - 103,679,335 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,590,314 - 103,634,047 (+)NCBIMGSCv36mm8
Celera11115,489,203 - 115,533,047 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.5NCBI
WNT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1910,073,019 - 10,124,454 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl910,077,567 - 10,124,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha910,173,950 - 10,225,430 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0911,663,529 - 11,714,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl911,668,090 - 11,714,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1910,674,575 - 10,725,693 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0916,796,275 - 16,847,494 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0916,743,753 - 16,795,272 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Wnt3
219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:264
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000005176
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat

Markers in Region
M32502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,722,606 - 88,722,689 (+)MAPPERmRatBN7.2
Rnor_6.01091,873,344 - 91,873,426NCBIRnor6.0
Rnor_5.01091,639,721 - 91,639,803UniSTSRnor5.0
RGSC_v3.41092,968,121 - 92,968,203UniSTSRGSC3.4
Celera1087,421,969 - 87,422,051UniSTS
Cytogenetic Map10q32.1UniSTS
Wnt3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,723,759 - 88,723,958 (+)MAPPERmRatBN7.2
Rnor_6.01091,874,497 - 91,874,695NCBIRnor6.0
Rnor_5.01091,640,874 - 91,641,072UniSTSRnor5.0
RGSC_v3.41092,969,274 - 92,969,472UniSTSRGSC3.4
Celera1087,423,122 - 87,423,320UniSTS
Cytogenetic Map10q32.1UniSTS
GDB:196138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,718,377 - 88,718,847 (+)MAPPERmRatBN7.2
Rnor_6.01091,869,115 - 91,869,584NCBIRnor6.0
Rnor_5.01091,635,492 - 91,635,961UniSTSRnor5.0
RGSC_v3.41092,963,892 - 92,964,361UniSTSRGSC3.4
Celera1087,417,740 - 87,418,209UniSTS
Cytogenetic Map10q32.1UniSTS
Wnt3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,718,479 - 88,718,637 (+)MAPPERmRatBN7.2
Rnor_6.01091,869,217 - 91,869,374NCBIRnor6.0
Rnor_5.01091,635,594 - 91,635,751UniSTSRnor5.0
RGSC_v3.41092,963,994 - 92,964,151UniSTSRGSC3.4
Celera1087,417,842 - 87,417,999UniSTS
Cytogenetic Map10q32.1UniSTS
Wnt3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,717,543 - 88,718,499 (+)MAPPERmRatBN7.2
Rnor_6.01091,868,281 - 91,869,236NCBIRnor6.0
Rnor_5.01091,634,658 - 91,635,613UniSTSRnor5.0
RGSC_v3.41092,963,058 - 92,964,013UniSTSRGSC3.4
Celera1087,416,909 - 87,417,861UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 3 68 22
Below cutoff 8 13 17 2 3 21 15 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005176   ⟹   ENSRNOP00000005176
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,680,248 - 88,724,099 (+)Ensembl
Rnor_6.0 Ensembl1091,830,654 - 91,874,793 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096241   ⟹   ENSRNOP00000097138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,716,834 - 88,724,099 (+)Ensembl
RefSeq Acc Id: NM_001105715   ⟹   NP_001099185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21088,680,248 - 88,724,099 (+)NCBI
Rnor_6.01091,830,709 - 91,874,836 (+)NCBI
Rnor_5.01091,597,106 - 91,641,213 (+)NCBI
RGSC_v3.41092,925,605 - 92,969,613 (+)RGD
Celera1087,379,436 - 87,423,461 (+)RGD
Sequence:
RefSeq Acc Id: XM_017597028   ⟹   XP_017452517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21088,714,509 - 88,724,170 (+)NCBI
Rnor_6.01091,867,179 - 91,874,907 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085240   ⟹   XP_038941168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21088,714,509 - 88,719,455 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099185 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452517 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941168 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06286 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099185   ⟸   NM_001105715
- UniProtKB: D3ZCR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452517   ⟸   XM_017597028
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AN69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005176   ⟸   ENSRNOT00000005176
RefSeq Acc Id: XP_038941168   ⟸   XM_039085240
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AN69 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097138   ⟸   ENSRNOT00000096241

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCR1-F1-model_v2 AlphaFold D3ZCR1 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697816
Promoter ID:EPDNEW_R8340
Type:single initiation site
Name:Wnt3_1
Description:Wnt family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01091,830,731 - 91,830,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3972 AgrOrtholog
BioCyc Gene G2FUF-23026 BioCyc
Ensembl Genes ENSRNOG00000003845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005176 ENTREZGENE
  ENSRNOP00000005176.4 UniProtKB/TrEMBL
  ENSRNOP00000097138 ENTREZGENE
  ENSRNOP00000097138.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005176 ENTREZGENE
  ENSRNOT00000005176.6 UniProtKB/TrEMBL
  ENSRNOT00000096241 ENTREZGENE
  ENSRNOT00000096241.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt3 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
KEGG Report rno:24882 UniProtKB/TrEMBL
NCBI Gene 24882 ENTREZGENE
PANTHER Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt3 PhenoGen
PRINTS WNT3PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8I6AN69 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCR1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt3  Wnt family member 3  Wnt3  wingless-type MMTV integration site family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt3  wingless-type MMTV integration site family, member 3  Wnt3  wingless-related MMTV integration site 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Wnt3  wingless-related MMTV integration site 3  Wnt3_predicted  wingless-type MMTV integration site family, member 3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-17 Wnt3_predicted  wingless-type MMTV integration site family, member 3 (predicted)  Wnt3  wingless-type MMTV integration site family, member 3  Symbol and name updated to reflect predicted status 1299863 APPROVED
2007-02-19 Wnt3  wingless-type MMTV integration site family, member 3  Wnt3_mapped  wingless-type MMTV integration site family, member 3 (mapped)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 PROVISIONAL
2007-02-19 Wnt3_mapped  wingless-type MMTV integration site family, member 3 (mapped)  Wnt3_retired  wingless-type MMTV integration site family, member 3 (mapped)  Data Merged 737654 PROVISIONAL
2007-02-19 Wnt3_retired    Wnt3  wingless-type MMTV integration site family, member 3 (mapped)  Symbol updated 1299863 PROVISIONAL
2006-11-20 Wnt3  wingless-type MMTV integration site family, member 3 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Wnt3_mapped  wingless-type MMTV integration site family, member 3 (mapped)      Symbol and Name updated 1556543 APPROVED
2003-04-09 Wnt3  wingless-type MMTV integration site family, member 3    Wingless-type MMTV integration site 3, homolog  Name updated 629478 APPROVED
2002-06-10 Wnt3  Wingless-type MMTV integration site 3, homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product predicted to be a member of the Wnt family of glycoproteins which regulate cell proliferation, cell differentiation, and determination of cell fate 1300513