Kat2a (lysine acetyltransferase 2A) - Rat Genome Database

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Gene: Kat2a (lysine acetyltransferase 2A) Rattus norvegicus
Analyze
Symbol: Kat2a
Name: lysine acetyltransferase 2A
RGD ID: 1307242
Description: Enables chromatin binding activity and protein phosphatase binding activity. Involved in several processes, including alpha-tubulin acetylation; intracellular distribution of mitochondria; and positive regulation of cardiac muscle cell differentiation. Located in chromatin and nucleus. Orthologous to human KAT2A (lysine acetyltransferase 2A); PARTICIPATES IN histone modification pathway; p53 signaling pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH amphetamine; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gcn5; GCN5 general control of amino acid synthesis-like 2; GCN5 general control of amino acid synthesis-like 2 (yeast); Gcn5l2; general control of amino acid synthesis 5-like 2; histone acetyltransferase KAT2A; K(lysine) acetyltransferase 2A; LOC303539
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,632,216 - 85,640,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,632,216 - 85,640,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,668,667 - 90,676,617 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01090,147,250 - 90,155,439 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,540,459 - 85,548,409 (-)NCBIRnor_WKY
Rnor_6.01088,611,586 - 88,619,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,611,586 - 88,619,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,405,799 - 88,413,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,642,002 - 89,649,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,656,393 - 89,664,314 (-)NCBI
Celera1084,347,901 - 84,355,851 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-tubulin acetylation  (IMP)
cell population proliferation  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
chromatin remodeling  (IBA)
fibroblast proliferation  (ISO)
gluconeogenesis  (ISO)
histone acetylation  (ISO)
histone deubiquitination  (ISO)
histone H3 acetylation  (IBA,ISO)
histone H3-K14 acetylation  (IBA,ISO)
histone H4-K12 acetylation  (ISO)
histone modification  (ISO)
histone succinylation  (ISO)
in utero embryonic development  (ISO)
internal peptidyl-lysine acetylation  (ISO)
intracellular distribution of mitochondria  (IMP)
long-term memory  (ISO)
metencephalon development  (ISO)
midbrain development  (ISO)
monoubiquitinated histone deubiquitination  (ISO)
monoubiquitinated histone H2A deubiquitination  (ISO)
multicellular organism growth  (ISO)
negative regulation of centriole replication  (ISO)
nervous system development  (ISO)
neural tube closure  (ISO)
peptidyl-lysine glutarylation  (ISO)
positive regulation of cardiac muscle cell differentiation  (IMP)
positive regulation of cell projection organization  (IMP)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of histone modification  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of bone development  (ISO)
regulation of cartilage development  (ISO)
regulation of cell cycle  (ISO)
regulation of cell division  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of embryonic development  (ISO)
regulation of histone deacetylation  (ISO)
regulation of protein stability  (ISO)
regulation of regulatory T cell differentiation  (ISO)
regulation of stem cell population maintenance  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of T cell activation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tubulin deacetylation  (ISO)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
somitogenesis  (ISO)
telencephalon development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Bu P, etal., Mol Cell Biol. 2007 May;27(9):3405-16. Epub 2007 Feb 26.
3. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, etal., J Biol Chem. 2013 May 17;288(20):14510-21. doi: 10.1074/jbc.M113.458737. Epub 2013 Mar 29.
4. Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Conacci-Sorrell M, etal., Cell. 2010 Aug 6;142(3):480-93. doi: 10.1016/j.cell.2010.06.037.
5. Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan. Conti Ad, etal., Toxicol Sci. 2014 Jun;139(2):371-80. doi: 10.1093/toxsci/kfu044. Epub 2014 Mar 10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. Inoue S, etal., J Nutr Sci Vitaminol (Tokyo). 2011;57(2):162-9.
9. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Kurabe N, etal., Oncogene. 2007 Aug 16;26(38):5626-34. Epub 2007 Mar 5.
10. A role for Gcn5 in cardiomyocyte differentiation of rat mesenchymal stem cells. Li L, etal., Mol Cell Biochem. 2010 Dec;345(1-2):309-16. doi: 10.1007/s11010-010-0586-3. Epub 2010 Sep 12.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Palhan VB, etal., Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8472-7. Epub 2005 Jun 2.
13. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
14. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis. Sandoval J, etal., Cell Mol Life Sci. 2010 May;67(10):1687-97. doi: 10.1007/s00018-010-0272-3. Epub 2010 Feb 4.
19. ATAC-king the complexity of SAGA during evolution. Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
20. GCN5 acetyltransferase inhibits PGC1alpha-induced hepatitis B virus biosynthesis. Tian X, etal., Virol Sin. 2013 Aug;28(4):216-22. doi: 10.1007/s12250-013-3344-3. Epub 2013 Jul 2.
21. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. Wareski P, etal., J Biol Chem. 2009 Aug 7;284(32):21379-85. doi: 10.1074/jbc.M109.018911. Epub 2009 Jun 19.
22. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. Wong K, etal., J Biol Chem. 2004 Dec 31;279(53):55667-74. Epub 2004 Oct 20.
23. PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. Xiong S, etal., J Biol Chem. 2010 Jan 22;285(4):2474-87. doi: 10.1074/jbc.M109.065235. Epub 2009 Nov 23.
Additional References at PubMed
PMID:9742083   PMID:10373431   PMID:11564863   PMID:12887892   PMID:15937931   PMID:16109736   PMID:17301242   PMID:18206972   PMID:18838386   PMID:19103755   PMID:20508642   PMID:20562830  
PMID:22664934   PMID:23637336   PMID:24051374   PMID:24912190   PMID:25024434   PMID:27796307   PMID:28125090   PMID:28424240   PMID:29174768   PMID:29211711   PMID:29973595   PMID:30270482  
PMID:30424580   PMID:31527837   PMID:31542297   PMID:35490166   PMID:35716963  


Genomics

Comparative Map Data
Kat2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,632,216 - 85,640,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,632,216 - 85,640,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,668,667 - 90,676,617 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01090,147,250 - 90,155,439 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,540,459 - 85,548,409 (-)NCBIRnor_WKY
Rnor_6.01088,611,586 - 88,619,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,611,586 - 88,619,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,405,799 - 88,413,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,642,002 - 89,649,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,656,393 - 89,664,314 (-)NCBI
Celera1084,347,901 - 84,355,851 (-)NCBICelera
Cytogenetic Map10q31NCBI
KAT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,113,111 - 42,121,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,113,111 - 42,121,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,265,129 - 40,273,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,518,655 - 37,526,908 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,518,656 - 37,526,872NCBI
Celera1736,920,167 - 36,928,419 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,030,209 - 36,038,464 (-)NCBIHuRef
CHM1_11740,500,904 - 40,509,157 (-)NCBICHM1_1
T2T-CHM13v2.01742,969,613 - 42,977,870 (-)NCBIT2T-CHM13v2.0
Kat2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,595,572 - 100,604,427 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,595,572 - 100,603,291 (-)EnsemblGRCm39 Ensembl
GRCm3811100,704,746 - 100,712,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,704,746 - 100,712,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,566,062 - 100,573,768 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,520,838 - 100,528,544 (-)NCBIMGSCv36mm8
Celera11111,321,247 - 111,328,954 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.53NCBI
Kat2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,191,186 - 16,197,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,192,228 - 16,197,103 (-)NCBIChiLan1.0ChiLan1.0
KAT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,416,075 - 15,424,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,416,075 - 15,424,197 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,194,414 - 15,202,818 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KAT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,778,434 - 20,787,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,779,042 - 20,787,067 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,239,316 - 20,247,945 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,497,151 - 21,505,776 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,497,762 - 21,505,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,282,433 - 20,291,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,549,548 - 20,558,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,652,594 - 20,661,220 (+)NCBIUU_Cfam_GSD_1.0
Kat2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,114,702 - 20,122,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,952,363 - 16,960,489 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649016,952,698 - 16,960,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,638,497 - 20,647,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,638,493 - 20,647,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,928,657 - 20,937,624 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,146,146 - 64,154,726 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,146,207 - 64,154,252 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,962,125 - 34,971,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,782,366 - 1,788,951 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,782,367 - 1,787,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kat2a
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:203
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000055250
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat

Markers in Region
BE120261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,632,311 - 85,632,472 (+)MAPPERmRatBN7.2
Rnor_6.01088,611,682 - 88,611,842NCBIRnor6.0
Rnor_5.01088,405,895 - 88,406,055UniSTSRnor5.0
RGSC_v3.41089,642,098 - 89,642,258UniSTSRGSC3.4
Celera1084,347,997 - 84,348,157UniSTS
RH 3.4 Map10860.6UniSTS
Cytogenetic Map10q32.1UniSTS
AW529475  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,641,880 - 85,642,081 (+)MAPPERmRatBN7.2
Rnor_6.01088,621,252 - 88,621,452NCBIRnor6.0
Rnor_5.01088,415,465 - 88,415,665UniSTSRnor5.0
RGSC_v3.41089,651,668 - 89,651,868UniSTSRGSC3.4
Celera1084,357,566 - 84,357,766UniSTS
RH 3.4 Map10874.3UniSTS
Cytogenetic Map10q32.1UniSTS
Gcn5l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,637,247 - 85,638,188 (+)MAPPERmRatBN7.2
Rnor_6.01088,616,619 - 88,617,559NCBIRnor6.0
Rnor_5.01088,410,832 - 88,411,772UniSTSRnor5.0
RGSC_v3.41089,647,035 - 89,647,975UniSTSRGSC3.4
Celera1084,352,933 - 84,353,873UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 25 21 11 21 1 74 26 37 6
Low 9 32 20 8 20 8 10 9 4 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055250   ⟹   ENSRNOP00000052125
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,632,216 - 85,640,166 (-)Ensembl
Rnor_6.0 Ensembl1088,611,586 - 88,619,537 (-)Ensembl
RefSeq Acc Id: NM_001107050   ⟹   NP_001100520
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,632,216 - 85,640,166 (-)NCBI
Rnor_6.01088,611,586 - 88,619,537 (-)NCBI
Rnor_5.01088,405,799 - 88,413,761 (-)NCBI
RGSC_v3.41089,642,002 - 89,649,953 (-)RGD
Celera1084,347,901 - 84,355,851 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247317   ⟹   XP_006247379
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,632,236 - 85,640,561 (-)NCBI
Rnor_6.01088,611,605 - 88,619,558 (-)NCBI
Rnor_5.01088,405,799 - 88,413,761 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086094   ⟹   XP_038942022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,632,236 - 85,638,138 (-)NCBI
RefSeq Acc Id: XM_039086095   ⟹   XP_038942023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,632,236 - 85,638,137 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100520 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247379 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942022 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942023 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06059 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100520   ⟸   NM_001107050
- UniProtKB: D4ACX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247379   ⟸   XM_006247317
- Peptide Label: isoform X1
- UniProtKB: D4ACX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052125   ⟸   ENSRNOT00000055250
RefSeq Acc Id: XP_038942022   ⟸   XM_039086094
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942023   ⟸   XM_039086095
- Peptide Label: isoform X2
Protein Domains
Bromo   N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACX5-F1-model_v2 AlphaFold D4ACX5 1-832 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697729
Promoter ID:EPDNEW_R8254
Type:multiple initiation site
Name:Kat2a_1
Description:lysine acetyltransferase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,619,523 - 88,619,583EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307242 AgrOrtholog
BioCyc Gene G2FUF-23220 BioCyc
Ensembl Genes ENSRNOG00000018364 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052125 ENTREZGENE
  ENSRNOP00000052125.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055250 ENTREZGENE
  ENSRNOT00000055250.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
InterPro AcTrfase_GCN5-related UniProtKB/TrEMBL
  Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  GCN5 UniProtKB/TrEMBL
  Hist_acetylase_PCAF UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
KEGG Report rno:303539 UniProtKB/TrEMBL
NCBI Gene 303539 ENTREZGENE
PANTHER PTHR45750 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
PhenoGen Kat2a PhenoGen
PIRSF Histone_acetylase_PCAF UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  GNAT UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
UniProt D4ACX5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kat2a  lysine acetyltransferase 2A  Kat2a  K(lysine) acetyltransferase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Kat2a  K(lysine) acetyltransferase 2A  Gcn5l2  GCN5 general control of amino acid synthesis-like 2 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gcn5l2  GCN5 general control of amino acid synthesis-like 2 (yeast)   Gcn5l2_predicted  GCN5 general control of amino acid synthesis-like 2 (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gcn5l2_predicted  GCN5 general control of amino acid synthesis-like 2 (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED