Hap1 (huntingtin-associated protein 1) - Rat Genome Database

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Gene: Hap1 (huntingtin-associated protein 1) Rattus norvegicus
Analyze
Symbol: Hap1
Name: huntingtin-associated protein 1
RGD ID: 68327
Description: Enables several functions, including brain-derived neurotrophic factor binding activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including axonal transport; positive regulation of cell communication; and positive regulation of cellular component organization. Located in dendrite; distal axon; and perinuclear region of cytoplasm. Is active in GABA-ergic synapse; postsynaptic cytosol; and presynaptic cytosol. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HAP1 (huntingtin associated protein 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HAP-1; HAP1-A; HAP1-B
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,277,890 - 85,286,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,277,890 - 85,286,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,318,023 - 90,326,248 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,795,958 - 89,804,191 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,186,168 - 85,194,404 (-)NCBIRnor_WKY
Rnor_6.01088,257,975 - 88,266,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,257,976 - 88,266,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,051,219 - 88,059,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,285,396 - 89,293,631 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,299,766 - 89,308,001 (-)NCBI
Celera1083,995,991 - 84,004,228 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Chan EY, etal., Hum Mol Genet 2002 Apr 15;11(8):945-59.
2. Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. Colin E, etal., EMBO J. 2008 Aug 6;27(15):2124-34. doi: 10.1038/emboj.2008.133. Epub 2008 Jul 10.
3. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Colomer V, etal., Hum Mol Genet 1997 Sep;6(9):1519-25.
4. Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Czeredys M, etal., Front Mol Neurosci. 2013 Nov 25;6:42. doi: 10.3389/fnmol.2013.00042. eCollection 2013.
5. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Engelender S, etal., Hum Mol Genet. 1997 Dec;6(13):2205-12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. Gutekunst CA, etal., J Neurosci. 1998 Oct 1;18(19):7674-86.
9. Age at onset in Huntington's disease: replication study on the association of HAP1. Karadima G, etal., Parkinsonism Relat Disord. 2012 Nov;18(9):1027-8. doi: 10.1016/j.parkreldis.2012.05.020. Epub 2012 Jun 12.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Kittler JT, etal., Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12736-41. doi: 10.1073/pnas.0401860101. Epub 2004 Aug 13.
12. Association of HAP1 isoforms with a unique cytoplasmic structure. Li SH, etal., J Neurochem. 1998 Nov;71(5):2178-85.
13. Interaction of huntingtin-associated protein with dynactin P150Glued. Li SH, etal., J Neurosci. 1998 Feb 15;18(4):1261-9.
14. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. Li SH, etal., J Neurosci. 2003 Jul 30;23(17):6956-64.
15. Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth. Li SH, etal., Mol Cell Neurosci 2000 Aug;16(2):168-83.
16. A huntingtin-associated protein enriched in brain with implications for pathology. Li XJ, etal., Nature 1995 Nov 23;378(6555):398-402.
17. Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. Li Y, etal., J Biol Chem 2002 Aug 2;277(31):28212-21.
18. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Metzger S, etal., Hum Mol Genet. 2008 Apr 15;17(8):1137-46. doi: 10.1093/hmg/ddn003. Epub 2008 Jan 11.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. Rong J, etal., J Biol Chem. 2007 Feb 16;282(7):4748-56. Epub 2006 Dec 13.
24. Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1. Taherzadeh-Fard E, etal., Neurogenetics. 2010 Oct;11(4):435-9. doi: 10.1007/s10048-010-0248-3. Epub 2010 May 30.
25. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Tang TS, etal., Neuron. 2003 Jul 17;39(2):227-39.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Twelvetrees AE, etal., Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.
28. Molecular characterization of genes modifying the age at onset in Huntington's Disease in Uruguayan patients. Vital M, etal., Int J Neurosci. 2015 May 22:1-17.
29. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. Weng L, etal., J Neurosci. 2013 May 8;33(19):8172-84. doi: 10.1523/JNEUROSCI.0119-13.2013.
30. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. Wu LL, etal., J Biol Chem. 2010 Feb 19;285(8):5614-23. doi: 10.1074/jbc.M109.073197. Epub 2009 Dec 7.
31. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. Yang GZ, etal., J Neurochem. 2012 Sep;122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.
32. Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. Yang M, etal., J Biol Chem. 2011 May 6;286(18):16272-84. doi: 10.1074/jbc.M110.195347. Epub 2011 Feb 28.
33. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Yuen EY, etal., Neurobiol Dis. 2012 May;46(2):497-502. doi: 10.1016/j.nbd.2012.02.015. Epub 2012 Feb 28.
34. Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization. Zimdahl H, etal., Cytogenet Cell Genet 2001;94(1-2):101-4.
Additional References at PubMed
PMID:9668110   PMID:9751154   PMID:15242649   PMID:15379999   PMID:16339760   PMID:16738245   PMID:16782802   PMID:17687563   PMID:18636121   PMID:18922795   PMID:19901268   PMID:21386698  
PMID:21985783   PMID:24355921   PMID:24366265   PMID:24453320   PMID:25744490   PMID:26732589   PMID:27984179   PMID:28259758   PMID:33161374   PMID:35609730  


Genomics

Comparative Map Data
Hap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,277,890 - 85,286,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,277,890 - 85,286,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,318,023 - 90,326,248 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,795,958 - 89,804,191 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,186,168 - 85,194,404 (-)NCBIRnor_WKY
Rnor_6.01088,257,975 - 88,266,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,257,976 - 88,266,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,051,219 - 88,059,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,285,396 - 89,293,631 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,299,766 - 89,308,001 (-)NCBI
Celera1083,995,991 - 84,004,228 (-)NCBICelera
Cytogenetic Map10q31NCBI
HAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,717,739 - 41,734,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1741,717,742 - 41,734,644 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,873,991 - 39,890,898 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,132,417 - 37,144,424 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,132,417 - 37,144,422NCBI
Celera1736,530,004 - 36,542,110 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,641,052 - 35,653,084 (-)NCBIHuRef
CHM1_11740,114,361 - 40,126,487 (-)NCBICHM1_1
T2T-CHM13v2.01742,574,186 - 42,591,171 (-)NCBIT2T-CHM13v2.0
Hap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,238,153 - 100,247,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,238,153 - 100,246,954 (-)EnsemblGRCm39 Ensembl
GRCm3811100,347,327 - 100,356,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,347,327 - 100,356,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,208,641 - 100,217,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,163,417 - 100,172,177 (-)NCBIMGSCv36mm8
Celera11110,964,725 - 110,973,537 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
HAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,797,949 - 15,810,299 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,797,949 - 15,810,299 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,578,658 - 15,596,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,065,770 - 21,074,462 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,065,846 - 21,072,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,527,830 - 20,538,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,786,787 - 21,797,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,786,778 - 21,795,400 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,572,719 - 20,581,302 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,838,674 - 20,849,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,942,632 - 20,951,243 (+)NCBIUU_Cfam_GSD_1.0
Hap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,422,813 - 20,430,089 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,643,520 - 16,652,479 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649016,645,116 - 16,652,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,939,554 - 20,950,051 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,938,463 - 20,950,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,126,539 - 21,137,053 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,515,013 - 64,524,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607735,347,022 - 35,354,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hap1
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:233
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000020603
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat

Markers in Region
RH132191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,277,990 - 85,278,177 (+)MAPPERmRatBN7.2
Rnor_6.01088,258,073 - 88,258,259NCBIRnor6.0
Rnor_5.01088,051,320 - 88,051,506UniSTSRnor5.0
RGSC_v3.41089,285,494 - 89,285,680UniSTSRGSC3.4
Celera1083,996,088 - 83,996,274UniSTS
RH 3.4 Map10858.5UniSTS
Cytogenetic Map10q32.1UniSTS
Hap1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,279,449 - 85,279,569 (+)MAPPERmRatBN7.2
Rnor_6.01088,259,532 - 88,259,651NCBIRnor6.0
Rnor_5.01088,052,779 - 88,052,898UniSTSRnor5.0
RGSC_v3.41089,286,953 - 89,287,072UniSTSRGSC3.4
Celera1083,997,547 - 83,997,666UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 7 74 2 21 1
Low 3 33 15 7 12 7 25 20 10
Below cutoff 10 32 32 32 8 11 8 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020603   ⟹   ENSRNOP00000020603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,277,890 - 85,286,126 (-)Ensembl
Rnor_6.0 Ensembl1088,257,976 - 88,266,210 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090702   ⟹   ENSRNOP00000072494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,277,890 - 85,286,126 (-)Ensembl
Rnor_6.0 Ensembl1088,257,976 - 88,266,210 (-)Ensembl
RefSeq Acc Id: NM_024133   ⟹   NP_077047
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,277,890 - 85,286,126 (-)NCBI
Rnor_6.01088,257,975 - 88,266,210 (-)NCBI
Rnor_5.01088,051,219 - 88,059,478 (-)NCBI
RGSC_v3.41089,285,396 - 89,293,631 (-)RGD
Celera1083,995,991 - 84,004,228 (-)RGD
Sequence:
RefSeq Acc Id: NM_177982   ⟹   NP_817091
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,277,890 - 85,286,126 (-)NCBI
Rnor_6.01088,257,975 - 88,266,210 (-)NCBI
Rnor_5.01088,051,219 - 88,059,478 (-)NCBI
RGSC_v3.41089,285,396 - 89,293,631 (-)RGD
Celera1083,995,991 - 84,004,228 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_817091   ⟸   NM_177982
- Peptide Label: isoform B
- UniProtKB: F1LQG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_077047   ⟸   NM_024133
- Peptide Label: isoform A
- UniProtKB: A0A0G2K342 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072494   ⟸   ENSRNOT00000090702
RefSeq Acc Id: ENSRNOP00000020603   ⟸   ENSRNOT00000020603
Protein Domains
HAP1 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54256-F1-model_v2 AlphaFold P54256 1-629 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697715
Promoter ID:EPDNEW_R8240
Type:single initiation site
Name:Hap1_1
Description:huntingtin-associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,266,195 - 88,266,255EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68327 AgrOrtholog
BioCyc Gene G2FUF-23241 BioCyc
Ensembl Genes ENSRNOG00000014819 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020603 ENTREZGENE
  ENSRNOP00000020603.3 UniProtKB/TrEMBL
  ENSRNOP00000072494 ENTREZGENE
  ENSRNOP00000072494.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020603 ENTREZGENE
  ENSRNOT00000020603.6 UniProtKB/TrEMBL
  ENSRNOT00000090702 ENTREZGENE
  ENSRNOT00000090702.2 UniProtKB/TrEMBL
InterPro HAP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29430 UniProtKB/Swiss-Prot
NCBI Gene 29430 ENTREZGENE
Pfam HAP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hap1 PhenoGen
TIGR TC206381
UniProt A0A0G2K342 ENTREZGENE, UniProtKB/TrEMBL
  F1LQG0 ENTREZGENE, UniProtKB/TrEMBL
  HAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hap1  huntingtin-associated protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization isoform Hap1a is associated with synaptic vesicles in axon terminals in the adult 728841