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Gene: Nf1 (neurofibromin 1) Rattus norvegicus
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Symbol: Nf1
Name: neurofibromin 1
Description: Exhibits microtubule binding activity and syndecan binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and neurogenesis. Localizes to several cellular components, including the neuron projection; nucleus; and postsynaptic density. Biomarker of sciatic neuropathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; autistic disorder; juvenile myelomonocytic leukemia; malignant glioma; and optic nerve glioma. Orthologous to human NF1 (neurofibromin 1); PARTICIPATES IN forkhead class A signaling pathway; syndecan signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neurofibromatosis 1; Neurofibromatosis type 1; neurofibromatosis-related protein NF-1; neurofibromin
Orthologs:
Homo sapiens (human) : NF1 (neurofibromin 1)  HGNC  Alliance
Mus musculus (house mouse) : Nf1 (neurofibromin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nf1 (neurofibromin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NF1 (neurofibromin 1)
Canis lupus familiaris (dog) : NF1 (neurofibromin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nf1 (neurofibromin 1)
Sus scrofa (pig) : NF1 (neurofibromin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01066,732,460 - 66,928,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01064,826,693 - 64,916,699 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01064,719,521 - 64,758,677 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,574,833 - 65,766,305 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11065,545,464 - 65,779,928 (+)NCBI
Celera1063,277,856 - 63,507,181 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)