Prkca (protein kinase C, alpha) - Rat Genome Database

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Gene: Prkca (protein kinase C, alpha) Rattus norvegicus
Symbol: Prkca
Name: protein kinase C, alpha
RGD ID: 3395
Description: Enables calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; regulation of vesicle-mediated transport; and response to corticosterone. Located in cytosol and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (S)-nicotine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PKC-A; PKC-alpha; Pkca; protein kinase C alpha type
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10 Cia5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81093,388,991 - 93,787,617 (-)NCBIGRCr8
mRatBN7.21092,889,390 - 93,288,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,894,012 - 93,288,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,947,717 - 98,345,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,410,758 - 97,808,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,819,189 - 93,215,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,186,509 - 96,585,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,919,013 - 96,311,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,367,196 - 97,638,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,382,023 - 97,632,491 (-)NCBI
Celera1091,557,626 - 91,951,823 (-)NCBICelera
RH 3.4 Map101035.79RGD
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
baicalein  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brimonidine tartrate  (EXP)
bryostatin 1  (ISO)
butan-1-ol  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
Calphostin C  (EXP,ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP,ISO)
daidzein  (EXP)
dapagliflozin  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
disodium selenite  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
enalapril  (EXP)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Evodiamine  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
gallic acid  (ISO)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glyphosate  (EXP)
Goe 6976  (EXP,ISO)
heptachlor  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
imidaprilat  (ISO)
irinotecan  (ISO)
isophthalic acid  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
luteolin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
Mezerein  (ISO)
mianserin  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
miltefosine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (EXP)
o-cresol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
p-cresol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 12,13-dibutanoate  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirinixic acid  (EXP,ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
propranolol  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
ritonavir  (ISO)
Ro 31-8220  (EXP,ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sorafenib  (ISO)
staurosporine  (EXP,ISO)
streptozocin  (EXP)
SU6656  (ISO)
sulforaphane  (ISO)
superoxide  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
cell adhesion  (IEA)
cell population proliferation  (ISO)
cellular response to carbohydrate stimulus  (ISO)
central nervous system neuron axonogenesis  (IMP)
chondrocyte differentiation  (ISO)
chromatin remodeling  (IEA)
desmosome assembly  (IEA,ISO)
establishment of protein localization  (TAS)
induction of positive chemotaxis  (ISO)
intracellular calcium ion homeostasis  (ISO)
intracellular signal transduction  (IBA,IDA)
intrinsic apoptotic signaling pathway  (ISO)
learning or memory  (IMP)
muscle cell cellular homeostasis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of glial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of glucose import  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of translation  (IMP)
neutrophil chemotaxis  (ISO)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of angiotensin-activated signaling pathway  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of bone resorption  (ISO)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of cell adhesion  (IEA,ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of dense core granule biogenesis  (ISO,ISS)
positive regulation of endothelial cell migration  (ISO,ISS)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of exocytosis  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IEA,ISO,ISS)
positive regulation of macrophage differentiation  (ISO,ISS)
positive regulation of mitotic cell cycle  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of synapse assembly  (IMP)
post-translational protein modification  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IDA)
regulation of muscle contraction  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of platelet aggregation  (IEA,ISO,ISS)
regulation of response to osmotic stress  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of the force of heart contraction  (ISO)
response to corticosterone  (IEP)
response to estradiol  (IMP)
response to ethanol  (IMP)
response to interleukin-1  (IEA,ISO)
response to mechanical stimulus  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to phorbol 13-acetate 12-myristate  (IDA)
response to reactive oxygen species  (IMP)
response to toxic substance  (IEP)
stem cell differentiation  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. Ainsworth PD, etal., Eur J Cancer. 2004 Oct;40(15):2269-73.
2. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
3. Invasive human pituitary tumors express a point-mutated alpha-protein kinase-C. Alvaro V, etal., J Clin Endocrinol Metab. 1993 Nov;77(5):1125-9.
4. Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Ansar S and Edvinsson L, Stroke. 2008 Jan;39(1):185-90. Epub 2007 Nov 21.
5. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. Assender JW, etal., J Clin Pathol. 2007 Nov;60(11):1216-21.
6. Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. Badawi AF, etal., Carcinogenesis. 2004 Sep;25(9):1681-8. Epub 2004 Apr 29.
7. Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. Bayer AL, etal., Mol Cell Biochem. 2003 Jan;242(1-2):145-52.
8. Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Belin RJ, etal., Circ Res. 2007 Jul 20;101(2):195-204. Epub 2007 Jun 7.
9. Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Bouwman RA, etal., Br J Anaesth. 2007 Nov;99(5):639-45. Epub 2007 Sep 27.
10. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Bowling N, etal., Circulation. 1999 Jan 26;99(3):384-91.
11. Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. Braun MU, etal., Mol Cell Biochem. 2004 Jul;262(1-2):135-43.
12. PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). Braz JC, etal., J Cell Biol. 2002 Mar 4;156(5):905-19. Epub 2002 Feb 25.
13. Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Bullard TA, etal., Can J Physiol Pharmacol. 2007 Feb;85(2):243-50.
14. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Chen YM, etal., Proc Natl Acad Sci U S A. 2006 May 30;103(22):8534-9. doi: 10.1073/pnas.0509955103. Epub 2006 May 22.
15. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
16. Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Cosen-Binker LI, etal., Gastroenterology. 2007 Apr;132(4):1527-45. Epub 2007 Jan 26.
17. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. Crocenzi FA, etal., Hepatology. 2008 Dec;48(6):1885-95.
18. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
19. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev KK, etal., J Neurosci. 2000 Oct 1;20(19):7252-7.
20. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. Du J, etal., J Neurosci. 2004 Jul 21;24(29):6578-89.
21. Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. El-Armouche A, etal., J Mol Cell Cardiol. 2007 Sep;43(3):371-6. Epub 2007 Jun 7.
22. Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. Fournier DB, etal., Gynecol Oncol. 2001 Jun;81(3):366-72.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Geiger T, etal., Anticancer Drug Des. 1998 Jan;13(1):35-45.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1. Gonzalez MI, etal., J Neurochem. 2005 Sep;94(5):1180-8. Epub 2005 Jul 25.
27. Regulation of LPA receptor function by estrogens. Gonzalez-Arenas A, etal., Biochim Biophys Acta. 2008 Feb;1783(2):253-62. Epub 2007 Dec 5.
28. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Goode B, etal., Nat Commun. 2018 Feb 23;9(1):810. doi: 10.1038/s41467-018-02826-8.
29. Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. Hizli AA, etal., J Biol Chem. 2006 May 26;281(21):14596-603. Epub 2006 Mar 23.
30. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
31. A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Hongpaisan J and Alkon DL, Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19571-6. Epub 2007 Dec 4.
32. Effect of cigarette smoke extract on proliferation of rat pulmonary artery smooth muscle cells and the relevant roles of protein kinase C. Hu J, etal., Chin Med J (Engl). 2007 Sep 5;120(17):1523-8.
33. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. Hu T and Exton JH, J Biol Chem 2003 Jan 24;278(4):2348-55.
34. Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. Johnsen DD, etal., Mol Cell Biochem. 2005 Feb;270(1-2):63-9.
35. Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Kobayashi Y, etal., Liver Int. 2007 Oct;27(8):1066-75.
36. Role of protein kinase C-alpha in superficial bladder carcinoma recurrence. Kong C, etal., Urology. 2005 Jun;65(6):1228-32.
37. Molecular evolution of the metazoan protein kinase C multigene family. Kruse M, etal., J Mol Evol 1996 Oct;43(4):374-83.
38. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
39. Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. Lim ST, etal., J Biol Chem. 2003 Apr 18;278(16):13795-802. Epub 2003 Feb 5.
40. Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. Longo M, etal., Bone. 2004 Jan;34(1):100-11.
41. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
42. The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells. Marin-Vicente C, etal., Mol Biol Cell. 2005 Jun;16(6):2848-61. Epub 2005 Apr 6.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Targeting of protein kinase Calpha to caveolae. Mineo C, etal., J Cell Biol. 1998 May 4;141(3):601-10.
45. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. Mohammadi K, etal., J Biol Chem 2001 Nov 9;276(45):42050-6.
46. Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. Moriguchi S, etal., Neuroscience. 2010 Apr 14;166(4):1158-66. Epub 2010 Jan 13.
47. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Nawaratne R, etal., Mol Endocrinol. 2006 Aug;20(8):1838-52. Epub 2006 Mar 30.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
50. Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. Nikodemova M, etal., J Biol Chem. 2007 May 18;282(20):15208-16. Epub 2007 Mar 29.
51. Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C. Ono Y, etal., Nucleic Acids Res 1988 Jun 10;16(11):5199-200.
52. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Pages M, etal., Acta Neuropathol Commun. 2015 Dec 15;3:85. doi: 10.1186/s40478-015-0264-5.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Powner DJ, etal., Mol Biol Cell 2002 Apr;13(4):1252-62.
57. Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. Ranganathan S, etal., J Biol Chem. 2004 Sep 24;279(39):40536-44. Epub 2004 Jul 22.
58. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
59. GOA pipeline RGD automated data pipeline
60. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle. Somara S, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G240-9. Epub 2007 Apr 12.
63. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
64. Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. Taffetani S, etal., BMC Physiol. 2007 Jul 19;7:6.
65. Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9.
66. Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells. Tsao CC, etal., Cell Cycle. 2007 Aug;6(19):2377-85. Epub 2007 Jul 12.
67. Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons. Wang P, etal., Biochem Biophys Res Commun. 2008 Feb 8;366(2):393-400. Epub 2007 Dec 4.
68. Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. Weichert W, etal., Int J Oncol. 2003 Sep;23(3):633-9.
69. Characterization of calcium-dependent forms of protein kinase C in adult rat ventricular myocytes. Wientzek M, etal., Mol Cell Biochem 1997 Jan;166(1-2):11-23.
70. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
71. Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer. Yuen AR, etal., Clin Cancer Res. 1999 Nov;5(11):3357-63.
72. Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats. Zhang L, etal., Nephron Exp Nephrol. 2006;104(3):e103-11. Epub 2006 Jul 12.
73. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Zhang SW, etal., Toxicol In Vitro. 2007 Dec;21(8):1476-85. Epub 2007 Jul 7.
74. Role of glucocorticoids and glucocorticoid receptor in priming of macrophages caused by glucocorticoid receptor blockade. Zhu XY, etal., Endocrine. 2007 Apr;31(2):130-7.
75. Zhonghua wai ke za zhi [Chinese journal of surgery] Zhu YY, etal., Zhonghua Wai Ke Za Zhi. 2005 May 15;43(10):662-6.
76. Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. Zhu Z, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):27-32.
Additional References at PubMed
PMID:2023931   PMID:3045562   PMID:3666147   PMID:7520444   PMID:7539802   PMID:7741753   PMID:7828597   PMID:7864897   PMID:7929424   PMID:8083223   PMID:8631738   PMID:8947489  
PMID:9447980   PMID:9508782   PMID:9535877   PMID:9830023   PMID:9927633   PMID:10365161   PMID:10407019   PMID:10617144   PMID:10722046   PMID:10770950   PMID:10813773   PMID:10848585  
PMID:10871288   PMID:10879655   PMID:10882525   PMID:11118818   PMID:11123317   PMID:11278415   PMID:11306676   PMID:11738801   PMID:11795668   PMID:11850425   PMID:11906323   PMID:11909826  
PMID:11916978   PMID:11923480   PMID:11940581   PMID:11952172   PMID:11981754   PMID:12079385   PMID:12112001   PMID:12115694   PMID:12198656   PMID:12391145   PMID:12426311   PMID:12477932  
PMID:12525479   PMID:12551925   PMID:12562894   PMID:12612139   PMID:12618484   PMID:12637266   PMID:12637991   PMID:12647293   PMID:12700627   PMID:12700701   PMID:12724315   PMID:12785016  
PMID:12826667   PMID:12928424   PMID:12967633   PMID:12970181   PMID:12970360   PMID:14602083   PMID:14613966   PMID:14638691   PMID:14681019   PMID:14698304   PMID:14717343   PMID:14966518  
PMID:15100355   PMID:15149857   PMID:15157674   PMID:15182202   PMID:15187091   PMID:15262987   PMID:15271671   PMID:15383279   PMID:15388777   PMID:15456937   PMID:15557340   PMID:15574738  
PMID:15590069   PMID:15632189   PMID:15632699   PMID:15748507   PMID:15763930   PMID:15784685   PMID:15830100   PMID:15833739   PMID:15838306   PMID:16014375   PMID:16099831   PMID:16114872  
PMID:16131649   PMID:16155104   PMID:16205321   PMID:16342423   PMID:16407557   PMID:16476439   PMID:16585392   PMID:16630892   PMID:16648180   PMID:16814779   PMID:16870611   PMID:16900949  
PMID:17109817   PMID:17178122   PMID:17208995   PMID:17209006   PMID:17252537   PMID:17267947   PMID:17363267   PMID:17392515   PMID:17487264   PMID:17531159   PMID:17558679   PMID:17591920  
PMID:17644814   PMID:17728398   PMID:17786270   PMID:17893151   PMID:17956267   PMID:17959934   PMID:17983652   PMID:17989210   PMID:18265009   PMID:18304574   PMID:18315563   PMID:18323529  
PMID:18346469   PMID:18474624   PMID:18523655   PMID:18550542   PMID:18556656   PMID:18668351   PMID:18778746   PMID:19005059   PMID:19056867   PMID:19057126   PMID:19080278   PMID:19147982  
PMID:19166962   PMID:19249914   PMID:19281832   PMID:19321046   PMID:19339511   PMID:19373133   PMID:19420114   PMID:19429666   PMID:19519660   PMID:19544110   PMID:19581409   PMID:19586612  
PMID:19592485   PMID:19672103   PMID:19693770   PMID:19723805   PMID:19806888   PMID:19826069   PMID:19843630   PMID:20011604   PMID:20053794   PMID:20170615   PMID:20177957   PMID:20181831  
PMID:20228790   PMID:20448043   PMID:20629316   PMID:20673182   PMID:20807573   PMID:20833797   PMID:20973479   PMID:21097843   PMID:21172324   PMID:21180072   PMID:21281821   PMID:21465534  
PMID:21528054   PMID:21658591   PMID:21718540   PMID:21929289   PMID:22097723   PMID:22203737   PMID:22393054   PMID:22472890   PMID:22527640   PMID:22531886   PMID:22713544   PMID:22801596  
PMID:22855535   PMID:22872317   PMID:23099255   PMID:23152155   PMID:23295407   PMID:23374940   PMID:23508961   PMID:23585120   PMID:23686852   PMID:23824537   PMID:23863479   PMID:23874859  
PMID:23882690   PMID:23900841   PMID:23990668   PMID:24008114   PMID:24151077   PMID:24297175   PMID:24305805   PMID:24349196   PMID:24355769   PMID:24876385   PMID:24914766   PMID:24992834  
PMID:25150189   PMID:25231108   PMID:25300290   PMID:25332685   PMID:25489662   PMID:26078455   PMID:26199377   PMID:26206583   PMID:26333598   PMID:26505750   PMID:26591616   PMID:26660275  
PMID:26713421   PMID:26830133   PMID:26854722   PMID:27353086   PMID:27624386   PMID:27837432   PMID:28154205   PMID:28423323   PMID:28485503   PMID:29561757   PMID:29642029   PMID:29845266  
PMID:30053369   PMID:30230261   PMID:30790506   PMID:31366607   PMID:31578312   PMID:32084499   PMID:32244197   PMID:32645222   PMID:33250241   PMID:33673008   PMID:34753065   PMID:36745530  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81093,388,991 - 93,787,617 (-)NCBIGRCr8
mRatBN7.21092,889,390 - 93,288,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,894,012 - 93,288,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,947,717 - 98,345,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,410,758 - 97,808,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,819,189 - 93,215,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,186,509 - 96,585,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,919,013 - 96,311,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,367,196 - 97,638,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,382,023 - 97,632,491 (-)NCBI
Celera1091,557,626 - 91,951,823 (-)NCBICelera
RH 3.4 Map101035.79RGD
Cytogenetic Map10q32.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381766,302,613 - 66,810,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1766,302,613 - 66,810,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371764,298,731 - 64,806,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,729,388 - 62,237,324 (+)NCBINCBI36Build 36hg18NCBI36
Build 341761,729,387 - 62,237,324NCBI
Celera1760,870,958 - 61,379,534 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1759,689,927 - 60,196,110 (+)NCBIHuRef
CHM1_11764,362,982 - 64,870,449 (+)NCBICHM1_1
T2T-CHM13v2.01767,172,339 - 67,686,559 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911107,824,213 - 108,237,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,824,213 - 108,234,754 (-)EnsemblGRCm39 Ensembl
GRCm3811107,933,387 - 108,343,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,933,387 - 108,343,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,794,701 - 108,205,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611107,754,338 - 108,160,018 (-)NCBIMGSCv36mm8
Celera11119,670,475 - 120,082,817 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.8NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554785,686,640 - 6,083,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554785,686,639 - 6,090,356 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21982,339,665 - 82,840,386 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,159,077 - 87,659,700 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,246,485 - 60,747,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11765,454,911 - 65,954,610 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1765,454,907 - 65,947,903 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1913,638,106 - 13,879,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl913,644,010 - 13,967,630 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,532,025 - 14,927,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0915,300,837 - 15,695,928 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,305,948 - 15,696,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,247,910 - 14,642,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0912,891,369 - 13,286,136 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0912,891,959 - 13,287,663 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560212,615,841 - 12,962,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,233,110 - 6,488,052 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,231,604 - 6,488,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1212,882,064 - 13,263,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11212,882,287 - 13,268,647 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,197,691 - 13,602,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11654,638,548 - 55,144,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1654,642,729 - 54,948,256 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607725,683,064 - 26,190,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248701,596,102 - 2,023,172 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248701,589,775 - 2,023,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkca
3023 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:822
Count of miRNA genes:230
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000004699, ENSRNOT00000055073
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,184,764 - 93,184,904 (+)MAPPERmRatBN7.2
Rnor_6.01096,482,302 - 96,482,441NCBIRnor6.0
Rnor_5.01096,209,202 - 96,209,341UniSTSRnor5.0
Celera1091,849,622 - 91,849,761UniSTS
RH 3.4 Map101036.2RGD
RH 3.4 Map101036.2UniSTS
RH 2.0 Map101145.8RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,223,816 - 93,224,011 (+)MAPPERmRatBN7.2
Rnor_6.01096,520,816 - 96,521,010NCBIRnor6.0
Rnor_5.01096,247,437 - 96,247,631UniSTSRnor5.0
Celera1091,888,082 - 91,888,276UniSTS
RH 2.0 Map101138.3RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1091,706,718 - 91,707,295UniSTS
RH 2.0 Map101130.4RGD
SHRSP x BN Map1073.35RGD
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,997,482 - 92,997,642 (+)MAPPERmRatBN7.2
Rnor_6.01096,295,049 - 96,295,208NCBIRnor6.0
Rnor_5.01096,022,399 - 96,022,558UniSTSRnor5.0
RGSC_v3.41097,470,298 - 97,470,457UniSTSRGSC3.4
Celera1091,660,804 - 91,660,963UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,981,530 - 92,981,737 (+)MAPPERmRatBN7.2
Rnor_6.01096,279,083 - 96,279,287NCBIRnor6.0
Rnor_5.01096,006,498 - 96,006,702UniSTSRnor5.0
RGSC_v3.41097,454,479 - 97,454,683UniSTSRGSC3.4
Celera1091,644,856 - 91,645,060UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,894,507 - 92,894,747 (+)MAPPERmRatBN7.2
Rnor_6.01096,191,629 - 96,191,868NCBIRnor6.0
Rnor_5.01095,919,509 - 95,919,748UniSTSRnor5.0
RGSC_v3.41097,367,692 - 97,367,931UniSTSRGSC3.4
Celera1091,558,122 - 91,558,361UniSTS
RH 3.4 Map101035.79UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41097,368,649 - 97,368,778UniSTSRGSC3.4
RGSC_v3.41097,368,649 - 97,368,881UniSTSRGSC3.4
Celera1091,559,079 - 91,559,208UniSTS
Celera1091,559,079 - 91,559,311UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,894,869 - 92,895,073 (+)MAPPERmRatBN7.2
Rnor_6.01096,191,991 - 96,192,194NCBIRnor6.0
Rnor_5.01095,919,871 - 95,920,074UniSTSRnor5.0
RGSC_v3.41097,368,054 - 97,368,257UniSTSRGSC3.4
Celera1091,558,484 - 91,558,687UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,238,639 - 93,238,779 (+)MAPPERmRatBN7.2
Rnor_6.01096,535,775 - 96,535,914NCBIRnor6.0
Rnor_5.01096,261,992 - 96,262,131UniSTSRnor5.0
Celera1091,902,756 - 91,902,895UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01657,183,630 - 57,183,785UniSTSRnor5.0
Rnor_5.01096,021,469 - 96,022,449UniSTSRnor5.0
RGSC_v3.41657,645,822 - 57,645,977UniSTSRGSC3.4
RGSC_v3.41097,469,368 - 97,470,348UniSTSRGSC3.4
Celera1651,895,620 - 51,895,775UniSTS
Celera1091,659,874 - 91,660,854UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01095,920,466 - 95,920,698UniSTSRnor5.0
RGSC_v3.41097,368,649 - 97,368,881UniSTSRGSC3.4
Celera1091,559,079 - 91,559,311UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01095,920,466 - 95,920,595UniSTSRnor5.0
RGSC_v3.41097,368,649 - 97,368,778UniSTSRGSC3.4
Celera1091,559,079 - 91,559,208UniSTS
Cytogenetic Map10q32.1UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 26 15 8 18 8 8 10 52 26 16 9 8
Low 17 42 33 1 33 1 22 9 23 2
Below cutoff 2


RefSeq Acc Id: ENSRNOT00000004699   ⟹   ENSRNOP00000004699
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,287,756 (-)Ensembl
Rnor_6.0 Ensembl1096,191,385 - 96,584,896 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000055073   ⟹   ENSRNOP00000051949
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,012 - 93,287,807 (-)Ensembl
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100596   ⟹   ENSRNOP00000079110
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,895,139 - 93,287,807 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112512   ⟹   ENSRNOP00000083509
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,135,944 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115522   ⟹   ENSRNOP00000091320
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,288,012 (-)Ensembl
RefSeq Acc Id: NM_001399299   ⟹   NP_001386228
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,327 (-)NCBI
mRatBN7.21092,889,390 - 93,287,767 (-)NCBI
RefSeq Acc Id: XM_017597006   ⟹   XP_017452495
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,617 (-)NCBI
mRatBN7.21092,889,390 - 93,287,801 (-)NCBI
Rnor_6.01096,186,509 - 96,585,168 (-)NCBI
RefSeq Acc Id: XM_039085211   ⟹   XP_038941139
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,617 (-)NCBI
mRatBN7.21092,889,390 - 93,288,013 (-)NCBI
RefSeq Acc Id: XP_017452495   ⟸   XM_017597006
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000051949   ⟸   ENSRNOT00000055073
RefSeq Acc Id: ENSRNOP00000004699   ⟸   ENSRNOT00000004699
RefSeq Acc Id: XP_038941139   ⟸   XM_039085211
- Peptide Label: isoform X1
- UniProtKB: F1LS98 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091320   ⟸   ENSRNOT00000115522
RefSeq Acc Id: ENSRNOP00000083509   ⟸   ENSRNOT00000112512
RefSeq Acc Id: ENSRNOP00000079110   ⟸   ENSRNOT00000100596
RefSeq Acc Id: NP_001386228   ⟸   NM_001399299
- UniProtKB: P05696 (UniProtKB/Swiss-Prot),   B5DFC4 (UniProtKB/TrEMBL),   F1LS98 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05696-F1-model_v2 AlphaFold P05696 1-672 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697861
Promoter ID:EPDNEW_R8378
Type:initiation region
Description:protein kinase C, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01096,584,907 - 96,584,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3395 AgrOrtholog
BioCyc Gene G2FUF-22880 BioCyc
Ensembl Genes ENSRNOG00000003491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055029138 UniProtKB/Swiss-Prot
  ENSRNOG00060013871 UniProtKB/Swiss-Prot
  ENSRNOG00065019003 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004699 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000004699.9 UniProtKB/Swiss-Prot
  ENSRNOT00000055073.5 UniProtKB/TrEMBL
  ENSRNOT00000100596.1 UniProtKB/TrEMBL
  ENSRNOT00000112512.1 UniProtKB/TrEMBL
  ENSRNOT00000115522.1 UniProtKB/TrEMBL
  ENSRNOT00055050566 UniProtKB/Swiss-Prot
  ENSRNOT00060023763 UniProtKB/Swiss-Prot
  ENSRNOT00065032081 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cPKC_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_C_a/b/g UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24680 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkca PhenoGen
PIRSF PKC_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003491 RatGTEx
  ENSRNOG00055029138 RatGTEx
  ENSRNOG00060013871 RatGTEx
  ENSRNOG00065019003 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A0A8I6G952_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkca  Protein kinase C, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adult ventricular myocytes 731217
gene_pathway activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493
gene_regulation administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes 628493