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Gene: Prkca (protein kinase C, alpha) Rattus norvegicus
Symbol: Prkca
Name: protein kinase C, alpha
RGD ID: 3395
Description: Exhibits calcium-dependent protein kinase C activity. Involved in several processes, including protein phosphorylation; regulation of cellular protein metabolic process; and regulation of vesicle-mediated transport. Localizes to several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (S)-nicotine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: PKC-A; PKC-alpha; Pkca; protein kinase C alpha type
Homo sapiens (human) : PRKCA (protein kinase C alpha)  HGNC  Alliance
Mus musculus (house mouse) : Prkca (protein kinase C, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkca (protein kinase C alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCA (protein kinase C alpha)
Canis lupus familiaris (dog) : PRKCA (protein kinase C alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkca (protein kinase C alpha)
Sus scrofa (pig) : PRKCA (protein kinase C alpha)
Chlorocebus sabaeus (African green monkey) : PRKCA (protein kinase C alpha)
Heterocephalus glaber (naked mole-rat) : Prkca (protein kinase C alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01096,186,509 - 96,585,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,919,013 - 96,311,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,367,196 - 97,638,910 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11097,382,023 - 97,632,491 (-)NCBI
Celera1091,557,626 - 91,951,823 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
RH 3.4 Map101035.79RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkca
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3395
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.