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Gene: Src (SRC proto-oncogene, non-receptor tyrosine kinase) Rattus norvegicus
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Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Description: Exhibits several functions, including enzyme binding activity; ion channel binding activity; and signaling receptor binding activity. Involved in several processes, including cellular protein modification process; cellular response to lipid; and positive regulation of cellular metabolic process. Localizes to several cellular components, including the caveola; postsynaptic density; and postsynaptic specialization, intracellular component. Used to study brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colon cancer; ductal carcinoma in situ; prostate cancer; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase); PARTICIPATES IN dopamine signaling pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-Src; p60-Src; pp60c-src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Orthologs:
Homo sapiens (human) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Src (Rous sarcoma oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Canis lupus familiaris (dog) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)
Sus scrofa (pig) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03153,547,807 - 153,595,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03158,123,674 - 158,171,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,157,256 - 148,170,524 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13148,063,164 - 148,076,433 (+)NCBI
Celera3144,830,256 - 144,843,524 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Src
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620795
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.