Exhibits several functions, including enzyme binding activity; ion channel binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cellular metabolic process; and regulation of signal transduction. Localizes to several cellular components, including the caveola; glutamatergic synapse; and postsynaptic specialization, intracellular component. Used to study brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colon cancer; ductal carcinoma in situ; prostate cancer; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase); PARTICIPATES IN dopamine signaling pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin.
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein], SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein] more ...
SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]], SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein, [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein] more ...
allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA], allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA], SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
SRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 mRNA], SRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 protein]
Arsenic results in increased phosphorylation of and results in increased activity of SRC protein, Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein]
Arsenic results in increased phosphorylation of and results in increased activity of SRC protein, Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein]
bisphenol A inhibits the reaction [Genistein results in decreased expression of SRC protein], Genistein inhibits the reaction [bisphenol A results in increased expression of SRC protein]
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of SRC protein] more ...
SRC protein promotes the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]
[cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]] more ...
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein more ...
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein more ...
corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein], corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]
SRC protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein], SRC protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]
Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein], Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]
AG 1879 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of and results in increased activity of SRC protein], Oxygen deficiency results in increased phosphorylation of and results in increased activity of SRC protein
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein] more ...
Fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of SRC protein], Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of SRC protein]
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein], geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
bisphenol A inhibits the reaction [Genistein results in decreased expression of SRC protein], Genistein inhibits the reaction [bisphenol A results in increased expression of SRC protein]
SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of PPARG mRNA]], SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of SCD1 mRNA]]
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein] more ...
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of SRC protein], [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein]
SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of PPARG mRNA]], SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of SCD1 mRNA]]
[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein, Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein]
HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein], Lead results in increased phosphorylation of and results in increased expression of SRC protein
HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein], Lead results in increased phosphorylation of and results in increased expression of SRC protein
[Drugs, Chinese Herbal co-treated with niuhuang] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein] more ...
[AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]], [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein], maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of SRC protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SRC protein binds to NR1I3 protein]
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein], honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]
chromium hexavalent ion inhibits the reaction [Nickel results in increased phosphorylation of SRC protein], U 0126 inhibits the reaction [Nickel results in increased phosphorylation of SRC protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein]
Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of SRC protein], Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of SRC protein]
[[[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein] promotes the reaction [STAT3 protein binds to STAT3 protein] more ...
[resveratrol affects the phosphorylation of SRC protein] affects the reaction [sodium arsenite results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] more ...
Resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein], Resveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of SRC protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
[Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of EGFR protein more ...
[resveratrol affects the phosphorylation of SRC protein] affects the reaction [sodium arsenite results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]], [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of SRC mRNA
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] more ...
[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SRC mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SRC mRNA
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein
SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein], SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]
SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]], SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein], RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
[SRC protein results in increased phosphorylation of EGFR protein] affects the reaction [[Zinc co-treated with EGFR protein] results in increased activity of RAS protein] more ...
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]], zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]
[SRC protein results in increased phosphorylation of EGFR protein] affects the reaction [[Zinc co-treated with EGFR protein] results in increased activity of RAS protein] more ...
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
