Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) Rattus norvegicus
Analyze
Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
Description: Exhibits several functions, including enzyme binding activity; glutamate binding activity; and ligand-gated ion channel activity. Contributes to cation channel activity and extracellularly glutamate-gated ion channel activity. Involved in several processes, including cellular response to metal ion; central nervous system development; and modulation of chemical synaptic transmission. Localizes to several cellular components, including the integral component of plasma membrane; neuron projection; and parallel fiber to Purkinje cell synapse. Used to study hyperhomocysteinemia. Biomarker of cognitive disorder; placental insufficiency; and status epilepticus. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A); PARTICIPATES IN excitatory synaptic transmission pathway; long term depression; long term potentiation; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GluN2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; NMDAR2A; NR2A
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Celera104,645,710 - 5,048,399 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grin2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2737
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.