Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) - Rat Genome Database

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Gene: Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) Rattus norvegicus
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Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
RGD ID: 2737
Description: Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion gated channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including cellular response to metal ion; central nervous system development; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; postsynaptic density; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of cognitive disorder; placental insufficiency; and status epilepticus. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; colorectal cancer; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A); PARTICIPATES IN excitatory synaptic transmission pathway; long term depression; long term potentiation; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluN2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; NMDAR2A; NR2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2105,630,684 - 6,043,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIRnor_WKY
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Celera104,645,710 - 5,048,399 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-lipoic acid  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
26-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allopurinol  (EXP)
alpha-pinene  (EXP)
Amaranth  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
astragaloside IV  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brilliant Blue  (EXP)
celecoxib  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
clozapine  (EXP)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyanuric acid  (EXP)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP)
dextromethorphan  (EXP)
Diacetoxyscirpenol  (ISO)
diazepam  (ISO)
diazinon  (EXP)
dinitrogen oxide  (ISO)
dizocilpine maleate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
Fluorocitric acid  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indigo carmine  (EXP)
isocyanuric acid  (EXP)
kainic acid  (ISO)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
minocycline  (EXP)
morphine  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nobiletin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentobarbital  (EXP,ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(cytidylic acid)  (EXP)
profenofos  (EXP)
propofol  (ISO)
prostaglandin E2  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
Sunset Yellow FCF  (EXP)
suvorexant  (ISO)
T-2 toxin  (ISO)
tadalafil  (ISO)
tartrazine  (EXP)
tetrodotoxin  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
calcium ion transmembrane import into cytosol  (IEA,ISO,ISS)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to amino acid stimulus  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to dsRNA  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to zinc ion  (IMP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (IMP,ISO)
dendritic spine organization  (IMP)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
directional locomotion  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
excitatory postsynaptic potential  (IBA,IEA,IMP,ISO)
hippocampus development  (IEP)
ionotropic glutamate receptor signaling pathway  (IDA,IEA,ISS)
learning  (ISO)
learning or memory  (ISO)
locomotion  (ISO)
long-term synaptic potentiation  (IBA,IEA,ISO)
memory  (IDA,IEA,ISO)
modulation of chemical synaptic transmission  (ISO)
monoatomic cation transmembrane transport  (IDA,ISS)
negative regulation of protein catabolic process  (IEA,ISO)
neurogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IDA,ISS)
positive regulation of synaptic transmission, glutamatergic  (IDA,ISS)
protein catabolic process  (IEA,ISO)
protein localization to postsynaptic membrane  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of membrane potential  (ISO)
regulation of monoatomic cation transmembrane transport  (IDA,ISS)
regulation of neuronal synaptic plasticity  (NAS)
regulation of NMDA receptor activity  (IMP)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of synaptic plasticity  (ISO)
response to amine  (IEP)
response to ammonium ion  (IEP)
response to amphetamine  (IEA,ISO)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to cocaine  (IEP)
response to ethanol  (IEA,IEP,IMP,ISO)
response to fungicide  (IEP)
response to light stimulus  (IEP)
response to manganese ion  (IEP)
response to methylmercury  (IEP)
response to organic cyclic compound  (IEP)
response to other organism  (IEP)
response to wounding  (IEA,ISO)
response to xenobiotic stimulus  (IEA,IEP,ISO)
rhythmic process  (IDA)
sensory perception of pain  (IEA,ISO)
serotonin metabolic process  (IEA,ISO)
sleep  (IEA,ISO)
spinal cord development  (IEP)
startle response  (IEA,ISO)
synaptic transmission, glutamatergic  (IBA)
visual learning  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
Alzheimer's disease pathway  (IEA)
amyotrophic lateral sclerosis pathway  (IEA)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IDA)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IMP)
long term potentiation  (IEA,IMP)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
Reelin signaling pathway  (ISO,TAS)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
systemic lupus erythematosus pathway  (IEA)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex. Ampuero E, etal., Neuroscience. 2010 Apr 22.
3. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
4. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. Anson LC, etal., J Neurosci. 1998 Jan 15;18(2):581-9.
5. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
6. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
7. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
8. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
9. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Bassand P, etal., Eur J Neurosci. 1999 Jun;11(6):2031-43.
10. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
11. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
12. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Chapman DE, etal., J Neurophysiol 2003 Jan;89(1):69-80.
13. Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai. Chen C, etal., Neurosci Bull. 2010 Oct;26(5):395-400. doi: 10.1007/s12264-010-0729-2.
14. Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Chen M, etal., Neurosci Lett. 2003 Mar 13;339(1):29-32.
15. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
16. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
17. N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis. da Cunha AA, etal., Chest. 2010 Feb;137(2):297-302. Epub 2009 Oct 16.
18. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Dalby NO and Mody I, J Neurophysiol 2003 Aug;90(2):786-97.
19. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
20. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
21. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. Foster KA, etal., J Neurosci. 2010 Feb 17;30(7):2676-85.
22. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
23. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
24. Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Galic MA, etal., Neurobiol Dis. 2009 Nov;36(2):343-51. Epub 2009 Aug 4.
25. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. Gardoni F, etal., J Biol Chem 2003 Nov 7;278(45):44745-52. Epub 2003 Aug 21.
26. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. Gardoni F, etal., J Biol Chem. 2001 Mar 9;276(10):7609-13. Epub 2000 Dec 4.
27. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. Gardoni F, etal., J Neurosci. 2001 Mar 1;21(5):1501-9.
28. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
29. Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum. Garside ML, etal., Neuroscience. 2009 Aug 18;162(2):383-95. Epub 2009 May 3.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. Experience-dependent regulation of NMDA receptor subunit composition and phosphorylation in the retina and visual cortex. Giannakopoulos M, etal., Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1817-22. Epub 2009 Oct 22.
32. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
33. Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions. Groveman BR, etal., FEBS J. 2011 Feb;278(4):643-53. doi: 10.1111/j.1742-4658.2010.07985.x. Epub 2010 Dec 30.
34. The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Han LC, etal., Eur J Anaesthesiol. 2010 Feb;27(2):181-6.
35. Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Hansen KB, etal., Mol Pharmacol. 2013 Jul;84(1):114-27. doi: 10.1124/mol.113.085803. Epub 2013 Apr 26.
36. Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Hou XY, etal., Brain Res 2002 Nov 15;955(1-2):123-32.
37. Characterization of genomic alterations in Chinese colorectal cancer patients. Huang W, etal., Jpn J Clin Oncol. 2021 Jan 1;51(1):120-129. doi: 10.1093/jjco/hyaa182.
38. The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat. Huang Y and Goshgarian HG, Int J Dev Neurosci. 2009 Aug;27(5):477-83. Epub 2009 May 13.
39. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
40. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. Ishii T, etal., J Biol Chem 1993 Feb 5;268(4):2836-43.
41. Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans. Itokawa M, etal., Neurosci Lett 2003 Jul 10;345(1):53-6.
42. Structural insights into competitive antagonism in NMDA receptors. Jespersen A, etal., Neuron. 2014 Jan 22;81(2):366-78. doi: 10.1016/j.neuron.2013.11.033.
43. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
44. Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Jin DH, etal., Mol Cells. 1997 Dec 31;7(6):749-54.
45. The effect of ganglioside GQ1b on the NMDA receptor signaling pathway in H19-7 cells and rat hippocampus. Jung WR, etal., Neuroscience. 2010 Jan 13;165(1):159-67. Epub 2009 Oct 9.
46. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Kawashima H, etal., Neuroscience. 2010 Feb 17;165(4):1301-11. Epub 2009 Dec 1.
47. The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth. Kim MS, etal., Oncogene. 2008 Mar 27;27(14):2045-54. doi: 10.1038/sj.onc.1210842. Epub 2007 Oct 8.
48. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Kornau HC, etal., Science. 1995 Sep 22;269(5231):1737-40.
49. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
50. Amino terminal domains of the NMDA receptor are organized as local heterodimers. Lee CH and Gouaux E, PLoS One. 2011 Apr 22;6(4):e19180. doi: 10.1371/journal.pone.0019180.
51. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Lee FJ, etal., Cell. 2002 Oct 18;111(2):219-30.
52. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
53. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
54. Regulation of NMDA receptors by cyclin-dependent kinase-5. Li BS, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12742-7.
55. Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. Li R, etal., BMC Neurosci. 2007 Jul 26;8:55.
56. NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Li TT, etal., Pain. 2009 Nov;146(1-2):183-93. Epub 2009 Aug 19.
57. Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats. Liu W, etal., Toxicol Lett. 2009 Aug 10;188(3):230-5. Epub 2009 May 3.
58. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Liu Y, etal., Brain Res. 2001 Aug 3;909(1-2):51-8.
59. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
60. N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Miller BH and Gore AC, Endocrinology 2002 Sep;143(9):3568-74.
61. Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
62. Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes. Montori S, etal., Neurochem Int. 2010 Jul;56(8):878-85. Epub 2010 Mar 27.
63. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer H, etal., Science 1992 May 22;256(5060):1217-21.
64. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
65. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
66. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
67. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Ng D, etal., PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.
68. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. Niethammer M, etal., J Neurosci. 1996 Apr 1;16(7):2157-63.
69. Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF. Ninomiya M, etal., Neurosci Lett. 2010 May 31;476(2):104-9. Epub 2010 Apr 14.
70. Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Obara I, etal., Alcohol Clin Exp Res. 2009 Nov;33(11):1924-34. Epub 2009 Aug 10.
71. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
72. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
73. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
74. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
75. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
76. Reaction mechanism determines NMDA receptor response to repetitive stimulation. Popescu G, etal., Nature 2004 Aug 12;430(7001):790-3.
77. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Puddifoot CA, etal., Br J Pharmacol. 2009 Feb;156(3):509-18. Epub 2009 Jan 16.
78. Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. Qian A and Johnson JW, J Neurosci. 2006 Oct 18;26(42):10899-910.
79. Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating. Ren H, etal., Neuropharmacology. 2017 Mar 1;114:20-33. doi: 10.1016/j.neuropharm.2016.11.013. Epub 2016 Nov 19.
80. GOA pipeline RGD automated data pipeline
81. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
82. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
83. An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors. Riou M, etal., PLoS One. 2012;7(4):e35134. doi: 10.1371/journal.pone.0035134. Epub 2012 Apr 6.
84. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
85. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Schober ME, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R681-92. Epub 2009 Jan 14.
86. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Sheng Z, etal., Neuropharmacology. 2009 Aug;57(2):127-36. Epub 2009 May 8.
87. A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Siegler Retchless B, etal., Nat Neurosci. 2012 Jan 15;15(3):406-13, S1-2. doi: 10.1038/nn.3025.
88. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Siow NL, etal., Mol Pharmacol. 2010 Dec;78(6):1059-71. doi: 10.1124/mol.110.066506. Epub 2010 Sep 16.
89. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex. Stanic J, etal., Nat Commun. 2015 Dec 18;6:10181. doi: 10.1038/ncomms10181.
90. Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Sun W, etal., Neuron. 2017 Apr 5;94(1):58-64.e3. doi: 10.1016/j.neuron.2017.03.018.
91. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
92. GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation. Talukder I, etal., Biophys J. 2011 Nov 16;101(10):2389-98. doi: 10.1016/j.bpj.2011.10.015. Epub 2011 Nov 15.
93. Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. Tang J, etal., Neurosci Lett. 2006 Nov 27;409(1):80-2. Epub 2006 Oct 2.
94. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. Van de Ven TJ, etal., J Neurosci. 2005 Oct 12;25(41):9488-96.
95. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Wang J, etal., Nat Neurosci 2003 Oct;6(10):1039-47. Epub 2003 Sep 21.
96. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, etal., Brain Res. 2010 Apr 30;1328:162-70. Epub 2010 Mar 1.
97. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
98. Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition. Wise-Faberowski L, etal., Anesth Analg. 2009 Jul;109(1):205-10.
99. Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Woo TU, etal., Brain Res. 2008 Jul 7;1218:267-77. Epub 2008 Apr 16.
100. Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum. Xu B, etal., J Biochem Mol Toxicol. 2010 Jan;24(1):1-9.
101. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Xu B, etal., Neurotoxicology. 2009 Nov;30(6):941-9. Epub 2009 Jul 28.
102. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. Yang J, etal., J Neurosci. 2006 Jan 11;26(2):406-10.
103. Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain. Yang L, etal., Neuropharmacology. 2018 Jul 15;137:104-113. doi: 10.1016/j.neuropharm.2018.04.029. Epub 2018 Apr 30.
104. Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors. Yang Q, etal., Neurochem Res. 2010 Jun 5.
105. Effects of ammonia and allopurinol on rat hippocampal NMDA receptors. Yonden Z, etal., Cell Biochem Funct. 2010 Mar;28(2):159-63.
106. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. Yuan H, etal., J Biol Chem. 2009 May 8;284(19):12862-73. Epub 2009 Feb 24.
107. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
108. Protective effect of spleen-yin-nourishing recipe on amyloid beta-peptide-induced damage of primarily cultured rat hippocampal neurons and its mechanism. Zhan LB, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Mar;7(3):242-8.
109. Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. Zhang J and Diamond JS, J Neurosci. 2009 Apr 1;29(13):4274-86.
110. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Zhao MG, etal., Neuron. 2005 Sep 15;47(6):859-72.
111. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Zhao X, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7. Epub 2009 Jun 27.
112. Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance. Zhou XJ, etal., Genet Mol Res. 2015 Dec 17;14(4):17289-95. doi: 10.4238/2015.December.16.29.
Additional References at PubMed
PMID:1374164   PMID:1377365   PMID:7816096   PMID:7929101   PMID:8699248   PMID:8840015   PMID:8987814   PMID:9003035   PMID:9147327   PMID:9427357   PMID:9458051   PMID:9512392  
PMID:9556603   PMID:9647694   PMID:9694864   PMID:9712642   PMID:9718984   PMID:9822733   PMID:9892651   PMID:10480938   PMID:10694228   PMID:10771345   PMID:11160393   PMID:11160454  
PMID:11487658   PMID:11488959   PMID:11530236   PMID:11588171   PMID:11929923   PMID:12103442   PMID:12147342   PMID:12242020   PMID:12391275   PMID:12427824   PMID:12486601   PMID:12579524  
PMID:12676993   PMID:12695509   PMID:12711087   PMID:12746457   PMID:12754515   PMID:12764094   PMID:12859686   PMID:12890763   PMID:12941447   PMID:14503841   PMID:14622577   PMID:14645471  
PMID:14732708   PMID:14750973   PMID:14760703   PMID:14985927   PMID:15016095   PMID:15143284   PMID:15201510   PMID:15356193   PMID:15574735   PMID:15580338   PMID:15610162   PMID:15649985  
PMID:15731593   PMID:15737435   PMID:15790561   PMID:15804717   PMID:15888440   PMID:15908129   PMID:15924861   PMID:15967799   PMID:16045501   PMID:16190898   PMID:16281028   PMID:16540573  
PMID:16709630   PMID:16710293   PMID:16814779   PMID:16901514   PMID:16927803   PMID:16980547   PMID:17114649   PMID:17124177   PMID:17156360   PMID:17229826   PMID:17234586   PMID:17255096  
PMID:17451646   PMID:17455306   PMID:17459877   PMID:17486105   PMID:17545075   PMID:17670980   PMID:17717018   PMID:17803966   PMID:17853656   PMID:17854777   PMID:17962329   PMID:17986236  
PMID:18048007   PMID:18054859   PMID:18230675   PMID:18445116   PMID:18468585   PMID:18538939   PMID:18688011   PMID:18720514   PMID:18765272   PMID:18927268   PMID:19088076   PMID:19376094  
PMID:19490087   PMID:19533626   PMID:19587283   PMID:19626270   PMID:19726645   PMID:19771923   PMID:19772634   PMID:19934647   PMID:20107120   PMID:20145658   PMID:20418887   PMID:20441772  
PMID:20448042   PMID:20581725   PMID:20661302   PMID:20831617   PMID:20844142   PMID:20850419   PMID:20884369   PMID:20887777   PMID:20974938   PMID:21114966   PMID:21162311   PMID:21470075  
PMID:21554958   PMID:21558424   PMID:21608225   PMID:21664258   PMID:21669274   PMID:21719075   PMID:21862938   PMID:21883149   PMID:21883211   PMID:22055014   PMID:22089426   PMID:22108330  
PMID:22291020   PMID:22335236   PMID:22362014   PMID:22366650   PMID:22375001   PMID:22474321   PMID:22493505   PMID:22681877   PMID:22870316   PMID:22891278   PMID:23022504   PMID:23049922  
PMID:23113297   PMID:23212166   PMID:23221411   PMID:23352316   PMID:23383317   PMID:23431156   PMID:23611155   PMID:23621516   PMID:23672716   PMID:23676200   PMID:23760273   PMID:23839940  
PMID:24029697   PMID:24076085   PMID:24278457   PMID:24388786   PMID:24607230   PMID:24761931   PMID:24981431   PMID:25319628   PMID:25393018   PMID:25496357   PMID:25521238   PMID:25544544  
PMID:25772108   PMID:25829490   PMID:26088419   PMID:26220171   PMID:26370091   PMID:26548659   PMID:26609151   PMID:26627310   PMID:26682524   PMID:26875626   PMID:27457929   PMID:27497478  
PMID:27807032   PMID:27839871   PMID:27857196   PMID:28042872   PMID:28160495   PMID:28823933   PMID:29335819   PMID:29339324   PMID:30269991   PMID:30500536   PMID:31080121   PMID:31167782  
PMID:31277281   PMID:31936514   PMID:31978422   PMID:32015122   PMID:32032749   PMID:32070042   PMID:32197489   PMID:32320718   PMID:32929031   PMID:33420399   PMID:33550485   PMID:33759085  
PMID:34225758   PMID:34233182   PMID:34291567   PMID:34454977   PMID:36521778  


Genomics

Comparative Map Data
Grin2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2105,630,684 - 6,043,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIRnor_WKY
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Celera104,645,710 - 5,048,399 (+)NCBICelera
Cytogenetic Map10q11NCBI
GRIN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38169,753,404 - 10,182,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl169,753,404 - 10,182,928 (-)EnsemblGRCh38hg38GRCh38
GRCh37169,847,261 - 10,276,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36169,762,923 - 10,184,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 34169,762,922 - 10,184,112NCBI
Celera1610,014,039 - 10,444,548 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef169,767,577 - 9,952,307 (-)NCBIHuRef
HuRef1610,193,124 - 10,195,907 (-)NCBIHuRef
CHM1_1169,847,229 - 10,277,115 (-)NCBICHM1_1
T2T-CHM13v2.0169,786,917 - 10,217,640 (-)NCBIT2T-CHM13v2.0
Grin2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39169,385,765 - 9,813,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl169,385,762 - 9,813,424 (-)EnsemblGRCm39 Ensembl
GRCm38169,567,901 - 9,996,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl169,567,898 - 9,995,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv37169,577,803 - 9,992,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36169,491,265 - 9,906,111 (-)NCBIMGSCv36mm8
Celera1610,217,398 - 10,625,063 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.28NCBI
Grin2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554428,174,232 - 8,562,059 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554428,171,114 - 8,565,187 (+)NCBIChiLan1.0ChiLan1.0
GRIN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11614,057,703 - 14,490,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0168,682,169 - 9,105,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,909,406 - 10,339,147 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,919,143 - 10,336,167 (-)Ensemblpanpan1.1panPan2
GRIN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,132,070 - 32,678,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,303,121 - 32,668,960 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,514,238 - 34,067,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0632,315,346 - 32,865,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,484,833 - 32,856,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,128,354 - 32,680,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0632,000,797 - 32,549,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,426,676 - 32,972,580 (+)NCBIUU_Cfam_GSD_1.0
Grin2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,432,891 - 110,765,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,287,574 - 8,608,343 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365308,286,101 - 8,612,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,750,700 - 33,143,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,749,329 - 33,149,350 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,810,701 - 33,913,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,233,028 - 9,707,322 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,286,775 - 9,462,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606820,460,991 - 20,885,559 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin2a
3093 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir132rno-miR-132-3pMirtarbaseexternal_infoWestern blotFunctional MTI19958814

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000044626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat

Markers in Region
D10Got12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,801,990 - 5,802,227 (+)MAPPERmRatBN7.2
Rnor_6.0105,877,536 - 5,877,770NCBIRnor6.0
Rnor_5.0104,695,640 - 4,695,874UniSTSRnor5.0
RGSC_v3.4105,761,138 - 5,761,372RGDRGSC3.4
RGSC_v3.4105,761,139 - 5,761,373UniSTSRGSC3.4
RGSC_v3.1105,761,138 - 5,761,372RGD
Celera104,812,755 - 4,813,001UniSTS
RH 3.4 Map1060.5UniSTS
RH 3.4 Map1060.5RGD
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Got164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,933,009 - 5,933,133 (+)MAPPERmRatBN7.2
Rnor_6.0106,009,414 - 6,009,537NCBIRnor6.0
Rnor_5.0104,827,340 - 4,827,463UniSTSRnor5.0
RGSC_v3.4105,894,189 - 5,894,313RGDRGSC3.4
RGSC_v3.4105,894,190 - 5,894,313UniSTSRGSC3.4
RGSC_v3.1105,894,189 - 5,894,313RGD
Celera104,938,649 - 4,938,772UniSTS
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Got9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,684,047 - 5,684,259 (+)MAPPERmRatBN7.2
Rnor_6.0105,760,565 - 5,760,774NCBIRnor6.0
Rnor_5.0104,578,252 - 4,578,461UniSTSRnor5.0
RGSC_v3.4105,641,331 - 5,641,541RGDRGSC3.4
RGSC_v3.4105,641,332 - 5,641,541UniSTSRGSC3.4
RGSC_v3.1105,641,332 - 5,641,541RGD
Celera104,696,381 - 4,696,598UniSTS
RH 3.4 Map1066.7UniSTS
RH 3.4 Map1066.7RGD
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Ulb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,143,394 - 21,144,889 (+)MAPPERmRatBN7.2
mRatBN7.2105,796,328 - 5,796,484 (+)MAPPERmRatBN7.2
Rnor_6.0105,872,003 - 5,872,158NCBIRnor6.0
Rnor_6.0218,873,175 - 18,874,669NCBIRnor6.0
Rnor_5.0104,690,107 - 4,690,262UniSTSRnor5.0
Rnor_5.0218,748,955 - 18,750,449UniSTSRnor5.0
RGSC_v3.4220,104,168 - 20,105,662UniSTSRGSC3.4
RGSC_v3.4105,755,479 - 5,755,634UniSTSRGSC3.4
Celera104,807,109 - 4,807,263UniSTS
Celera217,271,726 - 17,273,220UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map10q11UniSTS
Grin2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2106,042,978 - 6,043,203 (+)MAPPERmRatBN7.2
Rnor_6.0106,119,535 - 6,119,759NCBIRnor6.0
Rnor_5.0104,936,511 - 4,936,735UniSTSRnor5.0
RGSC_v3.4106,004,418 - 6,004,642UniSTSRGSC3.4
Celera105,048,037 - 5,048,261UniSTS
Cytogenetic Map10q11UniSTS
BE120369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,670,580 - 5,670,760 (+)MAPPERmRatBN7.2
Rnor_6.0105,747,098 - 5,747,277NCBIRnor6.0
Rnor_5.0104,564,785 - 4,564,964UniSTSRnor5.0
RGSC_v3.4105,627,865 - 5,628,044UniSTSRGSC3.4
Celera104,682,926 - 4,683,105UniSTS
RH 3.4 Map1085.81UniSTS
Cytogenetic Map10q11UniSTS
BF413021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,629,039 - 5,629,155 (+)MAPPERmRatBN7.2
Rnor_6.0105,706,163 - 5,706,278NCBIRnor6.0
Rnor_5.0104,523,319 - 4,523,434UniSTSRnor5.0
RGSC_v3.4105,586,586 - 5,586,701UniSTSRGSC3.4
Celera104,644,067 - 4,644,182UniSTS
RH 3.4 Map1067.3UniSTS
Cytogenetic Map10q11UniSTS
ha2303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,783,618 - 5,784,012 (+)MAPPERmRatBN7.2
Rnor_6.0105,859,293 - 5,859,686NCBIRnor6.0
Rnor_5.0104,677,397 - 4,677,790UniSTSRnor5.0
RGSC_v3.4105,742,769 - 5,743,162UniSTSRGSC3.4
Celera104,794,399 - 4,794,792UniSTS
Cytogenetic Map10q11UniSTS
Grin2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2106,041,709 - 6,042,108 (+)MAPPERmRatBN7.2
Rnor_6.0106,118,266 - 6,118,664NCBIRnor6.0
Rnor_5.0104,935,242 - 4,935,640UniSTSRnor5.0
Celera105,046,768 - 5,047,166UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21
Low 1 41 2 1
Below cutoff 2 20 23 19 10 19 7 7 12 15 35 7 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044626   ⟹   ENSRNOP00000042235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)Ensembl
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)Ensembl
RefSeq Acc Id: NM_012573   ⟹   NP_036705
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2105,630,684 - 6,043,341 (+)NCBI
Rnor_6.0105,707,806 - 6,119,897 (+)NCBI
Rnor_5.0104,523,233 - 4,940,912 (+)NCBI
RGSC_v3.4105,588,229 - 6,004,780 (+)RGD
Celera104,645,710 - 5,048,399 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036705   ⟸   NM_012573
- Peptide Label: precursor
- UniProtKB: Q00959 (UniProtKB/Swiss-Prot),   G3V9C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042235   ⟸   ENSRNOT00000044626
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00959-F1-model_v2 AlphaFold Q00959 1-1464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2737 AgrOrtholog
BioCyc Gene G2FUF-26122 BioCyc
Ensembl Genes ENSRNOG00000033942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042235 ENTREZGENE
  ENSRNOP00000042235.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044626 ENTREZGENE
  ENSRNOT00000044626.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24409 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin2a PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V9C5 ENTREZGENE, UniProtKB/TrEMBL
  NMDE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CGM3_RAT UniProtKB/TrEMBL
UniProt Secondary O08948 UniProtKB/Swiss-Prot
  Q63728 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2a  glutamate ionotropic receptor NMDA type subunit 2A  Grin2a  glutamate receptor, ionotropic, N-methyl D-aspartate 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grin2a  glutamate receptor, ionotropic, N-methyl D-aspartate 2A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression colocalized with cdk 5 in cerebral cortex, hipppocampus 69667
gene_expression expressed in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_expression expressed abundantly in hypothalamus in females of all ages 625682
gene_function N-methyl-D-aspartate (NMDA) class, glutamate receptor subunit 69667
gene_process modulates neuronal function of N-methyl-D-aspartate (NMDA) 69667
gene_process may play a role in synaptic transmission 69667
gene_process receptor for glutamate that influences reproductive physiology in females 625682
gene_regulation phosphorylated by various kinases such as PKC, cdk5 and Fyn (a tyrosine kinase) 69667