DOPAMINE SIGNALING PATHWAY (PW:0000394)

View Ontology Report

Description

Dopamine (DA) acts a neurotransmitter and neuromodulator in the brain and peripherally as an autocrine/paracrine hormone. Dopamine exerts its major role in the nervous system where it is involved in motor control and action selection, reward and motivation, behavior, memory and cognition. The many effects are achieved through the projections dopaminergic (DA-producing) neurons establish and the inputs they receive and which shape DA release. DA neurons in midbrain areas such as the substantia ni

Pathway Diagram:

Elsevier Inc. Ptpn5 ventral tegmental area (VTA) <--> prefrontal cortex (PFC) substantia nigra pars compacta (SNc) ---> prefrontal cortex (PFC) ventral tegmental area (VTA) substantia nigra pars compacta (SNc) dopamine dopamine biosynthetic pathway Gnao1 Gnai2 Gnal G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphai family D1-like receptor Arrb2 ---> G protein independent DA signaling D2-like receptor ventral tegmental area (VTA) <--> nucleus accumbens (NAc) substantia nigra pars compacta (SNc) ---> dorsal striatum/caudate-putamen D1-like receptor ---- dopamine D2-like receptor ---- dopamine DA receptor heteromer ---- dopamine Ca2+ protein kinase C (PKC) signaling pathway calcium/calcium-mediated signaling pathway calcium transport pathway protein kinase A (PKA) signaling pathway Ppp1r1b kinases/phosphatases nucleus accumbens (NAc) prefrontal cortex (PFC) the extracellular signal-regulated Raf/Mek/Erk signaling pathway G protein mediated signaling pathway via Galphaq family thalamus --+> cortical areas DA receptor heteromer cortical areas G protein independent DA signaling motivation prefrontal cortex (PFC) --+> nucleus accumbens (NAc) reward action selection, motor function substantia nigra pars reticulata (SNr) ---| thalamus nucleus accumbens (NAc) ---> ventral pallidum (VP) ventral pallidum (VP) ---> cortical areas GRK in DA signaling Ppp1c Ptpn5 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ppp1c --+> Ptpn5 globus pallidus, external (GPe) subthalamic nucleus (STN) --+> substantia nigra pars reticulata (SNr) subthalamic nucleus (STN) thalamus Ppp1r1b kinases/phosphatases ---> Ppp1r1b Ppp1r1b ---> protein kinase A (PKA) signaling pathway protein kinase A (PKA) signaling pathway ---> Ppp1r1b GRK in DA signaling ---> D2-like receptor cortical areas --+> dorsal striatum/caudate-putamen dorsal striatum/caudate-putamen globus pallidus, external (GPe) ---| subthalamic nucleus (STN) Ppp1r1b ---| Ppp1c dorsal striatum/caudate-putamen ---| substantia nigra pars reticulata (SNr) dorsal striatum/caudate-putamen ---| globus pallidus, external (GPe) Ppp1r1b kinases/phosphatases ---> Ppp1r1b nucleus accumbens (NAc) ---> substantia nigra pars reticulata (SNr) diacylglycerol --+> protein kinase C (PKC) signaling pathway Arrb2 ---- D1-like receptor Arrb2 ---- D2-like receptor Arrb1 ---- D1-like receptor Arrb1 Arrb1 ---- D2-like receptor GRK in DA signaling ---> D1-like receptor Arrb2 Ppp1r1b cortical areas --+> nucleus accumbens (NAc) RGS in DA signaling ---| Gnal RGS in DA signaling ---| Gnai2 RGS in DA signaling RGS in DA signaling ---| Gnao1 cAMP --+> protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family --+> Adcy5 ATP ---> cAMP Adcy5 G protein mediated signaling pathway via Galphai family ---| Adcy5 IP3 --+> Ca2+ G protein mediated signaling pathway via Galphaq family --+> IP3 G protein mediated signaling pathway via Galphaq family --+> diacylglycerol substantia nigra pars reticulata (SNr) associative learning cognitive flexibility working memory ventral pallidum (VP) ATP cAMP IP3 diacylglycerol
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Genes in Pathway:

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dopamine signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:11041163
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:11041163
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1625010
RGD:11041142
RGD:1600981
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1581445
RGD:11041142
RGD:1625068
RGD:1625010
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1625068
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1625010
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:1600981
RGD:11041142
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:11041163
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:11041163
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:11041163
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B JBrowse link 10 86,303,727 86,312,770 RGD:11041163
RGD:11041134
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:11041163
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:11041163
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha JBrowse link 8 109,481,352 109,621,462 RGD:11041163
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta JBrowse link 9 16,580,995 16,610,425 RGD:11041163
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:11041163
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:11041163
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:11041163
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:11041163
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:11041163
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:11041134
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1581410
dopamine signaling pathway via D1 family of receptors term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:10402751
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:11041137
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:11041134
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:11041134
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:11041134
RGD:10402751
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:11041134
G Gnal G protein subunit alpha L JBrowse link 18 62,805,406 62,946,133 RGD:11041135
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:10402751
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:10402751
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:10402751
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:11041134
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:11041134
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:11041134
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:11041134
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:10402751
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:11041134
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:11041134
G Rgs7 regulator of G-protein signaling 7 JBrowse link 13 93,095,659 93,534,452 RGD:11041134
G Rgs7bp regulator of G-protein signaling 7 binding protein JBrowse link 2 35,072,081 35,619,085 RGD:11041134
G Rgs9 regulator of G-protein signaling 9 JBrowse link 10 97,509,971 97,582,188 RGD:11041134
dopamine signaling pathway via D2 family of receptors term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:11041137
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:11041134
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:11041134
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:11041134
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:11041134
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:11041134
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:11041136
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:11041136
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:11041134
RGD:13792715
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:11041134
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:11041134
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:11041134
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:11041134
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:11041134
G Rgs7 regulator of G-protein signaling 7 JBrowse link 13 93,095,659 93,534,452 RGD:11041134
G Rgs7bp regulator of G-protein signaling 7 binding protein JBrowse link 2 35,072,081 35,619,085 RGD:11041134
G Rgs9 regulator of G-protein signaling 9 JBrowse link 10 97,509,971 97,582,188 RGD:11041134

Pathway Gene Annotations

Disease Annotations Associated with Genes in the dopamine signaling pathway
Disease TermsGene Symbols
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsPrkaca
adult T-cell leukemiaCsnk1a1
AlbuminuriaDrd1
alcohol use disorderDrd2
Alcoholic IntoxicationDrd2
Alzheimer's diseaseCdk5 , Csnk1a1 , Drd1 , Drd2 , Drd3 , Drd4 , Drd5 , Ptpn5
amnestic disorderDrd3
amphetamine abuseDrd1 , Drd2 , Drd3 , Drd4
amyotrophic lateral sclerosisCdk5
antisocial personality disorderDrd4
anxiety disorderDrd2
aortic valve stenosisPpp3cb
asthmaPpp2ca
atrial fibrillationPpp2r3a
Attention Deficit and Disruptive Behavior DisordersDrd4
attention deficit hyperactivity disorderDrd2 , Drd4 , Drd5
autistic disorderDrd1 , Drd3
autonomic nervous system diseaseDrd4
autosomal dominant non-syndromic intellectual disability 35Ppp2r5d
autosomal recessive polycystic kidney diseaseSrc
basal ganglia diseaseDrd2 , Drd3
Benign Essential BlepharospasmDrd5
biliary tract benign neoplasmPrkacb
Binge-Eating DisorderDrd1 , Drd2 , Drd4
bipolar disorderDrd1 , Drd5 , Ppp1r1b
blepharospasmDrd5
BradycardiaDrd2
Brain ConcussionDrd2 , Drd3 , Drd4
Brain InjuriesDrd2 , Ppp3ca
Brain Injuries, TraumaticDrd1 , Drd2
brain ischemiaCdk5 , Drd2 , Prkaca , Prkacb , Src
Breast NeoplasmsSrc
CardiomegalyPpp3ca , Src
CatalepsyDrd1 , Drd2 , Ppp1r1b
cervical dystoniaDrd5
cholangiocarcinomaPrkaca , Prkacb
cocaine dependenceDrd2
Cocaine-Related DisordersCdk5 , Drd1 , Drd2 , Drd3
cognitive disorderDrd2 , Drd3
colitisSrc
colon cancerSrc
Colonic NeoplasmsSrc
colorectal cancerSrc
Colorectal NeoplasmsSrc
conduct disorderDrd4
congestive heart failurePpp1ca , Ppp1cc , Ppp2ca , Prkaca
Craniofacial AbnormalitiesCsnk1a1
dementiaDrd2
Developmental DisabilitiesDrd2
Diabetes Mellitus, Experimental Drd1 , Drd2
dilated cardiomyopathyPpp1ca , Ppp3ca
disease of cellular proliferationSrc
drug psychosisDrd2
Drug-Induced DyskinesiaDrd1 , Drd2 , Drd3 , Ppp1r1b
ductal carcinoma in situSrc
DyskinesiasDrd2 , Ppp1r1b
dyslexiaDrd4
dystoniaDrd2
end stage renal failureDrd1 , Drd2
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOODPpp3ca
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1Ppp3ca
essential tremorDrd3
Experimental ArthritisDrd1 , Drd2
Experimental Liver NeoplasmsPpp2ca
FeverDrd1
focal segmental glomerulosclerosisPpp3ca , Ppp3cb
genetic diseasePpp2r5d , Ppp3ca
Gilles de la Tourette syndromeDrd2 , Drd3 , Drd4
heart diseasePpp2ca
Hereditary Neoplastic SyndromesCsnk1a1 , Ppp2ca
heroin dependenceDrd1 , Drd2 , Drd3
HIV EncephalitisCdk5
Huntington's diseaseDrd1 , Drd2 , Drd3 , Drd5 , Ppp1r1b , Ppp3ca
HyperalgesiaDrd3 , Ppp2ca
hyperglycemiaDrd1
HyperkinesisDrd1 , Drd2 , Drd3
hyperprolactinemiaDrd2
hypertensionDrd1 , Drd2 , Drd3 , Drd5 , Src
hypertrophic cardiomyopathyPrkaca
Hypoglossal Nerve InjuriesPrkaca , Prkacb
HypotensionDrd1 , Drd2
Hypoxia-Ischemia, BrainPpp1r1b , Ptpn5
impulse control disorderDrd2 , Drd3
inclusion body myositisCsnk1a1
InflammationCdk5
Insulin ResistanceDrd1
intellectual disabilityDrd4
Intracranial HemorrhagesPpp1r1b
keratoconusPpp3cc
kidney diseasePpp3ca
kidney failureDrd1
Kidney Reperfusion InjuryDrd3 , Src
language disorderDrd2
Left Ventricular HypertrophyPpp3ca , Ppp3cb
LISSENCEPHALY 7 WITH CEREBELLAR HYPOPLASIACdk5
long QT syndromeCdk5
melanomaPpp2ca
Memory DisordersDrd2
mental depressionCdk5 , Drd1 , Drd2 , Drd5 , Ppp1r1b
middle cerebral artery infarctionCdk5
migraine with auraDrd2
morphine dependenceDrd2
movement diseaseDrd1 , Drd2 , Drd3
Myocardial IschemiaPpp2ca
myoclonic dystoniaDrd2
NeointimaDrd4
Neoplasm InvasivenessSrc
Neoplasm MetastasisSrc
Nerve DegenerationPtpn5
NeuralgiaDrd1 , Drd2
Neurodevelopmental DisordersPpp2r5d
Nocturnal EnuresisDrd4
nonalcoholic fatty liver diseasePrkaca
Noonan Syndrome-Like Disorder with Loose Anagen Hair 2Ppp1cb
Novelty Seeking Personality TraitDrd4
obesityDrd1 , Drd2 , Drd4
Optic Nerve InjuriesPtpn5
ovarian hyperstimulation syndromeDrd2
Ovarian NeoplasmsPpp1cc
PainDrd2
pancreatitisPpp3ca
Parkinson's diseaseDrd1 , Drd2 , Drd3 , Drd5 , Ppp2ca
Parkinsonian DisordersDrd2 , Drd3 , Src
pathological gamblingDrd3 , Drd4
Pervasive Child Development DisordersDrd4 , Drd5
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary NeoplasmsDrd2
primary hyperaldosteronismDrd2
primary pigmented nodular adrenocortical diseasePrkaca
prostate cancerPpp2ca
Prostatic NeoplasmsPpp2ca , Ppp3ca , Prkacb , Src
psychotic disorderDrd5
Reperfusion InjuryPpp3ca , Ppp3cb , Src
restless legs syndromeDrd3
Right Ventricular HypertrophyPpp3ca , Ppp3cb
schizophreniaDrd1 , Drd2 , Drd3 , Drd4 , Ppp1r1b , Ppp3ca , Ppp3cb , Ppp3cc
separation anxiety disorderDrd4
Sleep DeprivationDrd1
Smith-Magenis syndromePpp1r1b
Spinal Cord InjuriesPpp1cc
Spinal Cord Reperfusion InjuryCdk5
status epilepticusPpp1r1b , Src
StrokeSrc
substance-related disorderDrd2
TachycardiaDrd2
Tardive DyskinesiaDrd3
tauopathyCdk5 , Ppp2r5d
testicular diseasePpp3ca
THROMBOCYTOPENIA 6Src
tic disorderDrd4
TicsDrd4
Tobacco Use DisorderDrd2
toxic encephalopathyDrd2
tracheal stenosisDrd1
transient cerebral ischemiaCdk5 , Ptpn5
Tremor Hereditary Essential, 1Drd3
trigeminal neuralgiaCdk5
type 2 diabetes mellitusDrd2 , Ppp2ca , Src
ureteral obstructionDrd1
urinary bladder cancerSrc
vascular dementiaCdk5
Ventricular TachycardiaPpp3ca
visual epilepsyDrd1 , Drd2 , Drd3
Weight GainDrd2
Williams-Beuren syndromeSrc
Wilson diseasePpp3ca , Ppp3cb
withdrawal disorderDrd1 , Drd2 , Ppp1r1b
Pathway Annotations Associated with Genes in the dopamine signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp1cb , Ppp2ca
adenosine signaling pathwayPrkacb
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
alfentanil pharmacodynamics pathwayDrd1
altered Reelin signaling pathwaySrc
Alzheimer's disease pathwayCdk5 , Ppp3ca , Ppp3cb , Ppp3cc
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
amyotrophic lateral sclerosis pathwayPpp3ca , Ppp3cb , Ppp3cc
apoptotic cell death pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca , Prkacb
bisoprolol pharmacodynamics pathwayPrkaca
Bone morphogenetic proteins signaling pathwayPpp1ca
bupivacaine pharmacodynamics pathwayDrd1
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
buprenorphine pharmacodynamics pathwayDrd1
calcineurin signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
calcium/calcium-mediated signaling pathwayDrd1 , Drd5 , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
calcium/calmodulin dependent kinase 2 signaling pathwayPpp1cc , Ppp2ca
carvedilol pharmacodynamics pathwayPrkaca
Chagas disease pathwayPpp2ca , Ppp2cb
chemokine mediated signaling pathwayPrkaca , Prkacb
chloroprocaine pharmacodynamics pathwayDrd1
citalopram pharmacodynamics pathwayDrd1
cocaine pharmacodynamics pathwayDrd1
codeine and morphine pharmacodynamics pathwayDrd1
desipramine pharmacodynamics pathwayDrd1
dilated cardiomyopathy pathwayPrkaca , Prkacb
diltiazem pharmacodynamics pathwayPrkaca
diphenoxylate pharmacodynamics pathwayDrd1
disopyramide pharmacodynamics pathwayPrkaca
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayCdk5 , Csnk1a1 , Drd1 , Drd2 , Drd3 , Drd4 , Drd5 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r1b , Ppp2ca , Ppp2cb , Ppp2r3a , Ppp2r5d , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb , Ptpn5 , Src
dopamine signaling pathway via D1 family of receptorsDrd1 , Drd5 , Prkacb
dopamine signaling pathway via D2 family of receptorsDrd2 , Drd3 , Drd4
E-cadherin signaling pathwaySrc
eicosanoid signaling pathwayPrkaca , Src
endocytosis pathwaySrc
endothelin signaling pathwaySrc
Entamoebiasis pathwayPrkaca , Prkacb
ephrin - ephrin receptor bidirectional signaling axisCdk5 , Src
epidermal growth factor/neuregulin signaling pathwaySrc
escitalopram pharmacodynamics pathwayDrd1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwaySrc
ethylmorphine pharmacodynamics pathwayDrd1
excitatory synaptic transmission pathwayDrd2 , Drd4
FasL mediated signaling pathwaySrc
fentanyl pharmacodynamics pathwayDrd1
fibroblast growth factor signaling pathwaySrc
flecainde pharmacodynamics pathwayPrkaca
fluoxetine pharmacodynamics pathwayDrd1
follicle-stimulating hormone signaling pathwayPpp1ca , Prkacb
fosphenytoin pharmacodynamics pathwayPrkaca
G protein mediated signaling pathway via Galphai familyDrd2 , Drd3 , Drd4
G protein mediated signaling pathway via Galphaq familyDrd1 , Drd2 , Drd5
G protein mediated signaling pathway via Galphas familyDrd1 , Drd5
glutamate signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
glycogen biosynthetic pathwayPpp1ca , Ppp1cb , Ppp1cc
glycogen degradation pathwayPpp1ca , Ppp1cb , Ppp1cc
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayPrkaca , Prkacb , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayPrkaca , Prkacb
Hedgehog signaling pathwayCsnk1a1 , Prkaca , Prkacb
hepatitis C pathwayPpp2ca , Ppp2cb
heroin pharmacodynamics pathwayDrd1
histamine signaling pathway, immunologicalPpp1ca , Prkacb
hydrocodone pharmacodynamics pathwayDrd1
hydromorphone pharmacodynamics pathwayDrd1
ibutilide pharmacodynamics pathwayPrkaca
imipramine pharmacodynamics pathwayDrd1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPpp1cc
insulin signaling pathwayPpp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb
interleukin-12 signaling pathwayPpp3ca , Ppp3cb
interleukin-2 signaling pathwayPpp2r5d
interleukin-3 signaling pathwayPrkaca , Prkacb
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
levacetylmethadol pharmacodynamics pathwayDrd1
levobunolol pharmacodynamics pathwayPrkaca
levobupivacaine phgarmacodynamics pathwayDrd1
levorphanol pharmacodynamics pathwayDrd1
lidocaine pharmacodynamics pathwayDrd1 , Prkaca
long term depressionDrd1 , Drd5 , Ppp2ca , Ppp2cb
long term potentiationDrd1 , Drd5 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
luteinizing hormone signaling pathwayPpp1ca , Prkacb
melanocortin system pathwayPrkacb
mepivacaine pharmacodynamics pathwayDrd1
methadone pharmacodynamics pathwayDrd1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb , Ptpn5
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r3a , Ppp2r5d
nadolol pharmacodynamics pathwayPrkaca
nalbuphine pharmacodynamics pathwayDrd1
naloxone pharmacodynamics pathwayDrd1
naltrexone pharmacodynamics pathwayDrd1
nebivolol pharmacodynamics pathwayPrkaca
nerve growth factor signaling pathwaySrc
nicotine pharmacodynamics pathwayDrd1
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
nuclear factor kappa B signaling pathwaySrc
oxybuprocaine pharmacodynamics pathwayDrd1
oxycodone pharmacodynamics pathwayDrd1
oxymorphone pharmacodynamics pathwayDrd1
p53 signaling pathwayCsnk1a1 , Ppp2ca
penbutolol pharmacodynamics pathwayPrkaca
pentazocine pharmacodynamics pathwayDrd1
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwaySrc
phosphatidylinositol 3-kinase-Akt signaling pathwayPpp2ca , Ppp2cb , Prkaca , Src
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayPpp2ca , Src
prilocaine pharmacodynamics pathwayDrd1
prion disease pathwayPrkaca , Prkacb
procainamide pharmacodynamics pathwayPrkaca
procaine pharmacodynamics pathwayDrd1
propranolol pharmacodynamics pathwayPrkaca
prostaglandin D2 signaling pathwayPrkacb
prostaglandin I2 signaling pathwayPrkacb
protein kinase A (PKA) signaling pathwayPrkaca , Prkacb
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayCdk5 , Src
remifentanil pharmacodynamics pathwayDrd1
ropivacaine pharmacodynamics pathwayDrd1
scatter factor/hepatocyte growth factor signaling pathwaySrc
schizophrenia pathwayPpp3cc
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca , Prkacb
signaling pathway pertinent to the brain and nervous systemSrc
somatostatin signaling pathwaySrc
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwaySrc
syndecan signaling pathwayPrkaca , Src
T cell receptor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc
timolol pharmacodynamics pathwayPrkaca
tramadol pharmacodynamics pathwayDrd1
transforming growth factor-beta Smad dependent signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca , Ppp2cb
tuberculosis pathwayPpp3ca , Ppp3cb , Ppp3cc , Src
ubiquitin/proteasome degradation pathwaySrc
vascular endothelial growth factor signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Src
vasopressin signaling pathway via receptor type 2Prkaca , Prkacb
verapamil pharmacodynamics pathwayPrkaca
Wnt signaling pathwayCsnk1a1 , Ppp2ca , Ppp2cb , Ppp2r5d , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
Wnt signaling, canonical pathwayCsnk1a1
Wnt signaling, non-canonical pathwayCsnk1a1
Phenotype Annotations Associated with Genes in the dopamine signaling pathway

References Associated with the dopamine signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: