RGD Reference Report - Prolactin receptor is associated with c-src kinase in rat liver. - Rat Genome Database

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Prolactin receptor is associated with c-src kinase in rat liver.

Authors: Berlanga, J J  Fresno Vara, J A  Martín-Pérez, J  García-Ruiz, J P 
Citation: Berlanga JJ, etal., Mol Endocrinol. 1995 Nov;9(11):1461-7. doi: 10.1210/mend.9.11.8584023.
RGD ID: 150524325
Pubmed: PMID:8584023   (View Abstract at PubMed)
DOI: DOI:10.1210/mend.9.11.8584023   (Journal Full-text)

The mechanism of action of the pituitary hormone PRL was studied in hepatocytes of lactating rats. PRL receptor immune complexes obtained from liver lysates have an associated tyrosine kinase activity. The tyrosine kinase has been identified in isolated hepatocytes as pp60c-src. Incubation of hepatocytes with PRL induces the association of PRL receptor with pp60c-src and the resultant stimulation of its tyrosine kinase activity. Furthermore, PRL stimulates the gene expression of c-fos, c-jun, and c-src. All of these findings support the idea that the pp60c-src tyrosine kinase participates in the early steps of the PRL intracellular signaling that promotes cell growth in liver cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FosRatcellular response to prolactin  IEP  RGD 
JunRatcellular response to prolactin  IEP  RGD 
SrcRatcellular response to prolactin  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fos  (Fos proto-oncogene, AP-1 transcription factor subunit)
Jun  (Jun proto-oncogene, AP-1 transcription factor subunit)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)


Additional Information