Jun (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Jun (Jun proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2943
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to starvation; positive regulation of nucleobase-containing compound metabolic process; and response to peptide hormone. Part of chromatin. Used to study hypertension. Biomarker of depressive disorder and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; jun proto-oncogene; proto-oncogene c-jun; transcription factor AP-1; transcription factor AP-1 subunit Jun; transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Ciaa5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (EXP)
1,4-dithiothreitol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-aminobenzamide  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-tert-Octylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
9H-xanthine  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
AP20187  (ISO)
Apicularen A  (ISO)
apigenin  (ISO)
apocynin  (ISO)
apomorphine  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
auraptene  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
bacitracin  (EXP)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
benzophenanthridine  (ISO)
Benzoyl peroxide  (ISO)
benzyl isothiocyanate  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium sulfate  (ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bromodichloromethane  (EXP)
bucladesine  (ISO)
budesonide  (EXP)
bufalin  (ISO)
buspirone  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
Calphostin C  (EXP)
camostat  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
Cannabinol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
Carnosol  (EXP)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
Cinobufagin  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
D-glucitol  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
daidzein  (ISO)
DDE  (EXP)
DDT  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (EXP)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrolipoic acid  (EXP)
diiodine  (EXP)
Dimaprit  (ISO)
dimemorfan  (EXP,ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
Erionite  (EXP)
erythrosin B  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (EXP)
estriol  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
etoxazole  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fentin chloride  (EXP)
ferric oxide  (EXP)
ferrosoferric oxide  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
Flavokawain A  (ISO)
flavonol  (ISO)
flufenoxuron  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fotemustine  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP,ISO)
galactose  (ISO)
gallic acid  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glycitein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
haloperidol  (EXP)
hemin  (EXP,ISO)
heparin  (ISO)
heptachlor  (ISO)
herbimycin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP,ISO)
hyperforin  (ISO)
icariin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
Isorhapontigenin  (EXP)
kaempferol  (ISO)
kainic acid  (EXP)
kanamycin A  (EXP)
ketamine  (EXP)
kojic acid  (ISO)
KT 5720  (ISO)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lanthanum atom  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
limonene  (ISO)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lithocholic acid  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP,ISO)
maneb  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
maslinic acid  (ISO)
masoprocol  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
melittin  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methohexital  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metoprolol  (EXP)
metyrapone  (EXP)
mevinphos  (EXP)
Mezerein  (ISO)
mibolerone  (ISO)
microcystin-LR  (ISO)
minocycline  (ISO)
miquelianin  (ISO)
mitoxantrone  (ISO)
ML-7  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP,ISO)
morin  (EXP)
morphine  (ISO)
morusin  (ISO)
Muconic dialdehyde  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-feruloyltyramine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP,ISO)
neocuproine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nilotinib  (ISO)
nimodipine  (EXP)
nimustine  (ISO)
nitric oxide  (EXP)
nitrofurantoin  (EXP)
nitrofurazone  (EXP)
nitrogen dioxide  (EXP)
nitroprusside  (EXP)
nocodazole  (ISO)
Nodularin  (ISO)
Nonylphenol  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olmesartan  (ISO)
oltipraz  (ISO)
omipalisib  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (ISO)
oxybutynin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP,ISO)
palytoxin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
patulin  (EXP,ISO)
PD 0325901  (EXP)
pent-4-enoic acid  (EXP)
pentobarbital  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 12,13-dibutanoate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosphane  (EXP)
phylloquinone  (ISO)
physostigmine  (EXP)
piperine  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prazosin  (EXP)
prednisolone  (EXP)
prednisone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propofol  (EXP)
prostaglandin J2  (ISO)
protein kinase inhibitor  (EXP)
pterostilbene  (ISO)
pyridine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Riluzole  (EXP)
ritonavir  (ISO)
Ro 31-8220  (EXP,ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
saccharin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
sclareol  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
secobarbital  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP,ISO)
sertraline  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sodium hydroxide  (EXP)
Sodium salicylate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (EXP)
stavudine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
taurine  (EXP)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
tetrodotoxin  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiopental  (ISO)
thiourea  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
tofacitinib  (ISO)
topotecan  (EXP,ISO)
torcetrapib  (ISO)
trametinib  (ISO)
transplatin  (ISO)
triacsin C  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
trioxsalen  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tungsten  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
undecane  (EXP)
urethane  (ISO)
Urolithin A  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
Vernodalin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
wogonin  (ISO)
xanthones  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP,ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
cell population proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to calcium ion  (ISO)
cellular response to hypoxia  (IEP)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion starvation  (IMP)
cellular response to prolactin  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to zinc ion starvation  (IEP)
circadian rhythm  (IEP)
DNA-templated transcription  (IDA)
eyelid development in camera-type eye  (ISO)
immune response  (ISO)
leading edge cell differentiation  (ISO)
learning  (IMP)
liver development  (ISO)
membrane depolarization  (IDA)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA replication  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of DNA-templated transcription initiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of monocyte differentiation  (IDA)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of cell cycle  (IBA,ISO)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
release from viral latency  (ISO)
release of cytochrome c from mitochondria  (IMP)
response to cAMP  (IEP)
response to cytokine  (IEP)
response to endoplasmic reticulum stress  (ISO)
response to ethanol  (IEP)
response to hydrogen peroxide  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to muscle stretch  (ISO)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (IMP,TAS)
transforming growth factor beta receptor signaling pathway  (ISO)

References

References - curated
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34. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Kreutz MR, etal., Brain Res Mol Brain Res. 1999 Jun 8;69(2):232-41.
35. A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complex. Levkovitz Y and Baraban JM, J Neurosci. 2002 May 15;22(10):3845-54.
36. Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. Levy AM, etal., J Virol. 2003 Dec;77(23):12841-51.
37. Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network. Li CW, etal., Thorax. 2009 Apr;64(4):306-12. Epub 2009 Jan 21.
38. Differentiation of WEHI-3B D+ myelomonocytic leukemia cells induced by ectopic expression of the protooncogene c-jun. Li J, etal., Cell Growth Differ. 1994 Jul;5(7):743-51.
39. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
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42. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. Mathas S, etal., EMBO J 2002 Aug 1;21(15):4104-13.
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44. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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46. Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. Moraes JC, etal., FEBS Lett. 2006 Aug 21;580(19):4625-31. doi: 10.1016/j.febslet.2006.07.042. Epub 2006 Jul 21.
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48. Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels. Müller I, etal., Mol Pharmacol. 2011 Dec;80(6):1179-89. doi: 10.1124/mol.111.074781. Epub 2011 Sep 23.
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50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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59. GOA pipeline RGD automated data pipeline
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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68. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
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70. Distinct Expression of c-Jun and HSP27 in Axotomized and Spared Bulbospinal Neurons After Cervical Spinal Cord Injury. Vinit S, etal., J Mol Neurosci. 2010 Dec 4.
71. c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Vleugel MM, etal., Hum Pathol. 2006 Jun;37(6):668-74.
72. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.
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74. Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Williams JM, etal., Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.
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76. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
77. Prolonged c-Jun expression in the basolateral amygdala following bulbectomy: possible implications for antidepressant activity and time of onset. Wrynn AS, etal., Brain Res Mol Brain Res. 2000 Mar 10;76(1):7-17.
78. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. Xu Z, etal., EMBO J. 2003 Jan 15;22(2):252-61.
79. c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells. Yu Y, etal., Circulation. 2001 Sep 25;104(13):1557-63.
80. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Yuan Z, etal., Mol Cell Biol. 2009 May;29(9):2431-42. doi: 10.1128/MCB.01344-08. Epub 2009 Mar 2.
81. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. Zhang G, etal., J Natl Cancer Inst. 2004 May 5;96(9):683-96.
82. 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. Zhang H, etal., Am J Respir Cell Mol Biol. 2006 Feb;34(2):174-81. Epub 2005 Sep 29.
83. Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells. Zhang S, etal., J Mol Biol 2002 Nov 22;324(2):271-85.
Additional References at PubMed
PMID:1651323   PMID:2833704   PMID:8662824   PMID:8889548   PMID:9098922   PMID:9651196   PMID:9710592   PMID:9732876   PMID:9847304   PMID:10076871   PMID:10352021   PMID:10508860  
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PMID:20421303   PMID:20442316   PMID:20501438   PMID:20852630   PMID:20942268   PMID:20945380   PMID:21063128   PMID:21092560   PMID:21113145   PMID:21118817   PMID:21179834   PMID:21180051  
PMID:21181362   PMID:21624330   PMID:21818553   PMID:21925583   PMID:22097274   PMID:22229265   PMID:22379036   PMID:22402332   PMID:22611921   PMID:22634325   PMID:22644775   PMID:22681889  
PMID:23027619   PMID:23382074   PMID:23398888   PMID:23506737   PMID:23585120   PMID:23818969   PMID:23870463   PMID:23918802   PMID:23992404   PMID:24225225   PMID:24342046   PMID:24375836  
PMID:24421392   PMID:24492282   PMID:24623306   PMID:24755082   PMID:24877090   PMID:25062485   PMID:25098198   PMID:25100604   PMID:25110868   PMID:25148934   PMID:25224220   PMID:25476526  
PMID:25609649   PMID:26514923   PMID:26875149   PMID:27194296   PMID:27220977   PMID:27239846   PMID:27458160   PMID:27458189   PMID:28100486   PMID:28701355   PMID:29225069   PMID:29257252  
PMID:29339068   PMID:29440459   PMID:30277501   PMID:31376136   PMID:32518215   PMID:33086033   PMID:33278012   PMID:33760331   PMID:35906072   PMID:36713029  


Genomics

Comparative Map Data
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Jun
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000011731
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat

Markers in Region
D5Mgh23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,897,808 - 109,897,936 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,818 - 114,014,945NCBIRnor6.0
Rnor_5.05117,961,364 - 117,961,491UniSTSRnor5.0
RGSC_v3.45115,361,799 - 115,361,927RGDRGSC3.4
RGSC_v3.45115,361,800 - 115,361,927UniSTSRGSC3.4
RGSC_v3.15115,367,025 - 115,367,153RGD
Celera5108,513,674 - 108,513,801UniSTS
RH 3.4 Map5779.4UniSTS
RH 3.4 Map5779.4RGD
RH 2.0 Map5702.5RGD
Cytogenetic Map5q34.1UniSTS
D5Lev15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,810 - 109,895,102 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,820 - 114,012,111NCBIRnor6.0
Rnor_5.05117,958,366 - 117,958,657UniSTSRnor5.0
RGSC_v3.45115,358,802 - 115,359,093UniSTSRGSC3.4
Celera5108,510,676 - 108,510,967UniSTS
Cytogenetic Map5q34.1UniSTS
D5Arb17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,897,663 - 109,897,907 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,673 - 114,014,916NCBIRnor6.0
Rnor_5.05117,961,219 - 117,961,462UniSTSRnor5.0
RGSC_v3.45115,361,654 - 115,361,898RGDRGSC3.4
RGSC_v3.45115,361,655 - 115,361,898UniSTSRGSC3.4
RGSC_v3.15115,366,880 - 115,367,124RGD
Celera5108,513,529 - 108,513,772UniSTS
Cytogenetic Map5q34.1UniSTS
PMC129043P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,897,364 - 109,897,655 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,374 - 114,014,664NCBIRnor6.0
Rnor_5.05117,960,920 - 117,961,210UniSTSRnor5.0
RGSC_v3.45115,361,356 - 115,361,646UniSTSRGSC3.4
Celera5108,513,230 - 108,513,520UniSTS
Cytogenetic Map5q34.1UniSTS
Jun  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,896,604 - 109,897,030 (+)MAPPERmRatBN7.2
Rnor_6.05114,013,614 - 114,014,039NCBIRnor6.0
Rnor_5.05117,960,160 - 117,960,585UniSTSRnor5.0
RGSC_v3.45115,360,596 - 115,361,021UniSTSRGSC3.4
Celera5108,512,470 - 108,512,895UniSTS
Cytogenetic Map5q34.1UniSTS
RH142347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,384 - 109,894,576 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,394 - 114,011,585NCBIRnor6.0
Rnor_5.05117,957,940 - 117,958,131UniSTSRnor5.0
RGSC_v3.45115,358,376 - 115,358,567UniSTSRGSC3.4
Celera5108,510,250 - 108,510,441UniSTS
RH 3.4 Map5777.2UniSTS
Cytogenetic Map5q34.1UniSTS
PMC152658P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,800 - 109,895,148 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,810 - 114,012,157NCBIRnor6.0
Rnor_5.05117,958,356 - 117,958,703UniSTSRnor5.0
RGSC_v3.45115,358,792 - 115,359,139UniSTSRGSC3.4
Celera5108,510,666 - 108,511,013UniSTS
Cytogenetic Map5q34.1UniSTS
AI407572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,371 - 109,894,486 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,381 - 114,011,495NCBIRnor6.0
Rnor_5.05117,957,927 - 117,958,041UniSTSRnor5.0
RGSC_v3.45115,358,363 - 115,358,477UniSTSRGSC3.4
Celera5108,510,237 - 108,510,351UniSTS
RH 3.4 Map5779.4UniSTS
Cytogenetic Map5q34.1UniSTS
PMC153970P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,895,405 - 109,895,561 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,415 - 114,012,570NCBIRnor6.0
Rnor_5.05117,958,961 - 117,959,116UniSTSRnor5.0
RGSC_v3.45115,359,397 - 115,359,552UniSTSRGSC3.4
Celera5108,511,271 - 108,511,426UniSTS
Cytogenetic Map5q34.1UniSTS
UniSTS:256946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,895,884 - 109,896,151 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,894 - 114,013,160NCBIRnor6.0
Rnor_5.05117,959,440 - 117,959,706UniSTSRnor5.0
RGSC_v3.45115,359,876 - 115,360,142UniSTSRGSC3.4
Celera5108,511,750 - 108,512,016UniSTS
Cytogenetic Map5q34.1UniSTS
PMC55707P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,895,405 - 109,896,410 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,415 - 114,013,419NCBIRnor6.0
Rnor_5.05117,958,961 - 117,959,965UniSTSRnor5.0
RGSC_v3.45115,359,397 - 115,360,401UniSTSRGSC3.4
Celera5108,511,271 - 108,512,275UniSTS
Cytogenetic Map5q34.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 32 22 9 22 8 11 74 35 34 11 8
Low 25 19 10 19 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000011731   ⟹   ENSRNOP00000011732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)Ensembl
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)Ensembl
RefSeq Acc Id: NM_021835   ⟹   NP_068607
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85115,009,900 - 115,012,993 (-)NCBI
mRatBN7.25109,894,175 - 109,897,268 (-)NCBI
Rnor_6.05114,011,184 - 114,014,277 (-)NCBI
Rnor_5.05117,957,730 - 117,960,823 (-)NCBI
RGSC_v3.45115,358,166 - 115,361,259 (-)RGD
Celera5108,510,040 - 108,513,133 (-)RGD
Sequence:
RefSeq Acc Id: NP_068607   ⟸   NM_021835
- UniProtKB: P17325 (UniProtKB/Swiss-Prot),   A6JRH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011732   ⟸   ENSRNOT00000011731
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17325-F1-model_v2 AlphaFold P17325 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693844
Promoter ID:EPDNEW_R4369
Type:multiple initiation site
Name:Jun_1
Description:Jun proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05114,014,339 - 114,014,399EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2943 AgrOrtholog
BioCyc Gene G2FUF-40688 BioCyc
Ensembl Genes ENSRNOG00000026293 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007293 UniProtKB/Swiss-Prot
  ENSRNOG00060014128 UniProtKB/Swiss-Prot
  ENSRNOG00065018436 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011731 ENTREZGENE
  ENSRNOT00000011731.4 UniProtKB/Swiss-Prot
  ENSRNOT00055012148 UniProtKB/Swiss-Prot
  ENSRNOT00060024157 UniProtKB/Swiss-Prot
  ENSRNOT00065030925 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124370 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24516 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93192 IMAGE-MGC_LOAD
NCBI Gene 24516 ENTREZGENE
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11462:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB JUN RGD
PhenoGen Jun PhenoGen
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026293 RatGTEx
  ENSRNOG00055007293 RatGTEx
  ENSRNOG00060014128 RatGTEx
  ENSRNOG00065018436 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP A DNA-binding domain in eukaryotic transcription factors UniProtKB/TrEMBL
  Leucine zipper domain UniProtKB/TrEMBL
  SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A6JRH4 ENTREZGENE, UniProtKB/TrEMBL
  JUN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Jun  Jun proto-oncogene, AP-1 transcription factor subunit  Jun  jun proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Jun  jun proto-oncogene  Jun  Jun oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Jun  Jun oncogene    v-jun sarcoma virus 17 oncogene homolog (avian)  Name updated 1299863 APPROVED
2002-11-06 Jun  v-jun sarcoma virus 17 oncogene homolog (avian)    Avian sarcoma virus 17 (v-jun) oncogene homolog  Name updated 625702 APPROVED
2002-06-10 Jun  Avian sarcoma virus 17 (v-jun) oncogene homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in lung tissue 628503
gene_function transcription factor 628503
gene_mutations_overexpression overexpression increases gene expression involved in fibrotic tissue remodeling, such as collagen and collagenase 628503
gene_process mediates cellular proliferation 628503
gene_product member of the activator protein-1 (AP-1) family of inducible nuclear proteins 628503
gene_regulation expression is increased by the treatment of amiodarone (AM), an iodinated benzofuran derivative and effective antidysrhythmic agent 628503
gene_regulation mRNA expression induced by estrogens 729283