Jun (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Jun (Jun proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2943
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Colocalizes with chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; jun proto-oncogene; proto-oncogene c-jun; transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)Ensembl
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (EXP)
1,4-dithiothreitol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-aminobenzamide  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9H-xanthine  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
AP20187  (ISO)
apigenin  (ISO)
apocynin  (ISO)
apomorphine  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
auraptene  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
bacitracin  (EXP)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
benzophenanthridine  (ISO)
Benzoyl peroxide  (ISO)
benzyl isothiocyanate  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium sulfate  (ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bromodichloromethane  (EXP)
bucladesine  (ISO)
budesonide  (EXP)
bufalin  (ISO)
buspirone  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
camostat  (ISO)
camptothecin  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
Carnosol  (EXP)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
daidzein  (ISO)
DDE  (EXP)
DDT  (ISO)
Deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delphinidin  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane &nb