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Gene: Esr1 (estrogen receptor 1) Rattus norvegicus
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Symbol: Esr1
Name: estrogen receptor 1
Description: Exhibits several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and type 1 metabotropic glutamate receptor binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Localizes to several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Used to study several diseases, including infertility; obesity; peritonitis; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); rheumatic disease (multiple); and type 2 diabetes mellitus. Orthologous to human ESR1 (estrogen receptor 1); PARTICIPATES IN estrogen signaling pathway; insulin-like growth factor signaling pathway; bisphenol A response pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-terminally-truncated estrogen receptor alpha product-1; Er alpha; ER-alpha; Esr; estradiol receptor; estrogen receptor; estrogen receptor 1 (alpha); Estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha i45aL; estrogen receptor alpha i45aS; estrogen receptor alpha i45c; estrogen receptor alpha i56a; estrogen receptor alpha i56b; estrogen receptor alpha i56c; estrogen receptor alpha i56dL; estrogen receptor alpha i56dS; estrogen receptor alpha i56e; estrogen receptor alpha variant delta 4; nuclear receptor subfamily 3 group A member 1; RNESTROR; truncated estrogen receptor product-2; trunctaed estrogen receptor product-1
Orthologs:
Homo sapiens (human) : ESR1 (estrogen receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Esr1 (estrogen receptor 1 (alpha))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Esr1 (estrogen receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ESR1 (estrogen receptor 1)
Canis lupus familiaris (dog) : ESR1 (estrogen receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Esr1 (estrogen receptor 1)
Sus scrofa (pig) : ESR1 (estrogen receptor 1)
Chlorocebus sabaeus (African green monkey) : ESR1 (estrogen receptor 1)
Heterocephalus glaber (naked mole-rat) : Esr1 (estrogen receptor 1)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model