Esr1 (estrogen receptor 1) - Rat Genome Database

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Gene: Esr1 (estrogen receptor 1) Rattus norvegicus
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Symbol: Esr1
Name: estrogen receptor 1
RGD ID: 2581
Description: Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1); PARTICIPATES IN estrogen signaling pathway; insulin-like growth factor signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-terminally-truncated estrogen receptor alpha product-1; Er alpha; ER-alpha; Esr; estradiol receptor; estrogen receptor; estrogen receptor 1 (alpha); Estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha i45aL; estrogen receptor alpha i45aS; estrogen receptor alpha i45c; estrogen receptor alpha i56a; estrogen receptor alpha i56b; estrogen receptor alpha i56c; estrogen receptor alpha i56dL; estrogen receptor alpha i56dS; estrogen receptor alpha i56e; estrogen receptor alpha variant delta 4; nuclear receptor subfamily 3 group A member 1; RNESTROR; truncated estrogen receptor product-2; trunctaed estrogen receptor product-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Esr1em1Soar   Esr1em1Bra  
Genetic Models: SD-Esr1em1Bra-/- ACI.SD-Esr1em1Soar SD-Esr1em1Soar
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,511,685 - 43,904,454 (+)NCBIGRCr8
mRatBN7.2141,106,335 - 41,499,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,210,475 - 41,495,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,764,020 - 42,022,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,751,203 - 48,009,419 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,839,517 - 42,097,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model