RGD Reference Report - Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus. - Rat Genome Database

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Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus.

Authors: Saavedra, FR  Redondo, PC  Hernandez-Cruz, JM  Salido, GM  Pariente, JA  Rosado, JA 
Citation: Saavedra FR, etal., Arch Biochem Biophys. 2004 Dec 15;432(2):261-8.
RGD ID: 1601373
Pubmed: PMID:15542065   (View Abstract at PubMed)
DOI: DOI:10.1016/j.abb.2004.09.034   (Journal Full-text)

We have investigated the involvement of store-operated Ca(2+) entry (SOCE) in the abnormal platelet Ca(2+) homeostasis in patients with non insulin-dependent diabetes mellitus (NIDDM). In a medium containing 180 mg/dL glucose, platelets from NIDDM patients showed an increased SOCE compared to controls. We found that tyrosine phosphorylation was elevated in platelets from NIDDM patients. Consistent with this, the activity of the tyrosine kinase pp60(src) is enhanced in platelets from diabetic patients. When the experiments were performed in a medium containing 90 mg/dL both, SOCE and pp60(src) activity, were similar to those found in control platelets. Our results indicate that SOCE is altered in platelets from NIDDM patients probably due to the increased activity of the tyrosine kinase pp60(src). Both, SOCE and pp60(src) activity in platelets from NIDDM patients are more susceptible to the extracellular glucose concentration, which seems to be involved in the dysfunction of these mechanisms.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SRCHumantype 2 diabetes mellitus  IDA protein:increased tyrosine phosphorylation:plateletsRGD 
SrcRattype 2 diabetes mellitus  ISOSRC (Homo sapiens)protein:increased tyrosine phosphorylation:plateletsRGD 
SrcMousetype 2 diabetes mellitus  ISOSRC (Homo sapiens)protein:increased tyrosine phosphorylation:plateletsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)

Genes (Mus musculus)
Src  (Rous sarcoma oncogene)

Genes (Homo sapiens)
SRC  (SRC proto-oncogene, non-receptor tyrosine kinase)


Additional Information