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Gene: SRC (SRC proto-oncogene, non-receptor tyrosine kinase) Homo sapiens
Symbol: SRC
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Description: Exhibits several functions, including SH2 domain binding activity; heme binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of DNA biosynthetic process; negative regulation of apoptotic process; and positive regulation of phosphate metabolic process. Localizes to several cellular components, including caveola; late endosome; and perinuclear region of cytoplasm. Implicated in colon cancer; colorectal cancer; ductal carcinoma in situ; prostate cancer; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASV; c-SRC; p60-Src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; SRC1; THC6; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Mus musculus (house mouse) : Src (Rous sarcoma oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Canis lupus familiaris (dog) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)
Sus scrofa (pig) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : SRC (SRC proto-oncogene, non-receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Src (SRC proto-oncogene, non-receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2037,344,685 - 37,406,050 (+)EnsemblGRCh38hg38GRCh38
GRCh382037,344,685 - 37,406,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372035,973,088 - 36,033,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,406,502 - 35,467,235 (+)NCBINCBI36hg18NCBI36
Build 342035,407,970 - 35,467,233NCBI
Celera2032,680,370 - 32,741,098 (+)NCBI
Cytogenetic Map20q11.23NCBI
HuRef2032,708,654 - 32,769,187 (+)NCBIHuRef
CHM1_12035,876,016 - 35,936,689 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SRC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350530
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.