Ptk2b (protein tyrosine kinase 2 beta) - Rat Genome Database

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Gene: Ptk2b (protein tyrosine kinase 2 beta) Rattus norvegicus
Symbol: Ptk2b
Name: protein tyrosine kinase 2 beta
RGD ID: 628758
Description: Enables 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein ligase binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of apoptotic process; and positive regulation of cellular biosynthetic process. Located in several cellular components, including dendrite; focal adhesion; and postsynaptic density. Part of NMDA selective glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta); PARTICIPATES IN Jak-Stat signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: CADTK; CAK beta; CAK-beta; CAKB; CAKbeta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; FADK 2; focal adhesion kinase 2; MGC124628; proline-rich tyrosine kinase 2; protein-tyrosine kinase 2-beta; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; Pyk2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ptk2bem1Mcwi  
Genetic Models: SS-Ptk2bem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21540,360,722 - 40,481,235 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,228,028 - 42,348,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,378,225 - 43,499,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,821,037 - 41,941,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
alachlor  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
azoxystrobin  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butanal  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
captan  (ISO)
carbachol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP,ISO)
glyphosate  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP)
ionomycin  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Malonoben  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mefloquine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
niclosamide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercitrin  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IMP)
activation of GTPase activity  (IMP)
activation of Janus kinase activity  (IMP)
adaptive immune response  (IEA)
angiogenesis  (IEA,IMP)
blood vessel endothelial cell migration  (IMP)
bone resorption  (ISO,ISS)
cell adhesion  (IMP)
cell differentiation  (IEP)
cell surface receptor signaling pathway  (ISO,ISS)
cellular defense response  (IMP)
cellular response to fluid shear stress  (ISO)
cellular response to retinoic acid  (ISO)
chemokine-mediated signaling pathway  (ISO,ISS)
cortical cytoskeleton organization  (ISO,ISS)
endothelin receptor signaling pathway  (ISO,ISS)
epidermal growth factor receptor signaling pathway  (IBA,IMP)
focal adhesion assembly  (IMP)
glial cell proliferation  (IEP)
integrin-mediated signaling pathway  (ISO,ISS)
ionotropic glutamate receptor signaling pathway  (IMP)
long-term synaptic depression  (IMP)
long-term synaptic potentiation  (IMP)
MAPK cascade  (IMP)
marginal zone B cell differentiation  (ISO,ISS)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of bone mineralization  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of ossification  (IMP)
negative regulation of potassium ion transport  (ISO)
neuron projection development  (IMP)
oocyte maturation  (IMP)
peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of actin filament polymerization  (ISO,ISS)
positive regulation of angiogenesis  (ISO)
positive regulation of B cell chemotaxis  (ISO,ISS)
positive regulation of cell growth  (IMP)
positive regulation of cell migration  (IBA,IMP,ISO)
positive regulation of cell population proliferation  (IEA,IEP,ISO)
positive regulation of cell-matrix adhesion  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of JNK cascade  (ISO,ISS)
positive regulation of JUN kinase activity  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of nitric-oxide synthase activity  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of protein metabolic process  (IMP)
positive regulation of reactive oxygen species metabolic process  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of translation  (IMP)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO,ISS)
postsynaptic modulation of chemical synaptic transmission  (IDA,IMP)
regulation of actin cytoskeleton organization  (ISO,ISS)
regulation of biological quality  (IEA)
regulation of cell adhesion  (IBA,ISO,ISS)
regulation of cell shape  (ISO,ISS)
regulation of cellular component organization  (IEA)
regulation of macrophage chemotaxis  (ISO,ISS)
regulation of multicellular organismal process  (IEA)
regulation of postsynaptic density assembly  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO,ISS)
regulation of ubiquitin-dependent protein catabolic process  (ISO)
response to calcium ion  (IEP)
response to cAMP  (IEP)
response to cation stress  (IDA)
response to cocaine  (IEP)
response to ethanol  (IEP)
response to glucose  (IEP)
response to hormone  (IEP)
response to hydrogen peroxide  (IPI)
response to hypoxia  (IEP)
response to immobilization stress  (IEP)
response to ischemia  (IMP)
response to mechanical stimulus  (IEP)
response to organonitrogen compound  (IEP)
response to reactive oxygen species  (IEP)
response to xenobiotic stimulus  (IEP)
signal complex assembly  (IEA)
sprouting angiogenesis  (ISO,ISS)
stress fiber assembly  (IMP)
tumor necrosis factor-mediated signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Divergent regulation of Pyk2/CAKbeta phosphorylation by Ca2+ and cAMP in the hippocampus. Alier KA and Morris BJ, Biochim Biophys Acta. 2005 Sep 30;1745(3):342-9.
2. Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species. Andreolotti AG, etal., J Cell Biochem. 2006 Feb 1;97(2):359-67.
3. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. Babayan AH, etal., J Neurosci. 2012 Sep 12;32(37):12854-61. doi: 10.1523/JNEUROSCI.2024-12.2012.
4. Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway. Bajetto A, etal., J Neurochem. 2001 Jun;77(5):1226-36.
5. Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. Bandyopadhyay G, etal., J Biol Chem. 2001 Sep 21;276(38):35537-45. Epub 2001 Jul 19.
6. Postsynaptic clustering and activation of Pyk2 by PSD-95. Bartos JA, etal., J Neurosci. 2010 Jan 13;30(2):449-63. doi: 10.1523/JNEUROSCI.4992-08.2010.
7. PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy. Bayer AL, etal., Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H695-706.
8. Calcium-dependent activation of Pyk2 by hypoxia. Beitner-Johnson D, etal., Cell Signal. 2002 Feb;14(2):133-7.
9. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
10. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. Boutahar N, etal., J Biol Chem. 2004 Jul 16;279(29):30588-99. Epub 2004 Apr 19.
11. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Buckbinder L, etal., Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. Epub 2007 May 30.
12. Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking. Byron KL and Lucchesi PA, J Biol Chem. 2002 Mar 1;277(9):7298-307. Epub 2001 Dec 5.
13. Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury. Carini R, etal., J Hepatol. 2007 Apr;46(4):692-9. Epub 2006 Nov 27.
14. [Effects of prednisone on renal FAK and Pyk2 expressions in rats with adriamycin- induced nephritis]. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jul;34(8):1149-53.
15. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. Chow A, etal., FEBS Lett. 2000 Mar 3;469(1):88-92.
16. Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. Corvol JC, etal., J Biol Chem. 2005 Jan 7;280(1):660-8. Epub 2004 Nov 10.
17. Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells. Daou GB and Srivastava AK, Free Radic Biol Med. 2004 Jul 15;37(2):208-15.
18. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Dikic I, etal., Nature. 1996 Oct 10;383(6600):547-50. doi: 10.1038/383547a0.
19. Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation. Dougherty CJ, etal., FASEB J. 2004 Jul;18(10):1060-70.
20. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Frank GD, etal., Mol Endocrinol 2002 Feb;16(2):367-77.
21. Changes in rat frontal cortex gene expression following chronic cocaine. Freeman WM, etal., Brain Res Mol Brain Res. 2002 Jul 15;104(1):11-20.
22. Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury. Gadepalli R, etal., Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2652-61. doi: 10.1161/ATVBAHA.112.253112. Epub 2012 Aug 23.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor. Ghosh PM, etal., Am J Physiol Renal Physiol. 2001 Jun;280(6):F972-9.
25. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. Haglund K, etal., J Cell Sci. 2004 May 15;117(Pt 12):2557-68. Epub 2004 May 5.
26. Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2. Hirata A, etal., Br J Pharmacol. 2000 Dec;131(8):1521-30.
27. Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. Hirotani S, etal., J Mol Cell Cardiol. 2004 Jun;36(6):799-807.
28. Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Hodges RR, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3352-9.
29. Suppression of postsynaptic density protein 95 by antisense oligonucleotides diminishes postischemic pyramidal cell death in rat hippocampal CA1 subfield. Hou XY, etal., Neurosci Lett. 2005 Sep 16;385(3):230-3.
30. Proline-rich tyrosine kinase 2 regulates hippocampal long-term depression. Hsin H, etal., J Neurosci. 2010 Sep 8;30(36):11983-93. doi: 10.1523/JNEUROSCI.1029-10.2010.
31. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Huang Y, etal., Neuron. 2001 Feb;29(2):485-96.
32. Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. Huo JZ, etal., Neurosci Lett. 2006 Jul 3;401(3):266-70. Epub 2006 Apr 4.
33. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Ivankovic-Dikic I, etal., Nat Cell Biol. 2000 Sep;2(9):574-81.
34. Protein tyrosine kinase 2beta as a candidate gene for hypertension. Kamide K, etal., Pharmacogenet Genomics. 2007 Nov;17(11):931-9.
35. Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. Koh YH, etal., J Biochem (Tokyo). 2001 Sep;130(3):351-8.
36. The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. Kruljac-Letunic A, etal., J Biol Chem. 2003 Aug 8;278(32):29560-70. Epub 2003 May 27.
37. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, etal., Mol Cell Biol. 1999 Mar;19(3):2278-88.
38. Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus. Liu Y, etal., Neurosci Lett. 2005 Apr 29;379(1):55-8. Epub 2005 Jan 12.
39. Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia. Ma J, etal., Neurosci Res. 2004 Aug;49(4):357-62.
40. Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. Melendez J, etal., J Biol Chem 2002 Nov 22;277(47):45203-10.
41. FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern. Menegon A, etal., Eur J Neurosci. 1999 Nov;11(11):3777-88.
42. Proline-rich tyrosine kinase2 is involved in F-actin organization during in vitro maturation of rat oocyte. Meng XQ, etal., Reproduction. 2006 Dec;132(6):859-67.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Naylor TL, etal., Breast Cancer Res. 2005;7(6):R1186-98. Epub 2005 Nov 24.
45. Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats. Nemoto S, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2383-94. doi: 10.1152/ajpheart.00178.2011. Epub 2011 Sep 16.
46. Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro. Ogata Y, etal., Hypertension. 2003 May;41(5):1156-63. Epub 2003 Mar 31.
47. The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules. Pace A, etal., Biochim Biophys Acta. 2006 Apr;1763(4):356-65. Epub 2006 Apr 7.
48. RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement. Park SY, etal., Cell Signal. 2007 Feb;19(2):289-300. Epub 2006 Aug 30.
49. PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. Perez J, etal., Am J Physiol Cell Physiol. 2011 Jul;301(1):C242-51. doi: 10.1152/ajpcell.00315.2010. Epub 2011 Mar 30.
50. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
51. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
52. Chronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytes. Rachdaoui N, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E303-10.
53. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle. Rocic P, etal., Am J Physiol Cell Physiol. 2003 Dec;285(6):C1437-44. Epub 2003 Jul 30.
56. Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum. Sheehan TP, etal., Biol Psychiatry. 2003 Sep 1;54(5):540-51.
57. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression. Stanzione R, etal., Lab Invest. 2001 Jan;81(1):51-9.
58. Survival response-linked Pyk2 activation during potassium depletion-induced apoptosis of cerebellar granule neurons. Strappazzon F, etal., Mol Cell Neurosci. 2007 Mar;34(3):355-65. Epub 2006 Dec 22.
59. Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. Sugimura K, etal., Tohoku J Exp Med. 2010 Nov;222(3):201-10.
60. Increased expression of cell adhesion kinase beta in human and rat crescentic glomerulonephritis. Takagi C, etal., Am J Kidney Dis 2002 Jan;39(1):174-82.
61. Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells. Tang H, etal., J Biol Chem 2002 Feb 15;277(7):5441-7.
62. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Taniyama Y, etal., Mol Cell Biol. 2003 Nov;23(22):8019-29.
63. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. Tian D, etal., J Neurosci. 2000 Sep 1;20(17):6478-87.
64. The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes. Wang H and Reiser G, J Neurochem 2003 Mar;84(6):1349-57.
65. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. Xiong WC, etal., J Cell Sci 1998 Jul 30;111 ( Pt 14):1981-91.
66. Role of PYK2 in the development of obesity and insulin resistance. Yu Y, etal., Biochem Biophys Res Commun. 2005 Sep 9;334(4):1085-91.
Additional References at PubMed
PMID:7544443   PMID:7673154   PMID:8670418   PMID:8910543   PMID:8939945   PMID:9545257   PMID:9750131   PMID:10518561   PMID:10881171   PMID:11274221   PMID:12477932   PMID:12576483  
PMID:12651850   PMID:12746290   PMID:12900387   PMID:12950452   PMID:12960403   PMID:14739300   PMID:15050747   PMID:15172101   PMID:15322113   PMID:15705590   PMID:15911746   PMID:15967096  
PMID:16199135   PMID:16236484   PMID:17644565   PMID:17684059   PMID:17698736   PMID:17910947   PMID:18667434   PMID:18765415   PMID:18981321   PMID:19086031   PMID:19484266   PMID:19759375  
PMID:19880522   PMID:20180987   PMID:20688918   PMID:21245381   PMID:21640103   PMID:21852560   PMID:22802128   PMID:24718602   PMID:24841674   PMID:24981431   PMID:25349423   PMID:25708150  
PMID:25713079   PMID:28019664   PMID:28916471   PMID:30053369   PMID:31213568   PMID:32391653   PMID:32453021   PMID:37465947   PMID:38116014  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21540,360,722 - 40,481,235 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,228,028 - 42,348,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,378,225 - 43,499,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,821,037 - 41,941,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38827,310,506 - 27,459,391 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,311,482 - 27,459,391 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,168,995 - 27,316,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,224,916 - 27,372,820 (+)NCBINCBI36Build 36hg18NCBI36
Build 34827,238,970 - 27,372,820NCBI
Celera826,131,907 - 26,277,021 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,714,123 - 25,861,970 (+)NCBIHuRef
CHM1_1827,370,923 - 27,518,777 (+)NCBICHM1_1
T2T-CHM13v2.0827,583,138 - 27,736,745 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391466,390,706 - 66,518,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,390,706 - 66,518,501 (-)EnsemblGRCm39 Ensembl
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBIMGSCv36mm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1821,555,525 - 21,704,087 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,783,624 - 23,932,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12530,137,546 - 30,264,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,138,209 - 30,264,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,723,893 - 30,850,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,327,673 - 30,454,390 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,327,667 - 30,454,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,257,967 - 30,384,306 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,138,848 - 30,265,191 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,305,247 - 30,431,983 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049438,260,472 - 8,369,219 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675275,288 - 324,810 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675216,970 - 325,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1411,064,492 - 11,194,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,063,662 - 11,194,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,244,257 - 12,375,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1825,437,680 - 25,571,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,437,564 - 25,571,782 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,572,610 - 16,706,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475822,124,836 - 22,182,605 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptk2b
449 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1070
Count of miRNA genes:261
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000030007, ENSRNOT00000030036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,476,452 - 40,476,626 (+)MAPPERmRatBN7.2
Rnor_6.01542,943,009 - 42,943,182NCBIRnor6.0
Rnor_5.01548,651,092 - 48,651,265UniSTSRnor5.0
RGSC_v3.41545,713,220 - 45,713,393UniSTSRGSC3.4
Celera1540,149,347 - 40,149,520UniSTS
RH 3.4 Map15311.61UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,411,680 - 40,411,830 (+)MAPPERmRatBN7.2
Rnor_6.01542,878,251 - 42,878,400NCBIRnor6.0
Rnor_5.01548,715,589 - 48,715,738UniSTSRnor5.0
RGSC_v3.41545,640,451 - 45,640,600UniSTSRGSC3.4
Celera1540,084,831 - 40,084,980UniSTS
RH 3.4 Map15309.6UniSTS
Cytogenetic Map15p12UniSTS

Genetic Models
This gene Ptk2b is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 30 22 19 22 25 10 9 10
Low 43 27 19 19 8 11 33 25 32 1 8
Below cutoff 16


Nucleotide Sequences
RefSeq Transcripts NM_017318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF063890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000030007   ⟹   ENSRNOP00000031615
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)Ensembl
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000030036   ⟹   ENSRNOP00000036813
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)Ensembl
Rnor_6.0 Ensembl1542,827,846 - 42,898,150 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105571   ⟹   ENSRNOP00000078730
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)Ensembl
RefSeq Acc Id: NM_017318   ⟹   NP_059014
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,732 - 40,481,104 (-)NCBI
Rnor_6.01542,827,310 - 42,947,656 (-)NCBI
Rnor_5.01548,646,476 - 48,766,708 (+)NCBI
RGSC_v3.41545,589,222 - 45,717,866 (-)RGD
Celera1540,034,001 - 40,153,993 (-)RGD
RefSeq Acc Id: XM_006252145   ⟹   XP_006252207
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,722 - 40,481,235 (-)NCBI
Rnor_6.01542,827,306 - 42,947,796 (-)NCBI
Rnor_5.01548,646,476 - 48,766,708 (+)NCBI
RefSeq Acc Id: XM_008770773   ⟹   XP_008768995
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,722 - 40,429,442 (-)NCBI
Rnor_6.01542,827,306 - 42,897,560 (-)NCBI
RefSeq Acc Id: XM_008770774   ⟹   XP_008768996
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,722 - 40,423,256 (-)NCBI
Rnor_6.01542,827,306 - 42,894,599 (-)NCBI
RefSeq Acc Id: XM_039093607   ⟹   XP_038949535
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,722 - 40,481,235 (-)NCBI
RefSeq Acc Id: XM_039093608   ⟹   XP_038949536
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,360,722 - 40,414,740 (-)NCBI
RefSeq Acc Id: NP_059014   ⟸   NM_017318
- UniProtKB: Q3T1H4 (UniProtKB/Swiss-Prot),   O88489 (UniProtKB/Swiss-Prot),   Q63201 (UniProtKB/Swiss-Prot),   P70600 (UniProtKB/Swiss-Prot),   A6K6M1 (UniProtKB/TrEMBL),   A6K6M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252207   ⟸   XM_006252145
- Peptide Label: isoform X2
- UniProtKB: A6K6M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768995   ⟸   XM_008770773
- Peptide Label: isoform X1
- UniProtKB: Q3T1H4 (UniProtKB/Swiss-Prot),   O88489 (UniProtKB/Swiss-Prot),   Q63201 (UniProtKB/Swiss-Prot),   P70600 (UniProtKB/Swiss-Prot),   A6K6M1 (UniProtKB/TrEMBL),   A6K6M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768996   ⟸   XM_008770774
- Peptide Label: isoform X1
- UniProtKB: Q3T1H4 (UniProtKB/Swiss-Prot),   O88489 (UniProtKB/Swiss-Prot),   Q63201 (UniProtKB/Swiss-Prot),   P70600 (UniProtKB/Swiss-Prot),   A6K6M1 (UniProtKB/TrEMBL),   A6K6M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036813   ⟸   ENSRNOT00000030036
RefSeq Acc Id: ENSRNOP00000031615   ⟸   ENSRNOT00000030007
RefSeq Acc Id: XP_038949535   ⟸   XM_039093607
- Peptide Label: isoform X1
- UniProtKB: Q3T1H4 (UniProtKB/Swiss-Prot),   P70600 (UniProtKB/Swiss-Prot),   O88489 (UniProtKB/Swiss-Prot),   Q63201 (UniProtKB/Swiss-Prot),   A6K6M1 (UniProtKB/TrEMBL),   A6K6M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949536   ⟸   XM_039093608
- Peptide Label: isoform X3
- UniProtKB: A6K6M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078730   ⟸   ENSRNOT00000105571
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70600-F1-model_v2 AlphaFold P70600 1-1009 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699756
Promoter ID:EPDNEW_R10279
Type:initiation region
Description:protein tyrosine kinase 2 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,947,710 - 42,947,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628758 AgrOrtholog
BioCyc Gene G2FUF-13330 BioCyc
Ensembl Genes ENSRNOG00000027839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006720 UniProtKB/Swiss-Prot
  ENSRNOG00060011193 UniProtKB/Swiss-Prot
  ENSRNOG00065017701 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030007 ENTREZGENE
  ENSRNOT00000030007.4 UniProtKB/Swiss-Prot
  ENSRNOT00000030036.5 UniProtKB/Swiss-Prot
  ENSRNOT00000105571.1 UniProtKB/TrEMBL
  ENSRNOT00055010990 UniProtKB/Swiss-Prot
  ENSRNOT00060018945 UniProtKB/Swiss-Prot
  ENSRNOT00065029654 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FADK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAK1-like_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAK1/PYK2_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_adhe_kin_target_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_adhesion_kin_target_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50646 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_C_FAK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_AT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Ptk2b PhenoGen
PROSITE FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027839 RatGTEx
  ENSRNOG00055006720 RatGTEx
  ENSRNOG00060011193 RatGTEx
  ENSRNOG00065017701 RatGTEx
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68993 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAK2_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88489 UniProtKB/Swiss-Prot
  Q3T1H4 UniProtKB/Swiss-Prot
  Q63201 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Ptk2b  protein tyrosine kinase 2 beta  Ptk2b  PTK2B protein tyrosine kinase 2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-20 Ptk2b  PTK2B protein tyrosine kinase 2 beta  Ptk2b  PTK2 protein tyrosine kinase 2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ptk2b  PTK2 protein tyrosine kinase 2 beta  Ptk2b  protein tyrosine kinase 2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ptk2b  protein tyrosine kinase 2 beta      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Ptk2b  protein tyrosine kinase 2 beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression selectively expressed in the lung and pulmonary vascular endothelial cells 70597
gene_physical_interaction forms a complex with Src tyrosine kinase in response to thrombin stimulation 729770
gene_process involved in cell motility, cell spreading, migration and morphogenesis processes 70597
gene_process involved in angiogenesis 70597
gene_process kinase activity may be involved in the expression of FAK and Cas proteins 70597
gene_process regulator of pulmonary angiogenesis 70597