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Gene: Ptk2b (protein tyrosine kinase 2 beta) Rattus norvegicus
Symbol: Ptk2b
Name: protein tyrosine kinase 2 beta
Description: Exhibits 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein ligase binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell communication; and positive regulation of cellular biosynthetic process. Localizes to several cellular components, including NMDA selective glutamate receptor complex; dendrite; and focal adhesion. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta); PARTICIPATES IN Jak-Stat signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: CADTK; CAK beta; CAK-beta; CAKB; CAKbeta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; FADK 2; focal adhesion kinase 2; MGC124628; proline-rich tyrosine kinase 2; protein-tyrosine kinase 2-beta; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; Pyk2
Homo sapiens (human) : PTK2B (protein tyrosine kinase 2 beta)  HGNC  Alliance
Mus musculus (house mouse) : Ptk2b (PTK2 protein tyrosine kinase 2 beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2b (protein tyrosine kinase 2 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2B (protein tyrosine kinase 2 beta)
Canis lupus familiaris (dog) : PTK2B (protein tyrosine kinase 2 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2b (protein tyrosine kinase 2 beta)
Sus scrofa (pig) : PTK2B (protein tyrosine kinase 2 beta)
Chlorocebus sabaeus (African green monkey) : PTK2B (protein tyrosine kinase 2 beta)
Heterocephalus glaber (naked mole-rat) : Ptk2b (protein tyrosine kinase 2 beta)
more info ...
Allele / Splice: Ptk2bem1Mcwi  
Genetic Models: SS-Ptk2bem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptk2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628758
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.