(+)-pilocarpine multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 (S)-colchicine multiple interactions ISO RGD:1346204 6480464 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein] CTD PMID:11478917 (S)-colchicine increases phosphorylation ISO RGD:1346204 6480464 Colchicine results in increased phosphorylation of PTK2B protein CTD PMID:11478917 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of PTK2B mRNA CTD PMID:30723492 1-octadec-9-enoylglycero-3-phosphate increases phosphorylation ISO RGD:733599 6480464 lysophosphatidic acid results in increased phosphorylation of PTK2B protein CTD PMID:11792571 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733599 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:733599 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PTK2B mRNA CTD PMID:22298810 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PTK2B mRNA CTD PMID:21346803 2-butoxyethanol decreases expression ISO RGD:733599 6480464 n-butoxyethanol results in decreased expression of PTK2B mRNA CTD PMID:19812364 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 4,4'-diaminodiphenylmethane increases expression ISO RGD:733599 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PTK2B mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:733599 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of PTK2B mRNA CTD PMID:30951980 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of PTK2B mRNA CTD PMID:22504374 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1346204 6480464 Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases phosphorylation ISO RGD:1346204 6480464 Uric Acid results in increased phosphorylation of PTK2B protein CTD PMID:29960001 7-ketocholesterol multiple interactions ISO RGD:1346204 6480464 7-ketocholesterol results in increased phosphorylation of and results in increased activity of PTK2B protein CTD PMID:15955068 [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol increases response to substance EXP 6480464 PTK2B protein results in increased susceptibility to Mefloquine CTD PMID:21241737 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of PTK2B mRNA CTD PMID:28959563 acrylamide increases phosphorylation ISO RGD:1346204 6480464 Acrylamide results in increased phosphorylation of PTK2B protein CTD PMID:11478917 acrylamide multiple interactions ISO RGD:1346204 6480464 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Acrylamide results in increased phosphorylation of PTK2B protein] CTD PMID:11478917 aflatoxin B1 increases expression ISO RGD:733599 6480464 Aflatoxin B1 results in increased expression of PTK2B mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1346204 6480464 Aflatoxin B1 results in increased methylation of PTK2B exon, Aflatoxin B1 results in increased methylation of PTK2B intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:1346204 6480464 Aflatoxin B1 results in decreased methylation of PTK2B gene CTD PMID:27153756 aflatoxin B2 increases methylation ISO RGD:1346204 6480464 aflatoxin B2 results in increased methylation of PTK2B exon, aflatoxin B2 results in increased methylation of PTK2B intron CTD PMID:30157460 AICA ribonucleotide multiple interactions EXP 6480464 AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein more ... CTD PMID:11978788 alachlor multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 all-trans-retinoic acid multiple interactions ISO RGD:1346204 6480464 [Tretinoin co-treated with CXCL12 protein] results in increased expression of PTK2B protein CTD PMID:17656649 all-trans-retinoic acid increases expression ISO RGD:1346204 6480464 Tretinoin results in increased expression of PTK2B mRNA CTD PMID:15498508 more ... ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PTK2B mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of PTK2B protein, Ammonium Chloride results in increased expression of PTK2B protein modified form CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of PTK2B protein modified form CTD PMID:16483693 apigenin multiple interactions ISO RGD:1346204 6480464 Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 arsane affects methylation ISO RGD:1346204 6480464 Arsenic affects the methylation of PTK2B gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1346204 6480464 Arsenic affects the methylation of PTK2B gene CTD PMID:25304211 arsenous acid affects expression ISO RGD:1346204 6480464 Arsenic Trioxide affects the expression of PTK2B mRNA CTD PMID:28786057 asbestos decreases expression ISO RGD:1346204 6480464 Asbestos results in decreased expression of PTK2B mRNA CTD PMID:22076105 benzo[a]pyrene increases expression ISO RGD:733599 6480464 Benzo(a)pyrene results in increased expression of PTK2B mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1346204 6480464 Benzo(a)pyrene affects the methylation of PTK2B exon CTD PMID:30157460 benzo[b]fluoranthene increases expression ISO RGD:733599 6480464 benzo(b)fluoranthene results in increased expression of PTK2B mRNA CTD PMID:26377693 benzo[e]pyrene increases methylation ISO RGD:1346204 6480464 benzo(e)pyrene results in increased methylation of PTK2B exon, benzo(e)pyrene results in increased methylation of PTK2B intron CTD PMID:30157460 bisphenol A increases expression ISO RGD:733599 6480464 bisphenol A results in increased expression of PTK2B mRNA CTD PMID:26063408 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PTK2B mRNA CTD PMID:25181051 buta-1,3-diene decreases expression ISO RGD:733599 6480464 1, 3-butadiene results in decreased expression of PTK2B mRNA CTD PMID:29038090 butan-1-ol multiple interactions EXP 6480464 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein], 1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein] CTD PMID:15705590 , PMID:18004999 butanal decreases expression ISO RGD:1346204 6480464 butyraldehyde results in decreased expression of PTK2B mRNA CTD PMID:26079696 calcium atom multiple interactions ISO RGD:1346204 6480464 Calcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein] CTD PMID:16236484 calcium atom multiple interactions EXP 6480464 Calcium affects the phosphorylation of and affects the activity of PTK2B protein CTD PMID:16877402 calcium(0) multiple interactions ISO RGD:1346204 6480464 Calcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein] CTD PMID:16236484 calcium(0) multiple interactions EXP 6480464 Calcium affects the phosphorylation of and affects the activity of PTK2B protein CTD PMID:16877402 captan multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 carbachol multiple interactions EXP 6480464 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3 more ... CTD PMID:16877402 carbon nanotube decreases expression ISO RGD:1346204 6480464 Nanotubes, Carbon results in decreased expression of PTK2B mRNA CTD PMID:22076105 carbon nanotube decreases expression ISO RGD:733599 6480464 Nanotubes, Carbon analog results in decreased expression of PTK2B mRNA, Nanotubes, Carbon results in decreased expression of PTK2B mRNA CTD PMID:25620056 choline multiple interactions ISO RGD:733599 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA CTD PMID:20938992 chromium(6+) increases expression ISO RGD:1346204 6480464 chromium hexavalent ion results in increased expression of PTK2B mRNA CTD PMID:27793765 cocaine increases expression EXP 6480464 Cocaine results in increased expression of PTK2B protein CTD PMID:12117546 dexamethasone multiple interactions ISO RGD:1346204 6480464 NR3C1 protein affects the reaction [Dexamethasone results in increased phosphorylation of PTK2B protein] CTD PMID:18515658 dexamethasone increases expression ISO RGD:1346204 6480464 Dexamethasone results in increased expression of PTK2B mRNA CTD PMID:12782123 , PMID:25047013 diarsenic trioxide affects expression ISO RGD:1346204 6480464 Arsenic Trioxide affects the expression of PTK2B mRNA CTD PMID:28786057 diazinon multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 dibutyl phthalate increases expression ISO RGD:733599 6480464 Dibutyl Phthalate results in increased expression of PTK2B mRNA CTD PMID:17361019 , PMID:21266533 dicrotophos increases expression ISO RGD:1346204 6480464 dicrotophos results in increased expression of PTK2B mRNA CTD PMID:28302478 dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of PTK2B mRNA CTD PMID:16122865 doxorubicin multiple interactions ISO RGD:1346204 6480464 PTK2B protein inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] CTD PMID:16168102 doxorubicin decreases expression ISO RGD:1346204 6480464 Doxorubicin results in decreased expression of PTK2B mRNA CTD PMID:29803840 endosulfan multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of PTK2B mRNA CTD PMID:29391264 ethanol increases phosphorylation ISO RGD:1346204 6480464 Ethanol results in increased phosphorylation of PTK2B protein CTD PMID:18182400 ethanol affects splicing ISO RGD:733599 6480464 Ethanol affects the splicing of PTK2B mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:1346204 6480464 sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein] CTD PMID:18182400 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions EXP 6480464 Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of PTK2B mRNA CTD PMID:18035473 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of PTK2B mRNA CTD PMID:17033635 folic acid multiple interactions ISO RGD:733599 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA CTD PMID:20938992 furan decreases expression ISO RGD:733599 6480464 furan results in decreased expression of PTK2B mRNA CTD PMID:24183702 furan increases expression EXP 6480464 furan results in increased expression of PTK2B mRNA CTD PMID:25539665 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of PTK2B gene CTD PMID:31011160 hydralazine multiple interactions ISO RGD:1346204 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNA CTD PMID:17183730 hydrogen peroxide multiple interactions EXP 6480464 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein] more ... CTD PMID:15705590 , PMID:16187300 hydrogen peroxide increases phosphorylation EXP 6480464 Hydrogen Peroxide results in increased phosphorylation of PTK2B protein CTD PMID:15705590 ionomycin multiple interactions EXP 6480464 Ionomycin results in increased phosphorylation of and results in increased activity of PTK2B protein CTD PMID:16877402 L-methionine multiple interactions ISO RGD:733599 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA CTD PMID:20938992 lead(0) decreases expression ISO RGD:1346204 6480464 Lead results in decreased expression of PTK2B mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:1346204 6480464 Lead results in decreased expression of PTK2B mRNA CTD PMID:19921347 lithium atom multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 lithium hydride multiple interactions EXP 6480464 [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 Malonoben multiple interactions ISO RGD:1346204 6480464 tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein] CTD PMID:16948116 mancozeb multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 maneb multiple interactions ISO RGD:733599 6480464 [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 manganese atom decreases expression ISO RGD:1346204 6480464 Manganese results in decreased expression of PTK2B mRNA CTD PMID:17175027 manganese(0) decreases expression ISO RGD:1346204 6480464 Manganese results in decreased expression of PTK2B mRNA CTD PMID:17175027 manganese(II) chloride decreases expression ISO RGD:1346204 6480464 manganese chloride results in decreased expression of PTK2B mRNA CTD PMID:17175027 mefloquine increases response to substance EXP 6480464 PTK2B protein results in increased susceptibility to Mefloquine CTD PMID:21241737 methapyrilene increases methylation ISO RGD:1346204 6480464 Methapyrilene results in increased methylation of PTK2B exon, Methapyrilene results in increased methylation of PTK2B intron CTD PMID:30157460 methimazole increases expression EXP 6480464 Methimazole results in increased expression of PTK2B mRNA CTD PMID:22504374 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:733599 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of PTK2B mRNA CTD PMID:22401849 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 naphthalene increases expression ISO RGD:733599 6480464 naphthalene results in increased expression of PTK2B mRNA CTD PMID:18978301 paracetamol increases expression ISO RGD:1346204 6480464 Acetaminophen results in increased expression of PTK2B mRNA CTD PMID:22230336 paraoxon increases expression ISO RGD:1346204 6480464 Paraoxon results in increased expression of PTK2B mRNA CTD PMID:24413757 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of PTK2B protein CTD PMID:16877402 pirinixic acid decreases expression ISO RGD:733599 6480464 pirinixic acid results in decreased expression of PTK2B mRNA CTD PMID:23811191 ponatinib decreases activity ISO RGD:1346204 6480464 ponatinib results in decreased activity of PTK2B protein CTD PMID:19878872 potassium chloride multiple interactions EXP 6480464 1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein] more ... CTD PMID:18004999 potassium chloride increases phosphorylation EXP 6480464 Potassium Chloride results in increased phosphorylation of PTK2B protein CTD PMID:18004999 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:733599 6480464 Pregnenolone Carbonitrile results in decreased expression of PTK2B mRNA CTD PMID:28903501 propiconazole decreases expression ISO RGD:733599 6480464 propiconazole results in decreased expression of PTK2B mRNA CTD PMID:21278054 prostaglandin F2alpha increases expression EXP 6480464 Dinoprost results in increased expression of PTK2B mRNA CTD PMID:11517196 quercitrin affects expression ISO RGD:1346204 6480464 quercitrin affects the expression of PTK2B mRNA CTD PMID:25193878 silicon dioxide decreases expression ISO RGD:1346204 6480464 Silicon Dioxide results in decreased expression of PTK2B mRNA CTD PMID:23623845 sodium arsenite multiple interactions ISO RGD:1346204 6480464 sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein] CTD PMID:18182400 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PTK2B protein CTD PMID:19072884 Soman decreases expression EXP 6480464 Soman results in decreased expression of PTK2B mRNA CTD PMID:19281266 tamibarotene increases expression ISO RGD:1346204 6480464 tamibarotene results in increased expression of PTK2B mRNA CTD PMID:15498508 tamoxifen decreases expression ISO RGD:1346204 6480464 Tamoxifen results in decreased expression of PTK2B mRNA CTD PMID:15590111 titanium dioxide increases expression ISO RGD:733599 6480464 titanium dioxide results in increased expression of PTK2B mRNA CTD PMID:23557971 , PMID:29264374 trichloroethene decreases expression ISO RGD:733599 6480464 Trichloroethylene results in decreased expression of PTK2B mRNA CTD PMID:25549359 tungsten decreases expression ISO RGD:733599 6480464 Tungsten results in decreased expression of PTK2B mRNA CTD PMID:30912803 urethane decreases expression ISO RGD:1346204 6480464 Urethane results in decreased expression of PTK2B mRNA CTD PMID:28818685 valproic acid multiple interactions ISO RGD:1346204 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNA CTD PMID:17183730 vanadium atom decreases expression ISO RGD:1346204 6480464 Vanadium results in decreased expression of PTK2B mRNA CTD PMID:19000753 vanadium(0) decreases expression ISO RGD:1346204 6480464 Vanadium results in decreased expression of PTK2B mRNA CTD PMID:19000753 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PTK2B mRNA CTD PMID:23034163 vincristine increases phosphorylation ISO RGD:1346204 6480464 Vincristine results in increased phosphorylation of PTK2B protein CTD PMID:11478917 zinc atom increases expression ISO RGD:1346204 6480464 Zinc deficiency results in increased expression of PTK2B mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:1346204 6480464 Zinc deficiency results in increased expression of PTK2B mRNA CTD PMID:22171008
Biological Process actin filament organization IMP 1642612 RGD activation of GTPase activity IMP 1642626 RGD activation of Janus kinase activity IMP 633057 RGD activation of Janus kinase activity ISO RGD:1346204 1624291 (PMID:8670418) RGD PMID:8670418 adaptive immune response IEA UniProtKB-KW:KW-1064 1600115 GO_REF:0000037 UniProt GO_REF:0000037 angiogenesis IMP 70597 RGD angiogenesis IBA MGI:MGI:95481 more ... 13792537 PMID:21873635 GO_Central angiogenesis IBA MGI:MGI:104908 more ... 13792537 PMID:21873635 GO_Central blood vessel endothelial cell migration IMP 70597 RGD bone resorption ISO RGD:733599 1624291 (MGI:MGI:3040548, PMID:14739300) RGD MGI:MGI:3040548 , PMID:14739300 bone resorption ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell adhesion IMP 70597 RGD cell differentiation IEP 1642647 RGD cell surface receptor signaling pathway ISO RGD:1346204 1624291 (PMID:8849729) RGD PMID:8849729 cell surface receptor signaling pathway ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular defense response IMP 8554817 PMID:17188509 Alzheimers_University_of_Toronto cellular response to fluid shear stress ISO RGD:733599 1624291 (MGI:MGI:5608648, PMID:24841674) RGD MGI:MGI:5608648 , PMID:24841674 cellular response to fluid shear stress IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to retinoic acid ISO RGD:1346204 1624291 (PMID:17910947) RGD PMID:17910947 cellular response to retinoic acid IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemokine-mediated signaling pathway ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 chemokine-mediated signaling pathway ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endothelin receptor signaling pathway ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endothelin receptor signaling pathway ISO RGD:1346204 1624291 (PMID:19086031) RGD PMID:19086031 epidermal growth factor receptor signaling pathway IMP 1642613 RGD epidermal growth factor receptor signaling pathway IBA PANTHER:PTN001231249 , RGD:628758 13792537 PMID:21873635 GO_Central focal adhesion assembly IMP 1581775 RGD glial cell proliferation IEP 1642644 RGD integrin-mediated signaling pathway ISO RGD:1346204 1624291 (PMID:15050747) RGD PMID:15050747 integrin-mediated signaling pathway ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ionotropic glutamate receptor signaling pathway IMP 8655534 PMID:15814199 Alzheimers_University_of_Toronto long-term synaptic depression IMP 10041066 RGD long-term synaptic potentiation IMP 8553497 PMID:11239437 Alzheimers_University_of_Toronto MAPK cascade IMP 1642630 RGD marginal zone B cell differentiation ISO RGD:733599 1624291 (MGI:MGI:1860716, PMID:10881171) RGD MGI:MGI:1860716 , PMID:10881171 marginal zone B cell differentiation ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of apoptotic process ISO RGD:1346204 1624291 (PMID:19880522) RGD PMID:19880522 negative regulation of apoptotic process ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of apoptotic process ISO RGD:733599 1624291 (MGI:MGI:4453113, PMID:19880522) RGD MGI:MGI:4453113 , PMID:19880522 negative regulation of bone mineralization ISO RGD:733599 1624291 (MGI:MGI:3713957, PMID:17537919) RGD MGI:MGI:3713957 , PMID:17537919 negative regulation of bone mineralization ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation ISO RGD:1346204 1624291 (PMID:15050747) RGD PMID:15050747 negative regulation of cell population proliferation ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of muscle cell apoptotic process IMP 1642633 RGD negative regulation of myeloid cell differentiation ISO RGD:1346204 1624291 (PMID:15050747) RGD PMID:15050747 negative regulation of myeloid cell differentiation IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron apoptotic process IMP 8554817 PMID:17188509 Alzheimers_University_of_Toronto negative regulation of ossification IMP 1642610 RGD negative regulation of potassium ion transport ISO RGD:1346204 1624291 (PMID:7544443) RGD PMID:7544443 negative regulation of potassium ion transport IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection development IMP 1642629 RGD oocyte maturation IMP 1642612 RGD peptidyl-tyrosine autophosphorylation IDA 8553497 PMID:11239437 Alzheimers_University_of_Toronto peptidyl-tyrosine autophosphorylation ISO RGD:1346204 1624291 (PMID:10518561), (PMID:9545257) RGD PMID:10518561 , PMID:9545257 peptidyl-tyrosine autophosphorylation IMP 8655534 PMID:15814199 Alzheimers_University_of_Toronto peptidyl-tyrosine autophosphorylation IDA 8554817 PMID:17188509 Alzheimers_University_of_Toronto peptidyl-tyrosine autophosphorylation IDA 8554065 PMID:15537634 Alzheimers_University_of_Toronto peptidyl-tyrosine phosphorylation IDA 1581775 RGD peptidyl-tyrosine phosphorylation ISO RGD:733599 1624291 (MGI:MGI:3713957, PMID:17537919) RGD MGI:MGI:3713957 , PMID:17537919 peptidyl-tyrosine phosphorylation IMP 8655534 PMID:15814199 Alzheimers_University_of_Toronto peptidyl-tyrosine phosphorylation ISO RGD:1346204 1624291 (PMID:7544443) RGD PMID:7544443 positive regulation of actin filament polymerization ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 positive regulation of actin filament polymerization ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of angiogenesis ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 positive regulation of angiogenesis IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of B cell chemotaxis ISO RGD:733599 1624291 (MGI:MGI:1860716, PMID:10881171) RGD MGI:MGI:1860716 , PMID:10881171 positive regulation of B cell chemotaxis ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cell growth IMP 1642626 RGD positive regulation of cell migration IMP 1642613 RGD positive regulation of cell migration ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 positive regulation of cell population proliferation IEP 1642645 RGD positive regulation of cell population proliferation ISO RGD:733599 1624291 (MGI:MGI:4453113, PMID:19880522) RGD MGI:MGI:4453113 , PMID:19880522 positive regulation of cell population proliferation ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 positive regulation of cell-matrix adhesion ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 positive regulation of cell-matrix adhesion ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cellular protein metabolic process IMP 10041071 RGD positive regulation of cytosolic calcium ion concentration IMP 1642639 RGD positive regulation of DNA biosynthetic process IMP 10041071 RGD positive regulation of endothelial cell migration ISO RGD:1346204 1624291 (PMID:21245381) RGD PMID:21245381 positive regulation of endothelial cell migration IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endothelial cell migration IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endothelial cell migration ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 positive regulation of ERK1 and ERK2 cascade ISO RGD:1346204 1624291 (PMID:7544443) RGD PMID:7544443 positive regulation of ERK1 and ERK2 cascade ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of excitatory postsynaptic potential IMP 8553497 PMID:11239437 Alzheimers_University_of_Toronto positive regulation of JNK cascade ISO RGD:1346204 1624291 (PMID:8670418) RGD PMID:8670418 positive regulation of JNK cascade ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of JUN kinase activity IMP 1642623 RGD positive regulation of neuron projection development ISO RGD:1346204 1624291 (PMID:17910947) RGD PMID:17910947 positive regulation of neuron projection development IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nitric oxide biosynthetic process IMP 10041069 RGD positive regulation of nitric-oxide synthase activity IMP 10041069 RGD positive regulation of nitric-oxide synthase activity ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 positive regulation of peptidyl-tyrosine phosphorylation ISO RGD:1346204 1624291 (PMID:10022914), (PMID:10518561), (PMID:21245381) RGD PMID:10022914 more ... positive regulation of peptidyl-tyrosine phosphorylation IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of phosphatidylinositol 3-kinase activity ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 positive regulation of phosphatidylinositol 3-kinase activity ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of protein kinase activity ISO RGD:1346204 1624291 (PMID:7544443) RGD PMID:7544443 positive regulation of protein kinase activity ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of protein kinase activity ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 positive regulation of reactive oxygen species metabolic process IMP 1642626 RGD positive regulation of synaptic transmission, glutamatergic IMP 8553497 PMID:11239437 Alzheimers_University_of_Toronto positive regulation of translation IMP 1642632 RGD positive regulation of ubiquitin-dependent protein catabolic process ISO RGD:733599 1624291 (MGI:MGI:4453113, PMID:19880522) RGD MGI:MGI:4453113 , PMID:19880522 positive regulation of ubiquitin-dependent protein catabolic process ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein phosphorylation ISO RGD:733599 1624291 (MGI:MGI:2429328, PMID:11274221) RGD MGI:MGI:2429328 , PMID:11274221 regulation of actin cytoskeleton reorganization ISO RGD:733599 1624291 (MGI:MGI:3583523 more ... RGD MGI:MGI:3583523 more ... regulation of actin cytoskeleton reorganization ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of calcium-mediated signaling ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 regulation of calcium-mediated signaling IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cell adhesion ISO RGD:1346204 1624291 (PMID:19086031) RGD PMID:19086031 regulation of cell adhesion IBA PANTHER:PTN001231249 , UniProtKB:Q14289 13792537 PMID:21873635 GO_Central regulation of cell adhesion IBA PANTHER:PTN001231249 more ... 13792537 PMID:21873635 GO_Central regulation of cell adhesion ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of cell shape ISO RGD:1346204 1624291 (PMID:19086031) RGD PMID:19086031 regulation of cell shape ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of cell shape ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of cell shape ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 regulation of cGMP-mediated signaling ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 regulation of cGMP-mediated signaling IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of establishment of cell polarity ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 regulation of establishment of cell polarity ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of inositol trisphosphate biosynthetic process ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 regulation of inositol trisphosphate biosynthetic process ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of macrophage chemotaxis ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 regulation of macrophage chemotaxis ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of nitric oxide biosynthetic process ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 regulation of NMDA receptor activity IMP 8553497 PMID:11239437 Alzheimers_University_of_Toronto regulation of release of sequestered calcium ion into cytosol ISO RGD:733599 1624291 (MGI:MGI:3583523, PMID:12960403) RGD MGI:MGI:3583523 , PMID:12960403 regulation of release of sequestered calcium ion into cytosol ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of ubiquitin-dependent protein catabolic process ISO RGD:1346204 1624291 (PMID:19880522) RGD PMID:19880522 response to calcium ion IEP 1642620 ; 1642613 RGD response to cAMP IEP 1642620 RGD response to cocaine IEP 1642634 RGD response to drug IEP 1642646 RGD response to ethanol IEP 708317 RGD response to glucose IEP 1642643 RGD response to hormone IEP 1642616 RGD response to hydrogen peroxide IPI RGD:2405 1642619 RGD response to hypoxia IEP 1642636 RGD response to immobilization stress IEP 1642631 RGD response to lithium ion IEP 1642622 RGD response to mechanical stimulus IEP 1642630 RGD response to organonitrogen compound IEP 1642615 RGD response to osmotic stress IEP 1642640 RGD response to reactive oxygen species IEP 1642624 RGD signal complex assembly IEA InterPro:IPR005189 , InterPro:IPR036137 1600115 GO_REF:0000002 InterPro GO_REF:0000002 sprouting angiogenesis ISO RGD:733599 1624291 (MGI:MGI:5056252, PMID:21640103) RGD MGI:MGI:5056252 , PMID:21640103 sprouting angiogenesis ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 stress fiber assembly IMP 70597 RGD tumor necrosis factor-mediated signaling pathway ISO RGD:1346204 1624291 (PMID:8670418) RGD PMID:8670418 tumor necrosis factor-mediated signaling pathway IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor receptor signaling pathway ISO RGD:1346204 1624291 (PMID:21245381) RGD PMID:21245381 vascular endothelial growth factor receptor signaling pathway IEA UniProtKB:Q9QVP9 , ensembl:ENSMUSP000000226221600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor receptor signaling pathway IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor receptor signaling pathway ISO RGD:733599 1624291 (MGI:MGI:3810237, PMID:17698736) RGD MGI:MGI:3810237 , PMID:17698736 Cellular Component apical dendrite IDA 8553344 PMID:10583467 Alzheimers_University_of_Toronto axon IDA 1642627 RGD cell IEA GO:0007204 1600115 GO_REF:0000108 GOC GO_REF:0000108 cell body IDA 2304238 PMID:10022914 UniProt cell body IDA 8554065 PMID:15537634 Alzheimers_University_of_Toronto cell cortex IDA 1642612 RGD cell projection IDA 2304238 PMID:10022914 UniProt cytoskeleton IEA InterPro:IPR000299 1600115 GO_REF:0000002 InterPro GO_REF:0000002 dendrite IDA 8553344 PMID:10583467 Alzheimers_University_of_Toronto dendrite IDA 8554065 PMID:15537634 Alzheimers_University_of_Toronto dendritic spine IDA 12050116 PMID:22973009 SynGO dendritic spine IBA PANTHER:PTN000700474 more ... 13792537 PMID:21873635 GO_Central extrinsic component of cytoplasmic side of plasma membrane IEA InterPro:IPR030610 1600115 GO_REF:0000002 InterPro GO_REF:0000002 focal adhesion IDA 1625132 RGD focal adhesion IBA MGI:MGI:95481 more ... 13792537 PMID:21873635 GO_Central focal adhesion ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 glutamatergic synapse IDA 12050116 PMID:22973009 SynGO growth cone IDA 1642627 RGD growth cone IDA 8553344 PMID:10583467 Alzheimers_University_of_Toronto lamellipodium ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 lamellipodium ISS UniProtKB:Q14289 1600115 GO_REF:0000024 UniProt GO_REF:0000024 membrane raft IDA 1642627 RGD neuronal cell body IDA 8553344 PMID:10583467 Alzheimers_University_of_Toronto NMDA selective glutamate receptor complex IDA 8553497 PMID:11239437 Alzheimers_University_of_Toronto NMDA selective glutamate receptor complex IMP 8655534 PMID:15814199 Alzheimers_University_of_Toronto nucleus IDA 1642613 RGD nucleus ISO RGD:733599 1624291 (MGI:MGI:4453113 more ... RGD MGI:MGI:4453113 more ... nucleus ISO RGD:1346204 1624291 (PMID:19880522) RGD PMID:19880522 perinuclear region of cytoplasm IDA 1642613 RGD perinuclear region of cytoplasm ISO RGD:733599 1624291 (MGI:MGI:5608648, PMID:24841674) RGD MGI:MGI:5608648 , PMID:24841674 perinuclear region of cytoplasm ISO RGD:1346204 1624291 (PMID:18765415) RGD PMID:18765415 postsynapse IDA 12050116 PMID:22973009 SynGO postsynaptic density IDA 1581409 RGD postsynaptic density IDA 8553497 PMID:11239437 Alzheimers_University_of_Toronto Molecular Function 3-phosphoinositide-dependent protein kinase binding IDA 1581775 RGD ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000037 UniProt GO_REF:0000037 calmodulin-dependent protein kinase activity IDA 8554817 PMID:17188509 Alzheimers_University_of_Toronto enzyme binding IPI RGD:1561386 1642613 RGD NMDA glutamate receptor activity contributes_to IMP 8655534 PMID:15814199 Alzheimers_University_of_Toronto non-membrane spanning protein tyrosine kinase activity ISO RGD:1346204 1624291 (PMID:10518561), (PMID:7544443) RGD PMID:10518561 , PMID:7544443 non-membrane spanning protein tyrosine kinase activity ISS UniProtKB:Q9QVP9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 non-membrane spanning protein tyrosine kinase activity ISO RGD:733599 1624291 (MGI:MGI:3713957, PMID:17537919) RGD MGI:MGI:3713957 , PMID:17537919 protein binding IPI RGD:620795 1642611 RGD protein binding ISO RGD:1346204 1624291 UniProtKB:O15259 more ... RGD PMID:10521452 more ... protein binding IPI UniProtKB:Q9WUD9 15023465 PMID:8849729 UniProt protein binding ISO RGD:1346204 1624291 UniProtKB:O15259 more ... RGD PMID:10521452 more ... protein binding ISO RGD:733599 1624291 UniProtKB:P02786 more ... RGD MGI:MGI:1931659 more ... protein binding IPI RGD:2405 1642619 RGD protein binding IPI RGD:1308200 2304238 RGD protein C-terminus binding IEA UniProtKB:Q14289 , ensembl:ENSP000003806381600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein C-terminus binding ISO RGD:1346204 1624291 (PMID:10022914) RGD PMID:10022914 protein kinase activity ISO RGD:733599 1624291 (MGI:MGI:2429328, PMID:11274221) RGD MGI:MGI:2429328 , PMID:11274221 protein-containing complex binding IPI RGD:621172 , RGD:3537 1642649 RGD ubiquitin protein ligase binding IPI RGD:1561386 1642613 RGD
Gene-Chemical Interaction Annotations
