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Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.

Authors: Babayan, Alex H  Kramár, Enikö A  Barrett, Ruth M  Jafari, Matiar  Häettig, Jakob  Chen, Lulu Y  Rex, Christopher S  Lauterborn, Julie C  Wood, Marcelo A  Gall, Christine M  Lynch, Gary 
Citation: Babayan AH, etal., J Neurosci. 2012 Sep 12;32(37):12854-61. doi: 10.1523/JNEUROSCI.2024-12.2012.
Pubmed: (View Article at PubMed) PMID:22973009
DOI: Full-text: DOI:10.1523/JNEUROSCI.2024-12.2012

Memory consolidation theory posits that newly acquired information passes through a series of stabilization steps before being firmly encoded. We report here that in rat and mouse, hippocampus cell adhesion receptors belonging to the ß1-integrin family exhibit dynamic properties in adult synapses and that these contribute importantly to a previously unidentified stage of consolidation. Quantitative dual immunofluorescence microscopy showed that induction of long-term potentiation (LTP) by theta burst stimulation (TBS) activates ß1 integrins, and integrin-signaling kinases, at spine synapses in adult hippocampal slices. Neutralizing antisera selective for ß1 integrins blocked these effects. TBS-induced integrin activation was brief (<7 min) and followed by an ~45 min period during which the adhesion receptors did not respond to a second application of TBS. Brefeldin A, which blocks integrin trafficking to the plasma membrane, prevented the delayed recovery of integrin responses to TBS. ß1 integrin-neutralizing antisera erased LTP when applied during, but not after, the return of integrin responsivity. Similarly, infusions of anti-ß1 into rostral mouse hippocampus blocked formation of long-term, object location memory when started 20 min after learning but not 40 min later. The finding that ß1 integrin neutralization was effective in the same time window for slice and behavioral experiments strongly suggests that integrin recovery triggers a temporally discrete, previously undetected second stage of consolidation for both LTP and memory.


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RGD ID: 12050116
Created: 2017-01-21
Species: All species
Last Modified: 2017-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.