Ptk2b (protein tyrosine kinase 2 beta) - Rat Genome Database

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Gene: Ptk2b (protein tyrosine kinase 2 beta) Chinchilla lanigera
Analyze
Symbol: Ptk2b
Name: protein tyrosine kinase 2 beta
RGD ID: 8981518
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase binding (ortholog); calmodulin-dependent protein kinase activity (ortholog); enzyme binding (ortholog); INVOLVED IN actin filament organization (ortholog); activation of GTPase activity (ortholog); activation of Janus kinase activity (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anti-basement membrane glomerulonephritis (ortholog); brain ischemia (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein-tyrosine kinase 2-beta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
activation of GTPase activity  (ISO)
activation of Janus kinase activity  (ISO)
angiogenesis  (ISO)
blood vessel endothelial cell migration  (ISO)
bone resorption  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular defense response  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to retinoic acid  (ISO)
chemokine-mediated signaling pathway  (ISO)
endothelin receptor signaling pathway  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
focal adhesion assembly  (ISO)
glial cell proliferation  (ISO)
integrin-mediated signaling pathway  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (ISO)
marginal zone B cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of potassium ion transport  (ISO)
neuron projection development  (ISO)
oocyte maturation  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of B cell chemotaxis  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of translation  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton reorganization  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of cell adhesion  (ISO)
regulation of cell shape  (ISO)
regulation of cGMP-mediated signaling  (ISO)
regulation of establishment of cell polarity  (ISO)
regulation of inositol trisphosphate biosynthetic process  (ISO)
regulation of macrophage chemotaxis  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of ubiquitin-dependent protein catabolic process  (ISO)
response to calcium ion  (ISO)
response to cAMP  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to lithium ion  (ISO)
response to mechanical stimulus  (ISO)
response to organonitrogen compound  (ISO)
response to osmotic stress  (ISO)
response to reactive oxygen species  (ISO)
response to xenobiotic stimulus  (ISO)
sprouting angiogenesis  (ISO)
stress fiber assembly  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Ptk2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBIChiLan1.0ChiLan1.0
PTK2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,311,482 - 27,459,391 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,311,478 - 27,459,391 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,168,995 - 27,316,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,224,916 - 27,372,820 (+)NCBINCBI36hg18NCBI36
Build 34827,238,970 - 27,372,820NCBI
Celera826,131,907 - 26,277,021 (+)NCBI
Cytogenetic Map8p21.2NCBI
HuRef825,714,123 - 25,861,970 (+)NCBIHuRef
CHM1_1827,370,923 - 27,518,777 (+)NCBICHM1_1
Ptk2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,390,706 - 66,518,549 (-)NCBIGRCm39mm39
GRCm39 Ensembl1466,390,706 - 66,518,501 (-)Ensembl
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBImm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Ptk2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,360,722 - 40,481,235 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)Ensembl
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
PTK2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1823,783,624 - 23,932,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBIMhudiblu_PPA_v0panPan3
PTK2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,137,546 - 30,264,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,138,209 - 30,264,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,723,893 - 30,850,311 (-)NCBI
ROS_Cfam_1.02530,327,673 - 30,454,390 (-)NCBI
UMICH_Zoey_3.12530,257,967 - 30,384,306 (-)NCBI
UNSW_CanFamBas_1.02530,138,848 - 30,265,191 (-)NCBI
UU_Cfam_GSD_1.02530,305,247 - 30,431,983 (-)NCBI
Ptk2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,260,472 - 8,369,219 (-)NCBI
SpeTri2.0NW_004936675216,970 - 325,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,064,492 - 11,194,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,063,662 - 11,194,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,244,257 - 12,375,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTK2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,437,680 - 25,571,594 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl825,437,564 - 25,571,782 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605216,572,610 - 16,706,737 (-)NCBIVero_WHO_p1.0
Ptk2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022492   ⟹   ENSCLAP00000022287
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000022493   ⟹   ENSCLAP00000022288
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000022494   ⟹   ENSCLAP00000022289
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540349,891,668 - 49,973,225 (+)Ensembl
RefSeq Acc Id: XM_005373738   ⟹   XP_005373795
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,856,057 - 49,970,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373739   ⟹   XP_005373796
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,892,160 - 49,970,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373740   ⟹   XP_005373797
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,856,057 - 49,970,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373741   ⟹   XP_005373798
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013514189   ⟹   XP_013369643
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,896,916 - 49,970,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013514191   ⟹   XP_013369645
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,864,347 - 49,970,800 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005373795   ⟸   XM_005373738
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005373798   ⟸   XM_005373741
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005373797   ⟸   XM_005373740
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005373796   ⟸   XM_005373739
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013369645   ⟸   XM_013514191
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013369643   ⟸   XM_013514189
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000022287   ⟸   ENSCLAT00000022492
RefSeq Acc Id: ENSCLAP00000022289   ⟸   ENSCLAT00000022494
RefSeq Acc Id: ENSCLAP00000022288   ⟸   ENSCLAT00000022493


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015285 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000022287 ENTREZGENE
  ENSCLAP00000022288 ENTREZGENE
  ENSCLAP00000022289 ENTREZGENE
Ensembl Transcript ENSCLAT00000022492 ENTREZGENE
  ENSCLAT00000022493 ENTREZGENE
  ENSCLAT00000022494 ENTREZGENE
NCBI Gene Ptk2b ENTREZGENE