PTK2B (protein tyrosine kinase 2 beta) - Rat Genome Database
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Gene: PTK2B (protein tyrosine kinase 2 beta) Pan paniscus
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Symbol: PTK2B
Name: protein tyrosine kinase 2 beta
RGD ID: 11885413
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase binding (ortholog); calmodulin-dependent protein kinase activity (ortholog); enzyme binding (ortholog); INVOLVED IN actin filament organization (ortholog); activation of GTPase activity (ortholog); activation of Janus kinase activity (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); brain ischemia (ortholog); breast cancer (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta
Orthologs:
Homo sapiens (human) : PTK2B (protein tyrosine kinase 2 beta)  HGNC  Alliance
Mus musculus (house mouse) : Ptk2b (PTK2 protein tyrosine kinase 2 beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptk2b (protein tyrosine kinase 2 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2b (protein tyrosine kinase 2 beta)
Canis lupus familiaris (dog) : PTK2B (protein tyrosine kinase 2 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2b (protein tyrosine kinase 2 beta)
Sus scrofa (pig) : PTK2B (protein tyrosine kinase 2 beta)
Chlorocebus sabaeus (African green monkey) : PTK2B (protein tyrosine kinase 2 beta)
Heterocephalus glaber (naked mole-rat) : Ptk2b (protein tyrosine kinase 2 beta)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1823,783,624 - 23,932,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
activation of GTPase activity  (ISO)
activation of Janus kinase activity  (ISO)
angiogenesis  (ISO)
blood vessel endothelial cell migration  (ISO)
bone resorption  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular defense response  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to retinoic acid  (ISO)
chemokine-mediated signaling pathway  (ISO)
endothelin receptor signaling pathway  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
focal adhesion assembly  (ISO)
glial cell proliferation  (ISO)
integrin-mediated signaling pathway  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (ISO)
marginal zone B cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of potassium ion transport  (ISO)
neuron projection development  (ISO)
oocyte maturation  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of B cell chemotaxis  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of translation  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton reorganization  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of cell adhesion  (ISO)
regulation of cell shape  (ISO)
regulation of cGMP-mediated signaling  (ISO)
regulation of establishment of cell polarity  (ISO)
regulation of inositol trisphosphate biosynthetic process  (ISO)
regulation of macrophage chemotaxis  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of ubiquitin-dependent protein catabolic process  (ISO)
response to calcium ion  (ISO)
response to cAMP  (ISO)
response to cocaine  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to lithium ion  (ISO)
response to mechanical stimulus  (ISO)
response to organonitrogen compound  (ISO)
response to osmotic stress  (ISO)
response to reactive oxygen species  (ISO)
sprouting angiogenesis  (ISO)
stress fiber assembly  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
PTK2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1823,783,624 - 23,932,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBIMhudiblu_PPA_v0panPan3
PTK2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,311,482 - 27,459,391 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,311,478 - 27,459,391 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,168,999 - 27,316,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,224,916 - 27,372,820 (+)NCBINCBI36hg18NCBI36
Build 34827,238,970 - 27,372,820NCBI
Celera826,131,907 - 26,277,021 (+)NCBI
Cytogenetic Map8p21.2NCBI
HuRef825,714,123 - 25,861,970 (+)NCBIHuRef
CHM1_1827,370,923 - 27,518,777 (+)NCBICHM1_1
Ptk2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,390,706 - 66,518,549 (-)NCBI
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBImm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Ptk2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
Ptk2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBIChiLan1.0ChiLan1.0
PTK2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2530,138,209 - 30,264,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12530,137,546 - 30,264,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptk2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936675216,970 - 325,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,064,492 - 11,194,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,063,662 - 11,194,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,244,257 - 12,375,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTK2B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl825,437,564 - 25,571,782 (+)Ensembl
ChlSab1.1825,437,680 - 25,571,594 (+)NCBI
Ptk2b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000053011   ⟹   ENSPPAP00000030153
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053025   ⟹   ENSPPAP00000030167
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl823,869,866 - 23,932,472 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053046   ⟹   ENSPPAP00000030187
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl823,869,866 - 23,931,592 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053051   ⟹   ENSPPAP00000030192
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl823,869,866 - 23,931,592 (+)Ensembl
RefSeq Acc Id: XM_008956236   ⟹   XP_008954484
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1823,783,624 - 23,932,472 (+)NCBI
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008956238   ⟹   XP_008954486
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1823,799,018 - 23,932,470 (+)NCBI
Mhudiblu_PPA_v0826,596,120 - 26,729,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008956239   ⟹   XP_008954487
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1823,797,586 - 23,932,472 (+)NCBI
Mhudiblu_PPA_v0826,594,861 - 26,729,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024929844   ⟹   XP_024785612
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1823,797,586 - 23,932,470 (+)NCBI
Mhudiblu_PPA_v0826,594,861 - 26,729,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034965874   ⟹   XP_034821765
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0826,594,862 - 26,729,378 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_008954484   ⟸   XM_008956236
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008954487   ⟸   XM_008956239
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008954486   ⟸   XM_008956238
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024785612   ⟸   XM_024929844
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034821765   ⟸   XM_034965874
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000030153   ⟸   ENSPPAT00000053011
RefSeq Acc Id: ENSPPAP00000030167   ⟸   ENSPPAT00000053025
RefSeq Acc Id: ENSPPAP00000030187   ⟸   ENSPPAT00000053046
RefSeq Acc Id: ENSPPAP00000030192   ⟸   ENSPPAT00000053051
Protein Domains
FERM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037974 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000030153 UniProtKB/TrEMBL
  ENSPPAP00000030167 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000030187 UniProtKB/TrEMBL
  ENSPPAP00000030192 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053011 UniProtKB/TrEMBL
  ENSPPAT00000053025 UniProtKB/TrEMBL
  ENSPPAT00000053046 UniProtKB/TrEMBL
  ENSPPAT00000053051 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FADK_N UniProtKB/TrEMBL
  FAK1/PYK2_FERM_C UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  Focal_adhe_kin_target_dom_sf UniProtKB/TrEMBL
  Focal_adhesion_kin_target_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  PTK2B UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report pps:100991936 UniProtKB/TrEMBL
NCBI Gene PTK2B ENTREZGENE
PANTHER PTHR24418:SF94 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  FERM_N_2 UniProtKB/TrEMBL
  Focal_AT UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF68993 UniProtKB/TrEMBL
UniProt A0A2R9BL74_PANPA UniProtKB/TrEMBL
  A0A2R9BP01_PANPA UniProtKB/TrEMBL
  A0A2R9BP22_PANPA UniProtKB/TrEMBL
  A0A2R9BP28_PANPA UniProtKB/TrEMBL