Crk (CRK proto-oncogene, adaptor protein) - Rat Genome Database

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Gene: Crk (CRK proto-oncogene, adaptor protein) Rattus norvegicus
Analyze
Symbol: Crk
Name: CRK proto-oncogene, adaptor protein
RGD ID: 2405
Description: Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to nitric oxide; regulation of intracellular signal transduction; and response to peptide hormone. Predicted to be located in actin cytoskeleton and membrane. Predicted to be part of protein-containing complex. Predicted to be active in neuromuscular junction. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein); PARTICIPATES IN E-cadherin signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CrkII; Crko; p38; proto-oncogene C-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,028,736 - 61,054,971 (+)NCBIGRCr8
mRatBN7.21060,530,469 - 60,556,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,530,464 - 60,553,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,177,353 - 65,200,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,682,772 - 64,705,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,145,348 - 60,168,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,829,731 - 63,855,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,829,807 - 63,852,780 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,149,243 - 64,175,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,017,662 - 63,040,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11063,031,284 - 63,054,043 (+)NCBI
Celera1059,556,811 - 59,579,568 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
D-glucitol  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
dieldrin  (EXP)
diuron  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nickel dichloride  (EXP)
nitric oxide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sincalide  (EXP)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO,ISS)
cell chemotaxis  (ISO)
cell migration  (IBA,IEA)
cell population proliferation  (ISO)
cellular response to endothelin  (IPI)
cellular response to insulin-like growth factor stimulus  (IPI)
cellular response to nerve growth factor stimulus  (IDA)
cellular response to nitric oxide  (IPI)
cellular response to transforming growth factor beta stimulus  (IPI)
cerebellar neuron development  (ISO)
cerebral cortex development  (ISO)
dendrite development  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
ephrin receptor signaling pathway  (ISO,ISS)
establishment of cell polarity  (ISO)
helper T cell diapedesis  (ISO)
hippocampus development  (ISO)
lipid metabolic process  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (IMP)
negative regulation of wound healing  (ISO)
neuron migration  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of JNK cascade  (IMP)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of substrate adhesion-dependent cell spreading  (ISO,ISS)
postsynaptic specialization assembly  (ISO)
protein localization to membrane  (IMP)
reelin-mediated signaling pathway  (ISO)
regulation of actin cytoskeleton organization  (ISO,ISS)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of cell motility  (IEA,ISO)
regulation of cell shape  (ISO,ISS)
regulation of dendrite development  (ISO)
regulation of intracellular signal transduction  (ISO)
regulation of leukocyte migration  (ISO)
regulation of Rac protein signal transduction  (IMP)
regulation of signal transduction  (ISO)
regulation of T cell migration  (ISO)
regulation of wound healing  (ISO)
response to cholecystokinin  (IDA)
response to hepatocyte growth factor  (IPI)
response to hydrogen peroxide  (IPI)
response to peptide  (IPI)
response to yeast  (IEP)
signal transduction  (IBA,IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. Abassi YA and Vuori K, EMBO J 2002 Sep 2;21(17):4571-82.
2. Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes. Andreolotti AG, etal., Eur J Biochem 2003 Dec;270(23):4706-13.
3. Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species. Andreolotti AG, etal., J Cell Biochem. 2006 Feb 1;97(2):359-67.
4. Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5.
5. Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa. Buts JP and De Keyser N, Scand J Gastroenterol. 2010;45(2):175-85.
6. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Dadke S and Chernoff J, Biochem J. 2002 Jun 1;364(Pt 2):377-83.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. Haglund K, etal., J Cell Sci. 2004 May 15;117(Pt 12):2557-68. Epub 2004 May 5.
10. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. Huang J, etal., J Biol Chem 2002 Jul 26;277(30):27265-72. Epub 2002 May 14.
11. Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors. Ishiki M, etal., Endocrinology. 1997 Nov;138(11):4950-8.
12. CrkII signals from epidermal growth factor receptor to Ras. Kizaka-Kondoh S, etal., Proc Natl Acad Sci U S A 1996 Oct 29;93(22):12177-82.
13. Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Kodama H, etal., Hypertension. 2003 Jun;41(6):1372-9. Epub 2003 Apr 28.
14. Electroacupuncture inhibits apoptosis in annulus fibrosis cells through suppression of the mitochondria-dependent pathway in a rat model of cervical intervertebral disc degradation. Liao J, etal., Genet Mol Biol. 2012 Jul;35(3):686-92. doi: 10.1590/S1415-47572012005000046. Epub 2012 Jul 13.
15. Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk. Lin Y, etal., Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H710-21. Epub 2003 Apr 24.
16. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells. Mincione G, etal., Exp Cell Res. 2003 Jul 15;287(2):411-23.
19. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Nakamura T, etal., Mol Cell Biol. 2002 Dec;22(24):8721-34.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Peterson ME and Long EO, Immunity. 2008 Oct 17;29(4):578-88. doi: 10.1016/j.immuni.2008.07.014. Epub 2008 Oct 2.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
26. p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration. Tazaki T, etal., Hepatology. 2010 Sep;52(3):1089-99. doi: 10.1002/hep.23767.
Additional References at PubMed
PMID:8631760   PMID:9447983   PMID:9472046   PMID:9729467   PMID:9915838   PMID:11146548   PMID:11864995   PMID:11870224   PMID:12384576   PMID:15167895   PMID:15308668   PMID:15326184  
PMID:17515907   PMID:18477607   PMID:19004829   PMID:19056867   PMID:19074029   PMID:20624904   PMID:20980600   PMID:23376485   PMID:24480980   PMID:25621495   PMID:29581031   PMID:31311869  


Genomics

Comparative Map Data
Crk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,028,736 - 61,054,971 (+)NCBIGRCr8
mRatBN7.21060,530,469 - 60,556,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,530,464 - 60,553,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,177,353 - 65,200,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,682,772 - 64,705,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,145,348 - 60,168,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,829,731 - 63,855,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,829,807 - 63,852,780 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,149,243 - 64,175,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,017,662 - 63,040,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11063,031,284 - 63,054,043 (+)NCBI
Celera1059,556,811 - 59,579,568 (+)NCBICelera
Cytogenetic Map10q24NCBI
CRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,420,693 - 1,456,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,420,689 - 1,463,162 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,323,987 - 1,359,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,272,190 - 1,306,294 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,272,198 - 1,306,294NCBI
Celera171,340,062 - 1,374,733 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,225,393 - 1,259,684 (-)NCBIHuRef
CHM1_1171,333,439 - 1,368,323 (-)NCBICHM1_1
T2T-CHM13v2.0171,309,416 - 1,344,954 (-)NCBIT2T-CHM13v2.0
Crk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,570,020 - 75,599,254 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,570,085 - 75,597,734 (+)EnsemblGRCm39 Ensembl
GRCm381175,679,194 - 75,708,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,679,259 - 75,706,908 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,492,812 - 75,519,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,495,505 - 75,522,289 (+)NCBIMGSCv36mm8
Celera1183,188,410 - 83,215,203 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Crk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,705,520 - 1,734,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,705,595 - 1,748,363 (+)NCBIChiLan1.0ChiLan1.0
CRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,993,868 - 9,026,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11710,960,254 - 10,992,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,406,335 - 1,438,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,304,309 - 1,336,698 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,306,509 - 1,336,569 (-)Ensemblpanpan1.1panPan2
CRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,594,657 - 45,627,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,598,899 - 45,627,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,745,712 - 44,779,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,417,939 - 46,455,274 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1945,192,581 - 45,225,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,487,008 - 45,520,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,560,222 - 45,573,637 (-)NCBIUU_Cfam_GSD_1.0
Crk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,703,503 - 44,731,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,581,498 - 7,609,544 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,581,453 - 7,609,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,657,865 - 47,685,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,656,805 - 47,685,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,779,584 - 49,779,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,102,485 - 1,135,225 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,102,348 - 1,135,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,858,701 - 20,893,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,153,889 - 4,177,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,153,783 - 4,177,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crk
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:573
Count of miRNA genes:271
Interacting mature miRNAs:369
Transcripts:ENSRNOT00000006407
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat

Markers in Region
RH94394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,553,285 - 60,553,403 (+)MAPPERmRatBN7.2
Rnor_6.01063,852,589 - 63,852,706NCBIRnor6.0
Rnor_5.01064,152,536 - 64,152,653UniSTSRnor5.0
RGSC_v3.41063,040,300 - 63,040,417UniSTSRGSC3.4
Celera1059,579,448 - 59,579,565UniSTS
Cytogenetic Map10q24UniSTS
CRK  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,541,413 - 60,541,732 (+)MAPPERmRatBN7.2
Rnor_6.01063,840,675 - 63,840,993NCBIRnor6.0
Rnor_5.01064,164,249 - 64,164,567UniSTSRnor5.0
RGSC_v3.41063,028,428 - 63,028,746UniSTSRGSC3.4
Celera1059,567,577 - 59,567,895UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 74 35 40 11 8
Low 1 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006407   ⟹   ENSRNOP00000006407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,530,647 - 60,553,406 (+)Ensembl
Rnor_6.0 Ensembl1063,829,807 - 63,852,780 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102449   ⟹   ENSRNOP00000094573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,530,464 - 60,542,532 (+)Ensembl
RefSeq Acc Id: NM_019302   ⟹   NP_062175
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,028,917 - 61,051,675 (+)NCBI
mRatBN7.21060,530,647 - 60,553,406 (+)NCBI
Rnor_6.01063,829,909 - 63,852,709 (+)NCBI
Rnor_5.01064,149,243 - 64,175,511 (-)NCBI
RGSC_v3.41063,017,662 - 63,040,420 (+)RGD
Celera1059,556,811 - 59,579,568 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246913   ⟹   XP_006246975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,028,736 - 61,054,971 (+)NCBI
mRatBN7.21060,530,469 - 60,556,703 (+)NCBI
Rnor_6.01063,829,731 - 63,855,999 (+)NCBI
Rnor_5.01064,149,243 - 64,175,511 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062175   ⟸   NM_019302
- UniProtKB: Q63768 (UniProtKB/Swiss-Prot),   A6HGT2 (UniProtKB/TrEMBL),   A0A8I6ANJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246975   ⟸   XM_006246913
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000006407   ⟸   ENSRNOT00000006407
RefSeq Acc Id: ENSRNOP00000094573   ⟸   ENSRNOT00000102449
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63768-F1-model_v2 AlphaFold Q63768 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697444
Promoter ID:EPDNEW_R7968
Type:initiation region
Name:Crk_1
Description:CRK proto-oncogene, adaptor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,829,834 - 63,829,894EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2405 AgrOrtholog
BioCyc Gene G2FUF-24190 BioCyc
Ensembl Genes ENSRNOG00000025792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030050 UniProtKB/Swiss-Prot
  ENSRNOG00060022412 UniProtKB/Swiss-Prot
  ENSRNOG00065021729 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006407 ENTREZGENE
  ENSRNOT00000006407.5 UniProtKB/Swiss-Prot
  ENSRNOT00000102449.1 UniProtKB/TrEMBL
  ENSRNOT00055052122 UniProtKB/Swiss-Prot
  ENSRNOT00060038874 UniProtKB/Swiss-Prot
  ENSRNOT00065036955 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRK_SH3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRK_SH3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54245 ENTREZGENE
PANTHER ADAPTER MOLECULE CRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025792 RatGTEx
  ENSRNOG00055030050 RatGTEx
  ENSRNOG00060022412 RatGTEx
  ENSRNOG00065021729 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ANJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HGT2 ENTREZGENE, UniProtKB/TrEMBL
  CRK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Crk  CRK proto-oncogene, adaptor protein  Crk  v-crk avian sarcoma virus CT10 oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Crk  v-crk avian sarcoma virus CT10 oncogene homolog  Crk  v-crk sarcoma virus CT10 oncogene homolog (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Crk  v-crk sarcoma virus CT10 oncogene homolog (avian)  Crko  avian sarcoma virus CT10 (v-crk) oncogene homolog  Symbol and Name updated 1299863 APPROVED
2002-11-06 Crko  avian sarcoma virus CT10 (v-crk) oncogene homolog  Crk  v-crk avian sarcoma virus CT10 oncogene homolog  Symbol and Name updated 625702 APPROVED
2002-06-10 Crk  v-crk avian sarcoma virus CT10 oncogene homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with Cas 1298802
gene_physical_interaction interacts with tyrosine-phosphorylated proteins to transduce signals 1298804
gene_process mediates oncogenic growth signals from epidermal growth factor receptor to Ras in fibroblasts 1298801
gene_process adaptor protein that functions in signal transduction cascades from multiple cellular stimuli 1298803
gene_process mediates attachment-induced JNK activation, membrane ruffling and cell motility via facilitating membrane localization of Rac 1298803
gene_process faciliates signaling through cholecystokinin receptor in pancreatic cells 1298804
gene_regulation Cas-Crk complex dissociated by production of nitric oxide or by overexpression of PTP-PEST 1298802