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Gene: Ptk2b (PTK2 protein tyrosine kinase 2 beta) Mus musculus
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Symbol: Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Description: Exhibits non-membrane spanning protein tyrosine kinase activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Localizes to nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-octadec-9-enoylglycero-3-phosphate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CADTK; CAK-beta; CAKB; CAKbeta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK 2; FADK2; FAK2; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PYK2; Raftk; related adhesion focal tyrosine kinase
Orthologs:
Homo sapiens (human) : PTK2B (protein tyrosine kinase 2 beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptk2b (protein tyrosine kinase 2 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2b (protein tyrosine kinase 2 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2B (protein tyrosine kinase 2 beta)
Canis lupus familiaris (dog) : PTK2B (protein tyrosine kinase 2 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2b (protein tyrosine kinase 2 beta)
Sus scrofa (pig) : PTK2B (protein tyrosine kinase 2 beta)
Chlorocebus sabaeus (African green monkey) : PTK2B (protein tyrosine kinase 2 beta)
Heterocephalus glaber (naked mole-rat) : Ptk2b (protein tyrosine kinase 2 beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBImm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptk2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733599
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.