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Gene: Ptk2b (PTK2 protein tyrosine kinase 2 beta) Mus musculus
Symbol: Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Description: Exhibits non-membrane spanning protein tyrosine kinase activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Localizes to nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-octadec-9-enoylglycero-3-phosphate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CADTK; CAK-beta; CAKB; CAKbeta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK 2; FADK2; FAK2; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PYK2; Raftk; related adhesion focal tyrosine kinase
Homo sapiens (human) : PTK2B (protein tyrosine kinase 2 beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptk2b (protein tyrosine kinase 2 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2b (protein tyrosine kinase 2 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2B (protein tyrosine kinase 2 beta)
Canis lupus familiaris (dog) : PTK2B (protein tyrosine kinase 2 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2b (protein tyrosine kinase 2 beta)
Sus scrofa (pig) : PTK2B (protein tyrosine kinase 2 beta)
Chlorocebus sabaeus (African green monkey) : PTK2B (protein tyrosine kinase 2 beta)
Heterocephalus glaber (naked mole-rat) : Ptk2b (protein tyrosine kinase 2 beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBImm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptk2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733599
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.