Fer (FER tyrosine kinase) - Rat Genome Database

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Gene: Fer (FER tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Fer
Name: FER tyrosine kinase
RGD ID: 1306273
Description: Predicted to enable several functions, including epidermal growth factor receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein phosphatase 1 binding activity. Involved in adherens junction organization; germ cell development; and male gonad development. Located in adherens junction. Part of protein-containing complex. Orthologous to human FER (FER tyrosine kinase); PARTICIPATES IN N-cadherin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fms/fps related) protein kinase, testis specific 2 (predicted); fer (fps/fes related) tyrosine kinase; Fert2; Fert2_predicted; Flk; Flk_retired; LOC367326; p94-FER; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; tyrosine protein kinase FLK; tyrosine-protein kinase Fer; tyrosine-protein kinase FLK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89110,967,317 - 111,274,315 (+)NCBIGRCr8
mRatBN7.29103,520,452 - 103,827,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9103,520,493 - 103,821,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9111,932,827 - 112,227,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09117,046,130 - 117,352,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09115,398,721 - 115,693,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,557,804 - 111,868,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,597,037 - 111,862,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09111,103,930 - 111,410,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49102,645,929 - 102,861,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19102,805,652 - 102,969,235 (+)NCBI
Celera9101,013,100 - 101,221,975 (+)NCBICelera
Cytogenetic Map9q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO,ISS)
adherens junction assembly  (IEP)
adherens junction disassembly  (IEP)
cell adhesion  (IBA,IEA,ISO)
cell-cell adhesion mediated by cadherin  (IEA,ISO,ISS)
cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to reactive oxygen species  (IEA,ISO,ISS)
chemotaxis  (IBA,IEA,ISO)
cytokine-mediated signaling pathway  (IEA,ISO,ISS)
diapedesis  (IEA,ISO,ISS)
extracellular matrix-cell signaling  (IEA,ISO,ISS)
Fc-epsilon receptor signaling pathway  (IBA,IEA,ISO,ISS)
germ cell development  (IEP)
insulin receptor signaling pathway  (IEA,ISO,ISS)
interleukin-6-mediated signaling pathway  (IEA,ISO)
Kit signaling pathway  (IEA,ISO,ISS)
male gonad development  (IEP)
microtubule cytoskeleton organization  (IEA,ISO,ISS)
negative regulation of mast cell activation involved in immune response  (IEA,ISO,ISS)
peptidyl-tyrosine phosphorylation  (ISO,ISS)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of actin filament polymerization  (IEA,ISO,ISS)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO,ISS)
regulation of fibroblast migration  (IEA,ISO)
regulation of lamellipodium assembly  (IEA,ISO,ISS)
regulation of protein phosphorylation  (ISO,ISS)
response to lipopolysaccharide  (IEA,ISO,ISS)
response to platelet-derived growth factor  (IEA,ISO,ISS)
seminiferous tubule development  (IEP)
Sertoli cell development  (IEP)
signal transduction  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO,ISS)
tyrosine phosphorylation of STAT protein  (ISO)

Cellular Component
actin cytoskeleton  (IEA,ISO,ISS)
adherens junction  (IDA)
anchoring junction  (IEA)
cell cortex  (IEA)
cell junction  (IEA,ISO,ISS)
cell projection  (IEA)
chromatin  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytoplasmic side of plasma membrane  (IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
lamellipodium  (IEA,ISO,ISS)
membrane  (IEA)
microtubule cytoskeleton  (IEA,ISO,ISS)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1990274   PMID:2485255   PMID:7623846   PMID:9722593   PMID:11006284   PMID:12192036   PMID:12972546   PMID:16009680   PMID:16176974   PMID:16731527   PMID:16732323   PMID:17606629  
PMID:18985748   PMID:19047464   PMID:19147545   PMID:19738202   PMID:21518868   PMID:22223638   PMID:25540073  


Genomics

Comparative Map Data
Fer
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89110,967,317 - 111,274,315 (+)NCBIGRCr8
mRatBN7.29103,520,452 - 103,827,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9103,520,493 - 103,821,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9111,932,827 - 112,227,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09117,046,130 - 117,352,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09115,398,721 - 115,693,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,557,804 - 111,868,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,597,037 - 111,862,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09111,103,930 - 111,410,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49102,645,929 - 102,861,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19102,805,652 - 102,969,235 (+)NCBI
Celera9101,013,100 - 101,221,975 (+)NCBICelera
Cytogenetic Map9q37NCBI
FER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385108,747,897 - 109,196,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5108,747,841 - 109,196,841 (+)EnsemblGRCh38hg38GRCh38
GRCh375108,083,598 - 108,532,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365108,111,422 - 108,551,272 (+)NCBINCBI36Build 36hg18NCBI36
Build 345108,111,421 - 108,551,272NCBI
Celera5104,021,685 - 104,463,167 (+)NCBICelera
Cytogenetic Map5q21.3NCBI
HuRef5103,255,853 - 103,696,708 (+)NCBIHuRef
CHM1_15107,516,662 - 107,956,463 (+)NCBICHM1_1
T2T-CHM13v2.05109,250,514 - 109,700,301 (+)NCBIT2T-CHM13v2.0
Fer
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391764,136,945 - 64,453,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1764,170,057 - 64,446,491 (+)EnsemblGRCm39 Ensembl
GRCm381763,862,073 - 64,146,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1763,863,062 - 64,139,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv371764,245,367 - 64,488,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361763,581,484 - 63,824,640 (+)NCBIMGSCv36mm8
Celera1768,237,664 - 68,455,526 (+)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1733.06NCBI
Fer
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554185,614,950 - 5,981,636 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554185,612,919 - 5,981,549 (-)NCBIChiLan1.0ChiLan1.0
FER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24104,000,498 - 104,451,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15102,156,957 - 102,596,934 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05104,099,620 - 104,548,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15109,915,751 - 110,350,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5109,964,823 - 110,350,576 (+)Ensemblpanpan1.1panPan2
FER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132,863,804 - 3,295,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32,867,726 - 3,295,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha34,272,340 - 4,700,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032,756,396 - 3,188,729 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32,758,188 - 3,187,807 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132,707,992 - 3,136,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032,735,868 - 3,165,523 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.032,872,292 - 3,307,139 (-)NCBIUU_Cfam_GSD_1.0
Fer
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213157,705,239 - 158,134,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365313,551,350 - 3,897,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365313,512,976 - 3,898,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2113,774,412 - 114,206,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12113,774,120 - 114,207,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22118,230,513 - 118,512,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FER
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12312,252,135 - 12,629,584 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2312,192,800 - 12,620,443 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660361,598,008 - 2,044,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fer
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474326,694,465 - 27,091,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474326,663,440 - 27,097,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fer
1601 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:904
Count of miRNA genes:230
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000021758, ENSRNOT00000056430
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat

Markers in Region
D9Rat140  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr89110,979,148 - 110,979,249 (+)Marker Load Pipeline
mRatBN7.29103,532,184 - 103,532,285 (+)MAPPERmRatBN7.2
Rnor_6.09111,571,379 - 111,571,479NCBIRnor6.0
Rnor_5.09111,115,647 - 111,115,747UniSTSRnor5.0
RGSC_v3.49102,570,430 - 102,570,530UniSTSRGSC3.4
RGSC_v3.49102,570,429 - 102,570,530RGDRGSC3.4
RGSC_v3.19102,779,909 - 102,780,010RGD
FHH x ACI Map983.53UniSTS
FHH x ACI Map983.53RGD
Cytogenetic Map9q37UniSTS
AI010628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29103,819,978 - 103,820,146 (+)MAPPERmRatBN7.2
Rnor_6.09111,861,198 - 111,861,365NCBIRnor6.0
Rnor_5.09111,403,242 - 111,403,409UniSTSRnor5.0
RGSC_v3.49102,860,226 - 102,860,393UniSTSRGSC3.4
Celera9101,220,503 - 101,220,670UniSTS
Cytogenetic Map9q37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000021758   ⟹   ENSRNOP00000021758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,557,987 - 103,820,142 (+)Ensembl
Rnor_6.0 Ensembl9111,597,037 - 111,861,366 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000056430   ⟹   ENSRNOP00000053268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,608,388 - 103,821,451 (+)Ensembl
Rnor_6.0 Ensembl9111,649,631 - 111,862,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097737   ⟹   ENSRNOP00000090379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,520,493 - 103,820,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112759   ⟹   ENSRNOP00000095206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,558,044 - 103,820,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117309   ⟹   ENSRNOP00000077379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9103,520,508 - 103,558,360 (+)Ensembl
RefSeq Acc Id: NM_001106928   ⟹   NP_001100398
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,055,349 - 111,268,402 (+)NCBI
mRatBN7.29103,608,388 - 103,821,451 (+)NCBI
Rnor_6.09111,649,631 - 111,862,670 (+)NCBI
Rnor_5.09111,103,930 - 111,410,627 (+)NCBI
RGSC_v3.49102,645,929 - 102,861,698 (+)RGD
Celera9101,013,100 - 101,221,975 (+)RGD
Sequence:
RefSeq Acc Id: NM_001395758   ⟹   NP_001382687
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,463 - 111,274,315 (+)NCBI
mRatBN7.29103,520,497 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_008767367   ⟹   XP_008765589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,974,307 - 111,274,315 (+)NCBI
mRatBN7.29103,527,342 - 103,827,364 (+)NCBI
Rnor_6.09111,566,509 - 111,868,583 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083433   ⟹   XP_038939361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,274,315 (+)NCBI
mRatBN7.29103,520,453 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083436   ⟹   XP_038939364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,035,049 - 111,274,315 (+)NCBI
mRatBN7.29103,587,997 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083438   ⟹   XP_038939366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,059,377 - 111,274,315 (+)NCBI
mRatBN7.29103,612,417 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083439   ⟹   XP_038939367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,059,377 - 111,274,315 (+)NCBI
mRatBN7.29103,612,417 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083440   ⟹   XP_038939368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,059,377 - 111,274,315 (+)NCBI
mRatBN7.29103,612,417 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083441   ⟹   XP_038939369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,054,979 - 111,274,315 (+)NCBI
mRatBN7.29103,607,948 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083442   ⟹   XP_038939370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,054,979 - 111,274,315 (+)NCBI
mRatBN7.29103,607,948 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083443   ⟹   XP_038939371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,059,377 - 111,274,315 (+)NCBI
mRatBN7.29103,612,417 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083444   ⟹   XP_038939372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,059,377 - 111,274,315 (+)NCBI
mRatBN7.29103,612,417 - 103,827,364 (+)NCBI
RefSeq Acc Id: XM_039083445   ⟹   XP_038939373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,059,520 (+)NCBI
mRatBN7.29103,520,452 - 103,612,560 (+)NCBI
RefSeq Acc Id: XM_039083446   ⟹   XP_038939374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,251 (+)NCBI
mRatBN7.29103,520,452 - 103,627,474 (+)NCBI
RefSeq Acc Id: XM_039083447   ⟹   XP_038939375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,438 (+)NCBI
mRatBN7.29103,520,452 - 103,628,477 (+)NCBI
RefSeq Acc Id: XM_039083448   ⟹   XP_038939376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,288 (+)NCBI
mRatBN7.29103,520,452 - 103,628,328 (+)NCBI
RefSeq Acc Id: XM_063267046   ⟹   XP_063123116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,274,315 (+)NCBI
RefSeq Acc Id: XM_063267047   ⟹   XP_063123117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,199,591 (+)NCBI
RefSeq Acc Id: XM_063267048   ⟹   XP_063123118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89111,055,020 - 111,274,315 (+)NCBI
RefSeq Acc Id: XR_005488882
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,154,455 (+)NCBI
mRatBN7.29103,520,452 - 103,707,498 (+)NCBI
RefSeq Acc Id: XR_005488883
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,251 (+)NCBI
mRatBN7.29103,520,452 - 103,627,476 (+)NCBI
RefSeq Acc Id: XR_005488884
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,407 (+)NCBI
mRatBN7.29103,520,452 - 103,628,447 (+)NCBI
RefSeq Acc Id: XR_005488885
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,383 (+)NCBI
mRatBN7.29103,520,452 - 103,628,421 (+)NCBI
RefSeq Acc Id: XR_005488886
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,075,391 (+)NCBI
mRatBN7.29103,520,452 - 103,628,429 (+)NCBI
RefSeq Acc Id: XR_010054586
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89110,967,317 - 111,095,943 (+)NCBI
RefSeq Acc Id: NP_001100398   ⟸   NM_001106928
- Peptide Label: isoform 1
- UniProtKB: A6JRA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765589   ⟸   XM_008767367
- Peptide Label: isoform X1
- UniProtKB: P09760 (UniProtKB/Swiss-Prot),   F1MA12 (UniProtKB/Swiss-Prot),   A0A140TAC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021758   ⟸   ENSRNOT00000021758
Ensembl Acc Id: ENSRNOP00000053268   ⟸   ENSRNOT00000056430
RefSeq Acc Id: XP_038939375   ⟸   XM_039083447
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038939376   ⟸   XM_039083448
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038939374   ⟸   XM_039083446
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038939373   ⟸   XM_039083445
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038939361   ⟸   XM_039083433
- Peptide Label: isoform X2
- UniProtKB: A0A140TAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939364   ⟸   XM_039083436
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ANB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939369   ⟸   XM_039083441
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038939370   ⟸   XM_039083442
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038939367   ⟸   XM_039083439
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038939366   ⟸   XM_039083438
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038939372   ⟸   XM_039083444
- Peptide Label: isoform X7
- UniProtKB: F1LPI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939368   ⟸   XM_039083440
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038939371   ⟸   XM_039083443
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000090379   ⟸   ENSRNOT00000097737
Ensembl Acc Id: ENSRNOP00000077379   ⟸   ENSRNOT00000117309
Ensembl Acc Id: ENSRNOP00000095206   ⟸   ENSRNOT00000112759
RefSeq Acc Id: NP_001382687   ⟸   NM_001395758
- Peptide Label: isoform 2
- UniProtKB: P09760 (UniProtKB/Swiss-Prot),   F1MA12 (UniProtKB/Swiss-Prot),   A0A140TAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123116   ⟸   XM_063267046
- Peptide Label: isoform X3
- UniProtKB: A0A140TAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123117   ⟸   XM_063267047
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123118   ⟸   XM_063267048
- Peptide Label: isoform X12
Protein Domains
F-BAR   FCH   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09760-F1-model_v2 AlphaFold P09760 1-823 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306273 AgrOrtholog
BioCyc Gene G2FUF-26520 BioCyc
Ensembl Genes ENSRNOG00000015898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056430 ENTREZGENE
  ENSRNOT00000097737 ENTREZGENE
  ENSRNOT00000097737.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112759 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  HR1 repeat UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  F_BAR UniProtKB/Swiss-Prot
  FCH_dom UniProtKB/Swiss-Prot
  Fer_F-BAR UniProtKB/Swiss-Prot
  Fes/Fps/Fer_SH2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  Tyr-prot_kinase_Fes/Fps UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
NCBI Gene Fer ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam FCH UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Fer PhenoGen
PIRSF TyrPK_fps UniProtKB/Swiss-Prot
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE F_BAR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015898 RatGTEx
SMART FCH UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A140TAC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5R1_RAT UniProtKB/TrEMBL
  A0A8I6ANB7 ENTREZGENE, UniProtKB/TrEMBL
  A6JRA6 ENTREZGENE, UniProtKB/TrEMBL
  F1LPI8 ENTREZGENE, UniProtKB/TrEMBL
  F1MA12 ENTREZGENE
  FER_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1MA12 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fer  FER tyrosine kinase  Fer  fer (fps/fes related) tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-09 Fer  fer (fps/fes related) tyrosine kinase  Fert2  fer (fms/fps related) protein kinase, testis specific 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-07 Fert2  fer (fms/fps related) protein kinase, testis specific 2  Fert2_predicted  fer (fms/fps related) protein kinase, testis specific 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2007-02-07 Fert2_predicted  fer (fms/fps related) protein kinase, testis specific 2 (predicted)  Flk_retired  tyrosine protein kinase FLK  Data merged from RGD:1597165 737654 APPROVED
2007-02-07 Flk_retired    Flk  tyrosine protein kinase FLK  Symbol withdrawn 1299863 PROVISIONAL