Fer (FER tyrosine kinase) - Rat Genome Database

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Gene: Fer (FER tyrosine kinase) Heterocephalus glaber
Analyze
Symbol: Fer
Name: FER tyrosine kinase
RGD ID: 18930541
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); lipid binding (ortholog); protein kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adherens junction assembly (ortholog); adherens junction disassembly (ortholog); PARTICIPATES IN N-cadherin signaling pathway; ASSOCIATED WITH Duane retraction syndrome (ortholog); familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN actin cytoskeleton (ortholog); adherens junction (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Proto-oncogene tyrosine-protein kinase FER; tyrosine-protein kinase Fer
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474326,694,465 - 27,091,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474326,663,440 - 27,097,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adherens junction assembly  (ISO)
adherens junction disassembly  (ISO)
cell adhesion  (ISO)
cell-cell adhesion mediated by cadherin  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
chemotaxis  (ISO)
cytokine-mediated signaling pathway  (ISO)
diapedesis  (ISO)
extracellular matrix-cell signaling  (ISO)
Fc-epsilon receptor signaling pathway  (ISO)
germ cell development  (ISO)
insulin receptor signaling pathway  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
Kit signaling pathway  (ISO)
male gonad development  (ISO)
microtubule cytoskeleton organization  (ISO)
negative regulation of mast cell activation involved in immune response  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of epidermal growth factor receptor signaling pathway  (ISO)
regulation of fibroblast migration  (ISO)
regulation of lamellipodium assembly  (ISO)
regulation of protein phosphorylation  (ISO)
response to lipopolysaccharide  (ISO)
response to platelet-derived growth factor  (ISO)
seminiferous tubule development  (ISO)
Sertoli cell development  (ISO)
signal transduction  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
tyrosine phosphorylation of STAT protein  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fer
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474326,694,465 - 27,091,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474326,663,440 - 27,097,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385108,747,897 - 109,196,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5108,747,841 - 109,196,841 (+)EnsemblGRCh38hg38GRCh38
GRCh375108,083,598 - 108,532,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365108,111,422 - 108,551,272 (+)NCBINCBI36Build 36hg18NCBI36
Build 345108,111,421 - 108,551,272NCBI
Celera5104,021,685 - 104,463,167 (+)NCBICelera
Cytogenetic Map5q21.3NCBI
HuRef5103,255,853 - 103,696,708 (+)NCBIHuRef
CHM1_15107,516,662 - 107,956,463 (+)NCBICHM1_1
T2T-CHM13v2.05109,250,514 - 109,700,301 (+)NCBIT2T-CHM13v2.0
Fer
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391764,136,945 - 64,453,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1764,170,057 - 64,446,491 (+)EnsemblGRCm39 Ensembl
GRCm381763,862,073 - 64,146,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1763,863,062 - 64,139,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv371764,245,367 - 64,488,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361763,581,484 - 63,824,640 (+)NCBIMGSCv36mm8
Celera1768,237,664 - 68,455,526 (+)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1733.06NCBI
Fer
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89110,967,317 - 111,274,315 (+)NCBIGRCr8
mRatBN7.29103,520,452 - 103,827,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9103,520,493 - 103,821,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9111,932,827 - 112,227,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09117,046,130 - 117,352,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09115,398,721 - 115,693,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,557,804 - 111,868,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,597,037 - 111,862,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09111,103,930 - 111,410,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49102,645,929 - 102,861,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19102,805,652 - 102,969,235 (+)NCBI
Celera9101,013,100 - 101,221,975 (+)NCBICelera
Cytogenetic Map9q37NCBI
Fer
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554185,614,950 - 5,981,636 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554185,612,919 - 5,981,549 (-)NCBIChiLan1.0ChiLan1.0
FER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24104,000,498 - 104,451,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15102,156,957 - 102,596,934 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05104,099,620 - 104,548,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15109,915,751 - 110,350,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5109,964,823 - 110,350,576 (+)Ensemblpanpan1.1panPan2
FER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132,863,804 - 3,295,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32,867,726 - 3,295,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha34,272,340 - 4,700,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032,756,396 - 3,188,729 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32,758,188 - 3,187,807 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132,707,992 - 3,136,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032,735,868 - 3,165,523 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.032,872,292 - 3,307,139 (-)NCBIUU_Cfam_GSD_1.0
Fer
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213157,705,239 - 158,134,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365313,551,350 - 3,897,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365313,512,976 - 3,898,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2113,774,412 - 114,206,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12113,774,120 - 114,207,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22118,230,513 - 118,512,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FER
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12312,252,135 - 12,629,584 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2312,192,800 - 12,620,443 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660361,598,008 - 2,044,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013071121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002393839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002393840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01022199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01022223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH166020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000009771   ⟹   ENSHGLP00000009664
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474326,694,465 - 27,091,250 (+)Ensembl
RefSeq Acc Id: XM_013071121   ⟹   XP_012926575
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,451 - 27,091,357 (+)NCBI
RefSeq Acc Id: XM_021255851   ⟹   XP_021111510
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,463 - 27,097,771 (+)NCBI
RefSeq Acc Id: XM_021255852   ⟹   XP_021111511
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,440 - 27,097,771 (+)NCBI
RefSeq Acc Id: XM_021255853   ⟹   XP_021111512
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,451 - 27,097,771 (+)NCBI
RefSeq Acc Id: XM_021255854   ⟹   XP_021111513
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,451 - 27,097,771 (+)NCBI
RefSeq Acc Id: XR_002393839
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,451 - 26,919,470 (+)NCBI
RefSeq Acc Id: XR_002393840
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474326,663,446 - 26,820,556 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012926575 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111510 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111511 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111512 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111513 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA98302 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009664
RefSeq Acc Id: XP_021111511   ⟸   XM_021255852
- Peptide Label: isoform X1
- UniProtKB: G5AMP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111513   ⟸   XM_021255854
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021111512   ⟸   XM_021255853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_012926575   ⟸   XM_013071121
- Peptide Label: isoform X1
- UniProtKB: G5AMP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111510   ⟸   XM_021255851
- Peptide Label: isoform X1
- UniProtKB: G5AMP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000009664   ⟸   ENSHGLT00000009771


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006933 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009771 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  HR1 repeat UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  Fer_F-BAR UniProtKB/TrEMBL
  Fes/Fps/Fer_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr-prot_kinase_Fes/Fps UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report hgl:101725868 UniProtKB/TrEMBL
NCBI Gene Fer ENTREZGENE
PANTHER PTHR24418:SF227 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PIRSF TyrPK_fps UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0AAX6SR44_HETGA UniProtKB/TrEMBL
  A0AAX6SS78_HETGA UniProtKB/TrEMBL
  G5AMP2 ENTREZGENE, UniProtKB/TrEMBL