Src (SRC proto-oncogene, non-receptor tyrosine kinase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Src (SRC proto-oncogene, non-receptor tyrosine kinase) Heterocephalus glaber
Analyze
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
RGD ID: 18915222
Description: ENCODES a protein that exhibits BMP receptor binding (ortholog); cell adhesion molecule binding (ortholog); connexin binding (ortholog); INVOLVED IN adherens junction organization (ortholog); angiotensin-activated signaling pathway (ortholog); bone resorption (ortholog); PARTICIPATES IN altered Reelin signaling pathway; dopamine signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 5 (ortholog); autosomal recessive polycystic kidney disease (ortholog); brain ischemia (ortholog); FOUND IN actin filament (ortholog); caveola (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene tyrosine-protein kinase Src; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,211,020 - 2,230,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,212,561 - 2,260,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (ISO)
angiotensin-activated signaling pathway  (ISO)
bone resorption  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cell migration  (ISO)
cell-cell adhesion  (ISO)
cellular response to angiotensin  (ISO)
cellular response to fatty acid  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
DNA biosynthetic process  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
focal adhesion assembly  (ISO)
forebrain development  (ISO)
integrin-mediated signaling pathway  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
intestinal epithelial cell development  (ISO)
intracellular signal transduction  (ISO)
learning or memory  (ISO)
myoblast proliferation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hippo signaling  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of neutrophil activation  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of telomere maintenance  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neurotrophin TRK receptor signaling pathway  (ISO)
odontogenesis  (ISO)
oogenesis  (ISO)
osteoclast development  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dephosphorylation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of lamellipodium morphogenesis  (ISO)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of outer hair cell apoptotic process  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of platelet-derived growth factor receptor-beta signaling pathway  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein processing  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of protein transport  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of TORC1 signaling  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
primary ovarian follicle growth  (ISO)
progesterone receptor signaling pathway  (ISO)
protein autophosphorylation  (ISO)
protein destabilization  (ISO)
protein phosphorylation  (ISO)
regulation of caveolin-mediated endocytosis  (ISO)
regulation of cell projection assembly  (ISO)
regulation of cell-cell adhesion  (ISO)
regulation of early endosome to late endosome transport  (ISO)
regulation of epithelial cell migration  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of intracellular estrogen receptor signaling pathway  (ISO)
regulation of toll-like receptor 3 signaling pathway  (ISO)
response to acidic pH  (ISO)
response to electrical stimulus  (ISO)
response to fatty acid  (ISO)
response to hydrogen peroxide  (ISO)
response to interleukin-1  (ISO)
response to mechanical stimulus  (ISO)
response to mineralocorticoid  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell proliferation  (ISO)
spermatogenesis  (ISO)
stress fiber assembly  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
transcytosis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
uterus development  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Src
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,211,020 - 2,230,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,212,561 - 2,260,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382037,344,699 - 37,406,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2037,344,685 - 37,406,050 (+)EnsemblGRCh38hg38GRCh38
GRCh372035,973,102 - 36,034,453 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,406,502 - 35,467,235 (+)NCBINCBI36Build 36hg18NCBI36
Build 342035,407,970 - 35,467,233NCBI
Celera2032,680,370 - 32,741,098 (+)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,708,654 - 32,769,187 (+)NCBIHuRef
CHM1_12035,876,016 - 35,936,689 (+)NCBICHM1_1
T2T-CHM13v2.02039,068,774 - 39,130,114 (+)NCBIT2T-CHM13v2.0
Src
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,265,828 - 157,313,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,260,364 - 157,313,782 (+)EnsemblGRCm39 Ensembl
GRCm382157,423,906 - 157,471,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,418,444 - 157,471,862 (+)EnsemblGRCm38mm10GRCm38
MGSCv372157,250,029 - 157,297,574 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,115,734 - 157,163,279 (+)NCBIMGSCv36mm8
Celera2163,383,913 - 163,416,616 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.35NCBI
Src
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,511,616 - 166,559,463 (+)NCBIGRCr8
mRatBN7.23146,091,969 - 146,139,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,091,841 - 146,139,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,950,044 - 149,963,314 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,451,340 - 158,464,620 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,193,067 - 156,206,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,547,807 - 153,595,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,580,861 - 153,595,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,123,674 - 158,171,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,157,256 - 148,170,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,063,164 - 148,076,433 (+)NCBI
Celera3144,830,256 - 144,843,524 (+)NCBICelera
Cytogenetic Map3q42NCBI
Src
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544519,215,161 - 19,228,695 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544519,213,210 - 19,227,670 (-)NCBIChiLan1.0ChiLan1.0
SRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22143,073,049 - 43,132,588 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12043,066,176 - 43,127,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,667,614 - 33,727,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,822,287 - 34,841,523 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,822,271 - 34,839,634 (+)Ensemblpanpan1.1panPan2
SRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,982,499 - 26,019,748 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,999,048 - 26,018,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,618,275 - 25,668,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,666,859 - 26,717,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,666,617 - 26,717,074 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,944,146 - 25,994,080 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,074,538 - 26,099,748 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,538,700 - 26,589,113 (+)NCBIUU_Cfam_GSD_1.0
Src
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,890,047 - 174,922,678 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,825,787 - 3,844,483 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,826,802 - 3,844,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,471,009 - 40,524,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,470,970 - 40,524,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,907,305 - 45,942,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,344,480 - 26,367,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,343,450 - 26,367,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,217,493 - 75,278,886 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023007   ⟹   ENSHGLP00000022793
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248422,211,020 - 2,230,132 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000023008   ⟹   ENSHGLP00000022794
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248422,211,020 - 2,230,132 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000023009   ⟹   ENSHGLP00000022795
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248422,214,458 - 2,228,861 (-)Ensembl
RefSeq Acc Id: XM_004867799   ⟹   XP_004867856
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,260,338 (-)NCBI
RefSeq Acc Id: XM_021246845   ⟹   XP_021102504
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,230,131 (-)NCBI
RefSeq Acc Id: XM_021246846   ⟹   XP_021102505
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,230,131 (-)NCBI
RefSeq Acc Id: XM_021246847   ⟹   XP_021102506
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,260,514 (-)NCBI
RefSeq Acc Id: XM_021246848   ⟹   XP_021102507
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,233,978 (-)NCBI
RefSeq Acc Id: XM_021246849   ⟹   XP_021102508
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,212,561 - 2,230,131 (-)NCBI
RefSeq Acc Id: XP_021102506   ⟸   XM_021246847
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004867856   ⟸   XM_004867799
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021102507   ⟸   XM_021246848
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021102508   ⟸   XM_021246849
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021102505   ⟸   XM_021246846
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021102504   ⟸   XM_021246845
- Peptide Label: isoform X1
Ensembl Acc Id: ENSHGLP00000022794   ⟸   ENSHGLT00000023008
Ensembl Acc Id: ENSHGLP00000022795   ⟸   ENSHGLT00000023009
Ensembl Acc Id: ENSHGLP00000022793   ⟸   ENSHGLT00000023007


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016257 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023007 ENTREZGENE
  ENSHGLT00000023008 ENTREZGENE
NCBI Gene Src ENTREZGENE