Kcnq3 (potassium voltage-gated channel subfamily Q member 3) - Rat Genome Database

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Gene: Kcnq3 (potassium voltage-gated channel subfamily Q member 3) Rattus norvegicus
Analyze
Symbol: Kcnq3
Name: potassium voltage-gated channel subfamily Q member 3
RGD ID: 69222
Description: Exhibits several functions, including calmodulin binding activity; enzyme binding activity; and ion channel binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Localizes to several cellular components, including axon initial segment; membrane raft; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: KQT-like 3; potassium channel subunit alpha KvLQT3; potassium channel, voltage-gated KQT-like subfamily Q, member 3; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; voltage-gated potassium channel subunit Kv7.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2797,730,219 - 98,025,652 (-)NCBI
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Celera794,285,105 - 94,579,630 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Charlier C, etal., Nat Genet. 1998 Jan;18(1):53-5.
2. Ekberg J, etal., J Biol Chem. 2007 Apr 20;282(16):12135-42. Epub 2007 Feb 23.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gilling M, etal., Front Genet. 2013 Apr 16;4:54. doi: 10.3389/fgene.2013.00054. eCollection 2013.
5. GOA data from the GO Consortium
6. Hadley JK, etal., J Neurosci. 2003 Jun 15;23(12):5012-9.
7. Hirose S, etal., Ann Neurol. 2000 Jun;47(6):822-6.
8. Li Y, etal., J Biol Chem. 2004 Oct 29;279(44):45399-407. Epub 2004 Aug 10.
9. Liu W and Devaux JJ, Mol Cell Neurosci. 2014 Jan;58:40-52. doi: 10.1016/j.mcn.2013.12.005. Epub 2013 Dec 11.
10. NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
12. Oldfield S, etal., Mol Pharmacol. 2009 Dec;76(6):1279-89. doi: 10.1124/mol.109.058008. Epub 2009 Sep 2.
13. OMIM Disease Annotation Pipeline
14. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. RGD automated import pipeline for gene-chemical interactions
16. Shah MM, etal., J Physiol 2002 Oct 1;544(Pt 1):29-37.
17. Wang HS, etal., Science 1998 Dec 4;282(5395):1890-3.
18. Wang W, etal., PLoS One. 2011;6(7):e21792. doi: 10.1371/journal.pone.0021792. Epub 2011 Jul 5.
19. Yus-Najera E, etal., J Biol Chem 2002 Aug 9;277(32):28545-53.
20. Zheng Q, etal., Pain. 2013 Mar;154(3):434-48. doi: 10.1016/j.pain.2012.12.005. Epub 2012 Dec 20.
Additional References at PubMed
PMID:10788442   PMID:11159685   PMID:12223552   PMID:14638935   PMID:16525039   PMID:16527853   PMID:17311847   PMID:17442834   PMID:17724161   PMID:18048450   PMID:18089837   PMID:18448631  
PMID:18786918   PMID:18827480   PMID:19060215   PMID:20885443   PMID:21787867   PMID:22871113   PMID:23623937   PMID:24599470   PMID:25796298   PMID:27445338   PMID:27450567   PMID:27564677  
PMID:31373759  


Genomics

Comparative Map Data
Kcnq3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2797,730,219 - 98,025,652 (-)NCBI
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Celera794,285,105 - 94,579,630 (-)NCBICelera
Cytogenetic Map7q34NCBI
KCNQ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8132,120,859 - 132,481,095 (-)EnsemblGRCh38hg38GRCh38
GRCh388132,120,858 - 132,481,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378133,133,108 - 133,493,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,210,438 - 133,562,186 (-)NCBINCBI36hg18NCBI36
Build 348133,210,437 - 133,562,186NCBI
Celera8129,316,946 - 129,668,720 (-)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8128,450,644 - 128,810,822 (-)NCBIHuRef
CHM1_18133,173,913 - 133,533,807 (-)NCBICHM1_1
Kcnq3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391565,858,223 - 66,158,485 (-)NCBIGRCm39mm39
GRCm39 Ensembl1565,858,236 - 66,158,491 (-)Ensembl
GRCm381565,986,374 - 66,286,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1565,986,387 - 66,286,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv371565,826,477 - 66,117,786 (-)NCBIGRCm37mm9NCBIm37
MGSCv361565,824,844 - 66,115,893 (-)NCBImm8
Celera1567,502,496 - 67,809,639 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.16NCBI
Kcnq3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554616,797,018 - 7,119,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554616,793,877 - 7,119,859 (-)NCBIChiLan1.0ChiLan1.0
KCNQ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18131,747,069 - 132,110,448 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8131,755,454 - 131,815,237 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08128,769,930 - 129,134,671 (-)NCBIMhudiblu_PPA_v0panPan3
KCNQ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11328,765,472 - 29,062,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1328,773,738 - 29,062,370 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1328,738,298 - 29,035,933 (-)NCBI
ROS_Cfam_1.01329,120,132 - 29,417,368 (-)NCBI
UMICH_Zoey_3.11328,847,191 - 29,144,520 (-)NCBI
UNSW_CanFamBas_1.01328,946,895 - 29,244,508 (-)NCBI
UU_Cfam_GSD_1.01329,258,881 - 29,556,646 (-)NCBI
Kcnq3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053039,286,465 - 9,587,259 (+)NCBI
SpeTri2.0NW_00493647016,712,508 - 17,009,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,670,176 - 8,970,342 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,669,969 - 8,978,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,707,508 - 9,006,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18126,566,288 - 126,921,354 (-)NCBI
ChlSab1.1 Ensembl8126,566,545 - 126,622,712 (-)Ensembl
Vero_WHO_p1.0NW_02366603913,185,447 - 13,545,986 (+)NCBI
Kcnq3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473523,441,042 - 23,752,197 (+)NCBI

Position Markers
D7Rat18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,011,396 - 98,011,544 (+)MAPPER
Rnor_6.07106,995,385 - 106,995,532NCBIRnor6.0
Rnor_5.07106,942,155 - 106,942,302UniSTSRnor5.0
RGSC_v3.47103,612,740 - 103,612,887UniSTSRGSC3.4
RGSC_v3.47103,612,739 - 103,612,887RGDRGSC3.4
RGSC_v3.17103,646,970 - 103,647,117RGD
Celera794,565,424 - 94,565,579UniSTS
RH 3.4 Map7678.2RGD
RH 3.4 Map7678.2UniSTS
RH 2.0 Map7531.1RGD
FHH x ACI Map746.7299RGD
Cytogenetic Map7q33UniSTS
D7Got81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,960,870 - 97,961,107 (+)MAPPER
Rnor_6.07106,944,740 - 106,944,974NCBIRnor6.0
Rnor_5.07106,892,767 - 106,893,001UniSTSRnor5.0
RGSC_v3.47103,561,783 - 103,562,018RGDRGSC3.4
RGSC_v3.47103,561,784 - 103,562,018UniSTSRGSC3.4
RGSC_v3.17103,596,014 - 103,596,248RGD
RH 3.4 Map7677.1UniSTS
RH 3.4 Map7677.1RGD
RH 2.0 Map7529.9RGD
Cytogenetic Map7q33UniSTS
BF400035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,963,860 - 97,963,995 (+)MAPPER
Rnor_6.07106,947,728 - 106,947,862NCBIRnor6.0
Rnor_5.07106,895,755 - 106,895,889UniSTSRnor5.0
RGSC_v3.47103,564,772 - 103,564,906UniSTSRGSC3.4
Celera794,518,301 - 94,518,435UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
RH144157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,712 - 97,730,880 (+)MAPPER
Rnor_6.07106,714,973 - 106,715,140NCBIRnor6.0
Rnor_5.07106,663,115 - 106,663,282UniSTSRnor5.0
RGSC_v3.47103,325,444 - 103,325,611UniSTSRGSC3.4
Celera794,285,599 - 94,285,766UniSTS
RH 3.4 Map7672.8UniSTS
Cytogenetic Map7q33UniSTS
BE102380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,599 - 97,730,775 (+)MAPPER
Rnor_6.07106,714,860 - 106,715,035NCBIRnor6.0
Rnor_5.07106,663,002 - 106,663,177UniSTSRnor5.0
RGSC_v3.47103,325,331 - 103,325,506UniSTSRGSC3.4
Celera794,285,486 - 94,285,661UniSTS
RH 3.4 Map7671.9UniSTS
Cytogenetic Map7q33UniSTS
AU046741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,736,536 - 97,736,823 (+)MAPPER
mRatBN7.2797,736,649 - 97,736,823 (+)MAPPER
Rnor_6.07106,720,910 - 106,721,251NCBIRnor6.0
Rnor_6.07106,721,078 - 106,721,251NCBIRnor6.0
Rnor_5.07106,669,220 - 106,669,393UniSTSRnor5.0
Rnor_5.07106,669,052 - 106,669,393UniSTSRnor5.0
RGSC_v3.47103,331,381 - 103,331,554UniSTSRGSC3.4
Celera794,291,536 - 94,291,709UniSTS
Cytogenetic Map7q33UniSTS
BF416665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,002,380 - 98,002,579 (+)MAPPER
Rnor_6.07106,986,265 - 106,986,463NCBIRnor6.0
Rnor_5.07106,933,035 - 106,933,233UniSTSRnor5.0
RGSC_v3.47103,603,721 - 103,603,919UniSTSRGSC3.4
Celera794,556,405 - 94,556,603UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
BF390526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,877,581 - 97,877,781 (+)MAPPER
Rnor_6.07106,861,674 - 106,861,873NCBIRnor6.0
Rnor_5.07106,810,377 - 106,810,576UniSTSRnor5.0
RGSC_v3.47103,472,015 - 103,472,214UniSTSRGSC3.4
Celera794,432,370 - 94,432,569UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)768518460113518460Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)769399586111043530Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)769399586111043530Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)770421228115421228Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)777428105127748511Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)777428234122421148Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)781645773140745067Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)788365265119318087Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)788365265121986709Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)788365265133365265Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)788365265134673427Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)791018361136018361Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)793726906138726906Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)793726906138726906Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)798200188111043530Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)7100160423140335001Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)7102588256116249643Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)7103815550126525386Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)7103867802126080176Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:39
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000006930, ENSRNOT00000074573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52
Low 8 10 3 18 2 16 2
Below cutoff 1 26 17 11 16 11 5 5 4 28 20 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006930   ⟹   ENSRNOP00000006930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7106,717,229 - 106,753,592 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074573   ⟹   ENSRNOP00000065354
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7106,717,232 - 107,009,330 (-)Ensembl
RefSeq Acc Id: NM_031597   ⟹   NP_113785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2797,730,219 - 98,025,652 (-)NCBI
Rnor_6.07106,714,479 - 107,009,639 (-)NCBI
Rnor_5.07106,662,621 - 106,956,409 (-)NCBI
RGSC_v3.47103,325,185 - 103,627,045 (-)RGD
Celera794,285,105 - 94,579,630 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113785 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC79846 (Get FASTA)   NCBI Sequence Viewer  
  EDM16162 (Get FASTA)   NCBI Sequence Viewer  
  EDM16163 (Get FASTA)   NCBI Sequence Viewer  
  EDM16164 (Get FASTA)   NCBI Sequence Viewer  
  O88944 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113785   ⟸   NM_031597
- Sequence:
RefSeq Acc Id: ENSRNOP00000006930   ⟸   ENSRNOT00000006930
RefSeq Acc Id: ENSRNOP00000065354   ⟸   ENSRNOT00000074573
Protein Domains
Ion_trans   KCNQ_channel

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69222 AgrOrtholog
Ensembl Genes ENSRNOG00000005206 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006930 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000065354 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006930 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000074573 UniProtKB/TrEMBL
InterPro Ankyrin-G_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29682 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQC3-Ank-G_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnq3 PhenoGen
PRINTS KCNQ3CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI30_RAT UniProtKB/TrEMBL
  F1LPA2_RAT UniProtKB/TrEMBL
  KCNQ3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9Z240 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq3  potassium voltage-gated channel subfamily Q member 3  Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Kcnq3  potassium voltage-gated channel, subfamily Q, member 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnq3  potassium voltage-gated channel, subfamily Q, member 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in smooth muscle cells of the stomach 625508
gene_expression expressed at high levels in the brain but not in heart 625508
gene_physical_interaction interacts with calmodulin (CaM) 634683
gene_product 424 bp 625508