Prkcd (protein kinase C, delta) - Rat Genome Database

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Gene: Prkcd (protein kinase C, delta) Rattus norvegicus
Symbol: Prkcd
Name: protein kinase C, delta
RGD ID: 67383
Description: Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; cellular response to insulin stimulus; and positive regulation of glucose import. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and fatty liver disease. Orthologous to human PRKCD (protein kinase C delta); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; vascular endothelial growth factor signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nPKC-delta; Pkcd; protein kinase C delta type
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-formylpterin  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
aripiprazole  (ISO)
arjunolic acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
brimonidine tartrate  (EXP)
bromocriptine  (EXP)
butorphanol  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dextromethorphan  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (EXP,ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
folpet  (ISO)
fomepizole  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
heptachlor  (EXP)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
magnesium atom  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mitomycin C  (ISO)
morphine  (ISO)
Morroniside  (EXP)
motexafin gadolinium  (ISO)
myo-inositol hexakisphosphate  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naringin  (EXP)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
oroxylin A  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
phencyclidine  (ISO)
phenylephrine  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (EXP)
potassium cyanide  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
propranolol  (EXP)
puerarin  (ISO)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
rottlerin  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
staurosporine  (EXP,ISO)
streptozocin  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
testosterone  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
U50488  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,IMP,ISO,ISS)
B cell proliferation  (IEA,ISO)
cell chemotaxis  (IEA,ISO)
cellular response to angiotensin  (IEA,ISO,ISS)
cellular response to glucose starvation  (IEP)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to hydroperoxide  (IEA,ISO)
cellular response to insulin stimulus  (IEP)
cellular response to oxidative stress  (IDA)
cellular response to UV  (IEA,ISO,ISS)
cellular senescence  (IEA,ISO)
collagen metabolic process  (IMP)
D-aspartate import across plasma membrane  (IMP)
defense response to bacterium  (IEA,ISO,ISS)
DNA damage response  (IEA,ISO)
immunoglobulin mediated immune response  (IEA,ISO)
intracellular signal transduction  (IBA,IDA)
negative regulation of actin filament polymerization  (IEA,ISO,ISS)
negative regulation of filopodium assembly  (IEA,ISO,ISS)
negative regulation of glial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of platelet aggregation  (IEA,ISO,ISS)
neutrophil activation  (IEA,ISO)
phosphorylation  (IEA)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of ceramide biosynthetic process  (IEA,ISO)
positive regulation of glucose import  (IMP)
positive regulation of glucosylceramide catabolic process  (IEA,ISO)
positive regulation of MAP kinase activity  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of protein dephosphorylation  (IEA,ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of sphingomyelin catabolic process  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO,ISS)
post-translational protein modification  (IEA,ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IDA)
regulation of actin cytoskeleton organization  (ISO)
regulation of ceramide biosynthetic process  (ISO,ISS)
regulation of phosphorylation  (IDA)
response to amino acid  (IEP)
response to ethanol  (IEP)
response to glucose  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to mechanical stimulus  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to oxidative stress  (IMP)
response to xenobiotic stimulus  (IEP)
termination of signal transduction  (IEA,ISO)

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO,TAS)
endolysosome  (IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO,ISS)
membrane  (ISO)
mitochondrion  (IEA)
nuclear matrix  (IEA,ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA)
plasma membrane  (IEA,ISO)
postsynaptic cytosol  (IDA)


References - curated
# Reference Title Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Alpert E, etal., Biochem Pharmacol. 2007 Feb 1;73(3):368-77. Epub 2006 Oct 13.
3. Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Anantharam V, etal., Neurochem Int. 2007 May;50(6):834-47. Epub 2007 Feb 23.
4. Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Asaithambi A, etal., Mol Neurodegener. 2011 Jun 22;6:43. doi: 10.1186/1750-1326-6-43.
5. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Avignon A, etal., Diabetes. 1996 Oct;45(10):1396-404.
6. Effects of long-term elevated glucose on collagen formation by mesangial cells. Baccora MH, etal., Kidney Int. 2007 Aug 29;.
7. Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. Braun MU, etal., Mol Cell Biochem. 2004 Jul;262(1-2):135-43.
8. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Bright R, etal., Brain Res. 2007 May 4;1144:146-55. Epub 2007 Feb 2.
9. Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. Bull ND, etal., Curr Eye Res. 2007 Feb;32(2):123-31.
10. Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Bullard TA, etal., Can J Physiol Pharmacol. 2007 Feb;85(2):243-50.
11. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Calvert VS, etal., Hepatology. 2007 Jul;46(1):166-72.
12. Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. Carter RW and Kanagy NL, Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H309-16. Epub 2002 Sep 19.
13. Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue. Cataldi A, etal., Anat Rec (Hoboken). 2009 Aug;292(8):1135-42. doi: 10.1002/ar.20936.
14. Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Clavijo C, etal., Am J Physiol Cell Physiol. 2007 Jun;292(6):C2150-60.
15. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
16. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. DeVries TA, etal., EMBO J 2002 Nov 15;21(22):6050-60.
17. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Eitel K, etal., Diabetes. 2003 Apr;52(4):991-7.
18. Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Fareh J, etal., J Mol Cell Cardiol. 2000 Apr;32(4):665-76.
19. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Frank GD, etal., Mol Endocrinol 2002 Feb;16(2):367-77.
20. N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. Gareskog M and Wentzel P, J Endocrinol. 2007 Jan;192(1):207-14.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Giles TD, etal., Am J Physiol. 1998 Jan;274(1 Pt 2):H295-307.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. Goldberg HJ, etal., J Biol Chem 2002 Sep 13;277(37):33833-41.
25. Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. Ha H, etal., Am J Kidney Dis. 2001 Oct;38(4 Suppl 1):S204-7.
26. Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Horovitz-Fried M, etal., Cell Signal. 2007 Mar;19(3):556-62. Epub 2006 Aug 23.
27. BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Hsieh HL, etal., Cell Signal. 2007 Feb;19(2):330-40. Epub 2006 Jul 25.
28. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. Huang HC, etal., J Biol Chem 2002 Nov 8;277(45):42769-74.
29. Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. Hunter JC, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R800-9. Epub 2006 Sep 28.
30. Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. Johnsen DD, etal., Mol Cell Biochem. 2005 Feb;270(1-2):63-9.
31. Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms. Karagulova G, etal., J Pharmacol Exp Ther. 2007 May;321(2):517-25. Epub 2007 Feb 22.
32. Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia. Kolar F, etal., Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H224-30. Epub 2006 Aug 25.
33. Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Kubo-Murai M, etal., Mol Immunol. 2007 Mar;44(9):2257-64. Epub 2006 Dec 11.
34. Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Kuriyama M, etal., Biochem Biophys Res Commun. 2004 Dec 17;325(3):843-51.
35. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Lam TK, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E682-91.
36. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
37. Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system. Merchenthaler I, etal., J Comp Neurol. 1993 Oct 15;336(3):378-99. doi: 10.1002/cne.903360306.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. Mohammadi K, etal., J Biol Chem 2001 Nov 9;276(45):42050-6.
40. Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. Morabito D, etal., J Investig Med. 2001 Jul;49(4):310-8.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
43. Expression and characterization of protein kinase C-delta. Olivier AR and Parker PJ, Eur J Biochem. 1991 Sep 15;200(3):805-10.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. The structure, expression, and properties of additional members of the protein kinase C family. Ono Y, etal., J Biol Chem 1988 May 15;263(14):6927-32.
46. Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Papparella I, etal., Cardiovasc Res. 2007 Jan 15;73(2):432-8. Epub 2006 Oct 20.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Rosenzweig T, etal., Cell Signal. 2004 Nov;16(11):1299-308.
53. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. Saito S, etal., J Biol Chem. 2002 Nov 22;277(47):44695-700. Epub 2002 Sep 10.
54. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. Shizukuda Y, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1625-34.
55. Dual mechanism of autoregulation of protein kinase C in myocardial ischemia. Simonis G, etal., Mol Cell Biochem. 2007 Jan;295(1-2):121-8. Epub 2006 Aug 22.
56. Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Steiler TL, etal., Endocrinology. 2003 Dec;144(12):5259-67. Epub 2003 Aug 21.
57. Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. Stempka L, etal., J Biol Chem. 1999 Mar 26;274(13):8886-92.
58. PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. Talior I, etal., Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E405-11. Epub 2004 Oct 26.
59. Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC. Tan J, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R887-96. Epub 2006 Sep 21.
60. Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. Tan M, etal., J Biol Chem 2003 Jan 31;278(5):2824-8.
61. Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. Tapia JA, etal., Biochim Biophys Acta 2002 Dec 16;1593(1):99-113.
62. Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9.
63. Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). Wrede CE, etal., J Mol Endocrinol. 2003 Jun;30(3):271-86.
64. Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen identified by cDNA microarray. Yan F and Wang XM, World J Gastroenterol. 2007 Jun 28;13(24):3369-73.
65. Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. Zhang D, etal., J Neurosci. 2007 May 16;27(20):5349-62.
66. Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Zhang Y, etal., Cell Signal. 2007 Nov;19(11):2339-50. Epub 2007 Jul 27.
Additional References at PubMed
PMID:3691811   PMID:9447980   PMID:9677322   PMID:9687370   PMID:10431815   PMID:10446219   PMID:10617144   PMID:10708593   PMID:10713049   PMID:10721703   PMID:10770950   PMID:10882525  
PMID:11118818   PMID:11738801   PMID:11744693   PMID:11916978   PMID:11950946   PMID:11976687   PMID:11998977   PMID:12167703   PMID:12391145   PMID:12456804   PMID:12477932   PMID:12510148  
PMID:12566450   PMID:12606313   PMID:12619877   PMID:12700627   PMID:12809676   PMID:12826681   PMID:12878476   PMID:12893264   PMID:12904329   PMID:13679307   PMID:14555230   PMID:14561782  
PMID:14583092   PMID:14715667   PMID:15105418   PMID:15210825   PMID:15217780   PMID:15282327   PMID:15339931   PMID:15476586   PMID:15576445   PMID:15632189   PMID:15716854   PMID:15731106  
PMID:15769752   PMID:15774464   PMID:15817708   PMID:15838306   PMID:15935342   PMID:15961393   PMID:15963450   PMID:15978696   PMID:15991247   PMID:16118209   PMID:16361258   PMID:16361709  
PMID:16367743   PMID:16396499   PMID:16611985   PMID:16648180   PMID:16781675   PMID:16940418   PMID:16962999   PMID:16987961   PMID:17109817   PMID:17293847   PMID:17306383   PMID:17316401  
PMID:17531159   PMID:17569658   PMID:17728398   PMID:17825316   PMID:17901241   PMID:17938203   PMID:17959830   PMID:17978575   PMID:17989210   PMID:18097471   PMID:18158336   PMID:18180404  
PMID:18182053   PMID:18195168   PMID:18273864   PMID:18285345   PMID:18285462   PMID:18323529   PMID:18335519   PMID:18387943   PMID:18388183   PMID:18497307   PMID:18550549   PMID:18556656  
PMID:18583709   PMID:18668351   PMID:18725417   PMID:18836180   PMID:18991865   PMID:19056867   PMID:19057126   PMID:19059439   PMID:19063870   PMID:19246637   PMID:19249914   PMID:19279008  
PMID:19279011   PMID:19339511   PMID:19356729   PMID:19366211   PMID:19497417   PMID:19540196   PMID:19632305   PMID:19646462   PMID:19752773   PMID:19782747   PMID:19801500   PMID:19808702  
PMID:19820255   PMID:19837873   PMID:19837952   PMID:19879903   PMID:19900507   PMID:19914792   PMID:19914793   PMID:19965374   PMID:20395372   PMID:20578995   PMID:20610768   PMID:20686066  
PMID:20691763   PMID:20817341   PMID:20853175   PMID:21117027   PMID:21119009   PMID:21132404   PMID:21172324   PMID:21338602   PMID:21406958   PMID:21625957   PMID:21704002   PMID:21766206  
PMID:21789211   PMID:21865164   PMID:21984583   PMID:22259083   PMID:22265677   PMID:22282354   PMID:22371141   PMID:22499584   PMID:22554282   PMID:22577133   PMID:22648735   PMID:22684549  
PMID:22798525   PMID:22871113   PMID:22885697   PMID:22972957   PMID:23010893   PMID:23022406   PMID:23063429   PMID:23104422   PMID:23144458   PMID:23376485   PMID:23727579   PMID:23827392  
PMID:23932656   PMID:24008408   PMID:24018979   PMID:24107416   PMID:24211111   PMID:24519937   PMID:24840386   PMID:24909118   PMID:24914766   PMID:25489059   PMID:25659900   PMID:25707622  
PMID:25755284   PMID:26199377   PMID:26519110   PMID:26546672   PMID:27190303   PMID:27379421   PMID:27606614   PMID:28428613   PMID:28795305   PMID:29313986   PMID:29435096   PMID:29617417  
PMID:29705702   PMID:30641088   PMID:31257458   PMID:31908004   PMID:32291286  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh37353,195,225 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391430,317,310 - 30,348,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,317,311 - 30,348,167 (-)EnsemblGRCm39 Ensembl
GRCm381430,595,353 - 30,626,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,595,354 - 30,626,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,408,555 - 31,423,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,424,378 - 29,447,560 (-)NCBIMGSCv36mm8
Celera1426,853,019 - 26,867,962 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.82NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554303,124,738 - 3,153,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,125,066 - 3,151,857 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1353,162,376 - 53,193,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0353,104,137 - 53,135,588 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1354,330,328 - 54,357,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,330,328 - 54,357,910 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12036,723,491 - 36,751,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,723,809 - 36,752,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,660,459 - 36,673,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,001,697 - 37,030,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,001,704 - 37,031,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,438,983 - 36,452,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02036,800,686 - 36,814,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,015,742 - 37,029,186 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118170,754,028 - 170,788,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,892,366 - 3,923,515 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364733,892,625 - 3,923,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1335,290,610 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12214,561,401 - 14,592,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248224,033,130 - 4,059,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,035,819 - 4,062,907 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkcd
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:255
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000025858, ENSRNOT00000067639
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,407 - 5,769,550 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,313 - 6,655,455NCBIRnor6.0
Rnor_5.0166,589,172 - 6,589,314UniSTSRnor5.0
RGSC_v3.4165,954,398 - 5,954,541RGDRGSC3.4
RGSC_v3.4165,954,399 - 5,954,541UniSTSRGSC3.4
RGSC_v3.1165,954,396 - 5,954,539RGD
Celera169,419,482 - 9,419,624UniSTS
Cytogenetic Map16p16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,278 - 5,769,666 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,184 - 6,655,571NCBIRnor6.0
Rnor_5.0166,589,043 - 6,589,430UniSTSRnor5.0
RGSC_v3.4165,954,270 - 5,954,657UniSTSRGSC3.4
RGSC_v3.1165,954,266 - 5,954,655RGD
Celera169,419,366 - 9,419,753UniSTS
SHRSP x BN Map161.1599UniSTS
SHRSP x BN Map161.1599RGD
FHH x ACI Map165.3399RGD
Cytogenetic Map16p16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,531 - 5,769,780 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,437 - 6,655,685NCBIRnor6.0
Rnor_5.0166,589,296 - 6,589,544UniSTSRnor5.0
RGSC_v3.4165,954,523 - 5,954,771UniSTSRGSC3.4
Celera169,419,252 - 9,419,500UniSTS
RH 3.4 Map1631.5UniSTS
Cytogenetic Map16p16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,421 - 5,769,611 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,327 - 6,655,516NCBIRnor6.0
Rnor_5.0166,589,186 - 6,589,375UniSTSRnor5.0
RGSC_v3.4165,954,413 - 5,954,602UniSTSRGSC3.4
Celera169,419,421 - 9,419,610UniSTS
Cytogenetic Map16p16UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 39 35 19 19 19 46 35 41 11
Low 4 22 22 22 8 11 28 8
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NM_133307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF219629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC076505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000025858   ⟹   ENSRNOP00000025858
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)Ensembl
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067639   ⟹   ENSRNOP00000061108
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,772,620 - 5,799,352 (-)Ensembl
Rnor_6.0 Ensembl166,655,662 - 6,669,045 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112103   ⟹   ENSRNOP00000083061
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,769,215 - 5,789,049 (-)Ensembl
RefSeq Acc Id: NM_133307   ⟹   NP_579841
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2165,769,217 - 5,799,380 (-)NCBI
Rnor_6.0166,655,131 - 6,675,746 (-)NCBI
Rnor_5.0166,588,990 - 6,608,725 (-)NCBI
RGSC_v3.4165,954,218 - 5,975,743 (-)RGD
Celera169,398,816 - 9,419,806 (+)NCBI
RefSeq Acc Id: NP_579841   ⟸   NM_133307
- UniProtKB: Q9JL03 (UniProtKB/Swiss-Prot),   Q9JK29 (UniProtKB/Swiss-Prot),   Q6DG48 (UniProtKB/Swiss-Prot),   P09215 (UniProtKB/Swiss-Prot),   A0A140UHX0 (UniProtKB/TrEMBL),   A6KG32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061108   ⟸   ENSRNOT00000067639
RefSeq Acc Id: ENSRNOP00000025858   ⟸   ENSRNOT00000025858
RefSeq Acc Id: ENSRNOP00000083061   ⟸   ENSRNOT00000112103
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09215-F1-model_v2 AlphaFold P09215 1-673 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67383 AgrOrtholog
BIND 134041
BioCyc Gene G2FUF-12186 BioCyc
Ensembl Genes ENSRNOG00000016346 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025858 ENTREZGENE
  ENSRNOT00000025858.8 UniProtKB/TrEMBL
  ENSRNOT00000067639.4 UniProtKB/TrEMBL
  ENSRNOT00000112103.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170538 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkcd PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kin_C_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016346 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q6DG48 UniProtKB/Swiss-Prot
  Q9JK29 UniProtKB/Swiss-Prot
  Q9JL03 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkcd  protein kinase C, delta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocates from cytosol into the nucleus upon treatment with etoposide; Intralipid + heparin (IH) induces translocation from the cytosolic to membrane fraction 729633
gene_cellular_localization translocates from cytosol into the nucleus upon treatment with etoposide; Intralipid + heparin (IH) induces translocation from the cytosolic to membrane fraction 729667
gene_expression expressed in pancreatic acini 631304
gene_function binds phorbol esters 61695
gene_function binds phorbol esters 628336
gene_pathway activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 631304
gene_process involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation 61695
gene_process involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation 628336
gene_regulation maximal activation requires phosphatidylserine and diacylglycerol 61695
gene_regulation maximal activation requires phosphatidylserine and diacylglycerol 628336
gene_regulation tyrosine phosphorylation results in increased instability leading to degradation 631304
gene_regulation administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes 631304
gene_regulation protein is tyrosine phosphorylated by activated Cholecystokinin A receptor (Cckar) in pancreatic acinar cells 631304