Prkce (protein kinase C, epsilon) - Rat Genome Database

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Gene: Prkce (protein kinase C, epsilon) Rattus norvegicus
Analyze
Symbol: Prkce
Name: protein kinase C, epsilon
RGD ID: 61925
Description: Exhibits several functions, including SH3 domain binding activity; protein kinase C activity; and protein kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Localizes to several cellular components, including T-tubule; glutamatergic synapse; and presynaptic cytosol. Predicted to colocalize with Golgi apparatus. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: nPKC-epsilon; Pkce; protein kinase C epsilon type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,965,048 - 8,451,966 (-)NCBI
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arjunolic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
bisphenol A  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
CGS-21680  (EXP)
chelerythrine  (EXP,ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
daidzein  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dobutamine  (ISO)
dofetilide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Droloxifene  (ISO)
ethanol  (EXP,ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
gingerol  (ISO)
haloperidol  (EXP)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lysophosphatidylcholine  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylene blue  (ISO)
methylparaben  (ISO)
morin  (ISO)
myxothiazol  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
PD123319  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin E2  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
Ro 31-8220  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium cyanide  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin D  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell division  (IEA)
cellular response to ethanol  (ISO)
cellular response to hypoxia  (ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to prostaglandin E stimulus  (ISO)
intracellular signal transduction  (IBA,IDA,IEA)
lipopolysaccharide-mediated signaling pathway  (ISO,ISS)
locomotory exploration behavior  (ISO)
macrophage activation involved in immune response  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of mitochondrial calcium ion concentration  (IMP)
negative regulation of mitochondrial membrane potential  (IMP)
negative regulation of protein ubiquitination  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (IMP)
peptidyl-serine phosphorylation  (IBA,IMP,ISO)
positive regulation of actin filament polymerization  (ISO,ISS)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of cellular glucuronidation  (ISO)
positive regulation of cytokinesis  (ISO,ISS)
positive regulation of epithelial cell migration  (ISO,ISS)
positive regulation of fibroblast migration  (ISO,ISS)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of lipid catabolic process  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of wound healing  (ISO,ISS)
protein phosphorylation  (IEA,ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of synaptic vesicle exocytosis  (EXP)
response to morphine  (ISO)
TRAM-dependent toll-like receptor 4 signaling pathway  (ISO,ISS)

Cellular Component

References

References - curated
1. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
3. Csukai M, etal., J Biol Chem 1997 Nov 14;272(46):29200-6.
4. Dong S, etal., Mol Cell Biochem. 2010 Aug;341(1-2):195-206. doi: 10.1007/s11010-010-0450-5. Epub 2010 Apr 11.
5. Fenton RA, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
9. Housey GM, etal., Proc Natl Acad Sci U S A 1987 Feb;84(4):1065-9.
10. Jacob AI, etal., J Mol Endocrinol. 2010 Mar;44(3):155-69. Epub 2009 Dec 1.
11. Johnsen DD, etal., Mol Cell Biochem. 2005 Feb;270(1-2):63-9.
12. Kuroda S, etal., J Cell Biol 1999 Feb 8;144(3):403-11.
13. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
14. MGD data from the GO Consortium
15. Mohammadi K, etal., J Biol Chem 2001 Nov 9;276(45):42050-6.
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
18. Obis T, etal., Mol Brain. 2015 Dec 1;8(1):80. doi: 10.1186/s13041-015-0171-5.
19. Ono Y, etal., J Biol Chem 1988 May 15;263(14):6927-32.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated data pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Saito N, etal., Brain Res. 1993 Apr 2;607(1-2):241-8.
26. Seed Ahmed M, etal., PLoS One. 2015 Sep 23;10(9):e0135781. doi: 10.1371/journal.pone.0135781. eCollection 2015.
27. Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9.
28. Williams HC, etal., Circ Res. 2012 Jun 22;111(1):56-65. doi: 10.1161/CIRCRESAHA.111.255745. Epub 2012 May 22.
29. Young E, etal., Hippocampus 2002;12(4):457-64.
Additional References at PubMed
PMID:3691811   PMID:8940095   PMID:9447980   PMID:10407019   PMID:10431815   PMID:10879655   PMID:11118818   PMID:11696589   PMID:11738801   PMID:11746497   PMID:11884367   PMID:11934807  
PMID:11940581   PMID:11950946   PMID:12064598   PMID:12496267   PMID:12551921   PMID:12566450   PMID:12590138   PMID:12606313   PMID:12626328   PMID:12665507   PMID:12665800   PMID:12694383  
PMID:12763745   PMID:12829427   PMID:12837755   PMID:12943654   PMID:12967635   PMID:14529276   PMID:14534528   PMID:14561782   PMID:14578604   PMID:14613966   PMID:14679204   PMID:14963000  
PMID:15039458   PMID:15096499   PMID:15181371   PMID:15339253   PMID:15499382   PMID:15532718   PMID:15596539   PMID:15632189   PMID:15652511   PMID:15695813   PMID:15764590   PMID:15769752  
PMID:15805233   PMID:15838306   PMID:15886222   PMID:15905535   PMID:15949469   PMID:16084468   PMID:16270034   PMID:16336199   PMID:16564619   PMID:16574982   PMID:16648180   PMID:16720572  
PMID:16757566   PMID:16793902   PMID:16836642   PMID:16870611   PMID:16899053   PMID:16960097   PMID:17035302   PMID:17038313   PMID:17091491   PMID:17202284   PMID:17300177   PMID:17307294  
PMID:17350763   PMID:17513490   PMID:17553064   PMID:17569658   PMID:17577736   PMID:17603037   PMID:17611075   PMID:17660387   PMID:17673178   PMID:17675573   PMID:17728104   PMID:17728398  
PMID:17762167   PMID:17875639   PMID:17908177   PMID:17951366   PMID:17964599   PMID:17989210   PMID:18070622   PMID:18182053   PMID:18184652   PMID:18323529   PMID:18342576   PMID:18380541  
PMID:18388183   PMID:18390563   PMID:18408135   PMID:18417696   PMID:18480594   PMID:18486624   PMID:18496674   PMID:18534741   PMID:18556656   PMID:18586884   PMID:18604201   PMID:18668351  
PMID:18789391   PMID:18804478   PMID:18957990   PMID:18973552   PMID:19057126   PMID:19098115   PMID:19101610   PMID:19160413   PMID:19166962   PMID:19249914   PMID:19286950   PMID:19324912  
PMID:19339511   PMID:19373133   PMID:19401415   PMID:19429666   PMID:19432558   PMID:19470841   PMID:19563686   PMID:19593582   PMID:19685039   PMID:19842549   PMID:19879903   PMID:19929130  
PMID:20052676   PMID:20177957   PMID:20307649   PMID:20538683   PMID:20558438   PMID:20585956   PMID:20665664   PMID:20837910   PMID:20951185   PMID:21075822   PMID:21118579   PMID:21162303  
PMID:21183751   PMID:21236337   PMID:21625957   PMID:21855786   PMID:21880866   PMID:21899994   PMID:22139554   PMID:22233927   PMID:22259083   PMID:22323716   PMID:22426212   PMID:22427674  
PMID:22453000   PMID:22550975   PMID:22699119   PMID:22761303   PMID:22936275   PMID:23427086   PMID:23479225   PMID:23564461   PMID:23636617   PMID:23846691   PMID:23911427   PMID:24011917  
PMID:24058702   PMID:24298017   PMID:24667915   PMID:24742623   PMID:24770357   PMID:24827390   PMID:24828410   PMID:24998921   PMID:25450614   PMID:25470454   PMID:25761522   PMID:25857252  
PMID:26199377   PMID:26313243   PMID:26429793   PMID:26844384   PMID:27035121   PMID:27330081   PMID:27385722   PMID:27655723   PMID:27919679   PMID:27925653   PMID:28585865   PMID:29195789  
PMID:29266405   PMID:29470978   PMID:30053369   PMID:30352252   PMID:30392913   PMID:30607888  


Genomics

Comparative Map Data
Prkce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,965,048 - 8,451,966 (-)NCBI
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
PRKCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl245,651,345 - 46,187,990 (+)EnsemblGRCh38hg38GRCh38
GRCh38245,651,315 - 46,187,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37245,878,814 - 46,415,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,732,547 - 46,268,633 (+)NCBINCBI36hg18NCBI36
Build 34245,790,693 - 46,326,779NCBI
Celera245,717,245 - 46,253,470 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef245,617,217 - 46,153,158 (+)NCBIHuRef
CHM1_1245,810,047 - 46,345,904 (+)NCBICHM1_1
Prkce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391786,472,631 - 86,965,347 (+)NCBIGRCm39mm39
GRCm39 Ensembl1786,475,213 - 86,965,347 (+)Ensembl
GRCm381786,167,785 - 86,657,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,167,785 - 86,657,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,567,125 - 87,057,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,076,916 - 86,563,024 (+)NCBImm8
Celera1790,540,474 - 91,038,578 (+)NCBICelera
Cytogenetic Map17E4NCBI
Prkce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544112,642,697 - 13,139,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,642,703 - 13,142,396 (+)NCBIChiLan1.0ChiLan1.0
PRKCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A46,688,109 - 47,223,421 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A46,688,436 - 47,220,313 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A45,757,629 - 46,294,064 (+)NCBIMhudiblu_PPA_v0panPan3
PRKCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11047,976,929 - 48,464,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1047,976,768 - 48,535,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1047,832,146 - 48,319,423 (+)NCBI
ROS_Cfam_1.01048,849,986 - 49,335,766 (+)NCBI
UMICH_Zoey_3.11048,557,609 - 49,044,861 (+)NCBI
UNSW_CanFamBas_1.01048,849,404 - 49,334,809 (+)NCBI
UU_Cfam_GSD_1.01049,029,809 - 49,517,384 (+)NCBI
Prkce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,589,765 - 35,066,607 (-)NCBI
SpeTri2.0NW_0049365086,018,374 - 6,495,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,349,889 - 94,909,020 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,351,277 - 94,864,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,427,723 - 100,762,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11461,022,903 - 61,570,390 (-)NCBI
ChlSab1.1 Ensembl1461,026,017 - 61,242,343 (-)Ensembl
Vero_WHO_p1.0NW_02366604550,297,930 - 50,835,743 (+)NCBI
Prkce
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473827,118,764 - 27,630,733 (+)NCBI

Position Markers
D6Rat211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,275,655 - 8,275,790 (-)MAPPER
Rnor_6.069,659,961 - 9,660,095NCBIRnor6.0
Rnor_5.069,577,576 - 9,577,710UniSTSRnor5.0
RGSC_v3.469,807,867 - 9,808,002RGDRGSC3.4
RGSC_v3.469,807,868 - 9,808,002UniSTSRGSC3.4
RGSC_v3.169,807,867 - 9,808,002RGD
Celera68,004,968 - 8,005,102UniSTS
SHRSP x BN Map61.1099RGD
SHRSP x BN Map61.1099UniSTS
Cytogenetic Map6q12UniSTS
RH132957  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,232,099 - 8,232,286 (-)MAPPER
Rnor_6.069,704,663 - 9,704,849NCBIRnor6.0
Rnor_5.069,619,780 - 9,619,966UniSTSRnor5.0
Celera67,961,503 - 7,961,689UniSTS
Cytogenetic Map6q12UniSTS
RH133520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,964,891 - 7,965,091 (-)MAPPER
Rnor_6.069,973,353 - 9,973,552NCBIRnor6.0
Rnor_5.069,883,536 - 9,883,735UniSTSRnor5.0
RGSC_v3.4610,097,268 - 10,097,467UniSTSRGSC3.4
Celera67,696,005 - 7,696,204UniSTS
Cytogenetic Map6q12UniSTS
RH140883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,181,763 - 8,181,960 (-)MAPPER
Rnor_6.069,754,982 - 9,755,178NCBIRnor6.0
Rnor_5.069,669,040 - 9,669,236UniSTSRnor5.0
RGSC_v3.469,878,012 - 9,878,208UniSTSRGSC3.4
Celera67,911,138 - 7,911,334UniSTS
Cytogenetic Map6q12UniSTS
AL033630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,972,792 - 7,974,085 (-)MAPPER
Rnor_6.069,964,359 - 9,965,651NCBIRnor6.0
Rnor_5.069,874,542 - 9,875,834UniSTSRnor5.0
RGSC_v3.4610,088,274 - 10,089,566UniSTSRGSC3.4
Cytogenetic Map6q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6123620518Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6125048718Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)613505323600274Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000020959
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 34 3 2 11 2 64 19 27 11
Low 2 9 54 39 8 39 8 11 10 16 14 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020959   ⟹   ENSRNOP00000020959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)Ensembl
RefSeq Acc Id: NM_017171   ⟹   NP_058867
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.267,965,048 - 8,451,327 (-)NCBI
Rnor_6.069,483,400 - 9,973,396 (+)NCBI
Rnor_5.069,404,548 - 9,883,579 (+)NCBI
RGSC_v3.469,631,234 - 10,097,311 (+)RGD
Celera67,696,161 - 8,179,574 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111827   ⟹   XP_038967755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.267,965,352 - 8,451,966 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058867   ⟸   NM_017171
- Sequence:
RefSeq Acc Id: ENSRNOP00000020959   ⟸   ENSRNOT00000020959
RefSeq Acc Id: XP_038967755   ⟸   XM_039111827
- Peptide Label: isoform X1
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61925 AgrOrtholog
BIND 133998
Ensembl Genes ENSRNOG00000015603 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020959 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020959 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  nPKC_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29340 UniProtKB/Swiss-Prot
NCBI Gene 29340 ENTREZGENE
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkce PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kin_C_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LMV8_RAT UniProtKB/TrEMBL
  KPCE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6DUV1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkce  protein kinase C, epsilon      Name updated 70584 APPROVED
2001-12-12 Prkce  protein kinase C, epsilon      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED
2001-12-10 Prkce  protein kinase C, epsilon      --select from list or type below-- 69665 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493