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Gene: Prkce (protein kinase C, epsilon) Rattus norvegicus
Symbol: Prkce
Name: protein kinase C, epsilon
RGD ID: 61925
Description: Exhibits several functions, including SH3 domain binding activity; protein kinase C activity; and protein kinase binding activity. Involved in several processes, including negative regulation of mitochondrial calcium ion concentration; negative regulation of mitochondrial membrane potential; and negative regulation of release of sequestered calcium ion into cytosol. Localizes to several cellular components, including T-tubule; glutamatergic synapse; and presynaptic cytosol. Predicted to colocalize with Golgi apparatus. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,1-dichloroethene.
Type: protein-coding
Also known as: nPKC-epsilon; Pkce; protein kinase C epsilon type
Homo sapiens (human) : PRKCE (protein kinase C epsilon)  HGNC  Alliance
Mus musculus (house mouse) : Prkce (protein kinase C, epsilon)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkce (protein kinase C epsilon)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCE (protein kinase C epsilon)
Canis lupus familiaris (dog) : PRKCE (protein kinase C epsilon)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkce (protein kinase C epsilon)
Sus scrofa (pig) : PRKCE (protein kinase C epsilon)
Chlorocebus sabaeus (African green monkey) : PRKCE (protein kinase C epsilon)
Heterocephalus glaber (naked mole-rat) : Prkce (protein kinase C epsilon)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkce
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61925
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.