RGD Reference Report - Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. - Rat Genome Database

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Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway.

Authors: Sun, Qian  Lu, Na-Na  Feng, Lei 
Citation: Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
RGD ID: 127284846
Pubmed: PMID:29408335   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2018.02.009   (Journal Full-text)

Apigetrin (APG), as a flavonoid, has many cellular bioactivities, including regulation of oxidative stress, and induction of apoptosis. However, the means by which APG suppresses human gastric cancer are still little to be understood. In the present study, the anti-cancer effects of APG on human gastric cancer cells were investigated. The results indicated that APG could suppress the proliferation and induce apoptosis in gastric cancer cells. Its role in apoptosis induction was through reducing Bcl-2, and enhancing Bax, Caspase-9/-3 and poly ADP-ribose polymerase (PARP) cleavage. In addition, APG incubation resulted in the generation of intracellular reactive oxygen species (ROS) in cells. Meanwhile, APG suppressed constitutive and interleukin-6 (IL-6)-stimulated signal transducer and activator of transcription 3 (STAT3), Janus kinase 2 gene (JAK2) and Src activation. However, ROS scavenger, N-acety-l-cysteine (NAC), diminished apoptosis induced by APG. And APG-triggered de-phosphorylation of STAT3/JAK2 was rescued by NAC pre-treatment. In vivo, APG administration significantly inhibited the gastric cancer cell xenograft tumorigenesis through inducing apoptosis and inhibiting STAT3/JAK2 pathways. Taken together, the findings above illustrated that APG might be used as a promising candidate against human gastric cancer progression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
stomach cancer treatmentIEP 127284846; 127284846; 127284846; 127284846; 127284846; 127284846; 127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOBAX (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOBCL2 (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOCASP3 (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOCASP9 (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOJAK2 (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOMKI67 (Homo sapiens)127284846human cells in mouse modelRGD 
stomach cancer treatmentIEP 127284846human cells in a mouse modelRGD 
stomach cancer treatmentISOPARP1 (Homo sapiens)127284846human cells in a mouse modelRGD 
stomach cancer treatmentISOSRC (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 
stomach cancer treatmentISOSTAT3 (Homo sapiens)127284846; 127284846human cells in mouse modelRGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases expression of BAX protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases expression of BCL2 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOBAX (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases expression of BAX protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOBCL2 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases expression of BCL2 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP3 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP8 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP9 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOCASP3 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP3 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOCASP8 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP8 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOCASP9 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP9 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of JAK2 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOJAK2 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of JAK2 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of PARP protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOPARP1 (Homo sapiens)127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of PARP protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsEXP 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of SRC protein in the stomach)RGD 
N-acetyl-L-cysteine treatmentIEP 127284846N-acetyl-L-cysteine co-treated with Il-6 inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of STAT3 protein in the stomach)RGD 
N-acetyl-L-cysteine multiple interactionsISOSRC (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of SRC protein in the stomach)RGD 
N-acetyl-L-cysteine treatmentISOSTAT3 (Homo sapiens)127284846; 127284846N-acetyl-L-cysteine co-treated with Il-6 inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of STAT3 protein in the stomach)RGD 
stattic multiple interactionsEXP 127284846Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)RGD 
stattic multiple interactionsISOSTAT3 (Homo sapiens)127284846; 127284846Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bax  (BCL2 associated X, apoptosis regulator)
Bcl2  (BCL2, apoptosis regulator)
Casp3  (caspase 3)
Casp8  (caspase 8)
Casp9  (caspase 9)
Jak2  (Janus kinase 2)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Bax  (BCL2-associated X protein)
Bcl2  (B cell leukemia/lymphoma 2)
Casp3  (caspase 3)
Casp8  (caspase 8)
Casp9  (caspase 9)
Jak2  (Janus kinase 2)
Mki67  (antigen identified by monoclonal antibody Ki 67)
Parp1  (poly (ADP-ribose) polymerase family, member 1)
Src  (Rous sarcoma oncogene)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
BAX  (BCL2 associated X, apoptosis regulator)
BCL2  (BCL2 apoptosis regulator)
CASP3  (caspase 3)
CASP8  (caspase 8)
CASP9  (caspase 9)
JAK2  (Janus kinase 2)
MKI67  (marker of proliferation Ki-67)
PARP1  (poly(ADP-ribose) polymerase 1)
SRC  (SRC proto-oncogene, non-receptor tyrosine kinase)
STAT3  (signal transducer and activator of transcription 3)


Additional Information