RGD Reference Report - Activation of pp60c-src protein kinase activity in human colon carcinoma. - Rat Genome Database

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Activation of pp60c-src protein kinase activity in human colon carcinoma.

Authors: Bolen, J B  Veillette, A  Schwartz, A M  DeSeau, V  Rosen, N 
Citation: Bolen JB, etal., Proc Natl Acad Sci U S A. 1987 Apr;84(8):2251-5. doi: 10.1073/pnas.84.8.2251.
RGD ID: 150521541
Pubmed: PMID:2436227   (View Abstract at PubMed)
PMCID: PMC304627   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.84.8.2251   (Journal Full-text)

The tyrosine-specific protein kinase activity of pp60c-src molecules obtained from human colon carcinoma tissues and tumor-derived cell lines was found to be elevated over that from normal colon tissues or cultures of normal colon mucosal cells. The elevated pp60c-src protein kinase activity in tumor tissues and in cultured colon carcinoma cells does not appear to result solely from an increase in the abundance of the c-src-encoded protein, suggesting that the specific activity of the pp60c-src tyrosine phosphotransferase is enhanced. These results raise the possibility that activation of the pp60c-src protein kinase may contribute to the genesis of human colon tumors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colon carcinoma  IEP 150521541protein:increased phosphorylating activity:colon mucosaRGD 
colon carcinoma  ISOSRC (Homo sapiens)150521541; 150521541protein:increased phosphorylating activity:colon mucosaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)

Genes (Mus musculus)
Src  (Rous sarcoma oncogene)

Genes (Homo sapiens)
SRC  (SRC proto-oncogene, non-receptor tyrosine kinase)


Additional Information