Ceacam1 (CEA cell adhesion molecule 1) - Rat Genome Database

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Gene: Ceacam1 (CEA cell adhesion molecule 1) Rattus norvegicus
Analyze
Symbol: Ceacam1
Name: CEA cell adhesion molecule 1
RGD ID: 67396
Description: Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; and lateral plasma membrane. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adhesion molecule, CEA-like; adhesion molecule, CEA-like (mapped); ATP-dependent taurocolate-carrier protein; Bgp; BGPR; C-CAM 105; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule; carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Ccam1; Ccam1_mapped; CD66a; CEA-related cell adhesion molecule 1; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); cell adhesion molecule CEACAM1; cell-CAM 105; ecto-ATPase; GP110; osteocalcin; pp120; pp120/ecto-ATPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Ceacam1_v4   Ceacam1_v1   Ceacam1_v2   Ceacam1_v3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,171,401 - 90,187,810 (-)NCBIGRCr8
mRatBN7.2181,043,595 - 81,060,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,043,595 - 81,059,992 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,435,793 - 86,452,183 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,986,760 - 95,003,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,191,573 - 88,207,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,327,955 - 82,344,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,589,574 - 83,605,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,742,540 - 80,758,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,822,590 - 80,837,016NCBI
Celera175,484,279 - 75,500,669 (-)NCBICelera
RH 3.4 Map1826.0RGD
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
diosmin  (ISO)
diuron  (ISO)
doramapimod  (EXP)
entinostat  (ISO)
erythromycin estolate  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
glucose  (ISO)
hydrazines  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ibuprofen  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
kainic acid  (ISO)
kojic acid  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quinidine  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bile acid and bile salt transport  (IDA)
blood vessel development  (ISO,ISS)
cell adhesion  (IDA,IEA)
cell-cell adhesion via plasma-membrane adhesion molecules  (IDA)
cell-cell junction organization  (ISO)
cellular response to insulin stimulus  (IDA)
common myeloid progenitor cell proliferation  (ISO,ISS)
granulocyte colony-stimulating factor signaling pathway  (ISO,ISS)
homophilic cell adhesion via plasma membrane adhesion molecules  (IDA)
insulin catabolic process  (IMP,ISO,ISS)
insulin receptor internalization  (IDA)
negative regulation of bone resorption  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of cytotoxic T cell degranulation  (ISO,ISS)
negative regulation of fatty acid biosynthetic process  (IMP)
negative regulation of granulocyte differentiation  (ISO,ISS)
negative regulation of hepatocyte proliferation  (IMP,ISO,ISS)
negative regulation of interleukin-1 production  (ISO,ISS)
negative regulation of lipid biosynthetic process  (ISO,ISS)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (ISO,ISS)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of platelet aggregation  (ISO,ISS)
negative regulation of protein kinase activity  (ISO,ISS)
negative regulation of T cell mediated cytotoxicity  (ISO,ISS)
negative regulation of T cell proliferation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO,ISS)
negative regulation of vascular permeability  (ISO,ISS)
positive regulation of homophilic cell adhesion  (IDA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of vasculogenesis  (ISO,ISS)
regulation of blood vessel remodeling  (ISO,ISS)
regulation of cell growth  (IDA)
regulation of cell migration  (ISO,ISS)
regulation of endothelial cell differentiation  (ISO,ISS)
regulation of endothelial cell migration  (ISO,ISS)
regulation of epidermal growth factor receptor signaling pathway  (IMP,ISO,ISS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of homophilic cell adhesion  (IDA)
regulation of immune system process  (IBA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
regulation of sprouting angiogenesis  (ISO,ISS)
signal transduction  (IBA)
wound healing, spreading of cells  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. Abou-Rjaily GA, etal., J Clin Invest. 2004 Oct;114(7):944-52.
2. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Britt DE, etal., Exp Cell Res 2004 Oct 15;300(1):134-48.
3. Secreted CEACAM1 splice variants in rat cell lines and in vivo in rat serum. Budt M, etal., Biochem Biophys Res Commun 2002 Apr 5;292(3):749-55.
4. The cytoplasmic domain of C-CAM is required for C-CAM-mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron. Cheung PH, etal., Biochem J 1993 Oct 15;295 ( Pt 2):427-35.
5. Cell-CAM105 isoforms with different adhesion functions are coexpressed in adult rat tissues and during liver development. Cheung PH, etal., J Biol Chem. 1993 Mar 25;268(9):6139-46.
6. Structure and function of C-CAM1. The first immunoglobulin domain is required for intercellular adhesion. Cheung PH, etal., J Biol Chem. 1993 Nov 15;268(32):24303-10.
7. Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors. Choice CV, etal., J Biol Chem. 1998 Aug 28;273(35):22194-200.
8. Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. Edlund M, etal., J Biol Chem. 1996 Jan 19;271(3):1393-9.
9. Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. Formisano P, etal., J Biol Chem. 1995 Oct 13;270(41):24073-7.
10. Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain. Fournes B, etal., Mol Cell Biol 2003 Oct;23(20):7291-304.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells. Huff LP, etal., Am J Physiol Cell Physiol. 2019 May 1;316(5):C621-C631. doi: 10.1152/ajpcell.00208.2018. Epub 2019 Feb 6.
14. Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells. Hunter I, etal., Biochem J. 1996 Dec 15;320 ( Pt 3):847-53.
15. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. Klaile E, etal., J Biol Chem. 2007 Sep 7;282(36):26629-40. doi: 10.1074/jbc.M701807200. Epub 2007 Jul 9.
16. The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters. Klaile E, etal., J Cell Biol. 2009 Nov 16;187(4):553-67. doi: 10.1083/jcb.200904149.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I. Lin SH and Guidotti G, J Biol Chem 1989 Aug 25;264(24):14408-14.
19. A short isoform of carcinoembryonic-antigen-related rat liver cell-cell adhesion molecule (C-CAM/gp110) mediates intercellular adhesion. Sequencing and recombinant functional analysis. Lucka L, etal., Eur J Biochem 1995 Dec 1;234(2):527-35.
20. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. Muller MM, etal., J Cell Biol. 2009 Nov 16;187(4):569-81.
21. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Najjar SM, etal., Biochemistry. 1995 Jul 25;34(29):9341-9.
22. Insulin acutely decreases hepatic fatty acid synthase activity. Najjar SM, etal., Cell Metab. 2005 Jul;2(1):43-53.
23. Cell adhesion activity of the short cytoplasmic domain isoform of C-CAM (C-CAM2) in CHO cells. Olsson H, etal., FEBS Lett. 1995 May 22;365(1):51-6.
24. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. Poy MN, etal., J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.
25. CEACAM1 regulates insulin clearance in liver. Poy MN, etal., Nat Genet 2002 Mar;30(3):270-6.
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. Singer BB, etal., J Immunol 2002 May 15;168(10):5139-46.
28. Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. Sippel CJ, etal., J Biol Chem. 1994 Jul 29;269(30):19539-45.
29. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. C-CAM (cell-CAM 105) is an adhesive cell surface glycoprotein with homophilic binding properties. Tingstrom A, etal., J Cell Sci. 1990 May;96 ( Pt 1):17-25.
32. Homophilic intercellular adhesion mediated by C-CAM is due to a domain 1-domain 1 reciprocal binding. Wikstrom K, etal., Exp Cell Res. 1996 Sep 15;227(2):360-6.
Additional References at PubMed
PMID:1633107   PMID:1637321   PMID:1648219   PMID:1719235   PMID:1831973   PMID:1985902   PMID:2141577   PMID:2164599   PMID:6327825   PMID:7478590   PMID:8018919   PMID:8380065  
PMID:8380406   PMID:8402684   PMID:8420979   PMID:8504806   PMID:8513803   PMID:8621519   PMID:8896983   PMID:9343248   PMID:10436421   PMID:10491101   PMID:11483763   PMID:12477932  
PMID:12832451   PMID:15184366   PMID:15489334   PMID:15909305   PMID:15950623   PMID:16044082   PMID:16291724   PMID:16680193   PMID:17081782   PMID:17192268   PMID:18424730   PMID:18544705  
PMID:18794798   PMID:19008452   PMID:19199708   PMID:19358828   PMID:20036346   PMID:21029969   PMID:21081647   PMID:22179047   PMID:22235309   PMID:22496641   PMID:22962327   PMID:23123061  
PMID:23533145   PMID:23696226   PMID:23800882   PMID:24743304   PMID:25363763   PMID:25490771   PMID:26483485  


Genomics

Comparative Map Data
Ceacam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,171,401 - 90,187,810 (-)NCBIGRCr8
mRatBN7.2181,043,595 - 81,060,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,043,595 - 81,059,992 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,435,793 - 86,452,183 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,986,760 - 95,003,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,191,573 - 88,207,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,327,955 - 82,344,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,589,574 - 83,605,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,742,540 - 80,758,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,822,590 - 80,837,016NCBI
Celera175,484,279 - 75,500,669 (-)NCBICelera
RH 3.4 Map1826.0RGD
Cytogenetic Map1q21NCBI
CEACAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,507,306 - 42,528,481 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,507,304 - 42,561,234 (-)EnsemblGRCh38hg38GRCh38
GRCh371943,011,458 - 43,032,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,703,298 - 47,724,479 (-)NCBINCBI36Build 36hg18NCBI36
Build 341947,703,298 - 47,724,438NCBI
Celera1939,812,240 - 39,833,442 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,441,679 - 39,462,877 (-)NCBIHuRef
CHM1_11943,013,129 - 43,034,353 (-)NCBICHM1_1
T2T-CHM13v2.01945,326,710 - 45,347,884 (-)NCBIT2T-CHM13v2.0
Ceacam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,161,127 - 25,177,072 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,161,132 - 25,177,028 (-)EnsemblGRCm39 Ensembl
GRCm38725,461,702 - 25,477,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,461,707 - 25,477,603 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,246,721 - 26,262,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,170,462 - 25,186,385 (-)NCBIMGSCv36mm8
Celera720,077,172 - 20,093,096 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.84NCBI
Ceacam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955555426,894 - 446,235 (+)NCBIChiLan1.0ChiLan1.0
CEACAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,612,825 - 48,634,202 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,483,506 - 50,502,918 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,395,550 - 39,417,063 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,987,522 - 48,008,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,989,430 - 48,008,739 (-)Ensemblpanpan1.1panPan2
CEACAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,902,429 - 111,919,191 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,745,413 - 111,917,830 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,327,263 - 111,342,206 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,464,630 - 112,529,985 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,320,743 - 112,529,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,027,612 - 112,084,452 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,661,182 - 111,718,360 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,587,794 - 112,644,821 (+)NCBIUU_Cfam_GSD_1.0
LOC101954488
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,690,137 - 15,707,040 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493670637,480 - 53,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEACAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1649,437,308 - 49,460,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,330,417 - 45,353,721 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEACAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,708,368 - 36,731,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,708,311 - 36,730,189 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,956,410 - 14,978,884 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ceacam1
160 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1198
Count of miRNA genes:283
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000027933, ENSRNOT00000029487, ENSRNOT00000051892
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
BE097239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,044,505 - 81,044,706 (+)MAPPERmRatBN7.2
Rnor_6.0182,328,866 - 82,329,066NCBIRnor6.0
Rnor_5.0183,590,485 - 83,590,685UniSTSRnor5.0
RGSC_v3.4180,743,451 - 80,743,651UniSTSRGSC3.4
Celera175,485,190 - 75,485,390UniSTS
RH 3.4 Map1822.9UniSTS
Cytogenetic Map1q21-q22UniSTS
RH142426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,047,931 - 81,048,123 (+)MAPPERmRatBN7.2
Rnor_6.0182,332,292 - 82,332,483NCBIRnor6.0
Rnor_5.0183,593,911 - 83,594,102UniSTSRnor5.0
RGSC_v3.4180,746,890 - 80,747,081UniSTSRGSC3.4
Celera175,488,616 - 75,488,807UniSTS
RH 3.4 Map1826.0UniSTS
Cytogenetic Map1q21-q22UniSTS
BI274452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,044,721 - 81,044,928 (+)MAPPERmRatBN7.2
Rnor_6.0182,329,082 - 82,329,288NCBIRnor6.0
Rnor_5.0183,590,701 - 83,590,907UniSTSRnor5.0
RGSC_v3.4180,743,667 - 80,743,873UniSTSRGSC3.4
Celera175,485,406 - 75,485,612UniSTS
RH 3.4 Map1827.1UniSTS
Cytogenetic Map1q21-q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA333997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M92848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X71122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z12019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027214   ⟹   ENSRNOP00000027213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,053,305 - 81,059,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000027933   ⟹   ENSRNOP00000027933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,043,595 - 81,059,986 (-)Ensembl
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029487   ⟹   ENSRNOP00000031260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,043,595 - 81,059,986 (-)Ensembl
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051892   ⟹   ENSRNOP00000046654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,043,595 - 81,059,986 (-)Ensembl
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090629   ⟹   ENSRNOP00000074820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,043,595 - 81,059,986 (-)Ensembl
Rnor_6.0 Ensembl182,327,955 - 82,344,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103781   ⟹   ENSRNOP00000085270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,045,551 - 81,059,986 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111729   ⟹   ENSRNOP00000089582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,043,595 - 81,059,986 (-)Ensembl
RefSeq Acc Id: NM_001033860   ⟹   NP_001029032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,171,401 - 90,187,792 (-)NCBI
mRatBN7.2181,043,595 - 81,059,986 (-)NCBI
Rnor_6.0182,327,955 - 82,344,345 (-)NCBI
Rnor_5.0183,589,574 - 83,605,846 (-)NCBI
RGSC_v3.4180,742,540 - 80,758,943 (-)RGD
Celera175,484,279 - 75,500,669 (-)RGD
Sequence:
RefSeq Acc Id: NM_001033861   ⟹   NP_001029033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,171,401 - 90,187,792 (-)NCBI
mRatBN7.2181,043,595 - 81,059,986 (-)NCBI
Rnor_6.0182,327,955 - 82,344,345 (-)NCBI
Rnor_5.0183,589,574 - 83,605,846 (-)NCBI
RGSC_v3.4180,742,540 - 80,758,943 (-)RGD
Celera175,484,279 - 75,500,669 (-)RGD
Sequence:
RefSeq Acc Id: NM_001033862   ⟹   NP_001029034
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,171,401 - 90,187,792 (-)NCBI
mRatBN7.2181,043,595 - 81,059,986 (-)NCBI
Rnor_6.0182,327,955 - 82,344,345 (-)NCBI
Rnor_5.0183,589,574 - 83,605,846 (-)NCBI
RGSC_v3.4180,742,540 - 80,758,943 (-)RGD
Celera175,484,279 - 75,500,669 (-)RGD
Sequence:
RefSeq Acc Id: NM_031755   ⟹   NP_113943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,171,401 - 90,187,792 (-)NCBI
mRatBN7.2181,043,595 - 81,059,986 (-)NCBI
Rnor_6.0182,327,955 - 82,344,345 (-)NCBI
Rnor_5.0183,589,574 - 83,605,846 (-)NCBI
RGSC_v3.4180,742,540 - 80,758,943 (-)RGD
Celera175,484,279 - 75,500,669 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091997   ⟹   XP_038947925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,171,401 - 90,186,011 (-)NCBI
mRatBN7.2181,043,595 - 81,058,204 (-)NCBI
RefSeq Acc Id: XM_039092002   ⟹   XP_038947930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,185,909 - 90,187,810 (-)NCBI
mRatBN7.2181,058,098 - 81,060,050 (-)NCBI
RefSeq Acc Id: XM_063275061   ⟹   XP_063131131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,174,538 - 90,187,810 (-)NCBI
RefSeq Acc Id: NP_001029032   ⟸   NM_001033860
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63093 (UniProtKB/Swiss-Prot),   P16573 (UniProtKB/Swiss-Prot),   A6J963 (UniProtKB/TrEMBL),   A0A8I6A3J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029033   ⟸   NM_001033861
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9JHL6 (UniProtKB/TrEMBL),   F7EVH5 (UniProtKB/TrEMBL),   A0A8I6A3J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029034   ⟸   NM_001033862
- Peptide Label: isoform 3 precursor
- UniProtKB: A6J966 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_113943   ⟸   NM_031755
- Peptide Label: isoform 4 precursor
- UniProtKB: Q9JHL7 (UniProtKB/TrEMBL),   F7EUP5 (UniProtKB/TrEMBL),   F7F6B2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046654   ⟸   ENSRNOT00000051892
Ensembl Acc Id: ENSRNOP00000074820   ⟸   ENSRNOT00000090629
Ensembl Acc Id: ENSRNOP00000031260   ⟸   ENSRNOT00000029487
Ensembl Acc Id: ENSRNOP00000027933   ⟸   ENSRNOT00000027933
RefSeq Acc Id: XP_038947925   ⟸   XM_039091997
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947930   ⟸   XM_039092002
- Peptide Label: isoform X3
- UniProtKB: Q78E86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000027213   ⟸   ENSRNOT00000027214
Ensembl Acc Id: ENSRNOP00000089582   ⟸   ENSRNOT00000111729
Ensembl Acc Id: ENSRNOP00000085270   ⟸   ENSRNOT00000103781
RefSeq Acc Id: XP_063131131   ⟸   XM_063275061
- Peptide Label: isoform X1
- UniProtKB: A6J966 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16573-F1-model_v2 AlphaFold P16573 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689817
Promoter ID:EPDNEW_R342
Type:multiple initiation site
Name:Ceacam1_1
Description:carcinoembryonic antigen related cell adhesion molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,344,358 - 82,344,418EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67396 AgrOrtholog
BioCyc Gene G2FUF-60379 BioCyc
Ensembl Genes ENSRNOG00000020578 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027933 ENTREZGENE
  ENSRNOT00000029487 ENTREZGENE
  ENSRNOT00000051892 ENTREZGENE
  ENSRNOT00000051892.7 UniProtKB/Swiss-Prot
  ENSRNOT00000090629 ENTREZGENE
  ENSRNOT00000090629.2 UniProtKB/Swiss-Prot
  ENSRNOT00000103781 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599117 IMAGE-MGC_LOAD
InterPro CEA_cell_adhesion UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report rno:81613 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72387 IMAGE-MGC_LOAD
NCBI Gene 81613 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/Swiss-Prot
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Ceacam1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020578 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
TIGR TC205360
  TC205361
UniProt A0A8I6A3J5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACX8_RAT UniProtKB/TrEMBL
  A6J963 ENTREZGENE, UniProtKB/TrEMBL
  A6J966 ENTREZGENE, UniProtKB/TrEMBL
  CEAM1_RAT UniProtKB/Swiss-Prot
  F7EUP5 ENTREZGENE, UniProtKB/TrEMBL
  F7EVH5 ENTREZGENE, UniProtKB/TrEMBL
  F7F6B2 ENTREZGENE, UniProtKB/TrEMBL
  P16573 ENTREZGENE
  Q63093 ENTREZGENE
  Q78E86 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHL6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHL7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63093 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 Ceacam1  CEA cell adhesion molecule 1  Ceacam1  carcinoembryonic antigen related cell adhesion molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Ceacam1  carcinoembryonic antigen related cell adhesion molecule 1  Ceacam1  carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Ceacam1  carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)  Ceacam1  CEA-related cell adhesion molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-23 Ceacam1  CEA-related cell adhesion molecule 1  Ccam1_mapped  adhesion molecule, CEA-like (mapped)  Data merged from RGD:69055 737654 APPROVED
2005-11-17 Ccam1_mapped  adhesion molecule, CEA-like (mapped)  Ccam1  adhesion molecule, CEA-like  Symbol and Name updated 1556543 APPROVED
2004-09-10 Ceacam1  CEA-related cell adhesion molecule 1    carcinoembryonic antigen-related cell adhesion molecule 1  Name updated 1299863 APPROVED
2002-06-10 Ceacam1  carcinoembryonic antigen-related cell adhesion molecule 1      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Ccam1  adhesion molecule, CEA-like      Symbol and Name status set to provisional 70585 PROVISIONAL
2001-10-22 Ceacam1  carcinoembryonic antigen-related cell adhesion molecule      Name updated 68916 PENDING

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cell-cell contacts, but requires activated Cdc42 and Rac1 for localization 1299145
gene_expression expressed in liver 625473
gene_expression expressed on epithelia, endothelia, lymphocytes, granulocytes and platelets 625473
gene_process receptor for various pathogens such as Neisseria and Haemophilus 625473
gene_process acts as a tumor suppressor and plays a role in angiogenesis and cellular polarization 625473
gene_process homophilic cell adhesion molecule 625473
gene_process plays a role in cell proliferation, tumor growth, apoptosis, angiogenesis, T cell cytotoxicity, dendritic cell function, granulocyte activation and epithelial cell polarization; also may function as a microbial receptor 625644
gene_product transmembrane glycoprotein 625644
gene_transcript contains two differential splicing products- Ceacam1_v1 (Ceacam1-L) and Ceacam1_v2 (Ceacam1-S) that have the identical four extracellular Ig domains but differ in their cytoplasmic domain 625644