RGD Reference Report - Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. - Rat Genome Database

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Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.

Authors: Wei, H  Liu, L  Chen, Q 
Citation: Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
RGD ID: 10400888
Pubmed: PMID:25840011   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbamcr.2015.03.013   (Journal Full-text)

The efficient and selective elimination of damaged or excessive mitochondria in response to bioenergetic and environmental cues is critical for maintaining a healthy and appropriate population of mitochondria. Mitophagy is considered to be the central mechanism of mitochondrial quality and quantity control. Atg32, a mitophagy receptor in yeast, recruits mitochondria targeted for degradation into the isolation membrane via both direct and indirect interactions with Atg8. In mammals, different mitophagy effectors, including the mitophagy receptors NIX, BNIP3 and FUDNC1 and the PINK1/Parkin pathway, have been identified to participate in the selective clearance of mitochondria. One common feature of mitophagy receptors is that they harbor an LC3-interacting region (LIR) that interacts with LC3, thus promoting the sequestration of mitochondria into the isolation membrane. Additionally, both receptor- and Parkin/PINK1-mediated mitophagy have been found to be regulated by reversible phosphorylation. Here, we review the recent progress in the understanding of the molecular mechanisms involved in selective mitophagy at multiple levels. We also discuss different mitophagy receptors from an evolutionary perspective and highlight the specific functions of and possible cooperation between distinct mechanisms of mitophagy. This article is part of a Special Issue entitled: Mitophagy.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATG7Humanmitochondrial autophagy pathway   TAS  RGD 
Atg7Ratmitochondrial autophagy pathway   ISOATG7 (Homo sapiens) RGD 
Atg7Mousemitochondrial autophagy pathway   ISOATG7 (Homo sapiens) RGD 
BNIP3Humanmitochondrial autophagy pathway   TAS  RGD 
BNIP3LHumanmitochondrial autophagy pathway   TAS  RGD 
Bnip3Ratmitochondrial autophagy pathway   ISOBNIP3 (Homo sapiens) RGD 
Bnip3Mousemitochondrial autophagy pathway   ISOBNIP3 (Homo sapiens) RGD 
Bnip3lRatmitochondrial autophagy pathway   ISOBNIP3L (Homo sapiens) RGD 
Bnip3lMousemitochondrial autophagy pathway   ISOBNIP3L (Homo sapiens) RGD 
CSNK2A1Humanmitochondrial autophagy pathway   TAS  RGD 
CSNK2A2Humanmitochondrial autophagy pathway   TAS  RGD 
CSNK2BHumanmitochondrial autophagy pathway   TAS  RGD 
Csnk2a1Ratmitochondrial autophagy pathway   ISOCSNK2A1 (Homo sapiens) RGD 
Csnk2a1Mousemitochondrial autophagy pathway   ISOCSNK2A1 (Homo sapiens) RGD 
Csnk2a2Ratmitochondrial autophagy pathway   ISOCSNK2A2 (Homo sapiens) RGD 
Csnk2a2Mousemitochondrial autophagy pathway   ISOCSNK2A2 (Homo sapiens) RGD 
Csnk2bRatmitochondrial autophagy pathway   ISOCSNK2B (Homo sapiens) RGD 
Csnk2bMousemitochondrial autophagy pathway   ISOCSNK2B (Homo sapiens) RGD 
FUNDC1Humanmitochondrial autophagy pathway   TAS  RGD 
Fundc1Mousemitochondrial autophagy pathway   ISOFUNDC1 (Homo sapiens) RGD 
Fundc1Ratmitochondrial autophagy pathway   ISOFUNDC1 (Homo sapiens) RGD 
PGAM5Humanmitochondrial autophagy pathway   TAS  RGD 
PINK1Humanmitochondrial autophagy pathway   TAS  RGD 
PRKNHumanmitochondrial autophagy pathway   TAS  RGD 
Pgam5Ratmitochondrial autophagy pathway   ISOPGAM5 (Homo sapiens) RGD 
Pgam5Mousemitochondrial autophagy pathway   ISOPGAM5 (Homo sapiens) RGD 
Pink1Ratmitochondrial autophagy pathway   ISOPINK1 (Homo sapiens) RGD 
Pink1Mousemitochondrial autophagy pathway   ISOPINK1 (Homo sapiens) RGD 
PrknRatmitochondrial autophagy pathway   ISOPRKN (Homo sapiens) RGD 
PrknMousemitochondrial autophagy pathway   ISOPRKN (Homo sapiens) RGD 
SRCHumanmitochondrial autophagy pathway   TAS  RGD 
SrcRatmitochondrial autophagy pathway   ISOSRC (Homo sapiens) RGD 
SrcMousemitochondrial autophagy pathway   ISOSRC (Homo sapiens) RGD 
ULK1Humanmitochondrial autophagy pathway   TAS  RGD 
Ulk1Mousemitochondrial autophagy pathway   ISOULK1 (Homo sapiens) RGD 
Ulk1Ratmitochondrial autophagy pathway   ISOULK1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atg7  (autophagy related 7)
Bnip3  (BCL2 interacting protein 3)
Bnip3l  (BCL2 interacting protein 3 like)
Csnk2a1  (casein kinase 2 alpha 1)
Csnk2a2  (casein kinase 2 alpha 2)
Csnk2b  (casein kinase 2 beta)
Fundc1  (FUN14 domain containing 1)
Pgam5  (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)
Pink1  (PTEN induced kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Src  (SRC proto-oncogene, non-receptor tyrosine kinase)
Ulk1  (unc-51 like autophagy activating kinase 1)

Genes (Mus musculus)
Atg7  (autophagy related 7)
Bnip3  (BCL2/adenovirus E1B interacting protein 3)
Bnip3l  (BCL2/adenovirus E1B interacting protein 3-like)
Csnk2a1  (casein kinase 2, alpha 1 polypeptide)
Csnk2a2  (casein kinase 2, alpha prime polypeptide)
Csnk2b  (casein kinase 2, beta polypeptide)
Fundc1  (FUN14 domain containing 1)
Pgam5  (phosphoglycerate mutase family member 5)
Pink1  (PTEN induced putative kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Src  (Rous sarcoma oncogene)
Ulk1  (unc-51 like kinase 1)

Genes (Homo sapiens)
ATG7  (autophagy related 7)
BNIP3  (BCL2 interacting protein 3)
BNIP3L  (BCL2 interacting protein 3 like)
CSNK2A1  (casein kinase 2 alpha 1)
CSNK2A2  (casein kinase 2 alpha 2)
CSNK2B  (casein kinase 2 beta)
FUNDC1  (FUN14 domain containing 1)
PGAM5  (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)
PINK1  (PTEN induced kinase 1)
PRKN  (parkin RBR E3 ubiquitin protein ligase)
SRC  (SRC proto-oncogene, non-receptor tyrosine kinase)
ULK1  (unc-51 like autophagy activating kinase 1)

Additional Information